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While the nuclear shell provides broad protection against host nucleases, it necessitates transport of mRNA out of the nucleus-like compartment for translation by host ribosomes, and transport of specific proteins into the nucleus-like compartment to support DNA replication and mRNA transcription. Here, we identify a conserved phage nuclear shell-associated protein that we term Chimallin C (ChmC), which adopts a nucleic acid-binding fold, binds RNA with high affinity in vitro, and binds phage mRNAs in infected cells. ChmC also forms phase-separated condensates with RNA in vitro. Targeted knockdown of ChmC using mRNA-targeting dCas13d results in accumulation of phage-encoded mRNAs in the phage nucleus, reduces phage protein production, and compromises virion assembly. Taken together, our data show that the conserved ChmC protein plays crucial roles in the viral life cycle, potentially by facilitating phage mRNA translocation through the nuclear shell to promote protein production and virion development.<\/jats:p>","DOI":"10.1093\/nar\/gkae216","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T19:54:07Z","timestamp":1710359647000},"page":"4440-4455","source":"Crossref","is-referenced-by-count":25,"title":["A phage nucleus-associated RNA-binding protein is required for jumbo phage infection"],"prefix":"10.1093","volume":"52","author":[{"given":"Eray","family":"Enustun","sequence":"first","affiliation":[{"name":"Department of Molecular Biology, University of California San Diego , La Jolla , CA\u00a0 92093 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0377-1209","authenticated-orcid":false,"given":"Emily 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Jolla , CA\u00a0 92093 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qishan","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Medicine, University of California San Diego , La Jolla , CA\u00a0 92093 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Aigner","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Medicine, University of California San Diego , La Jolla , CA\u00a0 92093 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7488-3040","authenticated-orcid":false,"given":"Benjamin\u00a0A","family":"Adler","sequence":"additional","affiliation":[{"name":"California Institute for Quantitative Biosciences (QB3), University of California , Berkeley , CA\u00a0 94720 , USA"},{"name":"Innovative Genomics Institute, University of California , Berkeley , CA\u00a0 94720 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2948-2846","authenticated-orcid":false,"given":"Brady\u00a0F","family":"Cress","sequence":"additional","affiliation":[{"name":"Innovative Genomics Institute, University of California , Berkeley , CA\u00a0 94720 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer\u00a0A","family":"Doudna","sequence":"additional","affiliation":[{"name":"California Institute for Quantitative Biosciences (QB3), University of California , Berkeley , CA\u00a0 94720 , USA"},{"name":"Innovative Genomics Institute, University of California , Berkeley , CA\u00a0 94720 , USA"},{"name":"Department of Molecular and Cell Biology, University of California , Berkeley , CA\u00a0 94720 , USA"},{"name":"Department of Chemistry, University of California , Berkeley , CA\u00a0 94720 , USA"},{"name":"Howard Hughes Medical Institute, University of California , Berkeley , CA\u00a0 94720 , 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majid","family":"Ghassemian","sequence":"additional","affiliation":[{"name":"Biomolecular and Proteomics Mass Spectrometry Facility, University of California San Diego , La Jolla , CA\u00a0 92093 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogdan","family":"Bintu","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Medicine, University of California San Diego , La Jolla , CA\u00a0 92093 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gene\u00a0W","family":"Yeo","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Medicine, University of California San Diego , La Jolla , CA\u00a0 92093 , USA"},{"name":"Moores Cancer Center, University of California at San Diego , La Jolla , CA , 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