{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T17:13:18Z","timestamp":1769447598117,"version":"3.49.0"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002794","name":"Swedish Cancer Society","doi-asserted-by":"publisher","award":["CAN2018\/469"],"award-info":[{"award-number":["CAN2018\/469"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Swedish Cancer Society","doi-asserted-by":"publisher","award":["CAN2021\/1506Pj01H"],"award-info":[{"award-number":["CAN2021\/1506Pj01H"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Swedish Childhood Cancer Fund\/Barncancerfonden","award":["PR2018-0091"],"award-info":[{"award-number":["PR2018-0091"]}]},{"name":"Swedish Childhood Cancer Fund\/Barncancerfonden","award":["PR2020-0088"],"award-info":[{"award-number":["PR2020-0088"]}]},{"name":"Swedish Childhood Cancer Fund\/Barncancerfonden","award":["PR2023-0115"],"award-info":[{"award-number":["PR2023-0115"]}]},{"name":"Swedish Childhood Cancer Fund\/Barncancerfonden","award":["2018-02757"],"award-info":[{"award-number":["2018-02757"]}]},{"name":"Swedish Childhood Cancer Fund\/Barncancerfonden","award":["2023-02865"],"award-info":[{"award-number":["2023-02865"]}]},{"name":"Swedish Childhood Cancer Fund\/Barncancerfonden","award":["2020-01291"],"award-info":[{"award-number":["2020-01291"]}]},{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","award":["787472"],"award-info":[{"award-number":["787472"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004722","name":"Lars Hierta Memorial Foundation","doi-asserted-by":"publisher","award":["FO2023-0501"],"award-info":[{"award-number":["FO2023-0501"]}],"id":[{"id":"10.13039\/501100004722","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004722","name":"Lars Hierta Memorial Foundation","doi-asserted-by":"publisher","award":["BA24.0451"],"award-info":[{"award-number":["BA24.0451"]}],"id":[{"id":"10.13039\/501100004722","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Sigurd and Elsa Golje Memorial Foundation","award":["LA2024-0099"],"award-info":[{"award-number":["LA2024-0099"]}]},{"DOI":"10.13039\/501100001691","name":"KAKENHI","doi-asserted-by":"publisher","award":["JP-19KK0400"],"award-info":[{"award-number":["JP-19KK0400"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Swedish Cancer Fund\/Cancerfonden","award":["22-0555"],"award-info":[{"award-number":["22-0555"]}]},{"DOI":"10.13039\/501100007051","name":"Uppsala University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007051","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The transforming growth factor \u03b2 (TGF-\u03b2) pathway is a developmental signaling network that regulates tissue homeostasis and malfunctions in human diseases, including cancer. TGF-\u03b2 signals via two receptors, which activate SMAD and alternative signaling pathways. We show that TGF-\u03b2 induces the expression of the mammalian long noncoding RNA (lncRNA) VIM-AS1 (Vimentin antisense RNA1) variant-2 (v.2) via a transcriptional SMAD-GATA6-SPI1 complex. VIM-AS1 v.1 and v.2 localize in different cell compartments, including the nuclear border. Unbiased whole transcriptomic analysis and functional gain and loss of function assays establish that VIM-AS1 v.2 enhances TGF-\u03b2 signaling. Mechanistically, VIM-AS1 v.2 interacts with the nucleoporin Nup358\/RanBP2, contributing to the binding of Nup358\/RanBP2 to SMAD2\/3 and enhancing SMAD nuclear accumulation. In the context of cancer biology, VIM-AS1 did not affect the antiproliferative actions of TGF-\u03b2, yet had an impact on the epithelial\u2013mesenchymal transition gene program, and increased the invasion and motility of tumor cells, whereas its silencing sensitized cancer cells to chemotherapeutic agents. The molecular mechanism highlights how a lncRNA can modulate the nuclear pore\u2019s capacity to import SMAD complexes, by facilitating their capture by Nup358\/RanBP2 and thereby enhancing nuclear accumulation of SMADs with distinct isoform composition, thus promoting selectively TGF-\u03b2 signaling responses.<\/jats:p>","DOI":"10.1093\/nar\/gkaf1526","type":"journal-article","created":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T12:28:59Z","timestamp":1768652939000},"source":"Crossref","is-referenced-by-count":0,"title":["The long noncoding RNA\n                    <i>VIM-AS1<\/i>\n                    and nucleoporin Nup358\/RanBP2 regulate SMAD nuclear accumulation during TGF-\u03b2 signaling"],"prefix":"10.1093","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8861-9240","authenticated-orcid":false,"given":"Dorival Mendes","family":"Rodrigues-Junior","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Box 582, Biomedical Center, Uppsala University , SE-751 23 Uppsala ,","place":["Sweden"]}]},{"given":"Mohamad Moustafa","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Box 582, Biomedical Center, Uppsala University , SE-751 23 Uppsala ,","place":["Sweden"]}]},{"given":"Yuka","family":"Itoh","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Box 582, Biomedical Center, Uppsala University , SE-751 23 Uppsala ,","place":["Sweden"]},{"name":"Department of Biochemistry, University of Yamanashi , Shimokato 1110, Chuo, Yamanashi 409-3898 ,","place":["Japan"]}]},{"given":"Mafalda Sousa","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Zoology, Science for Life Laboratory, Stockholm University , Tomtebodav\u00e4gen 23A, SE-171 65 Stockholm ,","place":["Sweden"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0915-5303","authenticated-orcid":false,"given":"Johan","family":"Heldin","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Biosciences, Uppsala University , Husargatan 3, SE-75124 Uppsala ,","place":["Sweden"]}]},{"given":"Hao","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Yamanashi , Shimokato 1110, Chuo, Yamanashi 409-3898 ,","place":["Japan"]}]},{"given":"Andr\u00e9","family":"Hoelz","sequence":"additional","affiliation":[{"name":"Division of Chemistry and Chemical Engineering, California Institute of Technology , Pasadena, CA 91125, United States"},{"name":"Howard Hughes Medical Institute, California Institute of Technology , Pasadena, CA, United States"}]},{"given":"Carl-Henrik","family":"Heldin","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Box 582, Biomedical Center, Uppsala University , SE-751 23 Uppsala ,","place":["Sweden"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9131-3827","authenticated-orcid":false,"given":"Aristidis","family":"Moustakas","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Box 582, Biomedical Center, Uppsala University , SE-751 23 Uppsala ,","place":["Sweden"]}]}],"member":"286","published-online":{"date-parts":[[2026,1,20]]},"reference":[{"key":"2026012005331546200_B1","doi-asserted-by":"crossref","first-page":"4007","DOI":"10.1016\/j.cell.2023.07.036","article-title":"TGF-\u03b2 signaling in health and disease","volume":"186","author":"Massagu\u00e9","year":"2023","journal-title":"Cell"},{"key":"2026012005331546200_B2","doi-asserted-by":"publisher","first-page":"487","DOI":"10.3390\/biom10030487","article-title":"TGF-\u03b2 signaling","volume":"10","author":"Tzavlaki","year":"2020","journal-title":"Biomolecules"},{"key":"2026012005331546200_B3","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1038\/s41580-023-00638-3","article-title":"Context-dependent TGF\u03b2 family signalling in cell fate regulation","volume":"24","author":"Richardson","year":"2023","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2026012005331546200_B4","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/S1097-2765(02)00586-5","article-title":"Smad2 nucleocytoplasmic shuttling by nucleoporins CAN\/Nup214 and Nup153 feeds TGF\u03b2 signaling complexes in the cytoplasm and nucleus","volume":"10","author":"Xu","year":"2002","journal-title":"Mol Cell"},{"key":"2026012005331546200_B5","doi-asserted-by":"publisher","first-page":"2211","DOI":"10.1111\/cas.13626","article-title":"Long noncoding RNA NORAD regulates transforming growth factor-\u03b2 signaling and epithelial-to-mesenchymal transition-like phenotype","volume":"109","author":"Kawasaki","year":"2018","journal-title":"Cancer Sci"},{"key":"2026012005331546200_B6","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1091\/mbc.12.4.1079","article-title":"Transforming growth factor-\u03b2 induces nuclear import of Smad3 in an importin-\u03b21 and Ran-dependent manner","volume":"12","author":"Kurisaki","year":"2001","journal-title":"Mol Biol Cell"},{"key":"2026012005331546200_B7","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1038\/sj.onc.1206212","article-title":"An extended bipartite nuclear localization signal in Smad4 is required for its nuclear import and transcriptional activity","volume":"22","author":"Xiao","year":"2003","journal-title":"Oncogene"},{"key":"2026012005331546200_B8","doi-asserted-by":"publisher","first-page":"22867","DOI":"10.1074\/jbc.M801320200","article-title":"Preferential utilization of Imp7\/8 in nuclear import of Smads","volume":"283","author":"Yao","year":"2008","journal-title":"J Biol Chem"},{"key":"2026012005331546200_B9","doi-asserted-by":"publisher","first-page":"6608","DOI":"10.1073\/pnas.0710134105","article-title":"Mathematical modeling identifies Smad nucleocytoplasmic shuttling as a dynamic signal-interpreting system","volume":"105","author":"Schmierer","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026012005331546200_B10","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1128\/MCB.26.4.1318-1332.2006","article-title":"The mechanism of nuclear export of Smad3 involves exportin 4 and Ran","volume":"26","author":"Kurisaki","year":"2006","journal-title":"Mol Cell Biol"},{"key":"2026012005331546200_B11","doi-asserted-by":"publisher","first-page":"9041","DOI":"10.1128\/MCB.20.23.9041-9054.2000","article-title":"Transforming growth factor \u03b2-independent shuttling of Smad4 between the cytoplasm and nucleus","volume":"20","author":"Pierreux","year":"2000","journal-title":"Mol Cell Biol"},{"key":"2026012005331546200_B12","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.devcel.2009.01.022","article-title":"Nuclear export of Smad2 and Smad3 by RanBP3 facilitates termination of TGF-\u03b2 signaling","volume":"16","author":"Dai","year":"2009","journal-title":"Dev Cell"},{"key":"2026012005331546200_B13","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1038\/s41586-022-05528-w","article-title":"A quantitative map of nuclear pore assembly reveals two distinct mechanisms","volume":"613","author":"Otsuka","year":"2023","journal-title":"Nature"},{"key":"2026012005331546200_B14","doi-asserted-by":"crossref","first-page":"a041264","DOI":"10.1101\/cshperspect.a041264","article-title":"Structure and function of the nuclear pore complex","volume":"14","author":"Petrovic","year":"2022","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"2026012005331546200_B15","doi-asserted-by":"publisher","first-page":"1622","DOI":"10.1038\/s41556-025-01768-w","article-title":"Nuclear mechanics as a determinant of nuclear pore complex plasticity","volume":"27","author":"Lusk","year":"2025","journal-title":"Nat Cell Biol"},{"key":"2026012005331546200_B16","doi-asserted-by":"publisher","first-page":"2672","DOI":"10.1111\/cas.14509","article-title":"Long non-coding RNAs and TGF-\u03b2 signaling in cancer","volume":"111","author":"Papoutsoglou","year":"2020","journal-title":"Cancer Sci"},{"key":"2026012005331546200_B17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.48101\/ujms.v129.10614","article-title":"Unboxing the network among long non-coding RNAs and TGF-\u03b2 signaling in cancer","volume":"129","author":"Rodrigues-Junior","year":"2024","journal-title":"Ups J Med Sci"},{"key":"2026012005331546200_B18","doi-asserted-by":"publisher","first-page":"3182","DOI":"10.1016\/j.celrep.2019.08.028","article-title":"The TGFB2-AS1 lncRNA regulates TGF-\u03b2 signaling by modulating corepressor activity","volume":"28","author":"Papoutsoglou","year":"2019","journal-title":"Cell Rep"},{"key":"2026012005331546200_B19","doi-asserted-by":"publisher","first-page":"5785","DOI":"10.1073\/pnas.1421197112","article-title":"Head-to-head antisense transcription and R-loop formation promotes transcriptional activation","volume":"112","author":"Boque-Sastre","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026012005331546200_B20","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.ejcb.2018.04.004","article-title":"Long noncoding RNA VIM-AS1 promotes colorectal cancer progression and metastasis by inducing EMT","volume":"97","author":"Rezanejad\u00a0Bardaji","year":"2018","journal-title":"Eur J Cell Biol"},{"key":"2026012005331546200_B21","doi-asserted-by":"publisher","first-page":"4567","DOI":"10.3892\/mmr.2020.11577","article-title":"lncRNA VIM\u2013AS1 promotes cell proliferation, metastasis and epithelial\u2013mesenchymal transition by activating the Wnt\/\u03b2\u2013catenin pathway in gastric cancer","volume":"22","author":"Sun","year":"2020","journal-title":"Mol Med Rep"},{"key":"2026012005331546200_B22","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1186\/s12935-021-01841-y","article-title":"The VIM-AS1\/miR-655\/ZEB1 axis modulates bladder cancer cell metastasis by regulating epithelial\u2013mesenchymal transition","volume":"21","author":"Xiong","year":"2021","journal-title":"Cancer Cell Int"},{"key":"2026012005331546200_B23","doi-asserted-by":"publisher","first-page":"1987","DOI":"10.1091\/mbc.e04-08-0658","article-title":"TGF-\u03b2 and the Smad signaling pathway support transcriptomic reprogramming during epithelial\u2013mesenchymal cell transition","volume":"16","author":"Valcourt","year":"2005","journal-title":"Mol Biol Cell"},{"key":"2026012005331546200_B24","first-page":"885","article-title":"Snail mediates crosstalk between TGF\u03b2 and LXR\u03b1 in hepatocellular carcinoma","volume":"25","author":"Bellomo","year":"2018","journal-title":"Cell Death Differ"},{"key":"2026012005331546200_B25","doi-asserted-by":"publisher","first-page":"3748","DOI":"10.1038\/s41388-021-01803-8","article-title":"The noncoding MIR100HG RNA enhances the autocrine function of transforming growth factor \u03b2 signaling","volume":"40","author":"Papoutsoglou","year":"2021","journal-title":"Oncogene"},{"key":"2026012005331546200_B26","doi-asserted-by":"publisher","first-page":"21113","DOI":"10.1038\/s41598-022-25534-2","article-title":"Aporphine and isoquinoline derivatives block glioblastoma cell stemness and enhance temozolomide cytotoxicity","volume":"12","author":"Rodrigues-Junior","year":"2022","journal-title":"Sci Rep"},{"key":"2026012005331546200_B27","doi-asserted-by":"publisher","first-page":"W556","DOI":"10.1093\/nar\/gkz430","article-title":"GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis","volume":"47","author":"Tang","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"2026012005331546200_B28","doi-asserted-by":"publisher","first-page":"W70","DOI":"10.1093\/nar\/gkn188","article-title":"The Vienna RNA websuite","volume":"36","author":"Gruber","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"2026012005331546200_B29","doi-asserted-by":"publisher","first-page":"e112","DOI":"10.1093\/nar\/gks339","article-title":"Automated 3D structure composition for large RNAs","volume":"40","author":"Popenda","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"2026012005331546200_B30","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1101\/gr.1933104","article-title":"Aligning multiple genomic sequences with the threaded blockset aligner","volume":"14","author":"Blanchette","year":"2004","journal-title":"Genome Res"},{"key":"2026012005331546200_B31","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1101\/gr.809403","article-title":"Human-mouse alignments with BLASTZ","volume":"13","author":"Schwartz","year":"2003","journal-title":"Genome Res"},{"key":"2026012005331546200_B32","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1101\/gr.097857.109","article-title":"Detection of nonneutral substitution rates on mammalian phylogenies","volume":"20","author":"Pollard","year":"2010","journal-title":"Genome Res"},{"key":"2026012005331546200_B33","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1101\/gr.3715005","article-title":"Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes","volume":"15","author":"Siepel","year":"2005","journal-title":"Genome Res"},{"key":"2026012005331546200_B34","doi-asserted-by":"publisher","first-page":"2348","DOI":"10.1126\/science.1067179","article-title":"Resolution of the early placental mammal radiation using Bayesian phylogenetics","volume":"294","author":"Murphy","year":"2001","journal-title":"Science"},{"key":"2026012005331546200_B35","doi-asserted-by":"publisher","first-page":"2137","DOI":"10.1111\/cas.70091","article-title":"Identification of a distal enhancer that regulates TGF-\u03b2-induced SNAI1 expression","volume":"116","author":"Fu","year":"2025","journal-title":"Cancer Sci"},{"key":"2026012005331546200_B36","doi-asserted-by":"publisher","first-page":"2083","DOI":"10.1016\/j.ymthe.2020.05.026","article-title":"Enhancer reprogramming within pre-existing topologically associated domains promotes TGF-\u03b2-induced EMT and cancer metastasis","volume":"28","author":"Qiao","year":"2020","journal-title":"Mol Ther"},{"key":"2026012005331546200_B37","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1038\/s41419-022-05280-z","article-title":"Loss of SNAI1 induces cellular plasticity in invasive triple-negative breast cancer cells","volume":"13","author":"Tsirigoti","year":"2022","journal-title":"Cell Death Dis"},{"key":"2026012005331546200_B38","doi-asserted-by":"publisher","first-page":"eabm9129","DOI":"10.1126\/science.abm9129","article-title":"Architecture of the cytoplasmic face of the nuclear pore","volume":"376","author":"Bley","year":"2022","journal-title":"Science"},{"key":"2026012005331546200_B39","doi-asserted-by":"publisher","first-page":"5400","DOI":"10.1038\/s41598-018-23582-1","article-title":"Improved efficiency of in situ protein analysis by proximity ligation using UnFold probes","volume":"8","author":"Klaesson","year":"2018","journal-title":"Sci Rep"},{"key":"2026012005331546200_B40","doi-asserted-by":"publisher","first-page":"R100","DOI":"10.1186\/gb-2006-7-10-r100","article-title":"CellProfiler: image analysis software for identifying and quantifying cell phenotypes","volume":"7","author":"Carpenter","year":"2006","journal-title":"Genome Biol"},{"key":"2026012005331546200_B41","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1093\/bioinformatics\/btr260","article-title":"Molecular signatures database (MSigDB) 3.0","volume":"27","author":"Liberzon","year":"2011","journal-title":"Bioinformatics"},{"key":"2026012005331546200_B42","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1038\/s41467-018-03265-1","article-title":"PAN-cancer analysis of S-phase enriched lncRNAs identifies oncogenic drivers and biomarkers","volume":"9","author":"Ali","year":"2018","journal-title":"Nat Commun"},{"key":"2026012005331546200_B43","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1074\/mcp.TIR119.001646","article-title":"DEqMS: a method for accurate variance estimation in differential protein expression analysis","volume":"19","author":"Zhu","year":"2020","journal-title":"Mol Cell Proteomics"},{"key":"2026012005331546200_B44","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1038\/nprot.2017.147","article-title":"Proteome-wide identification of ubiquitin interactions using UbIA-MS","volume":"13","author":"Zhang","year":"2018","journal-title":"Nat Protoc"},{"key":"2026012005331546200_B45","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.1038\/s41596-020-0312-x","article-title":"The HDOCK server for integrated protein\u2013protein docking","volume":"15","author":"Yan","year":"2020","journal-title":"Nat Protoc"},{"key":"2026012005331546200_B46","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.bbamcr.2006.11.017","article-title":"TGF\u03b21 regulation of vimentin gene expression during differentiation of the C2C12 skeletal myogenic cell line requires Smads, AP-1 and Sp1 family members","volume":"1773","author":"Wu","year":"2007","journal-title":"Biochim Biophys Acta"},{"key":"2026012005331546200_B47","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1261\/rna.028639.111","article-title":"Identification of cis- and trans-acting factors involved in the localization of MALAT-1 noncoding RNA to nuclear speckles","volume":"18","author":"Miyagawa","year":"2012","journal-title":"RNA"},{"key":"2026012005331546200_B48","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/nature11247","article-title":"An integrated encyclopedia of DNA elements in the human genome","volume":"489","author":"Consortium","year":"2012","journal-title":"Nature"},{"key":"2026012005331546200_B49","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.stemcr.2018.12.003","article-title":"GATA6 cooperates with EOMES\/SMAD2\/3 to deploy the gene regulatory network governing human definitive endoderm and pancreas formation","volume":"12","author":"Chia","year":"2019","journal-title":"Stem Cell Rep"},{"key":"2026012005331546200_B50","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.cell.2011.08.050","article-title":"Master transcription factors determine cell-type-specific responses to TGF-\u03b2 signaling","volume":"147","author":"Mullen","year":"2011","journal-title":"Cell"},{"key":"2026012005331546200_B51","first-page":"2090","article-title":"Long non-coding RNA VIM-AS1 promotes prostate cancer growth and invasion by regulating epithelial\u2013mesenchymal transition","volume":"24","author":"Zhang","year":"2019","journal-title":"J BUON"},{"key":"2026012005331546200_B52","doi-asserted-by":"publisher","first-page":"8306","DOI":"10.12659\/MSM.916601","article-title":"Long noncoding RNA VIM antisense RNA 1 (VIM-AS1) plays an important role in development of preeclampsia by regulation of epithelial mesenchymal transition","volume":"25","author":"Zhao","year":"2019","journal-title":"Med Sci Monit"},{"key":"2026012005331546200_B53","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.semcancer.2012.04.002","article-title":"Induction of epithelial\u2013mesenchymal transition by transforming growth factor \u03b2","volume":"22","author":"Moustakas","year":"2012","journal-title":"Semin Cancer Biol"},{"key":"2026012005331546200_B54","doi-asserted-by":"publisher","first-page":"5293","DOI":"10.1021\/pr500880b","article-title":"Isobaric labeling-based relative quantification in shotgun proteomics","volume":"13","author":"Rauniyar","year":"2014","journal-title":"J Proteome Res"},{"key":"2026012005331546200_B55","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1038\/nmeth.1611","article-title":"Predicting protein associations with long noncoding RNAs","volume":"8","author":"Bellucci","year":"2011","journal-title":"Nat Methods"},{"key":"2026012005331546200_B56","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1111\/j.1600-0854.2011.01302.x","article-title":"The nucleoporin Nup358\/RanBP2 promotes nuclear import in a cargo- and transport receptor-specific manner","volume":"13","author":"W\u00e4lde","year":"2012","journal-title":"Traffic"},{"key":"2026012005331546200_B57","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/1471-2148-9-28","article-title":"Emergence, development and diversification of the TGF-\u03b2 signalling pathway within the animal kingdom","volume":"9","author":"Huminiecki","year":"2009","journal-title":"BMC Evol Biol"},{"key":"2026012005331546200_B58","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1083\/jcb.201102018","article-title":"Ran-dependent docking of importin-\u03b2 to RanBP2\/Nup358 filaments is essential for protein import and cell viability","volume":"194","author":"Hamada","year":"2011","journal-title":"J Cell Biol"},{"key":"2026012005331546200_B59","doi-asserted-by":"publisher","first-page":"11482","DOI":"10.1038\/ncomms11482","article-title":"The RanBP2\/RanGAP1*SUMO1\/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes","volume":"7","author":"Ritterhoff","year":"2016","journal-title":"Nat Commun"},{"key":"2026012005331546200_B60","doi-asserted-by":"publisher","first-page":"2564","DOI":"10.1242\/jcs.197905","article-title":"Importin-\u03b2 and CRM1 control a RANBP2 spatiotemporal switch essential for mitotic kinetochore function","volume":"130","author":"Gilistro","year":"2017","journal-title":"J Cell Sci"},{"key":"2026012005331546200_B61","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1016\/j.molcel.2005.10.031","article-title":"Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping","volume":"20","author":"Fenger-Gron","year":"2005","journal-title":"Mol Cell"},{"key":"2026012005331546200_B62","doi-asserted-by":"publisher","first-page":"a022087","DOI":"10.1101\/cshperspect.a022087","article-title":"Posttranslational regulation of Smads","volume":"8","author":"Xu","year":"2016","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"2026012005331546200_B63","doi-asserted-by":"publisher","first-page":"153807","DOI":"10.1016\/j.prp.2022.153807","article-title":"Clinical significance of Vimentin antisense RNA 1 and its correlation with other epithelial to mesenchymal transition markers in oral cancers","volume":"232","author":"Bozgeyik","year":"2022","journal-title":"Pathol Res Pract"},{"key":"2026012005331546200_B64","doi-asserted-by":"publisher","first-page":"34","DOI":"10.3892\/ijo.2023.5482","article-title":"VIM\u2013AS1 promotes proliferation and drives enzalutamide resistance in prostate cancer via IGF2BP2\u2013mediated HMGCS1 mRNA stabilization","volume":"62","author":"Shi","year":"2023","journal-title":"Int J Oncol"},{"key":"2026012005331546200_B65","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.ijrobp.2024.09.049","article-title":"Long noncoding VIM-AS1: biomarker of breast fibrosis susceptibility after radiation therapy and promoter of transforming growth factor B1-driven fibrosis","volume":"121","author":"Vinasco-Sandoval","year":"2024","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/54\/2\/gkaf1526\/66471180\/gkaf1526.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/54\/2\/gkaf1526\/66471180\/gkaf1526.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T10:33:26Z","timestamp":1768905206000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/doi\/10.1093\/nar\/gkaf1526\/8431143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,14]]},"references-count":65,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,1,14]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkaf1526","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,1,27]]},"published":{"date-parts":[[2026,1,14]]},"article-number":"gkaf1526"}}