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Here we report recent developments with DisProt (version 8), including the doubling of protein entries, a new disorder ontology, improvements of the annotation format and a completely new website. The website includes a redesigned graphical interface, a better search engine, a clearer API for programmatic access and a new annotation interface that integrates text mining technologies. The new entry format provides a greater flexibility, simplifies maintenance and allows the capture of more information from the literature. The new disorder ontology has been formalized and made interoperable by adopting the OWL format, as well as its structure and term definitions have been improved. The new annotation interface has made the curation process faster and more effective. We recently showed that new DisProt annotations can be effectively used to train and validate disorder predictors. We believe the growth of DisProt will accelerate, contributing to the improvement of function and disorder predictors and therefore to illuminate the \u2018dark\u2019 proteome.<\/jats:p>","DOI":"10.1093\/nar\/gkz975","type":"journal-article","created":{"date-parts":[[2019,10,12]],"date-time":"2019-10-12T19:28:51Z","timestamp":1570908531000},"source":"Crossref","is-referenced-by-count":51,"title":["DisProt: intrinsic protein disorder annotation in 2020"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9224-9820","authenticated-orcid":false,"given":"Andr\u00e1s","family":"Hatos","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, University of Padova, Padova\u00a035121, Italy"}]},{"given":"Borb\u00e1la","family":"Hajdu-Solt\u00e9sz","sequence":"additional","affiliation":[{"name":"MTA-ELTE Lend\u00fclet Bioinformatics Research Group, Department of Biochemistry, E\u00f6tv\u00f6s Lor\u00e1nd University, Budapest\u00a01117, Hungary"}]},{"given":"Alexander M","family":"Monzon","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Padova, Padova\u00a035121, Italy"}]},{"given":"Nicolas","family":"Palopoli","sequence":"additional","affiliation":[{"name":"Departamento de Ciencia y Tecnolog\u00eda, Universidad Nacional de Quilmes - CONICET, Bernal, Buenos Aires B1876BXD, Argentina"}]},{"given":"Luc\u00eda","family":"\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas. Instituto de Investigaciones Biotecnol\u00f3gicas IIBIO, Universidad Nacional de San Mart\u00edn, San Mart\u00edn, Buenos Aires, Argentina"}]},{"given":"Burcu","family":"Aykac-Fas","sequence":"additional","affiliation":[{"name":"Computational Biology Laboratory, Danish Cancer Society Research Center, Copenhagen DK-2100, Denmark"}]},{"given":"Claudio","family":"Bassot","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics and Science for Life Laboratory, Stockholm University, Box 1031, Solna\u00a017121, Sweden"}]},{"given":"Guillermo I","family":"Ben\u00edtez","sequence":"additional","affiliation":[{"name":"Departamento de Ciencia y Tecnolog\u00eda, Universidad Nacional de Quilmes - CONICET, Bernal, Buenos Aires B1876BXD, Argentina"}]},{"given":"Martina","family":"Bevilacqua","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Padova, Padova\u00a035121, Italy"}]},{"given":"Anastasia","family":"Chasapi","sequence":"additional","affiliation":[{"name":"Biological Computation & Process Laboratory, Chemical Process & Energy Resources Institute, Centre for Research & Technology Hellas, Thessalonica GR-57500, Greece"}]},{"given":"Lucia","family":"Chemes","sequence":"additional","affiliation":[{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas. Instituto de Investigaciones Biotecnol\u00f3gicas IIBIO, Universidad Nacional de San Mart\u00edn, San Mart\u00edn, Buenos Aires, Argentina"},{"name":"Departamento de Fisiolog\u00eda y Biolog\u00eda Molecular y Celular (DFBMC), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina"}]},{"given":"Norman E","family":"Davey","sequence":"additional","affiliation":[{"name":"Division of Cancer Biology, The Institute of Cancer Research, Chelsea, London SW3 6BJ, UK"}]},{"given":"Radoslav","family":"Davidovi\u0107","sequence":"additional","affiliation":[{"name":"Laboratory for Bioinformatics and Computational Chemistry, Institute of Nuclear Sciences Vinca, University of Belgrade, Belgrade\u00a011001, Serbia"}]},{"given":"A\u00a0Keith","family":"Dunker","sequence":"additional","affiliation":[{"name":"Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, IN 46202, USA"}]},{"given":"Arne","family":"Elofsson","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics and Science for Life Laboratory, Stockholm University, Box 1031, Solna\u00a017121, Sweden"}]},{"given":"Julien","family":"Gobeill","sequence":"additional","affiliation":[{"name":"Swiss Institute of Bioinformatics and HES-SO \\ HEG, Geneva\u00a01200, Switzerland"}]},{"given":"Nicol\u00e1s S\u00a0Gonz\u00e1lez","family":"Foutel","sequence":"additional","affiliation":[{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas. 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