{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:08:05Z","timestamp":1753877285423,"version":"3.41.2"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"Supplement_1","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and Aims<\/jats:title>\n                  <jats:p>In chronic kidney disease (CKD), hypertension (HT) is commonly found during its development and is a leading cause for its progression. HT, dyslipidemia and visceral obesity are among the components of metabolic syndrome (MetS) and seem to associate with progression of CKD to end-stage kidney disease (ESKD).<\/jats:p>\n                  <jats:p>Enhanced levels of soluble tumor necrosis factor receptor 2 (sTNFR2) are known to associate with progressive CKD; and this biomarker was reported as an independent predictor of all-cause mortality in ESKD patients under dialysis. Concerning the TNFRSF1B gene, the polymorphism rs1061624 (A &amp;gt; G), located in the 3\u2032-untranslated region (3\u2032-UTR), was associated with the development of HT in men and with increased risk of MetS.<\/jats:p>\n                  <jats:p>The aim of this study was to determine the genotype frequencies of TNFRSF1B rs1061624 in ESKD patients with and without HT, and to evaluate its relationship with the circulating levels of some MetS biomarkers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Method<\/jats:title>\n                  <jats:p>We studied 277 ESKD patients on dialysis (recruited between 2016-2019), 170 diagnosed with HT and 107 without HT (no-HT group); age, sex, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP) and statin therapy were recorded. Real time PCR TaqMan SNP genotyping assay was used to assess genotype frequencies of TNFRSF1B rs1061624. We also evaluated the conventional lipid profile and the levels of oxidized low-density lipoprotein, adiponectin and leptin.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The genotype frequencies in patients with and without HT were different (P = 0.002); the AA genotype was less frequent in HT than in no-HT group, while GG and AG genotypes were more frequent. Considering the AA genotype carriers, HT ESKD patients (n = 23), compared to the no-HT group (n = 33), presented lower adiponectin levels (P = 0.025); for the AG genotype carriers, HT group (n = 89) presented a trend towards lower adiponectin concentrations (P = 0.055), and were younger than no-HT patients (n = 48; P&amp;lt;0.001); in both comparisons, groups were matched for sex, BMI and number of patients under statins treatment, and in the first case also for age. Considering GG genotype, HT patients (n = 58) only differed from no-HT subjects (n = 26) in SBP, that was higher (P&amp;lt;0.001). Among HT patients, AG genotype carriers presented higher DBP (P = 0.004), lower values of leptin (P = 0.012) and leptin\/adiponectin ratio (P = 0.022) and were younger (P&amp;lt;0.001) than GG genotype patients; compared to AA carriers, cholesterol levels were lower (P = 0.012). For the no-HT group, AG genotype patients presented lower DBP (P = 0.008) than AA genotype carriers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The genotype frequencies were different in ESKD patients with and without HT, being G allele more frequent in HT. The HT ESKD patients with the AA or the AG genotypes seem to present lower adiponectin levels than the ESKD no-HT patients with the same genotypes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Acknowledgements<\/jats:title>\n                  <jats:p>This work was financed by CESPU, through the project SNPsCKD-GI2-CESPU-2022; FCT, in the scope of the project UIDP\/04378\/2020 and UIDB\/04378\/2020 of the Research Unit on Applied Molecular Biosciences\u2014UCIBIO and the project LA\/P\/0140\/2020 of the Associate Laboratory Institute for Health and Bioeconomy\u2014i4HB.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ndt\/gfae069.1741","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T15:02:24Z","timestamp":1716476544000},"source":"Crossref","is-referenced-by-count":0,"title":["#1358 The association between TNFRSF1B rs1061624 polymorphism and hypertension in end-stage kidney disease patients on dialysis"],"prefix":"10.1093","volume":"39","author":[{"given":"Susana","family":"Coimbra","sequence":"first","affiliation":[{"name":"UCIBIO\u2014Applied Molecular Biosciences Unit, Department of Biological Sciences ; Associate Laboratory i4HB, Institute for Health and Bioeconomy; Faculdade de Farm\u00e1cia, Universidade do Porto, Porto , Portugal"},{"name":"TOXRUN\u2014Toxicology Research Unit, University Institute of Health Sciences , CESPU, CRL, Gandra, Portugal"}]},{"given":"Susana","family":"Rocha","sequence":"additional","affiliation":[{"name":"UCIBIO\u2014Applied Molecular Biosciences Unit, Department of Biological Sciences, Faculdade de Farm\u00e1cia, Universidade do Porto; Associate Laboratory i4HB, Institute for Health and Bioeconomy , Faculdade de Farm\u00e1cia, Universidade do Porto, Porto , Portugal"}]},{"given":"Cristina","family":"Catarino","sequence":"additional","affiliation":[{"name":"UCIBIO\u2014Applied Molecular Biosciences Unit, Department of Biological Sciences, Faculdade de Farm\u00e1cia, Universidade do Porto; Associate Laboratory i4HB, Institute for Health and Bioeconomy , Faculdade de Farm\u00e1cia, Universidade do Porto, Porto , Portugal"}]},{"given":"Maria Jo\u00e3o","family":"Valente","sequence":"additional","affiliation":[{"name":"National Food Institute, Technical University of Denmark , Kgs Lyngby, Denmark"}]},{"given":"Petronila","family":"Rocha-Pereira","sequence":"additional","affiliation":[{"name":"UCIBIO\u2014Applied Molecular Biosciences Unit, Department of Biological Sciences, Faculdade de Farm\u00e1cia, Universidade do Porto; Associate Laboratory i4HB, Institute for Health and Bioeconomy , Faculdade de Farm\u00e1cia, Universidade do Porto, Porto , Portugal"},{"name":"Health Science Research Centre, University of Beira Interior , Covilh\u00e3 , Portugal"}]},{"given":"Maria Do Sameiro","family":"Faria","sequence":"additional","affiliation":[{"name":"UCIBIO\u2014Applied Molecular Biosciences Unit, Department of Biological Sciences, Faculdade de Farm\u00e1cia, Universidade do Porto; Associate Laboratory i4HB, Institute for Health and Bioeconomy , Faculdade de Farm\u00e1cia, Universidade do Porto, Porto , Portugal"},{"name":"Hemodialysis Clinic Hospital Agostinho Ribeiro , Felgueiras, Portugal"}]},{"given":"Jos\u00e9 Gerardo","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Center for Health Technology and Services Research (CINTESIS), Faculty of Medicine, University of Porto , Portugal"},{"name":"Hemodialysis Clinic of Porto (CHP) , Porto , Portugal"}]},{"given":"Jo\u00e3o","family":"Fernandes","sequence":"additional","affiliation":[{"name":"NefroServe Hemodialysis Clinic of Viana do Castelo , Viana do Castelo , Portugal"}]},{"given":"Vasco M P","family":"Miranda","sequence":"additional","affiliation":[{"name":"Hemodialysis Clinic of Gondomar , Gondomar , Portugal"}]},{"given":"Lu\u00eds","family":"Belo","sequence":"additional","affiliation":[{"name":"UCIBIO\u2014Applied Molecular Biosciences Unit, Department of Biological Sciences, Faculdade de Farm\u00e1cia, Universidade do Porto; Associate Laboratory i4HB, Institute for Health and Bioeconomy , Faculdade de Farm\u00e1cia, Universidade do Porto, Porto , Portugal"}]},{"given":"Elsa","family":"Bronze-Da-Rocha","sequence":"additional","affiliation":[{"name":"UCIBIO\u2014Applied Molecular Biosciences Unit, Department of Biological Sciences, Faculdade de Farm\u00e1cia, Universidade do Porto; Associate Laboratory i4HB, Institute for Health and Bioeconomy , Faculdade de Farm\u00e1cia, Universidade do Porto, Porto , Portugal"}]},{"given":"Alice","family":"Santos-Silva","sequence":"additional","affiliation":[{"name":"UCIBIO\u2014Applied Molecular Biosciences Unit, Department of Biological Sciences, Faculdade de Farm\u00e1cia, Universidade do Porto; Associate Laboratory i4HB, Institute for Health and Bioeconomy , Faculdade de Farm\u00e1cia, Universidade do Porto, Porto , Portugal"}]}],"member":"286","published-online":{"date-parts":[[2024,5,23]]},"container-title":["Nephrology Dialysis Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ndt\/article-pdf\/39\/Supplement_1\/gfae069-1741-1358\/57794051\/gfae069-1741-1358.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ndt\/article-pdf\/39\/Supplement_1\/gfae069-1741-1358\/57794051\/gfae069-1741-1358.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T15:02:25Z","timestamp":1716476545000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ndt\/article\/doi\/10.1093\/ndt\/gfae069.1741\/7678147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-online":{"date-parts":[[2024,5,23]]},"published-print":{"date-parts":[[2024,5,23]]}},"URL":"https:\/\/doi.org\/10.1093\/ndt\/gfae069.1741","relation":{},"ISSN":["0931-0509","1460-2385"],"issn-type":[{"type":"print","value":"0931-0509"},{"type":"electronic","value":"1460-2385"}],"subject":[],"published-other":{"date-parts":[[2024,5]]},"published":{"date-parts":[[2024,5]]},"article-number":"gfae069-1741-1358"}}