{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T11:08:12Z","timestamp":1775041692083,"version":"3.50.1"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T00:00:00Z","timestamp":1521072000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NEUROSURGERY","NEUROS"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>BACKGROUND<\/jats:title>\n            <jats:p>The Medtronic Registry for Epilepsy (MORE; Medtronic Inc, Dublin, Ireland) is an open label observational study evaluating the long-term effectiveness, safety, and performance of deep brain stimulation (DBS) of the anterior nucleus of thalamus (ANT) for the treatment of refractory epilepsy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>OBJECTIVE<\/jats:title>\n            <jats:p>To compare the difference in success rate of placing contacts at ANT-target region (ANT-TR) between transventricular (TV) and extraventricular (EV) lead trajectories in 73 ANT-DBS implants in 17 European centers participating in the MORE registry.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS<\/jats:title>\n            <jats:p>The success rate of placing contacts at ANT-TR was evaluated using a screening method combining both individual patient imaging information and stereotactic atlas information to identify contacts at ANT-TR.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS<\/jats:title>\n            <jats:p>EV lead trajectory was used in 53% of the trajectories. Approximately, 90% of the TV lead trajectories had at least 1 contact at ANT-TR, vs only 71% of the EV lead trajectories. The success rate for placing at least 1 contact at ANT-TR bilaterally was 84% for TV implants and 58% for EV implants (<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; .05; Fisher's exact). No intracranial bleedings were observed, but 1 cortical infarct was reported following EV lead trajectory.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSION<\/jats:title>\n            <jats:p>The results of this registry support the use of TV lead trajectories for ANT-DBS as they have a higher probability in placing contacts at ANT-TR, without appearing to compromise procedural safety. Follow-up data collection is continuing in the MORE registry. These data will provide outcomes associated with TV and EV trajectories.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1093\/neuros\/nyy023","type":"journal-article","created":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T12:11:30Z","timestamp":1516623090000},"page":"141-150","source":"Crossref","is-referenced-by-count":62,"title":["The Surgical Approach to the Anterior Nucleus of Thalamus in Patients With Refractory Epilepsy: Experience from the International Multicenter Registry (MORE)"],"prefix":"10.1227","volume":"84","author":[{"given":"Kai","family":"Lehtim\u00e4ki","sequence":"first","affiliation":[{"name":"Department of Neurosciences and Rehabilitation, Tampere University Hospital, Tampere, Finland"}]},{"given":"Volker A","family":"Coenen","sequence":"additional","affiliation":[{"name":"Department of Stereotactic and Functional Neurosurgery, Freiburg University Medical Center, Freiburg, Germany"}]},{"given":"Antonio","family":"Gon\u00e7alves Ferreira","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hospital de Santa Maria, Lisbon, Portugal"}]},{"given":"Paul","family":"Boon","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ghent University Hospital, Ghent, Belgium"},{"name":"Kempenhaeghe, Academic Center for Epileptology, Heeze, The Netherlands"}]},{"given":"Christian","family":"Elger","sequence":"additional","affiliation":[{"name":"Department of Epileptology, University of Bonn, Bonn, Germany"}]},{"given":"Rod S","family":"Taylor","sequence":"additional","affiliation":[{"name":"Institute of Health Research (Primary Care), University of Exeter Medical School, Exeter, United Kingdom"}]},{"given":"Philippe","family":"Ryvlin","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Le Centre hospitalier universitaire vaudois, Lausanne, Switzerland"}]},{"given":"Antonio","family":"Gil-Nagel","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Ruber Internacional, Madrid, Spain"}]},{"given":"Frans","family":"Gielen","sequence":"additional","affiliation":[{"name":"Medtronic Bakken Research Center, Maastricht, The Netherlands"}]},{"given":"Thomas C","family":"Brionne","sequence":"additional","affiliation":[{"name":"Medtronic International Trading Sarl, Tolochenaz, Switzerland"}]},{"given":"Abdallah","family":"Abouihia","sequence":"additional","affiliation":[{"name":"Medtronic International Trading Sarl, Tolochenaz, Switzerland"}]},{"given":"Gr\u00e9gory","family":"Beth","sequence":"additional","affiliation":[{"name":"Medtronic International Trading Sarl, Tolochenaz, Switzerland"}]},{"name":"MORE investigators","sequence":"additional","affiliation":[]}],"member":"276","published-online":{"date-parts":[[2019,1]]},"reference":[{"issue":"3\u20135","key":"bib1-20231011","first-page":"244","article-title":"Reversibility of chronic neurologic deficits. 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