{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T14:44:59Z","timestamp":1778424299344,"version":"3.51.4"},"reference-count":217,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T00:00:00Z","timestamp":1630540800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Erasmus+ Programme of the European Union, Key Action 2","award":["2020\u20131-CZ01-KA203-078218"],"award-info":[{"award-number":["2020\u20131-CZ01-KA203-078218"]}]},{"name":"EFSA-CDN (Efficiency and Safety Improvement of Current Drugs and Nutraceuticals: Advanced Methods \u2013 New Challenges","award":["CZ.02.1.01\/0.0\/0.0\/16_019\/0000841"],"award-info":[{"award-number":["CZ.02.1.01\/0.0\/0.0\/16_019\/0000841"]}]},{"name":"European Regional Development Fund. Kr.M. acknowledges support from Charles University","award":["260 548"],"award-info":[{"award-number":["260 548"]}]},{"name":"European Regional Development Fund. Kr.M. acknowledges support from Charles University","award":["360221"],"award-info":[{"award-number":["360221"]}]},{"DOI":"10.13039\/501100009553","name":"Czech Health Research Council","doi-asserted-by":"publisher","award":["NU21J-02\u201300021"],"award-info":[{"award-number":["NU21J-02\u201300021"]}],"id":[{"id":"10.13039\/501100009553","id-type":"DOI","asserted-by":"publisher"}]},{"name":"MHCZ-DRO (Ministry of Health Czech Republic \u2013 Development Research Organisation, University Hospital Hradec Kr\u00e1lov\u00e9","award":["00179906"],"award-info":[{"award-number":["00179906"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Vitamin K is traditionally connected with blood coagulation, since it is needed for the posttranslational modification of 7 proteins involved in this cascade. However, it is also involved in the maturation of another 11 or 12 proteins that play different roles, encompassing in particular the modulation of the calcification of connective tissues. Since this process is physiologically needed in bones, but is pathological in arteries, a great deal of research has been devoted to finding a possible link between vitamin K and the prevention of osteoporosis and cardiovascular diseases. Unfortunately, the current knowledge does not allow us to make a decisive conclusion about such a link. One possible explanation for this is the diversity of the biological activity of vitamin K, which is not a single compound but a general term covering natural plant and animal forms of vitamin K (K1 and K2) as well as their synthetic congeners (K3 and K4). Vitamin K1 (phylloquinone) is found in several vegetables. Menaquinones (MK4\u2013MK13, a series of compounds known as vitamin K2) are mostly of a bacterial origin and are introduced into the human diet mainly through fermented cheeses. Current knowledge about the kinetics of different forms of vitamin K, their detection, and their toxicity are discussed in this review.<\/jats:p>","DOI":"10.1093\/nutrit\/nuab061","type":"journal-article","created":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T11:12:39Z","timestamp":1625829159000},"page":"677-698","source":"Crossref","is-referenced-by-count":218,"title":["Vitamin K \u2013 sources, physiological role, kinetics, deficiency, detection, therapeutic use, and toxicity"],"prefix":"10.1093","volume":"80","author":[{"given":"P\u0159emysl","family":"Mlad\u011bnka","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kr\u00e1lov\u00e9, Charles University, Hradec Kr\u00e1lov\u00e9, Czech Republic"}]},{"given":"Kate\u0159ina","family":"Mac\u00e1kov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy in Hradec Kr\u00e1lov\u00e9, Charles University, Hradec Kr\u00e1lov\u00e9, Czech Republic"}]},{"given":"Lenka","family":"Kujovsk\u00e1 Kr\u010dmov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Pharmacy in Hradec Kr\u00e1lov\u00e9, Charles University, Hradec Kr\u00e1lov\u00e9, Czech Republic"},{"name":"Department of Clinical Biochemistry and Diagnostics, University Hospital Hradec Kr\u00e1lov\u00e9, Hradec Kr\u00e1lov\u00e9, Czech Republic"}]},{"given":"Lenka","family":"Javorsk\u00e1","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Pharmacy in Hradec Kr\u00e1lov\u00e9, Charles University, Hradec Kr\u00e1lov\u00e9, Czech Republic"}]},{"given":"Krist\u00fdna","family":"Mr\u0161tn\u00e1","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Pharmacy in Hradec Kr\u00e1lov\u00e9, Charles University, Hradec Kr\u00e1lov\u00e9, Czech Republic"},{"name":"Department of Clinical Biochemistry and Diagnostics, University Hospital Hradec Kr\u00e1lov\u00e9, Hradec Kr\u00e1lov\u00e9, Czech Republic"}]},{"given":"Alejandro","family":"Carazo","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kr\u00e1lov\u00e9, Charles University, Hradec Kr\u00e1lov\u00e9, Czech Republic"}]},{"given":"Michele","family":"Protti","sequence":"additional","affiliation":[{"name":"Research Group of Pharmaco-Toxicological Analysis (PTA Lab), Department of Pharmacy and Biotechnology (FaBiT), Alma Mater Studiorum\u2014University of Bologna, Bologna, Italy"}]},{"given":"Fernando","family":"Remi\u00e3o","sequence":"additional","affiliation":[{"name":"UCIBIO-REQUIMTE, Laboratory of Toxicology, The Biological Sciences Department, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, Porto, Portugal"}]},{"given":"Lucie","family":"Nov\u00e1kov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Pharmacy in Hradec Kr\u00e1lov\u00e9, Charles University, Hradec Kr\u00e1lov\u00e9, Czech Republic"}]},{"name":"the OEMONOM researchers and collaborators","sequence":"additional","affiliation":[]}],"member":"286","published-online":{"date-parts":[[2021,9,2]]},"reference":[{"key":"2022031006053392900_nuab061-B1","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S0140-6736(05)76139-0","article-title":"The Nobel Chronicles","volume":"353","author":"Raju","year":"1999","journal-title":"Lancet"},{"key":"2022031006053392900_nuab061-B2","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1194\/jlr.R045559","article-title":"Recent trends in the metabolism and cell biology of vitamin K with special reference to vitamin K cycling and MK-4 biosynthesis","volume":"55","author":"Shearer","year":"2014","journal-title":"J Lipid Res"},{"issue":"107243","key":"2022031006053392900_nuab061-B3","article-title":"Pilot-scale production of phylloquinone (vitamin K1) using a bubble column 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