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Nutritional interventions (NIs) for SCI have been proposed as a route to circumvent some of the problems associated with this condition. Results obtained in animal models point to a more holistic effect, rather than to specific modulation, of several relevant SCI pathophysiological processes. Indeed, published data have shown NI improves energetic imbalance, oxidative damage, and inflammation, which are promoters of improved proteostasis and neurotrophic signaling, leading ultimately to neuroprotection and neuroplasticity. This review focuses on the most well-documented Nis. The mechanistic implications and their translational potential for SCI are discussed.<\/jats:p>","DOI":"10.1093\/nutrit\/nuab068","type":"journal-article","created":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T11:10:22Z","timestamp":1629112222000},"page":"1206-1221","source":"Crossref","is-referenced-by-count":8,"title":["Nutritional interventions for spinal cord injury: preclinical efficacy and molecular mechanisms"],"prefix":"10.1093","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8487-6621","authenticated-orcid":false,"given":"Jonas","family":"Campos","sequence":"first","affiliation":[{"name":"Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal"},{"name":"ICVS\/3B\u2019s\u2014PT Government Associate Laboratory, Braga\/Guimar\u00e3es, Portugal"}]},{"given":"Nuno A","family":"Silva","sequence":"additional","affiliation":[{"name":"Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal"},{"name":"ICVS\/3B\u2019s\u2014PT Government Associate Laboratory, Braga\/Guimar\u00e3es, Portugal"}]},{"given":"Ant\u00f3nio J","family":"Salgado","sequence":"additional","affiliation":[{"name":"Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal"},{"name":"ICVS\/3B\u2019s\u2014PT Government Associate Laboratory, Braga\/Guimar\u00e3es, Portugal"}]}],"member":"286","published-online":{"date-parts":[[2021,9,2]]},"reference":[{"key":"2022040808080914500_nuab068-B1","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.apmr.2006.04.022","article-title":"Trends in life expectancy after spinal cord injury","volume":"87","author":"Strauss","year":"2006","journal-title":"Arch Phys Med Rehabil."},{"key":"2022040808080914500_nuab068-B2","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.12688\/f1000research.11633.1","article-title":"Promising neuroprotective strategies for 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