{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T06:13:42Z","timestamp":1763705622166,"version":"3.41.2"},"reference-count":56,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T00:00:00Z","timestamp":1567641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Context<\/jats:title><jats:p>Biochemical markers correlate positively with the development and severity of obesity, depression, and anxiety, and can be modulated by changes in intestinal microbiota composition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>A systematic review and meta-analysis was conducted to determine the effects of prebiotics or synbiotics on blood biomarkers of obesity, depression, and anxiety (including: ACTH [adrenocorticotropic hormone], cortisol, leptin, ghrelin, TSH [thyroid-stimulating hormone], PTH [parathyroid hormone], vitamin\u2009D, BDNF [brain-derived neurotrophic factor], and PCR [polymerase chain reaction]) in individuals with overweight or obesity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Sources<\/jats:title><jats:p>MEDLINE, Web of Science, Scopus, and CENTRAL databases were searched, along with the reference lists of included articles. Authors were contacted for unpublished data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Selection<\/jats:title><jats:p>RCT in individuals with overweight or obesity, supplemented with prebiotics or synbiotics, assessing any of the outcomes of interest.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Extraction<\/jats:title><jats:p>Data were extracted independently by three researchers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen studies were identified up to March 7, 2018. Regarding outcomes, 1 study assessed leptin, 4 studies assessed ghrelin, and 10 studies assessed CRP (C-reactive protein). Meta-analysis showed reduction in serum concentrations of ghrelin (\u221237.17\u2009pg\/mL; 95%CI = \u221269.62, \u22124.73; P\u2009=\u20090.025) and CRP (SMD [standardized mean difference] = \u22120.31; 95%CI = \u22120.58, \u22120.04; P\u2009=\u20090.027) after supplementation of inulin-type fructans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Prebiotics may help regulate blood concentrations of ghrelin and CRP in overweight or obese individuals.<\/jats:p><\/jats:sec>","DOI":"10.1093\/nutrit\/nuz045","type":"journal-article","created":{"date-parts":[[2019,5,18]],"date-time":"2019-05-18T19:08:38Z","timestamp":1558206518000},"source":"Crossref","is-referenced-by-count":13,"title":["Prebiotics may reduce serum concentrations of C-reactive protein and ghrelin in overweight and obese adults: a systematic review and meta-analysis"],"prefix":"10.1093","author":[{"given":"Dayanne","family":"da Silva Borges","sequence":"first","affiliation":[{"name":"Post-Graduate Program in Neuroscience, Center of Biological Sciences, Federal University of Santa Catarina, Florian\u00f3polis, SC, Brazil"}]},{"given":"Ricardo","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, MS, Brazil"}]},{"given":"Arthur","family":"Thives Mello","sequence":"additional","affiliation":[{"name":"Graduate Program in Nutrition, Center of Health Sciences, Federal University of Santa Catarina, Florian\u00f3polis, SC, Brazil"}]},{"given":"Ethiene","family":"da Silva Fontoura","sequence":"additional","affiliation":[{"name":"Post-Graduate Program in Nutrition, Center of Health Sciences, Federal University of Santa Catarina, Florian\u00f3polis, SC, Brazil"}]},{"given":"Adair Roberto","family":"Soares dos Santos","sequence":"additional","affiliation":[{"name":"Laboratory of Neurobiology of Pain and Inflammation, Department of Physiological Sciences, Center of Biological Sciences, Federal University of Santa Catarina, Florian\u00f3polis, SC, Brazil"}]},{"given":"Erasmo Benicio","family":"Santos de Moraes Trindade","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Center of Health Sciences, Federal University of Santa Catarina, Florian\u00f3polis, SC, Brazil"}]}],"member":"286","published-online":{"date-parts":[[2019,9,5]]},"reference":[{"key":"2019112610313510700_nuz045-B1","first-page":"236","article-title":"Neuro-hormonal control of food intake","volume":"10","year":"2011","journal-title":"CMBIO."},{"key":"2019112610313510700_nuz045-B2","first-page":"149","article-title":"Depression and medical comorbidity","volume":"32","year":"2005","journal-title":"Rev Psiquiatr Cl\u00edn."},{"key":"2019112610313510700_nuz045-B3","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1590\/S1516-44462004000300009","article-title":"The hypothalamic pituitary adrenal axis, glucocorticoid receptor 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