{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:10:51Z","timestamp":1790266251428,"version":"4.1.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T00:00:00Z","timestamp":1578268800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Traditional Medicine Research Program of Guangdong Province","award":["20181270"],"award-info":[{"award-number":["20181270"]}]},{"name":"Social Development Project of Dongguan City","award":["2016108101021"],"award-info":[{"award-number":["2016108101021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,1]]},"abstract":"Abstract<\/jats:title>\n \n Context<\/jats:title>\n Clinical trials examining the cardiovascular protective effects of quercetin in humans have reported conflicting results.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n The aim of this systematic review was to summarize evidence of the effects of quercetin supplementation on plasma lipid profiles, blood pressure (BP), and glucose levels in humans by performing a meta-analysis of randomized controlled trials.<\/jats:p>\n <\/jats:sec>\n \n Data Sources<\/jats:title>\n MEDLINE, Embase, and Scopus databases were searched electronically from their inception to July 2018 to identify randomized controlled trials that assessed the impact of quercetin on lipid profiles, BP, and glucose levels.<\/jats:p>\n <\/jats:sec>\n \n Study Selection<\/jats:title>\n Randomized controlled trials assessing the effects of quercetin or a standardized quercetin-enriched extract on plasma lipid profiles, BP, and glucose levels in humans were eligible for inclusion.<\/jats:p>\n <\/jats:sec>\n \n Data Extraction<\/jats:title>\n A random-effects model was used for data analysis. Continuous variables were expressed as weighted mean differences (WMDs) and 95%CIs. Subgroup analyses were conducted to explore possible influences of study characteristics. Sensitivity analyses were also performed, as were analyses of publication bias.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Seventeen trials (n\u2005=\u2005896 participants total) were included in the overall analysis. Pooled results showed that quercetin significantly lowered both systolic BP (WMD, \u22123.09\u2009mmHg; 95%CI, \u22124.59 to \u22121.59; P\u2009=\u20090.0001) and diastolic BP (WMD, \u22122.86\u2009mmHg; 95%CI, \u22125.09 to \u22120.63; P\u2009=\u20090.01). Neither lipid profiles nor glucose concentrations changed significantly. In subgroup analyses, significant changes in high-density lipoprotein cholesterol and triglycerides were observed in trials with a parallel design and in which participants consumed quercetin for 8\u00a0weeks or more.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Quercetin intake resulted in significantly decreased BP in humans. Moreover, participants who consumed quercetin for 8\u00a0weeks or more showed significantly changed levels of high-density lipoprotein cholesterol and triglycerides in trials with a parallel design.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/nutrit\/nuz071","type":"journal-article","created":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T15:14:13Z","timestamp":1566314053000},"page":"615-626","source":"Crossref","is-referenced-by-count":107,"title":["Effect of quercetin supplementation on plasma lipid profiles, blood pressure, and glucose levels: a systematic review and meta-analysis"],"prefix":"10.1093","volume":"78","author":[{"given":"Haohai","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy, Dongguan Third People\u2019s Hospital, Affiliated Dongguan Shilong People\u2019s Hospital of Southern Medical University, Dongguan, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Dongguan Third People\u2019s Hospital, Affiliated Dongguan Shilong People\u2019s Hospital of Southern Medical University, Dongguan, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Oncology, Dongguan Third People's Hospital, Affiliated Dongguan Shilong People\u2019s Hospital of Southern Medical University, Dongguan, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Pu","sequence":"additional","affiliation":[{"name":"Department of Laboratory, Dongguan Third People\u2019s Hospital, Affiliated Dongguan Shilong People's Hospital of Southern Medical University, Dongguan, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,1,6]]},"reference":[{"key":"2020073004570138300_nuz071-B1","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1161\/CIR.0b013e3182456d46","article-title":"Executive summary: heart disease and stroke statistics\u20142012 update: a report from the American Heart Association","volume":"125","author":"Roger","year":"2012","journal-title":"Circulation."},{"key":"2020073004570138300_nuz071-B2","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1161\/CIRCULATIONAHA.114.008720","article-title":"Global and regional patterns in cardiovascular mortality from 1990 to 2013","volume":"132","author":"Roth","year":"2015","journal-title":"Circulation."},{"key":"2020073004570138300_nuz071-B3","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1161\/CIR.0b013e318267e99f","article-title":"Our time: a call to save preventable death from cardiovascular disease (heart disease and stroke)","volume":"126","author":"Smith","year":"2012","journal-title":"Circulation."},{"key":"2020073004570138300_nuz071-B4","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1093\/eurheartj\/ehw106","article-title":"2016 European Guidelines on cardiovascular disease prevention in clinical practice: the Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts). 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