{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:07:16Z","timestamp":1789726036191,"version":"4.0.1"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012264","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01HL123336"],"award-info":[{"award-number":["U01HL123336"]}],"id":[{"id":"10.13039\/501100012264","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012264","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1UG3HL164285"],"award-info":[{"award-number":["1UG3HL164285"]}],"id":[{"id":"10.13039\/501100012264","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Clinical Coordinating Center","award":["U01HL123339"],"award-info":[{"award-number":["U01HL123339"]}],"id":[{"id":"https:\/\/ror.org\/00fzvsb30","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Clinical Coordinating Center","award":["1U24HL164284"],"award-info":[{"award-number":["1U24HL164284"]}],"id":[{"id":"https:\/\/ror.org\/00fzvsb30","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Data Coordinating Center","id":[{"id":"https:\/\/ror.org\/00fzvsb30","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Kowa Pharmaceuticals America, Inc"},{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010877","name":"ViiV Healthcare","doi-asserted-by":"publisher","award":["UM1 AI068636"],"award-info":[{"award-number":["UM1 AI068636"]}],"id":[{"id":"10.13039\/100010877","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Advancing Clinical Therapeutics Globally Leadership and Operations Center","award":["UM1 AI106701"],"award-info":[{"award-number":["UM1 AI106701"]}]},{"name":"ACTG Laboratory Center"},{"name":"Boston Area Nutrition Obesity Research Center","award":["P30DK040561"],"award-info":[{"award-number":["P30DK040561"]}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI24\/01386"],"award-info":[{"award-number":["PI24\/01386"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We evaluated baseline hypertension prevalence and control and risk of major adverse cardiovascular events (MACEs) among people with HIV in REPRIEVE who had low to moderate traditional cardiovascular disease (CVD) risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Hypertension at baseline was defined by (1) a preexisting diagnosis regardless of antihypertensive treatment or (2) systolic blood pressure \u2265140\u2005mm Hg and\/or diastolic blood pressure \u226590\u2005mm Hg without a prior diagnosis. We estimated the prevalence of the composite hypertension and control outcomes and calculated adjusted prevalence ratios controlling for traditional CVD risk factors using log binomial regression. We explored the relationship between hypertension and MACE using cause-specific Cox proportional hazards models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 7769 participants enrolled from 5 regions, the median age was 50 years, and 2419 (31%) were women. The prevalence of baseline hypertension was 36% (n = 2780) with geographic variation. Among these, 1911 (69%) individuals had a preexisting hypertension diagnosis; the remainder (n = 869, 31%) were undiagnosed. Region and traditional CVD risk factors were associated with hypertension prevalence, with obese and overweight body mass index having the highest adjusted prevalence ratios (1.80 [95% CI, 1.67\u20131.95] and 1.38 [95% CI, 1.28\u20131.49], respectively). Among those with preexisting hypertension, 40% were uncontrolled, with regional variation. Hypertension at baseline was associated with an increased hazard of MACE (hazard ratio, 2.00; 95% CI, 1.57\u20132.55) and key components of MACE, including myocardial infarction and stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Approximately 1 in 3 REPRIEVE participants had hypertension at baseline. Hypertension was frequently suboptimally controlled. These findings highlight the need for improved screening and optimized treatment of hypertension in people with HIV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ofid\/ofag507","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T11:25:55Z","timestamp":1786361155000},"source":"Crossref","is-referenced-by-count":0,"title":["Hypertension Prevalence and Control at Trial Entry in the REPRIEVE Study Population: Results From a Secondary Analysis"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9575-4574","authenticated-orcid":false,"given":"Risa","family":"Hoffman","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles , Los Angeles, California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health , Boston, Massachusetts ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esteban","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital Cl\u00ednic, IDIBAPS, University of Barcelona , Barcelona ,","place":["Spain"]},{"name":"CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III , Madrid ,","place":["Spain"]},{"name":"Reial Acad\u00e8mia de Medicina de Catalunya , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markella V","family":"Zanni","sequence":"additional","affiliation":[{"name":"Metabolism Unit, Massachusetts General Hospital and Harvard Medical School , Boston, Massachusetts ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4091-5323","authenticated-orcid":false,"given":"Anton","family":"Pozniak","sequence":"additional","affiliation":[{"name":"Chelsea and Westminster Hospital and London School of Hygiene and Tropical Medicine , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7775-006X","authenticated-orcid":false,"given":"Saate S","family":"Shakil","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, University of California, Los Angeles , Los Angeles, California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0289-1295","authenticated-orcid":false,"given":"Sara","family":"McCallum","sequence":"additional","affiliation":[{"name":"Metabolism Unit, Massachusetts General Hospital and Harvard Medical School , Boston, 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,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6778-7253","authenticated-orcid":false,"given":"Carl J","family":"Fichtenbaum","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, University of Cincinnati , Cincinnati, Ohio ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7176-1611","authenticated-orcid":false,"given":"Gerald S","family":"Bloomfield","sequence":"additional","affiliation":[{"name":"Department of Medicine, Duke Global Health Institute and Duke Clinical Research Institute, Duke University , Durham, North Carolina ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex B","family":"Lu","sequence":"additional","affiliation":[{"name":"Metabolism Unit, Massachusetts General Hospital and Harvard Medical School , Boston, Massachusetts 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