{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T08:45:20Z","timestamp":1772700320320,"version":"3.50.1"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2024,6,30]],"date-time":"2024-06-30T00:00:00Z","timestamp":1719705600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Lung cancer in never-smoker (LCINS) patients accounts for 20% of lung cancer cases, and its biology remains poorly understood, particularly in genetically admixed populations. We elucidated the molecular profile of driver genes in Brazilian LCINS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The mutational and gene fusion status of 119 lung adenocarcinomas from self-reported never-smoker patients, was assessed using targeted sequencing (NGS), nCounter, and immunohistochemistry. A panel of 46 ancestry-informative markers determined patients\u2019 genetic ancestry.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The most frequently mutated gene was EGFR (49.6%), followed by TP53 (39.5%), ALK (12.6%), ERBB2 (7.6%), KRAS (5.9%), PIK3CA (1.7%), and less than 1% alterations in RET, NTRK1, MET\u2206ex14, PDGFRA, and BRAF. Except for TP53 and PIK3CA, all other alterations were mutually exclusive. Genetic ancestry analysis revealed a predominance of European (71.1%), and a higher African ancestry was associated with TP53 mutations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Brazilian LCINS exhibited a similar molecular profile to other populations, except the increased ALK and TP53 alterations. Importantly, 73% of these patients have actionable alterations that are suitable for targeted treatments.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/oncolo\/oyae129","type":"journal-article","created":{"date-parts":[[2024,6,30]],"date-time":"2024-06-30T17:37:22Z","timestamp":1719769042000},"page":"e1419-e1424","source":"Crossref","is-referenced-by-count":5,"title":["Molecular profile of driver genes in lung adenocarcinomas of Brazilian patients who have never smoked: implications for targeted therapies"],"prefix":"10.1093","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9069-1295","authenticated-orcid":false,"given":"Rodrigo de Oliveira","family":"Cavagna","sequence":"first","affiliation":[{"name":"Barretos Cancer Hospital Molecular Oncology Research Center, , Barretos,","place":["Brazil"]}]},{"given":"Fl\u00e1via","family":"Escremim de Paula","sequence":"additional","affiliation":[{"name":"Barretos Cancer Hospital Molecular Diagnostic Laboratory, , Barretos,","place":["Brazil"]}]},{"given":"Gustavo Noriz","family":"Berardinelli","sequence":"additional","affiliation":[{"name":"Barretos Cancer Hospital Molecular Diagnostic Laboratory, , Barretos,","place":["Brazil"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7607-5119","authenticated-orcid":false,"given":"Murilo","family":"Bonatelli","sequence":"additional","affiliation":[{"name":"Barretos Cancer Hospital Molecular Diagnostic Laboratory, , Barretos,","place":["Brazil"]}]},{"given":"Iara","family":"Santana","sequence":"additional","affiliation":[{"name":"Barretos Cancer Hospital Department of Pathology, , Barretos,","place":["Brazil"]}]},{"given":"Eduardo Caetano","family":"Albino da Silva","sequence":"additional","affiliation":[{"name":"Barretos Cancer Hospital Department of Pathology, , Barretos,","place":["Brazil"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8363-3513","authenticated-orcid":false,"given":"Gustavo Ramos","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Barretos Cancer Hospital Department of Pathology, , Barretos,","place":["Brazil"]},{"name":"Dr. Paulo Prata \u2013 FACISB Barretos School of Health Sciences, , Barretos,","place":["Brazil"]}]},{"given":"Beatriz Garbe","family":"Zaniolo","sequence":"additional","affiliation":[{"name":"Barretos Cancer Hospital Molecular Oncology Research Center, , Barretos,","place":["Brazil"]},{"name":"Dr. Paulo Prata \u2013 FACISB Barretos School of Health Sciences, , Barretos,","place":["Brazil"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3760-912X","authenticated-orcid":false,"given":"Josiane","family":"Mour\u00e3o Dias","sequence":"additional","affiliation":[{"name":"Barretos Cancer Hospital Department of Medical Oncology, , Barretos,","place":["Brazil"]}]},{"given":"Fl\u00e1vio Augusto","family":"Ferreira da Silva","sequence":"additional","affiliation":[{"name":"Barretos Cancer Hospital Department of Medical Oncology, , Barretos,","place":["Brazil"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8520-0850","authenticated-orcid":false,"given":"Carlos Eduardo","family":"Baston Silva","sequence":"additional","affiliation":[{"name":"Barretos Cancer Hospital Department of Medical Oncology, , Barretos,","place":["Brazil"]}]},{"given":"Marcela Gondim Borges","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Barretos Cancer Hospital Department of Medical Oncology, , Barretos,","place":["Brazil"]}]},{"given":"Camila Pinto","family":"Barone","sequence":"additional","affiliation":[{"name":"Barretos Cancer Hospital Department of Medical Oncology, , Barretos,","place":["Brazil"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6353-2202","authenticated-orcid":false,"given":"Alexandre Arthur","family":"Jacinto","sequence":"additional","affiliation":[{"name":"Barretos Cancer Hospital Deparment of Radiation Therapy, , Barretos,","place":["Brazil"]}]},{"given":"Rachid Eduardo","family":"Noleto da N\u00f3brega Oliveira","sequence":"additional","affiliation":[{"name":"Barretos Cancer Hospital Deparment of Thoracic Surgery, , Barretos,","place":["Brazil"]}]},{"given":"Jos\u00e9 Elias","family":"Miziara","sequence":"additional","affiliation":[{"name":"Barretos Cancer Hospital Deparment of Thoracic Surgery, , Barretos,","place":["Brazil"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5259-0215","authenticated-orcid":false,"given":"Pedro","family":"De Marchi","sequence":"additional","affiliation":[{"name":"Barretos Cancer Hospital Molecular Oncology Research Center, , Barretos,","place":["Brazil"]},{"name":"Oncoclinicas , Rio de Janeiro ,","place":["Brazil"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8866-9881","authenticated-orcid":false,"given":"Miguel A","family":"Molina-Vila","sequence":"additional","affiliation":[{"name":"Dexeus University Hospital Laboratory of Oncology\/Pangaea Oncology, , Barcelona,","place":["Spain"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2200-3985","authenticated-orcid":false,"given":"Let\u00edcia Ferro","family":"Leal","sequence":"additional","affiliation":[{"name":"Barretos Cancer Hospital Molecular Oncology Research Center, , Barretos,","place":["Brazil"]},{"name":"Dr. Paulo Prata \u2013 FACISB Barretos School of Health Sciences, , Barretos,","place":["Brazil"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9639-7940","authenticated-orcid":false,"given":"Rui Manuel","family":"Reis","sequence":"additional","affiliation":[{"name":"Barretos Cancer Hospital Molecular Oncology Research Center, , Barretos,","place":["Brazil"]},{"name":"Barretos Cancer Hospital Molecular Diagnostic Laboratory, , Barretos,","place":["Brazil"]},{"name":"University of Minho Life and Health Sciences Research Institute (ICVS), School of Medicine, , Braga,","place":["Portugal"]},{"name":"ICVS\/3B\u2019s\u2014PT Government Associate Laboratory , 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