{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T12:10:38Z","timestamp":1716207038710},"edition-number":"1","reference-count":138,"publisher":"Oxford University PressNew York","isbn-type":[{"value":"0190634235","type":"print"},{"value":"9780190634230","type":"print"},{"value":"9780190634254","type":"electronic"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Alzheimer\u2019s disease (AD) is an intriguing and still unsolved puzzle that has attracted, over the last decades, the interest of the scientific community. Despite the limited knowledge regarding the initial cause(s) of AD, mitochondrial abnormalities have been pinpointed as one of the earliest and strongest events related with the pathological course of this complex neurodegenerative disease. In this sense, the present chapter addresses three distinct but connected pieces of the AD puzzle: (a) how could defects of mitochondrial bioenergetics and dynamics contribute to AD pathology? (b) Could mitochondrial defects promote the disease-defining amyloid-\u03b2 and tau pathologies, and vice versa? and (c) Are mitochondria feasible therapeutic targets to postpone AD symptomatology and neuropathology, and, if so, how and when? The understanding and connection of these puzzle pieces provide a more comprehensive picture about the fundamental role of mitochondrial (mal)function in the neurodegenerative processes that occur in AD and propels future research interventions aimed to forestall AD-related pathological phenotype by bolstering mitochondrial \u201chealth.\u201d<\/jats:p>","DOI":"10.1093\/oso\/9780190634230.003.0017","type":"book-chapter","created":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T04:21:02Z","timestamp":1592454062000},"page":"407-430","source":"Crossref","is-referenced-by-count":1,"title":["Unraveling the Role of Mitochondria in Alzheimer\u2019s Disease"],"prefix":"10.1093","author":[{"given":"S\u00f3nia C.","family":"Correia","sequence":"first","affiliation":[]},{"given":"Paula I.","family":"Moreira","sequence":"additional","affiliation":[]},{"given":"George","family":"Perry","sequence":"additional","affiliation":[]}],"member":"286","reference":[{"key":"2024052011133368000_oso-9780190634230-chapter-17-bibItem-1761","article-title":"Role of mitochondrial ROS in the brain: from physiology to neurodegeneration.","author":"","year":"2018","journal-title":"FEBS Letters"},{"key":"2024052011133368000_oso-9780190634230-chapter-17-bibItem-1762","article-title":"Physical exercise alleviates debilities of normal aging and Alzheimer\u2019s disease.","author":"","year":"2011","journal-title":"Acta Neurologica Scandinavica"},{"key":"2024052011133368000_oso-9780190634230-chapter-17-bibItem-1763","article-title":"Heme binding to Amyloid-beta peptide: Mechanistic role in Alzheimer\u2019s disease.","author":"","year":"2006","journal-title":"Journal of Alzheimer's Disease"},{"key":"2024052011133368000_oso-9780190634230-chapter-17-bibItem-1764","article-title":"A role for heme in Alzheimer\u2019s disease: Heme binds amyloid beta and has altered metabolism.","author":"","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"2024052011133368000_oso-9780190634230-chapter-17-bibItem-1765","article-title":"A disease with a sweet tooth: Exploring the Warburg effect in Alzheimer\u2019s disease.","author":"","year":"2017","journal-title":"Biogerontology,"},{"key":"2024052011133368000_oso-9780190634230-chapter-17-bibItem-1766","article-title":"Mitochondrial alterations in Alzheimer\u2019s disease.","author":"","year":"2006","journal-title":"Journal of Alzheimer's Disease"},{"key":"2024052011133368000_oso-9780190634230-chapter-17-bibItem-1767","article-title":"Mechanics of mitochondrial motility in neurons.","author":"","year":"2016","journal-title":"Current Opinion in Cell Biology"},{"key":"2024052011133368000_oso-9780190634230-chapter-17-bibItem-1768","article-title":"Mitochondrial fusion\/fission dynamics in neurodegeneration and neuronal plasticity.","author":"","year":"2016","journal-title":"Neurobiology of Disease"},{"key":"2024052011133368000_oso-9780190634230-chapter-17-bibItem-1769","article-title":"Cytochrome c oxidase and mitochondrial F1F0-ATPase (ATP synthase) activities in platelets and brain from patients with Alzheimer\u2019s disease.","author":"","year":"2002","journal-title":"Neurobiology of Aging"},{"key":"2024052011133368000_oso-9780190634230-chapter-17-bibItem-1770","article-title":"Staging of Alzheimer\u2019s disease-related neurofibrillary changes.","author":"","year":"1995","journal-title":"Neurobiology of Aging"},{"key":"2024052011133368000_oso-9780190634230-chapter-17-bibItem-1771","article-title":"Partial rescue of memory deficits induced by calorie restriction in a mouse model of tau deposition.","author":"","year":"2014","journal-title":"Behavioural Brain 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