{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T22:28:22Z","timestamp":1758925702019,"version":"3.41.2"},"reference-count":64,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T00:00:00Z","timestamp":1623801600000},"content-version":"vor","delay-in-days":166,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The production of antibodies can constitute a powerful protective mechanism against infection, but antibodies can also participate in autoimmunity and allergic responses. Recent advances in the understanding of the regulation of germinal centres (GC), the sites where B cells acquire the ability to produce high-affinity antibodies, offered new prospects for the modulation of antibody production in autoimmunity and vaccination. The process of B cell affinity maturation and isotype switching requires signals from T follicular helper (Tfh) cells. In addition, Foxp3+ T follicular regulatory (Tfr) cells represent the regulatory counterpart of Tfh in the GC reaction. Tfr cells were identified one decade ago and since then it has become clear their role in controlling the emergence of autoreactive B cell clones following infection and immunization. At the same time, Tfr cells are essential for fine-tuning important features of the humoral response directed to foreign antigens that are critical in vaccination. However, this regulation is complex and several aspects of Tfr cell biology are yet to be disclosed. Here, we review the current knowledge about the regulation of antibody responses against self and foreign antigens by Tfr cells and its implications for the future rational design of safer and more effective vaccines.<\/jats:p>","DOI":"10.1093\/oxfimm\/iqab012","type":"journal-article","created":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T19:14:13Z","timestamp":1623784453000},"source":"Crossref","is-referenced-by-count":7,"title":["Regulation of antibody responses against self and foreign antigens by Tfr cells: implications for vaccine development"],"prefix":"10.1093","volume":"2","author":[{"given":"Afonso P","family":"Basto","sequence":"first","affiliation":[{"name":"CIISA\u2014Centro de Investiga\u00e7\u00e3o Interdisciplinar em Sanidade Animal, Faculdade de Medicina Veterin\u00e1ria, Universidade de Lisboa , Lisboa, Portugal"},{"name":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa , Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6935-8500","authenticated-orcid":false,"given":"Luis","family":"Graca","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa , Lisboa, Portugal"},{"name":"Instituto Gulbenkian de Ci\u00eancia , Oeiras, Portugal"}]}],"member":"286","published-online":{"date-parts":[[2021,6,16]]},"reference":[{"key":"2023011714420814900_iqab012-B1","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1128\/CVI.00131-10","article-title":"Correlates of protection induced by vaccination","volume":"17","author":"Plotkin","year":"2010","journal-title":"Clin Vaccine Immunol"},{"key":"2023011714420814900_iqab012-B2","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.1016\/j.vaccine.2021.01.055","article-title":"Vaccine-associated enhanced disease: case definition and guidelines for data collection, analysis, and presentation of immunization safety data","volume":"39","author":"Munoz","year":"2021","journal-title":"Vaccine"},{"key":"2023011714420814900_iqab012-B3","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1146\/annurev-immunol-020711-075032","article-title":"Germinal centers","volume":"30","author":"Victora","year":"2012","journal-title":"Annu Rev Immunol"},{"key":"2023011714420814900_iqab012-B4","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nri3803","article-title":"A brief history of T cell help to B cells","volume":"15","author":"Crotty","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"2023011714420814900_iqab012-B5","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1146\/annurev-immunol-041015-055605","article-title":"Follicular helper T cells","volume":"34","author":"Vinuesa","year":"2016","journal-title":"Annu Rev Immunol"},{"key":"2023011714420814900_iqab012-B6","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/imr.12739","article-title":"T follicular regulatory (Tfr) cells: dissecting the complexity of Tfr-cell compartments","volume":"288","author":"Fonseca","year":"2019","journal-title":"Immunol Rev"},{"key":"2023011714420814900_iqab012-B7","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/imr.12411","article-title":"T follicular regulatory cells","volume":"271","author":"Sage","year":"2016","journal-title":"Immunol Rev"},{"key":"2023011714420814900_iqab012-B8","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1126\/science.1175870","article-title":"Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation","volume":"325","author":"Johnston","year":"2009","journal-title":"Science"},{"key":"2023011714420814900_iqab012-B9","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1126\/science.1176676","article-title":"Bcl6 mediates the development of T follicular helper cells","volume":"325","author":"Nurieva","year":"2009","journal-title":"Science"},{"key":"2023011714420814900_iqab012-B10","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.immuni.2009.07.002","article-title":"The transcriptional repressor Bcl-6 directs t follicular helper cell lineage commitment","volume":"31","author":"Yu","year":"2009","journal-title":"Immunity"},{"key":"2023011714420814900_iqab012-B11","doi-asserted-by":"crossref","first-page":"4553","DOI":"10.4049\/jimmunol.1101328","article-title":"Regulation of the germinal center reaction by Foxp3+ follicular regulatory T cells","volume":"187","author":"Wollenberg","year":"2011","journal-title":"J Immunol"},{"key":"2023011714420814900_iqab012-B12","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/nm.2425","article-title":"Foxp3+ follicular regulatory T cells control the germinal center response","volume":"17","author":"Linterman","year":"2011","journal-title":"Nat Med"},{"key":"2023011714420814900_iqab012-B13","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/nm.2426","article-title":"Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions","volume":"17","author":"Chung","year":"2011","journal-title":"Nat Med"},{"key":"2023011714420814900_iqab012-B14","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1084\/jem.20181134","article-title":"FoxP3 and Ezh2 regulate Tfr cell suppressive function and transcriptional program","volume":"216","author":"Hou","year":"2019","journal-title":"J Exp Med"},{"key":"2023011714420814900_iqab012-B15","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/83784","article-title":"Disruption of a new forkhead\/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse","volume":"27","author":"Brunkow","year":"2001","journal-title":"Nat Genet"},{"key":"2023011714420814900_iqab012-B16","doi-asserted-by":"crossref","first-page":"R75","DOI":"10.1172\/JCI11679","article-title":"JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity\u2013allergic disregulation syndrome","volume":"106","author":"Chatila","year":"2000","journal-title":"J Clin Invest"},{"key":"2023011714420814900_iqab012-B17","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1097\/00002281-200307000-00010","article-title":"Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis","volume":"15","author":"Gambineri","year":"2003","journal-title":"Curr Opin Rheumatol"},{"key":"2023011714420814900_iqab012-B18","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/83713","article-title":"The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3","volume":"27","author":"Bennett","year":"2001","journal-title":"Nat Genet"},{"key":"2023011714420814900_iqab012-B19","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/83707","article-title":"X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy","volume":"27","author":"Wildin","year":"2001","journal-title":"Nat Genet"},{"key":"2023011714420814900_iqab012-B20","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.3389\/fimmu.2018.02469","article-title":"Regulation of the germinal center response","volume":"9","author":"Stebegg","year":"2018","journal-title":"Front Immunol"},{"key":"2023011714420814900_iqab012-B21","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/imr.12888","article-title":"Control of foreign Ag-specific Ab responses by Treg and Tfr","volume":"296","author":"Wing","year":"2020","journal-title":"Immunol Rev"},{"key":"2023011714420814900_iqab012-B22","doi-asserted-by":"crossref","first-page":"eaan1487","DOI":"10.1126\/sciimmunol.aan1487","article-title":"Human blood T fr cells are indicators of ongoing humoral activity not fully licensed with suppressive function","volume":"2","author":"Fonseca","year":"2017","journal-title":"Sci Immunol"},{"key":"2023011714420814900_iqab012-B23","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1038\/ni.3837","article-title":"Dynamic regulation of T follicular regulatory cell responses by interleukin 2 during influenza infection","volume":"18","author":"Botta","year":"2017","journal-title":"Nat Immunol"},{"key":"2023011714420814900_iqab012-B24","doi-asserted-by":"crossref","first-page":"15067","DOI":"10.1038\/ncomms15067","article-title":"T follicular helper and T follicular regulatory cells have different TCR specificity","volume":"8","author":"Maceiras","year":"2017","journal-title":"Nat Commun"},{"key":"2023011714420814900_iqab012-B25","doi-asserted-by":"crossref","first-page":"9604","DOI":"10.1073\/pnas.1808594115","article-title":"High-resolution repertoire analysis reveals a major bystander activation of Tfh and Tfr cells","volume":"115","author":"Ritvo","year":"2018","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023011714420814900_iqab012-B26","doi-asserted-by":"crossref","first-page":"eabd8411","DOI":"10.1126\/sciimmunol.abd8411","article-title":"Developmental bifurcation of human T follicular regulatory cells","volume":"6","author":"Kumar","year":"2021","journal-title":"Sci Immunol"},{"key":"2023011714420814900_iqab012-B27","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1084\/jem.20170901","article-title":"Deficiency in T follicular regulatory cells promotes autoimmunity","volume":"215","author":"Fu","year":"2018","journal-title":"J Exp Med"},{"key":"2023011714420814900_iqab012-B28","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1016\/j.cell.2021.02.027","article-title":"Follicular regulatory T cells produce neuritin to regulate B cells","volume":"184","author":"Gonzalez-Figueroa","year":"2021","journal-title":"Cell"},{"key":"2023011714420814900_iqab012-B29","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1002\/eji.201546094","article-title":"Follicular regulatory T cells repress cytokine production by follicular helper T cells and optimize IgG responses in mice","volume":"46","author":"Wu","year":"2016","journal-title":"Eur J Immunol"},{"key":"2023011714420814900_iqab012-B30","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1038\/s41590-019-0472-4","article-title":"Follicular regulatory T cells control humoral and allergic immunity by restraining early B cell responses","volume":"20","author":"Clement","year":"2019","journal-title":"Nat Immunol"},{"key":"2023011714420814900_iqab012-B31","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/s41584-019-0254-2","article-title":"T follicular helper cells and T follicular regulatory cells in rheumatic diseases","volume":"15","author":"Deng","year":"2019","journal-title":"Nat Rev Rheumatol"},{"key":"2023011714420814900_iqab012-B32","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/imm.12774","article-title":"T follicular regulatory cells in mice and men","volume":"152","author":"Maceiras","year":"2017","journal-title":"Immunology"},{"key":"2023011714420814900_iqab012-B33","doi-asserted-by":"crossref","first-page":"10579","DOI":"10.1038\/ncomms10579","article-title":"Follicular regulatory T cells can be specific for the immunizing antigen and derive from naive T cells","volume":"7","author":"Aloulou","year":"2016","journal-title":"Nat Commun"},{"key":"2023011714420814900_iqab012-B34","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1126\/science.1169152","article-title":"Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer\u2019s patches","volume":"323","author":"Tsuji","year":"2009","journal-title":"Science"},{"key":"2023011714420814900_iqab012-B35","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1038\/s41467-018-03493-5","article-title":"Apolipoprotein AI prevents regulatory to follicular helper T cell switching during atherosclerosis","volume":"9","author":"Gaddis","year":"2018","journal-title":"Nat Commun"},{"key":"2023011714420814900_iqab012-B36","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.4049\/jimmunol.1601409","article-title":"Activation and functional specialization of regulatory T cells lead to the generation of Foxp3 instability","volume":"198","author":"Zhang","year":"2017","journal-title":"J Immunol"},{"key":"2023011714420814900_iqab012-B37","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.coi.2020.10.009","article-title":"The multifaceted functions of follicular regulatory T cells","volume":"67","author":"Sage","year":"2020","journal-title":"Curr Opin Immunol"},{"key":"2023011714420814900_iqab012-B38","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.celrep.2019.12.076","article-title":"Follicular regulatory T cells can access the germinal center independently of CXCR5","volume":"30","author":"Vanderleyden","year":"2020","journal-title":"Cell Rep"},{"key":"2023011714420814900_iqab012-B39","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1016\/j.immuni.2016.04.013","article-title":"Store-operated Ca 2+ entry in follicular t cells controls humoral immune responses and autoimmunity","volume":"44","author":"Vaeth","year":"2016","journal-title":"Immunity"},{"key":"2023011714420814900_iqab012-B40","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1084\/jem.20130604","article-title":"Follicular regulatory T cells control humoral autoimmunity via NFAT2-regulated CXCR5 expression","volume":"211","author":"Vaeth","year":"2014","journal-title":"J Exp Med"},{"key":"2023011714420814900_iqab012-B41","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1002\/art.38735","article-title":"Interleukin-21 promotes germinal center reaction by skewing the follicular regulatory T cell to follicular helper T cell balance in autoimmune BXD2 mice","volume":"66","author":"Ding","year":"2014","journal-title":"Arthritis Rheumatol (Hoboken, NJ"},{"key":"2023011714420814900_iqab012-B42","doi-asserted-by":"crossref","first-page":"3247","DOI":"10.4049\/jimmunol.2000748","article-title":"T follicular regulatory cell-derived fibrinogen-like protein 2 regulates production of autoantibodies and induction of systemic autoimmunity","volume":"205","author":"Sungnak","year":"2020","journal-title":"J Immunol"},{"key":"2023011714420814900_iqab012-B43","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1002\/art.40424","article-title":"The ratio of blood T follicular regulatory cells to T follicular helper cells marks ectopic lymphoid structure formation while activated follicular helper T cells indicate disease activity in primary Sj\u00f6gren\u2019s syndrome","volume":"70","author":"Fonseca","year":"2018","journal-title":"Arthritis Rheumatol"},{"key":"2023011714420814900_iqab012-B44","doi-asserted-by":"crossref","first-page":"5191","DOI":"10.1172\/JCI76861","article-title":"Circulating T follicular regulatory and helper cells have memory-like properties","volume":"124","author":"Sage","year":"2014","journal-title":"J Clin Invest"},{"key":"2023011714420814900_iqab012-B45","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20200547","article-title":"CD4+ follicular regulatory T cells optimize the influenza virus-specific B cell response","volume":"218","author":"Lu","year":"2021","journal-title":"J Exp Med"},{"key":"2023011714420814900_iqab012-B46","doi-asserted-by":"crossref","first-page":"eaan4767","DOI":"10.1126\/sciimmunol.aan4767","article-title":"Interleukin-10 from CD4+ follicular regulatory T cells promotes the germinal center response","volume":"2","author":"Laidlaw","year":"2017","journal-title":"Sci Immunol"},{"key":"2023011714420814900_iqab012-B47","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.128076","article-title":"Follicular regulatory T cells inhibit the development of granzyme B\u2013expressing follicular helper T cells","volume":"4","author":"Xie","year":"2019","journal-title":"JCI Insight"},{"key":"2023011714420814900_iqab012-B48","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.immuni.2014.12.006","article-title":"Regulatory T cells control antigen-specific expansion of Tfh cell number and humoral immune responses via the coreceptor CTLA-4","volume":"41","author":"Wing","year":"2014","journal-title":"Immunity"},{"key":"2023011714420814900_iqab012-B49","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.immuni.2016.09.001","article-title":"Germinal center B cell dynamics","volume":"45","author":"Mesin","year":"2016","journal-title":"Immunity"},{"key":"2023011714420814900_iqab012-B50","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.immuni.2014.05.016","article-title":"Foxp3+ T cells regulate immunoglobulin a selection and facilitate diversification of bacterial species responsible for immune homeostasis","volume":"41","author":"Kawamoto","year":"2014","journal-title":"Immunity"},{"key":"2023011714420814900_iqab012-B51","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.immuni.2014.12.005","article-title":"The coinhibitory receptor CTLA-4 controls B cell responses by modulating T follicular helper, T follicular regulatory, and T regulatory cells","volume":"41","author":"Sage","year":"2014","journal-title":"Immunity"},{"key":"2023011714420814900_iqab012-B52","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaw6433","article-title":"Identification of a T follicular helper cell subset that drives anaphylactic IgE","volume":"365","author":"Gowthaman","year":"2019","journal-title":"Science"},{"key":"2023011714420814900_iqab012-B53","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/ni.1715","article-title":"Cytokine-secreting follicular T cells shape the antibody repertoire","volume":"10","author":"Reinhardt","year":"2009","journal-title":"Nat Immunol"},{"key":"2023011714420814900_iqab012-B54","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1084\/jem.20090313","article-title":"IL-4-producing CD4+ T cells in reactive lymph nodes during helminth infection are T follicular helper cells","volume":"206","author":"King","year":"2009","journal-title":"J Exp Med"},{"key":"2023011714420814900_iqab012-B55","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1111\/cea.12750","article-title":"Follicular helper T cells are responsible for IgE responses to Der p 1 following house dust mite sensitization in mice","volume":"46","author":"Noble","year":"2016","journal-title":"Clin Exp Allergy"},{"key":"2023011714420814900_iqab012-B56","doi-asserted-by":"crossref","first-page":"244","DOI":"10.4049\/jimmunol.1700141","article-title":"T follicular helper cell-derived IL-4 is required for IgE production during intestinal helminth infection","volume":"199","author":"Meli","year":"2017","journal-title":"J Immunol"},{"key":"2023011714420814900_iqab012-B57","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.jaci.2016.04.021","article-title":"Follicular helper T cells mediate IgE antibody response to airborne allergens","volume":"139","author":"Kobayashi","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"2023011714420814900_iqab012-B58","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1084\/jem.20190493","article-title":"Regulatory roles of IL-10-producing human follicular T cells","volume":"216","author":"Ca\u00f1ete","year":"2019","journal-title":"J Exp Med"},{"key":"2023011714420814900_iqab012-B59","doi-asserted-by":"crossref","first-page":"88","DOI":"10.12688\/f1000research.7388.1","article-title":"Can follicular helper T cells be targeted to improve vaccine efficacy?","volume":"5","author":"Linterman","year":"2016","journal-title":"F1000Research"},{"key":"2023011714420814900_iqab012-B60","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/ni.2496","article-title":"The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood","volume":"14","author":"Sage","year":"2013","journal-title":"Nat Immunol"},{"key":"2023011714420814900_iqab012-B61","doi-asserted-by":"crossref","first-page":"eaan0368","DOI":"10.1126\/sciimmunol.aan0368","article-title":"Tfr cells lack IL-2R\u03b1 but express decoy IL-1R2 and IL-1Ra and suppress the IL-1-dependent activation of Tfh cells","volume":"2","author":"Ritvo","year":"2017","journal-title":"Sci Immunol"},{"key":"2023011714420814900_iqab012-B62","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1038\/ni.3578","article-title":"Suppression by TFR cells leads to durable and selective inhibition of B cell effector function","volume":"17","author":"Sage","year":"2016","journal-title":"Nat Immunol"},{"key":"2023011714420814900_iqab012-B63","doi-asserted-by":"crossref","first-page":"14647","DOI":"10.1038\/ncomms14647","article-title":"IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2","volume":"8","author":"Jandl","year":"2017","journal-title":"Nat Commun"},{"key":"2023011714420814900_iqab012-B64","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.it.2015.05.005","article-title":"T follicular regulatory cells in the regulation of B cell responses","volume":"36","author":"Sage","year":"2015","journal-title":"Trends Immunol"}],"container-title":["Oxford Open Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ooim\/advance-article-pdf\/doi\/10.1093\/oxfimm\/iqab012\/38660359\/iqab012.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ooim\/article-pdf\/2\/1\/iqab012\/48744393\/iqab012.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ooim\/article-pdf\/2\/1\/iqab012\/48744393\/iqab012.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T22:17:39Z","timestamp":1673993859000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ooim\/article\/doi\/10.1093\/oxfimm\/iqab012\/6300531"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,1]]},"references-count":64,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1,6]]}},"URL":"https:\/\/doi.org\/10.1093\/oxfimm\/iqab012","relation":{},"ISSN":["2633-6960"],"issn-type":[{"type":"electronic","value":"2633-6960"}],"subject":[],"published-other":{"date-parts":[[2021,1,1]]},"published":{"date-parts":[[2021,1,1]]},"article-number":"iqab012"}}