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To date, the role of SWEET-released sucrose for virulence remains unclear. We here identified the sux locus of Xoo consisting of a LacI-type repressor (SuxR), an outer membrane TonB-like porin (SuxA), an inner membrane MFS H+-symporter (SuxC), and a cytosolic sucrose hydrolase (SuxB). Structural and functional analyses demonstrate that SuxB has exclusive sucrose hydrolase activity. Mutant analyses show that the transporter SuxC and the sucrose hydrolase are necessary for growth of bacteria on sucrose, while SuxA is not essential, likely due to the ability of other porins to transport sucrose across the outer membrane. Consistent with a role of SuxR as a sucrose repressor, transcriptome studies show sucrose-dependent regulation of the suxA\/suxB genes. Besides a role of sucrose for reproduction, we found that sucrose promotes motility, extracellular polysaccharides production, biofilm formation, and virulence. Notably, the SuxC sucrose H+-symporter and the sucrose hydrolase SuxB were required for full virulence of Xoo on indica and japonica rice varieties. Our findings indicate that pathogen-induced sucrose efflux via SWEETs provides sucrose to Xoo, that Xoo uses the sux gene cluster to acquire and utilize sucrose, and that sucrose promotes bacterial fitness and xylem colonization.<\/jats:p>","DOI":"10.1093\/pnasnexus\/pgaf412","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T13:29:41Z","timestamp":1767878981000},"source":"Crossref","is-referenced-by-count":0,"title":["A critical role of\n                    <i>sux<\/i>\n                    cistron-mediated sucrose uptake for virulence of the rice blight pathogen\n                    <i>Xanthomonas oryzae<\/i>\n                    pv.\n                    <i>oryzae<\/i>"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0961-5680","authenticated-orcid":false,"given":"Nora R","family":"Z\u00f6llner","sequence":"first","affiliation":[{"name":"Heinrich Heine University D\u00fcsseldorf, Faculty of Mathematics and Natural Sciences, Institute for Molecular Physiology , 40225 D\u00fcsseldorf ,","place":["Germany"]}]},{"given":"Juying","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Genetics, Development and Cell Biology, Iowa State University , Ames, IA 50011 ,","place":["USA"]}]},{"given":"Congfeng","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Genetics, Development and Cell Biology, Iowa State University , Ames, IA 50011 ,","place":["USA"]}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1188-6482","authenticated-orcid":false,"given":"Jacob","family":"Sharkey","sequence":"additional","affiliation":[{"name":"Heinrich Heine University D\u00fcsseldorf, Faculty of Mathematics and Natural Sciences, Institute for Molecular Physiology , 40225 D\u00fcsseldorf ,","place":["Germany"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4332-369X","authenticated-orcid":false,"given":"Michael M","family":"Wudick","sequence":"additional","affiliation":[{"name":"Heinrich Heine University D\u00fcsseldorf, Faculty of Mathematics and Natural Sciences, Institute for Molecular Physiology , 40225 D\u00fcsseldorf ,","place":["Germany"]},{"name":"Cluster of Excellence on Plant Sciences (CEPLAS), Heinrich Heine University , 40225 D\u00fcsseldorf ,","place":["Germany"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7622-1139","authenticated-orcid":false,"given":"Eliza P I","family":"Loo","sequence":"additional","affiliation":[{"name":"Heinrich Heine University D\u00fcsseldorf, Faculty of Mathematics and Natural Sciences, Institute for Molecular Physiology , 40225 D\u00fcsseldorf ,","place":["Germany"]},{"name":"Cluster of Excellence on Plant Sciences (CEPLAS), Heinrich Heine University , 40225 D\u00fcsseldorf ,","place":["Germany"]}]},{"given":"Mayuri","family":"Sadoine","sequence":"additional","affiliation":[{"name":"Heinrich Heine University D\u00fcsseldorf, Faculty of Mathematics and Natural Sciences, Institute for Molecular Physiology , 40225 D\u00fcsseldorf ,","place":["Germany"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4120-7983","authenticated-orcid":false,"given":"Violetta","family":"Applegate","sequence":"additional","affiliation":[{"name":"Center for Structural Studies, Faculty of Mathematics and Natural Sciences, Heinrich Heine University , 40225 D\u00fcsseldorf ,","place":["Germany"]}]},{"given":"Astrid","family":"H\u00f6ppner","sequence":"additional","affiliation":[{"name":"Center for Structural Studies, Faculty of Mathematics and Natural Sciences, Heinrich Heine University , 40225 D\u00fcsseldorf ,","place":["Germany"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0780-9251","authenticated-orcid":false,"given":"Sander H J","family":"Smits","sequence":"additional","affiliation":[{"name":"Center for Structural Studies, Faculty of Mathematics and Natural Sciences, Heinrich Heine University , 40225 D\u00fcsseldorf ,","place":["Germany"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2293-3384","authenticated-orcid":false,"given":"Bing","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Plant Science and Technology, Bond Life Sciences Center, University of Missouri , Columbia, MO 65211 ,","place":["USA"]},{"name":"Donald Danforth Plant Science Center , St. Louis, MO 63132 ,","place":["USA"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6465-0115","authenticated-orcid":false,"given":"Wolf B","family":"Frommer","sequence":"additional","affiliation":[{"name":"Heinrich Heine University D\u00fcsseldorf, Faculty of Mathematics and Natural Sciences, Institute for Molecular Physiology , 40225 D\u00fcsseldorf ,","place":["Germany"]},{"name":"Institute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University , Nagoya, Aichi 464-0813 ,","place":["Japan"]}]}],"member":"286","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"2026011311565914000_pgaf412-B1","doi-asserted-by":"crossref","first-page":"e57596","DOI":"10.15252\/embr.202357596","article-title":"The mystery of an unprecedented plant disease in Africa","volume":"24","author":"Wolinsky","year":"2023","journal-title":"EMBO Rep"},{"key":"2026011311565914000_pgaf412-B2","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1364-3703.2006.00344.x","article-title":"Xanthomonas oryzae pathovars: model pathogens of a model crop","volume":"7","author":"Ni\u00f1o-Liu","year":"2006","journal-title":"Mol Plant Pathol."},{"key":"2026011311565914000_pgaf412-B3","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1094\/MPMI-22-1-0073","article-title":"Multiple adhesin-like functions of Xanthomonas oryzae pv. oryzae are involved in promoting leaf attachment, entry, and virulence on 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