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Patient-reported outcomes, including quality of life (European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30, QLQ-C30), anxiety, depression and sleep quality, were assessed in all evaluations. Model-based clustering was used to identify quality of life trajectories.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We identified four trajectories without intersection during 3 years. The two trajectories characterized by better quality of life depicted relatively stable scores; in the other trajectories, quality of life worsened until 1 year, though in one of them the score at 3 years improved. Sociodemographic and clinical characteristics at baseline did not differ between trajectories, except for mastectomy, which was higher in the worst trajectory. Anxiety, depression and poor sleep quality increased from the best to the worst trajectory.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The type of surgery and the variation of other patient-reported outcomes were associated with the course of quality of life over 3 years. More research to understand the heterogeneity of individual trajectories within these major patterns of variation is needed.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/pubmed\/fdz159","type":"journal-article","created":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T21:23:51Z","timestamp":1572557031000},"page":"521-531","source":"Crossref","is-referenced-by-count":6,"title":["Quality of life trajectories during the first three years after diagnosis of breast cancer: the NEON-BC study"],"prefix":"10.1093","volume":"43","author":[{"given":"Luisa","family":"Lopes-Concei\u00e7\u00e3o","sequence":"first","affiliation":[{"name":"EPIUnit\u2014Instituto de Sa\u00fade P\u00fablica, Universidade do Porto, 4050-600 Porto, Portugal"},{"name":"Departamento de Ci\u00eancias da Sa\u00fade P\u00fablica e Forenses e Educa\u00e7\u00e3o M\u00e9dica, Faculdade de Medicina da Universidade do Porto, 4200-319 Porto, Portugal"}]},{"given":"Mariana","family":"Brand\u00e3o","sequence":"additional","affiliation":[{"name":"EPIUnit\u2014Instituto de Sa\u00fade P\u00fablica, Universidade do Porto, 4050-600 Porto, Portugal"},{"name":"Academic Promoting Team, Institut Jules Bordet, 1000 Brussels, Belgium"}]},{"given":"Nat\u00e1lia","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"EPIUnit\u2014Instituto de Sa\u00fade P\u00fablica, Universidade do Porto, 4050-600 Porto, Portugal"},{"name":"Departamento de Ci\u00eancias da Sa\u00fade P\u00fablica e Forenses e Educa\u00e7\u00e3o M\u00e9dica, Faculdade de Medicina da Universidade do Porto, 4200-319 Porto, Portugal"}]},{"given":"Milton","family":"Severo","sequence":"additional","affiliation":[{"name":"EPIUnit\u2014Instituto de Sa\u00fade P\u00fablica, Universidade do Porto, 4050-600 Porto, Portugal"},{"name":"Departamento de Ci\u00eancias da Sa\u00fade P\u00fablica e Forenses e Educa\u00e7\u00e3o M\u00e9dica, Faculdade de Medicina da Universidade do Porto, 4200-319 Porto, Portugal"}]},{"given":"Teresa","family":"Dias","sequence":"additional","affiliation":[{"name":"Instituto Portugu\u00eas de Oncologia do Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida, 4200-075 Porto, Portugal"}]},{"given":"B\u00e1rbara","family":"Peleteiro","sequence":"additional","affiliation":[{"name":"EPIUnit\u2014Instituto de Sa\u00fade P\u00fablica, Universidade do Porto, 4050-600 Porto, Portugal"},{"name":"Departamento de Ci\u00eancias da Sa\u00fade P\u00fablica e Forenses e Educa\u00e7\u00e3o M\u00e9dica, Faculdade de Medicina da Universidade do Porto, 4200-319 Porto, Portugal"}]},{"given":"Filipa","family":"Fontes","sequence":"additional","affiliation":[{"name":"EPIUnit\u2014Instituto de Sa\u00fade P\u00fablica, Universidade do Porto, 4050-600 Porto, Portugal"},{"name":"Instituto Portugu\u00eas de Oncologia do Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida, 4200-075 Porto, Portugal"}]},{"given":"Susana","family":"Pereira","sequence":"additional","affiliation":[{"name":"EPIUnit\u2014Instituto de Sa\u00fade P\u00fablica, Universidade do Porto, 4050-600 Porto, Portugal"},{"name":"Instituto Portugu\u00eas de Oncologia do Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida, 4200-075 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1870-1430","authenticated-orcid":false,"given":"Nuno","family":"Lunet","sequence":"additional","affiliation":[{"name":"EPIUnit\u2014Instituto de Sa\u00fade P\u00fablica, Universidade do Porto, 4050-600 Porto, Portugal"},{"name":"Departamento de Ci\u00eancias da Sa\u00fade P\u00fablica e Forenses e Educa\u00e7\u00e3o M\u00e9dica, Faculdade de Medicina da Universidade do Porto, 4200-319 Porto, Portugal"}]}],"member":"286","published-online":{"date-parts":[[2019,12,27]]},"reference":[{"key":"2021092400013147300_ref1","volume-title":"GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 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