{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:05:24Z","timestamp":1761987924308},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,2]]},"DOI":"10.1093\/rheumatology\/39.2.156","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T22:33:32Z","timestamp":1027722812000},"page":"156-164","source":"Crossref","is-referenced-by-count":14,"title":["Microemulsion formulation of cyclosporin (Sandimmun Neoral\u00ae) vs Sandimmun\u00ae: comparative safety, tolerability and efficacy in severe active rheumatoid arthritis"],"prefix":"10.1093","volume":"39","author":[{"given":"D. E.","family":"Yocum","sequence":"first","affiliation":[]},{"given":"S.","family":"Allard","sequence":"additional","affiliation":[]},{"given":"S. B.","family":"Cohen","sequence":"additional","affiliation":[]},{"given":"P.","family":"Emery","sequence":"additional","affiliation":[]},{"given":"R. M.","family":"Flipo","sequence":"additional","affiliation":[]},{"given":"J.","family":"Goobar","sequence":"additional","affiliation":[]},{"given":"S.","family":"Jayawardena","sequence":"additional","affiliation":[]},{"given":"C.","family":"Job\u2010Deslandre","sequence":"additional","affiliation":[]},{"given":"R. W.","family":"Jubb","sequence":"additional","affiliation":[]},{"given":"K.","family":"Kr\u00fcger","sequence":"additional","affiliation":[]},{"given":"A.","family":"Lopes Vaz","sequence":"additional","affiliation":[]},{"given":"B.","family":"Manger","sequence":"additional","affiliation":[]},{"given":"E.","family":"Mur","sequence":"additional","affiliation":[]},{"given":"H.","family":"Nygaard","sequence":"additional","affiliation":[]},{"given":"S. M.","family":"Weiner","sequence":"additional","affiliation":[]},{"given":"F.","family":"Rainer","sequence":"additional","affiliation":[]},{"given":"M. R.","family":"Sack","sequence":"additional","affiliation":[]},{"given":"M. H.","family":"Schiff","sequence":"additional","affiliation":[]},{"given":"T. J.","family":"Schnitzer","sequence":"additional","affiliation":[]},{"given":"L. B.","family":"Trigg","sequence":"additional","affiliation":[]},{"given":"I.","family":"Whatmough","sequence":"additional","affiliation":[]},{"given":"A.\u2010G.","family":"Schmidt","sequence":"additional","affiliation":[]}],"member":"286","published-online":{"date-parts":[[2000,2]]},"reference":[{"key":"key\n\t\t\t\t20170703113317_R1","doi-asserted-by":"crossref","unstructured":"Waalen K, F\u00f8rre \u00d8, Linker\u2010Israeli M, Thoen J. Evidence of an activated T\u2010cell system with augmented turnover of interleukin 2 in rheumatoid arthritis. Scand J Immunol1987;25:367\u201373.","DOI":"10.1111\/j.1365-3083.1987.tb02202.x"},{"key":"key\n\t\t\t\t20170703113317_R2","doi-asserted-by":"crossref","unstructured":"Harris ED Jr. Rheumatoid arthritis. Pathophysiology and implications for therapy. N Engl J Med1990;322:1277\u201389.","DOI":"10.1056\/NEJM199005033221805"},{"key":"key\n\t\t\t\t20170703113317_R3","doi-asserted-by":"crossref","unstructured":"Panayi GS, Lanchbury JS, Kingsley GH. The importance of the T\u2009cell in initiating and maintaining the chronic synovitis of rheumatoid arthritis. Arthritis Rheum1992;35:729\u201335.","DOI":"10.1002\/art.1780350702"},{"key":"key\n\t\t\t\t20170703113317_R4","doi-asserted-by":"crossref","unstructured":"Salmon M, Gaston JSH. The role of T\u2010lymphocytes in rheumatoid arthritis. Br Med Bull1995;51:332\u201345.","DOI":"10.1093\/oxfordjournals.bmb.a072964"},{"key":"key\n\t\t\t\t20170703113317_R5","doi-asserted-by":"crossref","unstructured":"Schreiber SL, Crabtree GR. The mechanism of action of cyclosporin A and FK506. Immunol Today1992;13:136\u201342.","DOI":"10.1016\/0167-5699(92)90111-J"},{"key":"key\n\t\t\t\t20170703113317_R6","unstructured":"Baumann G. Molecular mechanism of immunosuppressive agents. Transplant Proc1992;24(Suppl. 2):4\u20137."},{"key":"key\n\t\t\t\t20170703113317_R7","doi-asserted-by":"crossref","unstructured":"Dougados M, Awada H, Amor B. Cyclosporin in rheumatoid arthritis: a double blind, placebo controlled study in 52 patients. Ann Rheum Dis1988;47:127\u201333.","DOI":"10.1136\/ard.47.2.127"},{"key":"key\n\t\t\t\t20170703113317_R8","doi-asserted-by":"crossref","unstructured":"Tugwell P, Bombardier C, Gent M et al. Low\u2010dose cyclosporin versus placebo in patients with rheumatoid arthritis. Lancet1990;335:1051\u20135.","DOI":"10.1016\/0140-6736(90)92630-Z"},{"key":"key\n\t\t\t\t20170703113317_R9","unstructured":"van Rijthoven AW, Dijkmans BB, Goei Th\u00e9 HS et al. Comparison of cyclosporine and D\u2010penicillamine for rheumatoid arthritis: a randomized, double blind, multicenter study. J Rheumatol1991;18:815\u201320."},{"key":"key\n\t\t\t\t20170703113317_R10","doi-asserted-by":"crossref","unstructured":"Kr\u00fcger K, Schattenkirchner M. Cyclosporine A vs azathioprine in the treatment of RA: results of a controlled multicentre double\u2010blind study. J Autoimmun1992;5:xix (abstr.).","DOI":"10.1016\/0896-8411(92)90093-6"},{"key":"key\n\t\t\t\t20170703113317_R11","doi-asserted-by":"crossref","unstructured":"Dougados M, Luchesne L, Awada H, Amor B. Assessment of efficacy and acceptability of low dose cyclosporin in patients with rheumatoid arthritis. Ann Rheum Dis1989;48:550\u20136.","DOI":"10.1136\/ard.48.7.550"},{"key":"key\n\t\t\t\t20170703113317_R12","doi-asserted-by":"crossref","unstructured":"Dijkmans BA, van Rijthoven AW, Goei Th\u00e9 HS, Boers M, Cats A. Cyclosporine in rheumatoid arthritis. Semin Arthritis Rheum1992;22:30\u20136.","DOI":"10.1016\/0049-0172(92)90046-G"},{"key":"key\n\t\t\t\t20170703113317_R13","doi-asserted-by":"crossref","unstructured":"Tugwell P. Cyclosporine in rheumatoid arthritis: documented efficacy and safety. Semin Arthritis Rheum1992;21(Suppl. 3):30\u20138.","DOI":"10.1016\/0049-0172(92)90011-2"},{"key":"key\n\t\t\t\t20170703113317_R14","doi-asserted-by":"crossref","unstructured":"F\u00f8rre \u00d8, The Norwegian Arthritis Study Group. Radiologic evidence of disease modification in rheumatoid arthritis patients treated with cyclosporine. Results of a 48\u2010week multicenter study comparing low\u2010dose cyclosporine with placebo. Arthritis Rheum1994;37:1506\u201312.","DOI":"10.1002\/art.1780371015"},{"key":"key\n\t\t\t\t20170703113317_R15","doi-asserted-by":"crossref","unstructured":"F\u00f8rre \u00d8. Cyclosporine in rheumatoid arthritis: an overview. Clin Rheumatol1995;14(Suppl. 2):33\u20136.","DOI":"10.1007\/BF02215856"},{"key":"key\n\t\t\t\t20170703113317_R16","doi-asserted-by":"crossref","unstructured":"Yocum DE, Torley H. Cyclosporine in rheumatoid arthritis. Rheum Dis Clin North Am1995;21:835\u201344.","DOI":"10.1016\/S0889-857X(21)00470-1"},{"key":"key\n\t\t\t\t20170703113317_R17","doi-asserted-by":"crossref","unstructured":"Landew\u00e9 RB, Goei Th\u00e9 HS, Van Rijthoven AWAM, Breedveld FC, Dijkmans BA. A randomized, double\u2010blind, 24\u2010week controlled study of low\u2010dose cyclosporine versus chloroquine for early rheumatoid arthritis. Arthritis Rheum1994;37:637\u201343.","DOI":"10.1002\/art.1780370506"},{"key":"key\n\t\t\t\t20170703113317_R18","doi-asserted-by":"crossref","unstructured":"Pasero G, Priolo F, Marubini E et al. Slow progression of joint damage in early rheumatoid arthritis treated with cyclosporin A. Arthritis Rheum1996;39:1006\u201315.","DOI":"10.1002\/art.1780390618"},{"key":"key\n\t\t\t\t20170703113317_R19","doi-asserted-by":"crossref","unstructured":"Rodr\u00edguez F, Krayenb\u00fchl JC, Harrision WB et al. Renal biopsy findings and followup of renal function in rheumatoid arthritis patients treated with cyclosporin A: an update from the International Kidney Biopsy Registry. Arthritis Rheum1996;39:1491\u20138.","DOI":"10.1002\/art.1780390908"},{"key":"key\n\t\t\t\t20170703113317_R20","unstructured":"von Graffenried B, Krupp P. Side effects of cyclosporin following kidney transplantation and in patients with autoimmune diseases. Internist Berl1985;26:542\u20138."},{"key":"key\n\t\t\t\t20170703113317_R21","doi-asserted-by":"crossref","unstructured":"Feutren G, Mihatsch MJ. Risk factors for cyclosporine\u2010induced nephropathy in patients with autoimmune diseases. N Engl J Med1992;326:1654\u201360.","DOI":"10.1056\/NEJM199206183262502"},{"key":"key\n\t\t\t\t20170703113317_R22","unstructured":"Feutren G. Renal morphology after cyclosporin A therapy in rheumatoid arthritis patients. International Kidney Biopsy Registry of Cyclosporin (Sandimmun) in Autoimmune Diseases. Br J Rheumatol1993;32(Suppl. 1):65\u201371."},{"key":"key\n\t\t\t\t20170703113317_R23","doi-asserted-by":"crossref","unstructured":"Kovarik JM, Mueller EA, van Bree JB, Tetzloff W, Kutz K. Reduced inter\u2010 and intraindividual variability in cyclosporine pharmacokinetics from a microemulsion formulation. J Pharm Sci1994;83:444\u20136.","DOI":"10.1002\/jps.2600830336"},{"key":"key\n\t\t\t\t20170703113317_R24","doi-asserted-by":"crossref","unstructured":"Taesch S, Niese D. Safety and tolerability of a new oral formulation of cyclosporin A, Sandimmun Neoral, in renal transplant patients. Transplant Int1994;7(Suppl. 1): S263\u2013S6.","DOI":"10.1111\/j.1432-2277.1994.tb01363.x"},{"key":"key\n\t\t\t\t20170703113317_R25","unstructured":"Niese D, and the International Sandimmun Neoral Study Group. A double\u2010blind randomized study of Sandimmun Neoral versus Sandimmun in new renal transplant recipients: results after 12 months. Transplant Proc1995;27:1849\u201356."},{"key":"key\n\t\t\t\t20170703113317_R26","doi-asserted-by":"crossref","unstructured":"Kovarik JM, Mueller EA, van Bree JB et al. Cyclosporine pharmacokinetics and variability from a microemulsion formulation\u2014a multicenter investigation in kidney transplant patients. Transplantation1994;58:658\u201363.","DOI":"10.1097\/00007890-199409000-00004"},{"key":"key\n\t\t\t\t20170703113317_R27","doi-asserted-by":"crossref","unstructured":"van den Borne BEEM, Landew\u00e9 RBM, Goei Th\u00e9 HS, Mattie H, Breedveld FC, Dijkmans BAC. Relative bioavailability of a new oral form of cyclosporin A in patients with rheumatoid arthritis. Br J Clin Pharmacol1995;39:172\u20135.","DOI":"10.1111\/j.1365-2125.1995.tb04425.x"},{"key":"key\n\t\t\t\t20170703113317_R28","unstructured":"Leirisalo\u2010Repo M, Anderson IF, Bjorneboe O, Kraag G, Schmidt A\u2010G, for the OLR 301 study group. A randomized, double\u2010blind study assessing the safety, tolerability and pharmacokinetic implications of a 1:1 dose conversion from stable Sandimmun\u00ae maintenance treatment to Sandimmun Neoral\u00ae, in RA patients. Rheumatol Eur1996;26(Suppl. 1):49 abstract 106."},{"key":"key\n\t\t\t\t20170703113317_R29","unstructured":"Panayi GS, Tugwell P. An international consensus report: the use of cyclosporin A in rheumatoid arthritis. Br J Rheumatol1993;32(Suppl. 1):1\u20133."},{"key":"key\n\t\t\t\t20170703113317_R30","doi-asserted-by":"crossref","unstructured":"Panayi GS, Tugwell P. The use of cyclosporin A in rheumatoid arthritis: conclusions of an international review. Br J Rheumatol1994;33:967\u20139.","DOI":"10.1093\/rheumatology\/33.10.967"},{"key":"key\n\t\t\t\t20170703113317_R31","doi-asserted-by":"crossref","unstructured":"Panayi GS, Tugwell P. The use of cyclosporin A in rheumatoid arthritis: conclusions of an international review. Br J Rheumatol1997;36:808\u201311.","DOI":"10.1093\/rheumatology\/36.7.808"},{"key":"key\n\t\t\t\t20170703113317_R32","doi-asserted-by":"crossref","unstructured":"Panayi G, Tugwell P. The use of cyclosporin A microemulsion in rheumatoid arthritis: conclusions of an international review. Br J Rheumatol1997;36:808\u201311.","DOI":"10.1093\/rheumatology\/36.7.808"},{"key":"key\n\t\t\t\t20170703113317_R33","doi-asserted-by":"crossref","unstructured":"Felson DT, Anderson JJ, Boers M et al. American College of Rheumatology preliminary definition of improvement in rheumatoid arthritis. Arthritis Rheum1995;38:727\u201335.","DOI":"10.1002\/art.1780380602"},{"key":"key\n\t\t\t\t20170703113317_R34","unstructured":"Ritchie DM, Boyle JA, McInnes JM et al. Clinical studies with an articular index for the assessment of joint tenderness in patients with rheumatoid arthritis. Q J Med1968;37:393\u2013406."},{"key":"key\n\t\t\t\t20170703113317_R35","doi-asserted-by":"crossref","unstructured":"Fries JF. The assessment of disability: from first to future principles. Br J Rheumatol1983;22(Suppl.):48\u201358.","DOI":"10.1093\/rheumatology\/XXII.suppl_1.48"}],"container-title":["Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/rheumatology\/article-pdf\/39\/2\/156\/18108853\/390156.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,23]],"date-time":"2023-04-23T04:01:38Z","timestamp":1682222498000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/rheumatology\/article-lookup\/doi\/10.1093\/rheumatology\/39.2.156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,2]]},"references-count":35,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2000,2]]},"published-print":{"date-parts":[[2000,2]]}},"URL":"https:\/\/doi.org\/10.1093\/rheumatology\/39.2.156","relation":{},"ISSN":["1462-0332","1462-0324"],"issn-type":[{"value":"1462-0332","type":"electronic"},{"value":"1462-0324","type":"print"}],"subject":[],"published":{"date-parts":[[2000,2]]}}}