{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T01:48:34Z","timestamp":1774921714364,"version":"3.50.1"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2020,5,23]],"date-time":"2020-05-23T00:00:00Z","timestamp":1590192000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"National Institute for Health Research Musculoskeletal Biomedical Research Unit"},{"DOI":"10.13039\/100007211","name":"Vasculitis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007211","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>ANCA-associated vasculitis (AAV) can affect all age groups. We aimed to show that differences in disease presentation and 6\u2009month outcome between younger- and older-onset patients are still incompletely understood.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We included patients enrolled in the Diagnostic and Classification Criteria for Primary Systemic Vasculitis (DCVAS) study between October 2010 and January 2017 with a diagnosis of AAV. We divided the population according to age at diagnosis: &amp;lt;65\u2009years or \u226565\u2009years. We adjusted associations for the type of AAV and the type of ANCA (anti-MPO, anti-PR3 or negative).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 1338 patients with AAV were included: 66% had disease onset at &amp;lt;65\u2009years of age [female 50%; mean age 48.4\u2009years (s.d. 12.6)] and 34% had disease onset at \u226565\u2009years [female 54%; mean age 73.6\u2009years (s.d. 6)]. ANCA (MPO) positivity was more frequent in the older group (48% vs 27%; P\u2009=\u20090.001). Younger patients had higher rates of musculoskeletal, cutaneous and ENT manifestations compared with older patients. Systemic, neurologic,cardiovascular involvement and worsening renal function were more frequent in the older-onset group. Damage accrual, measured with the Vasculitis Damage Index (VDI), was significantly higher in older patients, 12% of whom had a 6\u2009month VDI \u22655, compared with 7% of younger patients (P\u2009=\u20090.01). Older age was an independent risk factor for early death within 6\u2009months from diagnosis [hazard ratio 2.06 (95% CI 1.07, 3.97); P\u2009=\u20090.03].<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Within 6\u2009months of diagnosis of AAV, patients &amp;gt;65\u2009years of age display a different pattern of organ involvement and an increased risk of significant damage and mortality compared with younger patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/rheumatology\/keaa215","type":"journal-article","created":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T03:25:03Z","timestamp":1586489103000},"page":"617-628","source":"Crossref","is-referenced-by-count":31,"title":["Association between age at disease onset of anti-neutrophil cytoplasmic antibody\u2013associated vasculitis and clinical presentation and short-term outcomes"],"prefix":"10.1093","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1800-6772","authenticated-orcid":false,"given":"Sara","family":"Monti","sequence":"first","affiliation":[{"name":"Rheumatology, Fondazione IRCCS Policlinico S. 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