{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T15:29:56Z","timestamp":1778254196576,"version":"3.51.4"},"reference-count":82,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T00:00:00Z","timestamp":1660348800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008530","name":"Fundo Europeu de Desenvolvimento Regional","doi-asserted-by":"publisher","award":["CEECIND\/00654\/2020"],"award-info":[{"award-number":["CEECIND\/00654\/2020"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Different animal models have been used for hair research and regeneration studies based on the similarities between animal and human skins. Primary knowledge on hair follicle (HF) biology has arisen from research using mouse models baring spontaneous or genetically engineered mutations. These studies have been crucial for the discovery of genes underlying human hair cycle control and hair loss disorders. Yet, researchers have become increasingly aware that there are distinct architectural and cellular features between the mouse and human HFs, which might limit the translation of findings in the mouse models. Thus, it is enticing to reason that the spotlight on mouse models and the unwillingness to adapt to the human archetype have been hampering the emergence of the long-awaited human hair loss cure. Here, we provide an overview of the major limitations of the mainstream mouse models for human hair loss research, and we underpin a future course of action using human cell bioengineered models and the emergent artificial intelligence.<\/jats:p>","DOI":"10.1093\/stcltm\/szac059","type":"journal-article","created":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T10:07:48Z","timestamp":1660385268000},"page":"1021-1028","source":"Crossref","is-referenced-by-count":19,"title":["The Emergent Power of Human Cellular vs Mouse Models in Translational Hair Research"],"prefix":"10.1093","volume":"11","author":[{"given":"Ana Rita","family":"Castro","sequence":"first","affiliation":[{"name":"Aging and Aneuploidy Group, IBMC, Instituto de Biologia Molecular e Celular, Universidade do Porto , Porto , Portugal"},{"name":"i3S, Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto , Porto , Portugal"},{"name":"Sa\u00fade Vi\u00e1vel\u2014Insparya Hair Center , Porto , Portugal"},{"name":"Doctoral Program in Biomedical Engineering, Faculdade de Engenharia, Universidade do Porto , Porto , Portugal"}]},{"given":"Carlos","family":"Portinha","sequence":"additional","affiliation":[{"name":"Sa\u00fade Vi\u00e1vel\u2014Insparya Hair Center , Porto , Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8741-0744","authenticated-orcid":false,"given":"Elsa","family":"Logarinho","sequence":"additional","affiliation":[{"name":"Aging and Aneuploidy Group, IBMC, Instituto de Biologia Molecular e Celular, Universidade do Porto , Porto , Portugal"},{"name":"i3S, Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto , Porto , Portugal"},{"name":"Sa\u00fade Vi\u00e1vel\u2014Insparya Hair Center , Porto , Portugal"}]}],"member":"286","published-online":{"date-parts":[[2022,8,13]]},"reference":[{"issue":"3","key":"2022102113273420000_CIT0001","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1002\/sctm.19-0301","article-title":"Tissue engineering strategies for human hair follicle regeneration: how far from a hairy goal? 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