{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T18:50:37Z","timestamp":1776538237742,"version":"3.51.2"},"reference-count":126,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T00:00:00Z","timestamp":1606867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/BIA-EVF\/1624\/2014"],"award-info":[{"award-number":["PTDC\/BIA-EVF\/1624\/2014"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["EPSCoR OIA-1736249"],"award-info":[{"award-number":["EPSCoR OIA-1736249"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DEB-1907022"],"award-info":[{"award-number":["DEB-1907022"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ESF and Portuguese","award":["PD\/BD\/108131\/2015"],"award-info":[{"award-number":["PD\/BD\/108131\/2015"]}]},{"name":"FCT CEEC","award":["CEECIND\/00372\/2018"],"award-info":[{"award-number":["CEECIND\/00372\/2018"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hybridization may often be an important source of adaptive variation, but the extent and long-term impacts of introgression have seldom been evaluated in the phylogenetic context of a radiation. Hares (Lepus) represent a widespread mammalian radiation of 32 extant species characterized by striking ecological adaptations and recurrent admixture. To understand the relevance of introgressive hybridization during the diversification of Lepus, we analyzed whole exome sequences (61.7 Mb) from 15 species of hares (1\u20134 individuals per species), spanning the global distribution of the genus, and two outgroups. We used a coalescent framework to infer species relationships and divergence times, despite extensive genealogical discordance. We found high levels of allele sharing among species and show that this reflects extensive incomplete lineage sorting and temporally layered hybridization. Our results revealed recurrent introgression at all stages along the Lepus radiation, including recent gene flow between extant species since the last glacial maximum but also pervasive ancient introgression occurring since near the origin of the hare lineages. We show that ancient hybridization between northern hemisphere species has resulted in shared variation of potential adaptive relevance to highly seasonal environments, including genes involved in circadian rhythm regulation, pigmentation, and thermoregulation. Our results illustrate how the genetic legacy of ancestral hybridization may persist across a radiation, leaving a long-lasting signature of shared genetic variation that may contribute to adaptation. [Adaptation; ancient introgression; hybridization; Lepus; phylogenomics.]<\/jats:p>","DOI":"10.1093\/sysbio\/syaa088","type":"journal-article","created":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T23:43:39Z","timestamp":1605743019000},"page":"593-607","source":"Crossref","is-referenced-by-count":68,"title":["The Legacy of Recurrent Introgression during the Radiation of Hares"],"prefix":"10.1093","volume":"70","author":[{"given":"Mafalda S","family":"Ferreira","sequence":"first","affiliation":[{"name":"CIBIO, Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Gen\u00e9ticos, InBIO Laborat\u00f3rio Associado, Universidade do Porto, Vair\u00e3o, Portugal"},{"name":"Departamento de Biologia, Faculdade de Ci\u00eancias da Universidade do Porto, Porto, Portugal"},{"name":"Division of Biological Sciences, University of Montana, Missoula, Montana, United States of America"}]},{"given":"Matthew R","family":"Jones","sequence":"additional","affiliation":[{"name":"Division of Biological Sciences, University of Montana, Missoula, Montana, United States of America"}]},{"given":"Colin M","family":"Callahan","sequence":"additional","affiliation":[{"name":"Division of Biological Sciences, University of Montana, Missoula, Montana, United States of America"}]},{"given":"Liliana","family":"Farelo","sequence":"additional","affiliation":[{"name":"CIBIO, Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Gen\u00e9ticos, InBIO Laborat\u00f3rio Associado, Universidade do Porto, Vair\u00e3o, Portugal"}]},{"given":"Zelalem","family":"Tolesa","sequence":"additional","affiliation":[{"name":"Department of Biology, Hawassa University, Hawassa, Ethiopia"}]},{"given":"Franz","family":"Suchentrunk","sequence":"additional","affiliation":[{"name":"Department for Interdisciplinary Life Sciences, Research Institute of Wildlife Ecology, University of Veterinary Medicine Vienna, Vienna, Austria"}]},{"given":"Pierre","family":"Boursot","sequence":"additional","affiliation":[{"name":"Institut des Sciences de l\u2019\u00c9volution Montpellier (ISEM), Universit\u00e9 de Montpellier, CNRS, IRD, EPHE, France"}]},{"given":"L Scott","family":"Mills","sequence":"additional","affiliation":[{"name":"Wildlife Biology Program, College of Forestry and Conservation, University of Montana, Missoula, Montana, United States of America"},{"name":"Office of Research and Creative Scholarship, University of Montana, Missoula, Montana, United States of America; Jeffrey M. Good and Jos\u00e9 Melo-Ferreira shared the senior authorship"}]},{"given":"Paulo C","family":"Alves","sequence":"additional","affiliation":[{"name":"CIBIO, Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Gen\u00e9ticos, InBIO Laborat\u00f3rio Associado, Universidade do Porto, Vair\u00e3o, Portugal"},{"name":"Departamento de Biologia, Faculdade de Ci\u00eancias da Universidade do Porto, Porto, Portugal"},{"name":"Wildlife Biology Program, College of Forestry and Conservation, University of Montana, Missoula, Montana, United States of America"}]},{"given":"Jeffrey M","family":"Good","sequence":"additional","affiliation":[{"name":"Division of Biological Sciences, University of Montana, Missoula, Montana, United States of America"},{"name":"Wildlife Biology Program, College of Forestry and Conservation, University of Montana, Missoula, Montana, United States of America"}]},{"given":"Jos\u00e9","family":"Melo-Ferreira","sequence":"additional","affiliation":[{"name":"CIBIO, Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Gen\u00e9ticos, InBIO Laborat\u00f3rio Associado, Universidade do Porto, Vair\u00e3o, Portugal"},{"name":"Departamento de Biologia, Faculdade de Ci\u00eancias da Universidade do Porto, Porto, Portugal"}]}],"member":"286","published-online":{"date-parts":[[2020,12,2]]},"reference":[{"key":"2021041514021260600_B1","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/j.ympev.2007.11.010","article-title":"Evidence for genetic similarity of two allopatric European hares (Lepus corsicanus and L. castroviejoi) inferred from nuclear DNA sequences","volume":"46","author":"Alves","year":"2008","journal-title":"Mol. 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