{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:51:47Z","timestamp":1777337507967,"version":"3.51.4"},"reference-count":94,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"vor","delay-in-days":232,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia and Minist\u00e9rio da Educa\u00e7\u00e3o"},{"name":"Ci\u00eancia e Inova\u00e7\u00e3o"},{"name":"Laborat\u00f3rio Associado para a Qu\u00edmica Verde - Tecnologias e Processos Limpos"},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>There has been a growing interest in insect meals as a sustainable alternative protein source for animal food and feed. In parallel, insect hydrolysates have been investigated in vitro for their bioactive properties, but the impact of dietary inclusion on dog\u2019s nutritional parameters needs to be elucidated. This study aimed to evaluate the chemical composition and bioactive properties of four insect hydrolysates obtained from the enzymatic hydrolysis of Tenebrio molitor and Hermetia illucens using ALCALASE 2.5L and Corolase PP enzymes and investigate the effects of their dietary inclusion on diet palatability, digestibility, and fecal characteristics and metabolites of adult Beagle dogs. Four two-bowl tests were performed using 12 adult Beagle dogs to assess palatability by the pairwise comparison between the control diet (a commercial diet with 3% of shrimp hydrolysate) and each of the four experimental diets (control diet with the replacement of 3% (w\/w) of shrimp hydrolysate by 3% of each insect protein hydrolysate). A digestibility trial designed according to a replicated Latin square 5\u2005\u00d7\u20055 design, with ten adult dogs, five periods of 10 d each, and five diets was performed to evaluate the effects on food intake, fecal characteristics and metabolites, apparent total tract digestibility, and estimated metabolizable energy content of the control and experimental diets. Chemical composition and in vitro antioxidant and antihypertensive activities of insect hydrolysates depended on the insect species and enzyme used. No differences were observed in the first diet approached or tasted, but the inclusion of hydrolysates of T. molitor obtained from Corolase PP hydrolysis showed a greater intake ratio (P\u2005=\u20050.032). Food intake, diet digestibility and fecal characteristics were not different between diets, except for an increased fecal caproate concentration in dogs fed the control diet (P\u2005=\u20050.024). The dietary inclusion of insect hydrolysates did not affect nutritional parameters, and further investigation is needed to evaluate their health-promoting properties for pet foods and supplements.<\/jats:p>","DOI":"10.1093\/tas\/txaf106","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T11:48:00Z","timestamp":1754567280000},"source":"Crossref","is-referenced-by-count":2,"title":["Protein hydrolysates from\n                    <i>Tenebrio molitor<\/i>\n                    and\n                    <i>Hermetia illucens<\/i>\n                    as novel food sources for dogs"],"prefix":"10.1093","volume":"9","author":[{"given":"D","family":"Leal","sequence":"first","affiliation":[{"name":"LAQV, REQUIMTE, ICBAS, Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, Universidade do Porto , Porto, 4050-313 ,","place":["Portugal"]}]},{"given":"S","family":"Borges","sequence":"additional","affiliation":[{"name":"Universidade Cat\u00f3lica Portuguesa, CBQF - Centro de Biotecnologia e Qu\u00edmica Fina - Laborat\u00f3rio Associado, Escola Superior de Biotecnologia , Porto, 4169-005 ,","place":["Portugal"]}]},{"given":"A","family":"Almeida","sequence":"additional","affiliation":[{"name":"ETSA, SGPS, S.A , Loures, 2660-119 ,","place":["Portugal"]}]},{"given":"M","family":"Pintado","sequence":"additional","affiliation":[{"name":"Universidade Cat\u00f3lica Portuguesa, CBQF - Centro de Biotecnologia e Qu\u00edmica Fina - Laborat\u00f3rio Associado, Escola Superior de Biotecnologia , Porto, 4169-005 ,","place":["Portugal"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6237-417X","authenticated-orcid":false,"given":"A J M","family":"Fonseca","sequence":"additional","affiliation":[{"name":"LAQV, REQUIMTE, ICBAS, Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, Universidade do Porto , Porto, 4050-313 ,","place":["Portugal"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1904-0358","authenticated-orcid":false,"given":"A R J","family":"Cabrita","sequence":"additional","affiliation":[{"name":"LAQV, REQUIMTE, ICBAS, Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, Universidade do Porto , Porto, 4050-313 ,","place":["Portugal"]}]}],"member":"286","published-online":{"date-parts":[[2025,8,19]]},"reference":[{"key":"2025110920024836900_CIT0001","doi-asserted-by":"publisher","first-page":"2525","DOI":"10.3390\/ani11092525","article-title":"Insect larvae meal (Hermetia illucens) as a sustainable protein source of canine food and its impacts on nutrient digestibility and fecal quality","volume":"11","author":"Abd El-Wahab","year":"2021","journal-title":"Animals (Basel)"},{"key":"2025110920024836900_CIT0002","doi-asserted-by":"publisher","first-page":"e0276398","DOI":"10.1371\/journal.pone.0276398","article-title":"Effects of poultry by-products inclusion in dry food on nutrient digestibility and fecal quality in Beagle dogs","volume":"17","author":"Abd El-Wahab","year":"2022","journal-title":"PLoS One"},{"key":"2025110920024836900_CIT0003","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/0141-0229(95)00232-4","article-title":"Characterization of casein phosphopeptides prepared using alcalase: Determination of enzyme specificity","volume":"19","author":"Adamson","year":"1996","journal-title":"Enzyme Microb. 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