{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T22:06:10Z","timestamp":1768082770795,"version":"3.49.0"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1093\/toxsci\/kfx142","type":"journal-article","created":{"date-parts":[[2017,7,11]],"date-time":"2017-07-11T12:45:28Z","timestamp":1499777128000},"page":"422-435","source":"Crossref","is-referenced-by-count":44,"title":["From the Cover: Metabolism Modulation in Different Organs by Silver Nanoparticles: An NMR Metabolomics Study of a Mouse Model"],"prefix":"10.1093","volume":"159","author":[{"given":"Ivana","family":"Jarak","sequence":"first","affiliation":[]},{"given":"Joana","family":"Carrola","sequence":"additional","affiliation":[]},{"given":"Ant\u00f3nio S.","family":"Barros","sequence":"additional","affiliation":[]},{"given":"Ana M.","family":"Gil","sequence":"additional","affiliation":[]},{"given":"Maria de Lourdes","family":"Pereira","sequence":"additional","affiliation":[]},{"given":"Maria Luisa","family":"Corvo","sequence":"additional","affiliation":[]},{"given":"Iola F.","family":"Duarte","sequence":"additional","affiliation":[]}],"member":"286","published-online":{"date-parts":[[2017,7,14]]},"reference":[{"key":"key\n\t\t\t\t20170925085605_kfx142-B1","first-page":"5","article-title":"Pulmonary surfactants and their role in pathophysiology of lung disorders","volume":"51","year":"2013","journal-title":"Indian J. Exp. Biol"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B2","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s00580-012-1589-0","article-title":"Antioxidant and methyl donor effects of betaine versus ethanol-induced oxidative stress in the rat liver","volume":"23","year":"2014","journal-title":"Comp. Clin. Path"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B3","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3109\/01913123.2016.1150377","article-title":"Ultrastructural hepatocytic alterations induced by silver nanoparticle toxicity","volume":"40","year":"2016","journal-title":"Ultrastruct. Pathol"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B4","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.ijnurstu.2012.01.015","article-title":"Effect size estimation: Methods and examples","volume":"49","year":"2012","journal-title":"Int. J. Nurs. Stud"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B5","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1177\/0192623309332992","article-title":"Discovery of metabolomics biomarkers for early detection of nephrotoxicity","volume":"37","year":"2009","journal-title":"Toxicol. Pathol"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B6","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.abb.2015.08.022","article-title":"Insights into the impact of silver nanoparticles on human keratinocytes metabolism through NMR metabolomics","volume":"589","year":"2016","journal-title":"Arch. Biochem. Biophys"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B7","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1080\/17435390.2016.1177744","article-title":"Metabolomics of silver nanoparticles toxicity in HaCaT cells: Structure\u2013activity relationships and role of ionic silver and oxidative stress","volume":"10","year":"2016","journal-title":"Nanotoxicology"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B8","first-page":"602","article-title":"Silver nanoparticles induced oxidative and endoplasmic reticulum stresses in mouse tissues: Implications for the development of acute toxicity after intravenous administration","volume":"1","year":"2016","journal-title":"Toxicol. Res"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B9","first-page":"653","article-title":"Iodine-125 radiolabeling of silver nanoparticles for invivo SPECT imaging","volume":"5","year":"2010","journal-title":"Int. J. Nanomedicine"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B10","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1021\/ac048630x","article-title":"Statistical total correlation spectroscopy: An exploratory approach for latent biomarker identification from metabolic 1H NMR data sets","volume":"77","year":"2005","journal-title":"Anal. Chem"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B11","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ntt.2015.08.006","article-title":"Systemic and behavioral effects of intranasal administration of silver nanoparticles","volume":"51","year":"2015","journal-title":"Neurotoxicol. Teratol"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B12","doi-asserted-by":"crossref","first-page":"8333","DOI":"10.1016\/j.biomaterials.2013.06.048","article-title":"Systemic and immunotoxicity of silver nanoparticles in an intravenous 28 days repeated dose toxicity study in rats","volume":"34","year":"2013","journal-title":"Biomaterials"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B13","doi-asserted-by":"crossref","first-page":"4281","DOI":"10.1021\/ac051632c","article-title":"Probabilistic quotient normalization as robust method to account for dilution of complex biological mixtures. Application in 1\u2009H NMR metabonomics","volume":"78","year":"2006","journal-title":"Anal. Chem"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B14","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jconrel.2011.03.008","article-title":"Following dynamic biological processes through NMR-based metabonomics: A new tool in nanomedicine?","volume":"153","year":"2011","journal-title":"J. Control. Release"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B15","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.cis.2015.02.007","article-title":"Perturbation of cellular mechanistic system by silver nanoparticle toxicity: Cytotoxic, genotoxic and epigenetic potentials","volume":"221","year":"2015","journal-title":"Adv. Colloid Interface Sci"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B16","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1002\/jat.2758","article-title":"Time-dependent biodistribution and excretion of silver nanoparticles in male Wistar rats","volume":"32","year":"2012","journal-title":"J. Appl. Toxicol"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B17","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.etp.2014.09.005","article-title":"Evaluation of hepatotoxic and genotoxic potential of silver nanoparticles in albino rats","volume":"67","year":"2015","journal-title":"Exp. Toxicol. Pathol"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B18","doi-asserted-by":"crossref","first-page":"6558","DOI":"10.1016\/j.biomaterials.2011.05.035","article-title":"A metabonomic analysis of organ specific response to USPIO administration","volume":"32","year":"2011","journal-title":"Biomaterials"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B19","first-page":"2399","article-title":"Nanosilver particles in medical applications: Synthesis, performance, and toxicity","volume":"9","year":"2014","journal-title":"Int. J. Nanomedicine"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B20","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0014-5793(00)01843-3","article-title":"The initial pathogenesis of cadmium induced renal toxicity","volume":"478","year":"2000","journal-title":"FEBS Lett"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yrtph.2013.11.002","article-title":"Oral toxicity of silver ions, silver nanoparticles and colloidal silver - A review","volume":"68","year":"2014","journal-title":"Regul. Toxicol. Pharmacol"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B22","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1002\/jat.2779","article-title":"Nanoparticulate silver increases uric acid and allantoin excretion in rats, as identified by metabolomics","volume":"32","year":"2012","journal-title":"J. Appl. Toxicol"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B23","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/nbm.3485","article-title":"Investigation of relative metabolic changes in the organs and plasma of rats exposed to X-ray radiation using HR-MAS 1 H NMR and solution 1 H NMR","volume":"29","year":"2016","journal-title":"NMR Biomed"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B24","doi-asserted-by":"crossref","first-page":"455102.","DOI":"10.1088\/0957-4484\/24\/45\/455102","article-title":"Understanding the metabolic fate and assessing the biosafety of MnO nanoparticles by metabonomic analysis","volume":"24","year":"2013","journal-title":"Nanotechnology"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B25","first-page":"340","article-title":"Studies on the anti-inflammatory activity of creatine","volume":"231","year":"1978","journal-title":"Arch. Int. Pharmacodyn. Ther"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B26","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/jat.2792","article-title":"Silver nanoparticle-induced oxidative stress, genotoxicity and apoptosis in cultured cells and animal tissues","volume":"33","year":"2013","journal-title":"J. Appl. Toxicol"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B27","first-page":"855","article-title":"Acute and subchronic dermal toxicity of nanosilver in guinea pig","volume":"6","year":"2011","journal-title":"Int. J. Nanomedicine"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B28","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1007\/s11051-014-2411-5","article-title":"NMR-based metabonomic analysis of MnO-embedded iron oxide nanoparticles as potential dual-modal contrast agents","volume":"16","year":"2014","journal-title":"J. Nanoparticle Res"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B29","doi-asserted-by":"crossref","first-page":"792","DOI":"10.3109\/17435390.2014.976851","article-title":"Both released silver ions and particulate Ag contribute to the toxicity of AgNPs to earthworm Eisenia fetida","volume":"9","year":"2015","journal-title":"Nanotoxicology"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B30","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ecoenv.2015.05.005","article-title":"A metabolomic study on the responses of daphnia magna exposed to silver nitrate and coated silver nanoparticles","volume":"119","year":"2015","journal-title":"Ecotoxicol. Environ. Saf"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B31","first-page":"36","article-title":"Cytotoxicity and genotoxicity assessment of silver nanoparticles in mouse","volume":"8(Suppl. 1)","year":"2014","journal-title":"Nanotoxicology"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B32","doi-asserted-by":"crossref","first-page":"236.","DOI":"10.1186\/1556-276X-8-236","article-title":"Studies of single-walled carbon nanotubes-induced hepatotoxicity by NMR-based metabonomics of rat blood plasma and liver extracts","volume":"8","year":"2013","journal-title":"Nanoscale Res. Lett"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B33","doi-asserted-by":"crossref","first-page":"175101.","DOI":"10.1088\/0957-4484\/26\/17\/175101","article-title":"The effects of size and surface modification of amorphous silica particles on biodistribution and liver metabolism in mice","volume":"26","year":"2015","journal-title":"Nanotechnology"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B34","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.jcis.2005.03.005","article-title":"The role of poly(ethylene glycol) in the formation of silver nanoparticles","volume":"288","year":"2005","journal-title":"J. Colloid Interface Sci"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B35","doi-asserted-by":"crossref","first-page":"55101.","DOI":"10.1088\/0957-4484\/22\/5\/055101","article-title":"Integrated metabonomics analysis of the size-response relationship of silica nanoparticles-induced toxicity in mice","volume":"22","year":"2011","journal-title":"Nanotechnology"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B36","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.4155\/bio.15.83","article-title":"Metabolomics techniques for nanotoxicity investigations","volume":"7","year":"2015","journal-title":"Bioanalysis"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B37","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.nano.2013.06.008","article-title":"New long circulating magnetoliposomes as contrast agents for detection of ischemia\u2013reperfusion injuries by MRI","volume":"10","year":"2014","journal-title":"Nanomedicine"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B38","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.burns.2010.09.006","article-title":"Acticoat dressings and major burns: Systemic silver absorption","volume":"37","year":"2011","journal-title":"Burns"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B39","first-page":"353","article-title":"The nature and significance of liver cell vacuolation following hepatocellular injury\u2013An analysis based on observations on rats rendered tolerant to hepatotoxic damage","volume":"428","year":"1996","journal-title":"Virchows Arch"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B40","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.tox.2007.11.021","article-title":"The current state of serum biomarkers of hepatotoxicity","volume":"245","year":"2008","journal-title":"Toxicology"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B41","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1085\/jgp.26.4.391","article-title":"Studies on the mechanism of hydrogen transport in animal tissues","volume":"26","year":"1943","journal-title":"J. Gen. Physiol"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B42","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","article-title":"Dose translation from animal to human studies revisited","volume":"22","year":"2007","journal-title":"faseb J"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B43","first-page":"12.","article-title":"Tissue distribution and acute toxicity of silver after single intravenous administration in mice: Nano-specific and size-dependent effects","volume":"13","year":"2016","journal-title":"Part. Fibre Toxicol"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B44","first-page":"3937","article-title":"Differential cytotoxic and radiosensitizing effects of silver nanoparticles on triple-negative breast cancer and non-triple-negative breast cells","volume":"10","year":"2015","journal-title":"Int. J. Nanomedicine"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B45","doi-asserted-by":"crossref","first-page":"3534","DOI":"10.3748\/wjg.v19.i23.3534","article-title":"Liver-spleen axis: Intersection between immunity, infections and metabolism","volume":"19","year":"2013","journal-title":"World J. Gastroenterol"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B46","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.2217\/nnm-2016-0049","article-title":"Low-dose, subchronic exposure to silver nanoparticles causes mitochondrial alterations in Sprague\u2013Dawley rats","volume":"11","year":"2016","journal-title":"Nanomedicine"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B47","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0969-2126(99)80023-9","article-title":"The physiological structure of human C-reactive protein and its complex with phosphocholine","volume":"7","year":"1999","journal-title":"Structure"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B48","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3109\/15376516.2010.529184","article-title":"Dose-dependent in-vivo toxicity assessment of silver nanoparticle in Wistar rats","volume":"21","year":"2011","journal-title":"Toxicol. Mech. Methods"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B49","doi-asserted-by":"crossref","first-page":"33001.","DOI":"10.1088\/2043-6262\/4\/3\/033001","article-title":"Silver nanoparticles: Synthesis, properties, toxicology, applications and perspectives","volume":"4","year":"2013","journal-title":"Adv. Nat. Sci. Nanosci. Nanotechnol"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B50","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1021\/ac8011544","article-title":"Recursive segment-wise peak alignment of biological 1H NMR spectra for improved metabolic biomarker recovery","volume":"81","year":"2009","journal-title":"Anal. Chem"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B51","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.burns.2007.07.014","article-title":"The safety of nanocrystalline silver dressings on burns: A study of systemic silver absorption","volume":"33","year":"2007","journal-title":"Burns"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B52","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1039\/C4MB00622D","article-title":"The toxicity of acute exposure to T-2 toxin evaluated by the metabonomics technique","volume":"11","year":"2015","journal-title":"Mol. BioSyst. Mol. BioSyst"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B53","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1021\/ar2003336","article-title":"Metabolism of nanomaterials invivo: Blood circulation and organ clearance","volume":"46","year":"2013","journal-title":"Acc. Chem. Res"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B54","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.drudis.2014.11.014","article-title":"Silver nanoparticles: Synthesis, properties, and therapeutic applications","volume":"20","year":"2015","journal-title":"Drug Discov. Today"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B55","doi-asserted-by":"crossref","first-page":"D521","DOI":"10.1093\/nar\/gkl923","article-title":"HMDB: The Human Metabolome Database","volume":"35","year":"2007","journal-title":"Nucleic Acids Res"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B56","first-page":"4103","article-title":"Inhibition of A\/Human\/Hubei\/3\/2005 (H3N2) influenza virus infection by silver nanoparticles invitro and invivo","volume":"8","year":"2013","journal-title":"Int. J. Nanomedicine"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B57","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.msec.2006.05.029","article-title":"Modification of nanostructured materials for biomedical applications","volume":"27","year":"2007","journal-title":"Mater. Sci. Eng. C"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B58","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1002\/jat.2742","article-title":"Acute toxic effects and gender-related biokinetics of silver nanoparticles following an intravenous injection in mice","volume":"32","year":"2012","journal-title":"J. Appl. Toxicol"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B59","doi-asserted-by":"crossref","first-page":"9.","DOI":"10.1186\/1550-2783-7-9","article-title":"Creatine-induced activation of antioxidative defence in myotube cultures revealed by explorative NMR-based metabonomics and proteomics","volume":"7","year":"2010","journal-title":"J. Int. Soc. Sports Nutr"},{"key":"key\n\t\t\t\t20170925085605_kfx142-B60","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1093\/jn\/119.5.800","article-title":"Conversion of dietary choline to trimethylamine and dimethylamine in rats: Dose-response relationship","volume":"119","year":"1989","journal-title":"J. Nutr"}],"container-title":["Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/toxsci\/article-pdf\/159\/2\/422\/20094430\/kfx142.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,29]],"date-time":"2019-09-29T13:48:35Z","timestamp":1569764915000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/toxsci\/article\/159\/2\/422\/4036056\/From-the-Cover-Metabolism-Modulation-in-Different"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,14]]},"references-count":60,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,7,14]]},"published-print":{"date-parts":[[2017,10]]}},"URL":"https:\/\/doi.org\/10.1093\/toxsci\/kfx142","relation":{},"ISSN":["1096-6080","1096-0929"],"issn-type":[{"value":"1096-6080","type":"print"},{"value":"1096-0929","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,14]]}}}