{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T22:32:21Z","timestamp":1766269941141,"version":"3.44.0"},"reference-count":93,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Knut and Alice Wallenberg Foundation as part of the National Bioinformatics Infrastructure Sweden at Science for Life Laboratory","award":["PTDC\/BIA-EVL\/1307\/2020","2021.00150.CEECIND"],"award-info":[{"award-number":["PTDC\/BIA-EVL\/1307\/2020","2021.00150.CEECIND"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Demographic declines have important consequences for population viability, since they can lead to losses in genome diversity, as well as increased inbreeding and expression of deleterious mutations. Scandinavia was colonized by the Arctic fox (Vulpes lagopus) at the Pleistocene\/Holocene transition, and the population has since been on the periphery of the global distribution. The Scandinavian population became even more fragmented in the early 1900s due to human persecution, and experienced an additional decline in the 1980s. We generated high-coverage genomes from pre-bottleneck, as well as modern Scandinavian and Russian specimens, and found that genome-wide diversity was lower and inbreeding higher in Scandinavia compared to the Siberian population, even prior to the historical bottleneck, most likely reflecting the long-term partial isolation and recent postglacial origin of the Scandinavian population. The southern subpopulation has the highest inbreeding levels, likely due to having been recently founded and highly isolated. Our results also show that although inbreeding increased substantially over the past century, the amount of total genetic load did not change. Overall, these findings illustrate the utility of a temporal approach to disentangle the genomic consequences of recent declines from ancient biogeographic processes.<\/jats:p>","DOI":"10.1093\/zoolinnean\/zlaf078","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T07:52:40Z","timestamp":1750233160000},"source":"Crossref","is-referenced-by-count":1,"title":["Temporal genomic change in the Scandinavian Arctic fox (<i>Vulpes lagopus<\/i>)"],"prefix":"10.1093","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1324-7489","authenticated-orcid":false,"given":"Johanna","family":"von Seth","sequence":"first","affiliation":[{"name":"Department of Organismal Biology, Evolutionsbiologiskt Centrum EBC, Uppsala University , Norbyv\u00e4gen 18 A , 752 36 Uppsala,","place":["Sweden"]},{"name":"Centre for Palaeogenetics , Svante Arrhenius v\u00e4g 20C , Stockholm, SE-10691,","place":["Sweden"]},{"name":"Department of Bioinformatics and Genetics, Swedish Museum of Natural History , Box 50007 , Stockholm, SE-10405,","place":["Sweden"]},{"name":"Department of Zoology, Stockholm University , Stockholm, SE-10691,","place":["Sweden"]}]},{"given":"Petter","family":"Larsson","sequence":"additional","affiliation":[{"name":"Centre for Palaeogenetics , Svante Arrhenius v\u00e4g 20C , Stockholm, SE-10691,","place":["Sweden"]}]},{"given":"Malin","family":"Hasselgren","sequence":"additional","affiliation":[{"name":"Department of Zoology, Stockholm University , Stockholm, SE-10691,","place":["Sweden"]}]},{"given":"Nicolas","family":"Dussex","sequence":"additional","affiliation":[{"name":"Centre for Palaeogenetics , Svante Arrhenius v\u00e4g 20C , Stockholm, SE-10691,","place":["Sweden"]},{"name":"Department of Zoology, Stockholm University , Stockholm, SE-10691,","place":["Sweden"]},{"name":"Department of Population Analysis and Monitoring, Swedish Museum of Natural History , Box 50007 , Stockholm, SE-10405,","place":["Sweden"]}]},{"given":"Liliana","family":"Farelo","sequence":"additional","affiliation":[{"name":"InBIO Laborat\u00f3rio Associado, CIBIO, Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Gen\u00e9ticos, Universidade do Porto , Campus de Vair\u00e3o , 4485-661 Vair\u00e3o,","place":["Portugal"]},{"name":"BIOPOLIS Program in Genomics, Biodiversity and Land Planning, CIBIO , Campus de Vair\u00e3o , 4485-661 Vair\u00e3o,","place":["Portugal"]}]},{"given":"Johan","family":"Wall\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Zoology, Stockholm University , Stockholm, SE-10691,","place":["Sweden"]},{"name":"Department of Population Analysis and Monitoring, Swedish Museum of Natural History , Box 50007 , Stockholm, SE-10405,","place":["Sweden"]}]},{"given":"Verena E","family":"Kutschera","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Stockholm University , SE\u2011171 65 Solna,","place":["Sweden"]}]},{"given":"Nina E","family":"Eide","sequence":"additional","affiliation":[{"name":"Land and biodiversity, Norwegian Institute for Nature Research , Trondheim, NO-7485,","place":["Norway"]}]},{"given":"Arild","family":"Landa","sequence":"additional","affiliation":[{"name":"NINA-Bergen, Norwegian Institute for Nature Research , Thorm\u00f8hlensgate 55 , Bergen, NO-5006,","place":["Norway"]}]},{"given":"Anders","family":"Angerbj\u00f6rn","sequence":"additional","affiliation":[{"name":"Department of Zoology, Stockholm University , Stockholm, SE-10691,","place":["Sweden"]}]},{"given":"\u00d8ystein","family":"Flagstad","sequence":"additional","affiliation":[{"name":"Land and biodiversity, Norwegian Institute for Nature Research , Trondheim, NO-7485,","place":["Norway"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4473-1908","authenticated-orcid":false,"given":"Jos\u00e9","family":"Melo-Ferreira","sequence":"additional","affiliation":[{"name":"InBIO Laborat\u00f3rio Associado, CIBIO, Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Gen\u00e9ticos, Universidade do Porto , Campus de Vair\u00e3o , 4485-661 Vair\u00e3o,","place":["Portugal"]},{"name":"BIOPOLIS Program in Genomics, Biodiversity and Land Planning, CIBIO , Campus de Vair\u00e3o , 4485-661 Vair\u00e3o,","place":["Portugal"]},{"name":"Department of Biology, Faculty of Sciences, University of Porto , Rua Campo Alegre s\/n , 4169-007 Porto,","place":["Portugal"]}]},{"given":"Karin","family":"Nor\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Zoology, Stockholm University , Stockholm, SE-10691,","place":["Sweden"]}]},{"given":"Love","family":"Dal\u00e9n","sequence":"additional","affiliation":[{"name":"Centre for Palaeogenetics , 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