{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:03:45Z","timestamp":1791911025470,"version":"4.3.4"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,4,1]]},"DOI":"10.1095\/biolreprod.102.010504","type":"journal-article","created":{"date-parts":[[2004,10,20]],"date-time":"2004-10-20T18:30:50Z","timestamp":1098297050000},"page":"1232-1240","source":"Crossref","is-referenced-by-count":68,"title":["Neonatal Hypothyroidism Alters the Localization of Gap Junctional Protein Connexin 43 in the Testis and Messenger RNA Levels in the Epididymis of the Rat1"],"prefix":"10.1093","volume":"68","author":[{"given":"Nancy","family":"St-Pierre","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Dufresne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew A.","family":"Rooney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel G.","family":"Cyr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"key\n\t\t\t\t20170224172522_R1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s004180050409","article-title":"Expression of connexin 43 in human testis","volume":"112","year":"1999","journal-title":"Histochem Cell Biol"},{"key":"key\n\t\t\t\t20170224172522_R2","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1095\/biolreprod65.3.829","article-title":"Failure of spermatogenesis in mice lacking Cx43","volume":"65","year":"2001","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224172522_R3","first-page":"103","article-title":"Cellular interactions and the blood-epididymal barrier","volume-title":"The Epididymis: From Molecules to Clinical Practice","year":"2002"},{"key":"key\n\t\t\t\t20170224172522_R4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1432-1033.1996.0001q.x","article-title":"Connections with connexins: the molecular basis of direct intercellular signaling","volume":"238","year":"1996","journal-title":"Eur J Biochem"},{"key":"key\n\t\t\t\t20170224172522_R5","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0962-8924(98)01372-5","article-title":"Diverse function of vertebrate gap junctions","volume":"8","year":"1998","journal-title":"Trends Cell Biol"},{"key":"key\n\t\t\t\t20170224172522_R6","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1242\/jcs.103.1.81","article-title":"Cell-, age- and stage-dependent distribution of connexin 43 gap junctions in testes","volume":"103","year":"1992","journal-title":"J Cell Sci"},{"key":"key\n\t\t\t\t20170224172522_R7","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1177\/002215540004800608","article-title":"Connexin43 gene expression and regulation in the rodent seminiferous epithelium","volume":"48","year":"2000","journal-title":"J Histochem Cytochem"},{"key":"key\n\t\t\t\t20170224172522_R8","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/ar.1164","article-title":"Developmental regulation of connexin 43 expression in fetal mouse testicular cells","volume":"264","year":"2001","journal-title":"Anat Rec"},{"key":"key\n\t\t\t\t20170224172522_R9","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1210\/endo.137.4.8625926","article-title":"Immunocytochemical localization and regulation of connexin43 in the adult rat epididymis","volume":"137","year":"1996","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224172522_R10","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1095\/biolreprod54.6.1300","article-title":"Regulated assembly of connexin33 and connexin43 into rat Sertoli cell gap junctions","volume":"54","year":"1996","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224172522_R11","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1095\/biolreprod62.3.748","article-title":"Connexin gene expression in seminiferous tubules of the Sprague-Dawley rat","volume":"62","year":"2000","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224172522_R12","doi-asserted-by":"crossref","first-page":"C33","DOI":"10.1152\/ajpcell.00111.2002","article-title":"Developmental changes in the expression of multiples connexins in the rat epididymis indicates a complex regulation of gap junctional communication","volume":"284","year":"2003","journal-title":"Am J Physiol Cell Physiol"},{"key":"key\n\t\t\t\t20170224172522_R13","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S0006-2952(97)00473-5","article-title":"Enhancement of gap junctional communication and connexin43 expression by thyroid hormones","volume":"55","year":"1998","journal-title":"Biochem Pharmacol"},{"key":"key\n\t\t\t\t20170224172522_R14","first-page":"973","article-title":"Thyroid hormone receptors bind to an element in the connexin43 promoter","volume":"381","year":"2000","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170224172522_R15","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/978-94-011-3060-8_8","article-title":"Thyroid hormones","volume-title":"Hormones","year":"1990"},{"key":"key\n\t\t\t\t20170224172522_R16","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/j.1749-6632.1991.tb27305.x","article-title":"Thyroid hormones and testis development: a model system for increasing testis growth and sperm production","volume":"637","year":"1991","journal-title":"Ann NY Acad Sci"},{"key":"key\n\t\t\t\t20170224172522_R17","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1210\/endo-129-1-237","article-title":"Early hypothyroidism in rats causes increased adult testis and reproductive organ size but does not change testosterone levels","volume":"129","year":"1991","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224172522_R18","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1210\/endo.132.6.8504761","article-title":"Adult testicular enlargement induced by neonatal hypothyroidism is accompanied by increased Sertoli and germ cell numbers","volume":"132","year":"1993","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224172522_R19","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1210\/endo.132.6.8504746","article-title":"Leydig cells increase their numbers but decline in steroidogenic function in the adult rat after neonatal hypothyroidism","volume":"132","year":"1993","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224172522_R20","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3109\/01485017908985043","article-title":"Thyroid gland and epididymal function in rats\u2014histological study","volume":"3","year":"1979","journal-title":"Arch Androl"},{"key":"key\n\t\t\t\t20170224172522_R21","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1126\/science.3672126","article-title":"A novel thyroid hormone receptor encoded by a cDNA clone from a human testis library","volume":"238","year":"1987","journal-title":"Science"},{"key":"key\n\t\t\t\t20170224172522_R22","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1095\/biolreprod62.3.664","article-title":"Developmental expression of thyroid hormone receptors in the rat testis","volume":"62","year":"2000","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224172522_R23","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1002\/j.1939-4640.2001.tb02182.x","article-title":"Thyroid hormone receptors in neonatal, prepubertal, and adult rat testis","volume":"22","year":"2001","journal-title":"J Androl"},{"key":"key\n\t\t\t\t20170224172522_R24","first-page":"844","article-title":"Expression profiles of the three iodothyronine deiodinases, D1, D2, and D3, in the developing rat","volume":"440","year":"1999","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224172522_R25","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1080\/014850100262155","article-title":"High-affinity binding of T3 to epididymis nuclei","volume":"44","year":"2000","journal-title":"Arch Androl"},{"key":"key\n\t\t\t\t20170224172522_R26","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1210\/endo.138.7.5287","article-title":"Neonatal hypothyroidism permanently alters follicle-stimulating hormone and luteinizing hormone production in the male rat","volume":"138","year":"1997","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224172522_R27","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/ar.1091760309","article-title":"The normal development of the blood-testis barrier and the effects of Clomiphene and estrogen treatment","volume":"176","year":"1973","journal-title":"Anat Rec"},{"key":"key\n\t\t\t\t20170224172522_R28","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/j.1939-4640.1989.tb00132.x","article-title":"Ultrastructural studies on the development of the blood-epididymis barrier in immature rat","volume":"10","year":"1989","journal-title":"J Androl"},{"key":"key\n\t\t\t\t20170224172522_R29","article-title":"Molecular Cloning: A Laboratory Manual","year":"1991"},{"key":"key\n\t\t\t\t20170224172522_R30","first-page":"156","article-title":"Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction","volume":"162","year":"1987","journal-title":"Ann Biochem"},{"key":"key\n\t\t\t\t20170224172522_R31","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1083\/jcb.105.6.2621","article-title":"Connexin 43: a protein from rat heart homologous to a gap junction protein from liver","volume":"105","year":"1987","journal-title":"J Cell Biol"},{"key":"key\n\t\t\t\t20170224172522_R32","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1210\/endo.141.2.7334","article-title":"Multiple cadherin superfamily members with unique expression profiles are produced in rat testis","volume":"141","year":"2000","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224172522_R33","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1210\/endo.130.1.1727709","article-title":"Distribution and regulation of epithelial cadherin messenger ribonucleic acid and immunocytochemical localization of epithelial cadherin in the rat epididymis","volume":"130","year":"1992","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224172522_R34","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1083\/jcb.114.3.545","article-title":"Regulation of connexin 43-mediated gap junctional intercellular communication by CA2+ in mouse epidermal cells is controlled by E-cadherin","volume":"114","year":"1991","journal-title":"J Cell Biol"},{"key":"key\n\t\t\t\t20170224172522_R35","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1530\/eje.0.1350251","article-title":"Gap junction-mediated cell-to-cell communication in endocrine glands\u2014molecular and functional aspects: a review","volume":"135","year":"1996","journal-title":"Eur J Endocrinol"},{"key":"key\n\t\t\t\t20170224172522_R36","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1161\/01.RES.83.6.679","article-title":"Gap junction proteins. Where they live and how they die","volume":"83","year":"1998","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170224172522_R37","doi-asserted-by":"crossref","first-page":"3815","DOI":"10.1210\/endo.140.8.6903","article-title":"Cellular immunolocalization of occludin during embryonic and postnatal development of the mouse testis and epididymis","volume":"140","year":"1999","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224172522_R38","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1083\/jcb.143.2.391","article-title":"A single gene product, claudin-1 or -2, reconstitutes tight junction strands and recruits occludin in fibroblasts","volume":"143","year":"1998","journal-title":"J Cell Biol"},{"key":"key\n\t\t\t\t20170224172522_R39","doi-asserted-by":"crossref","first-page":"C1708","DOI":"10.1152\/ajpcell.1998.274.6.C1708","article-title":"Occludin is concentrated at tight junctions of mouse\/rat but not human\/guinea pig Sertoli cells in testes","volume":"274","year":"1998","journal-title":"Am J Physiol"},{"key":"key\n\t\t\t\t20170224172522_R40","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0092-8674(00)81553-6","article-title":"CNS myelin and Sertoli cell tight junction strands are absent in Osp\/claudin-11 null mice","volume":"99","year":"1999","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170224172522_R41","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/S0960-9822(07)00375-2","article-title":"The gap junction protein connexin 43 interacts with the second PDZ domain of the zona occludens-1 protein","volume":"8","year":"1998","journal-title":"Curr Biol"},{"key":"key\n\t\t\t\t20170224172522_R42","doi-asserted-by":"crossref","first-page":"12725","DOI":"10.1074\/jbc.273.21.12725","article-title":"Direct association of the gap junction protein connexin-43 with ZO-1 in cardiac myocytes","volume":"273","year":"1998","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170224172522_R43","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1006\/bbrc.1999.1778","article-title":"Induction of tight junctions in human connexin 32 (hCx32)-transfected mouse hepatocytes: connexin 32 interacts with occludin","volume":"266","year":"1999","journal-title":"Biochem Biophys Res Comm"},{"key":"key\n\t\t\t\t20170224172522_R44","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1210\/endo.133.2.8344214","article-title":"High neonatal triiodothyronine levels reduce the period of Sertoli cell proliferation and accelerate tubular lumen formation in the rat testis, and increase serum inhibin levels","volume":"133","year":"1993","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224172522_R45","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1210\/endo.137.7.8770903","article-title":"Reduced cell-cell communication in experimentally induced autoimmune thyroid disease","volume":"137","year":"1996","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224172522_R46","first-page":"13","article-title":"Elevation of protein kinase C in thymocytes isolated from a Lewis rat model of autoimmune thyroiditis prevents assembly of immunodetectable connexin43 gap junctions and reduces intercellular communication","volume":"7","year":"1997","journal-title":"Thyroid"},{"key":"key\n\t\t\t\t20170224172522_R47","first-page":"559","article-title":"Developmental hormonal profiles accompanying the neonatal hypothyroidism-induced increase in adult testicular size and sperm production in the rat","volume":"131","year":"1992","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224172522_R48","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1210\/endo.142.2.7975","article-title":"Claudin-1 is not restricted to tight junctions in the rat epididymis","volume":"142","year":"2001","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224172522_R49","first-page":"47","article-title":"Testicular regulation of epididymal gene expression","volume":"53","year":"1998","journal-title":"J Reprod Fertil"},{"key":"key\n\t\t\t\t20170224172522_R50","first-page":"2160","article-title":"Regulation of sulfated glycoprotein-2 (clusterin) messenger ribonucleic acid in the rat epididymis","volume":"130","year":"2002","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224172522_R51","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1210\/endo.132.3.7679970","article-title":"Developmental regulation of epithelial cadherin messenger ribonucleic acid and immunocytochemical localization of epithelial cadherin in the rat epididymis","volume":"132","year":"1993","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224172522_R52","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1083\/jcb.119.1.179","article-title":"Inhibition of gap junction and adherens junction assembly by connexin and A-CAM antibodies","volume":"119","year":"1992","journal-title":"J Cell Biol"},{"key":"key\n\t\t\t\t20170224172522_R53","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1242\/jcs.110.3.301","article-title":"An inhibition of gap junctional communication by cadherins","volume":"110","year":"1997","journal-title":"J Cell Sci"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/biolreprod\/article-pdf\/68\/4\/1232\/10558678\/biolreprod1232.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T02:31:29Z","timestamp":1734575489000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-lookup\/doi\/10.1095\/biolreprod.102.010504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,4,1]]},"references-count":53,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2003,4,1]]}},"URL":"https:\/\/doi.org\/10.1095\/biolreprod.102.010504","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,4,1]]}}}