{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:40:58Z","timestamp":1788543658495,"version":"build-2803163510"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,6,1]]},"DOI":"10.1095\/biolreprod.102.010785","type":"journal-article","created":{"date-parts":[[2004,10,20]],"date-time":"2004-10-20T18:30:50Z","timestamp":1098297050000},"page":"2274-2280","source":"Crossref","is-referenced-by-count":28,"title":["Smoking Enhances Oxytocin-Induced Rhythmic Myometrial Contraction1"],"prefix":"10.1093","volume":"68","author":[{"given":"Makoto","family":"Egawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhiko","family":"Yasuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetaka","family":"Okada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoo","family":"Yoshimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Yuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Yasuhara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Nakamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumie","family":"Nagata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideharu","family":"Kanzaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"key\n\t\t\t\t20170224171025_R1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1053\/siny.2000.0025","article-title":"Perinatal complications associated with maternal tobacco use","volume":"5","year":"2000","journal-title":"Semin Neonatol"},{"key":"key\n\t\t\t\t20170224171025_R2","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/0002-9378(57)90391-5","article-title":"A preliminary report of cigarette smoking and the incidence of prematurity","volume":"73","year":"1957","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t20170224171025_R3","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/0002-9378(95)90287-2","article-title":"Factors associated with preterm birth in Cardiff, Wales. I. Univariable and multivariable analysis","volume":"173","year":"1995","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t20170224171025_R4","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/0002-9378(77)90031-X","article-title":"Maternal smoking, pregnancy complications, and perinatal mortality","volume":"128","year":"1977","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t20170224171025_R5","doi-asserted-by":"crossref","first-page":"87","DOI":"10.2105\/AJPH.82.1.87","article-title":"Cigarette, alcohol, and coffee consumption and prematurity","volume":"82","year":"1992","journal-title":"Am J Public Health"},{"key":"key\n\t\t\t\t20170224171025_R6","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S0950-3552(05)80447-X","article-title":"Biochemistry and physiology of preterm labour and delivery","volume":"7","year":"1993","journal-title":"Baillieres Clinic Obstet Gynecol"},{"key":"key\n\t\t\t\t20170224171025_R7","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1006\/bbrc.1997.7397","article-title":"The prostaglandin E2 and F2\u03b1 receptor genes are expressed in human myometrium and are down-regulated during pregnancy","volume":"238","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"key\n\t\t\t\t20170224171025_R8","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1210\/endo.137.2.8593830","article-title":"Expression of oxytocin receptor in human pregnant myometrium","volume":"137","year":"1996","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224171025_R9","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/978-1-4471-1931-9_17","article-title":"Inhibition of prostaglandin synthesis for treatment of preterm labour","volume-title":"Prostaglandins and the Uterus","year":"1992"},{"key":"key\n\t\t\t\t20170224171025_R10","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/0002-9378(80)90455-X","article-title":"Uterine contractility and oxytocin sensitivity in preterm, term, and postterm pregnancy","volume":"136","year":"1980","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t20170224171025_R11","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1111\/j.1471-0528.1987.tb02287.x","article-title":"Inhibition of uterine contractions of premature labour with an oxytocin analogue. Results from a pilot study","volume":"94","year":"1987","journal-title":"Br J Obstet Gynecol"},{"key":"key\n\t\t\t\t20170224171025_R12","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1067\/mob.2000.104950","article-title":"Double-blind, randomized, controlled trial of atociban and ritodrine in the treatment of preterm labor: a multicenter effectiveness and safety study","volume":"182","year":"2000","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t20170224171025_R13","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1073\/pnas.92.1.200","article-title":"Structure, characterization, and expression of rat oxytocin receptor gene","volume":"92","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170224171025_R14","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/0014-5793(94)01198-2","article-title":"Cloning of the rat and human prostaglandin F2\u03b1 receptors and the expression of the rat prostaglandin F2\u03b1 receptor","volume":"355","year":"1994","journal-title":"FEBS Lett"},{"key":"key\n\t\t\t\t20170224171025_R15","first-page":"13","article-title":"Occupational and socio-medical factors in preterm birth","volume":"74","year":"1989","journal-title":"Obstet Gynecol"},{"key":"key\n\t\t\t\t20170224171025_R16","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1093\/ije\/19.1.101","article-title":"Determinants of preterm delivery and intrauterine growth retardation in North-East Brazil","volume":"19","year":"1990","journal-title":"Int J Epidemiol"},{"key":"key\n\t\t\t\t20170224171025_R17","first-page":"1290","article-title":"Spontaneous preterm birth: A case-control study","volume-title":"Am J Obstet Gynecol","year":"1991"},{"key":"key\n\t\t\t\t20170224171025_R18","first-page":"347","article-title":"Risk factors associated with preterm deliveries among racial groups in a national sample of married mothers","volume":"5","year":"1991","journal-title":"Am J Perinatol"},{"key":"key\n\t\t\t\t20170224171025_R19","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1093\/oxfordjournals.aje.a116535","article-title":"Maternal nutrition and spontaneous birth","volume":"136","year":"1992","journal-title":"Am J Epidemiol"},{"key":"key\n\t\t\t\t20170224171025_R20","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/S0002-9378(12)90878-9","article-title":"Effect of age, parity, and smoking on pregnancy outcome: A population based study","volume":"168","year":"1993","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t20170224171025_R21","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1111\/j.1471-0528.1996.tb09877.x","article-title":"Smoking during pregnancy and preterm birth","volume":"103","year":"1996","journal-title":"Br J Obstet Gynecol"},{"key":"key\n\t\t\t\t20170224171025_R22","first-page":"687","article-title":"Review on prostaglandin and oxytocin activity in preterm labor","volume":"2","year":"2001","journal-title":"Coll Antropol"},{"key":"key\n\t\t\t\t20170224171025_R23","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/0002-9378(84)90677-X","article-title":"Oxytocin receptors in the human uterus during pregnancy and parturition","volume":"150","year":"1984","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t20170224171025_R24","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/S1071-5576(01)00105-8","article-title":"Oxytocin and its receptor in the process of parturition","volume":"8","year":"2001","journal-title":"J Soc Gynecol Investig"},{"key":"key\n\t\t\t\t20170224171025_R25","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1139\/o83-078","article-title":"Regulation of oxytocin receptor concentration in rat uterine explants by estrogen and progesterone","volume":"61","year":"1983","journal-title":"Can J Biochem Cell Biol"},{"key":"key\n\t\t\t\t20170224171025_R26","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0006-291X(75)80080-5","article-title":"Uterine receptors for oxytocin: effects of estrogen","volume":"65","year":"1975","journal-title":"Biochem Biophys Res Commun"},{"key":"key\n\t\t\t\t20170224171025_R27","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1540\/jsmr.31.175","article-title":"The regulation of oxytocin receptor expression in human myometrial monolayer culture","volume":"31","year":"1995","journal-title":"J Smooth Muscle Res"},{"key":"key\n\t\t\t\t20170224171025_R28","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0301-2115(00)00254-2","article-title":"Cytotoxic effects of cigarette smoke alkaloids inhibit the progesterone production and cell growth of cultured MA-10 Leydig tumor cells","volume":"93","year":"2000","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"key\n\t\t\t\t20170224171025_R29","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1095\/biolreprod67.1.178","article-title":"Placental endocrine disruption induced by cadmium: effects on P450 cholesterol side-chain cleavage and 3\u03b2-hydroxysteroid dehydrogenase enzymes in cultured human trophoblasts","volume":"67","year":"2002","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224171025_R30","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/0002-9378(84)90156-X","article-title":"Effects of smoking on fetoplacental-maternal system during pregnancy","volume":"149","year":"1984","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t20170224171025_R31","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/j.1471-0528.1989.tb01582.x","article-title":"Cigarette smoking in pregnancy results in marked decrease in maternal hCG and oestradiol levels","volume":"96","year":"1989","journal-title":"Br J Obstet Gynaecol."},{"key":"key\n\t\t\t\t20170224171025_R32","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1172\/JCI112494","article-title":"Nicotine, cotinine, and anabasine inhibit aromatase in human trophoblast in vitro","volume":"77","year":"1986","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20170224171025_R33","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/S0015-0282(16)49517-8","article-title":"Constituents of cigarette smoke inhibit human granulosa cell aromatase","volume":"46","year":"1986","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20170224171025_R34","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/0890-6238(94)90032-9","article-title":"Acute cadmium exposure and ovarian steroidogenesis in cycling and pregnant rats","volume":"8","year":"1994","journal-title":"Reprod Toxicol"},{"key":"key\n\t\t\t\t20170224171025_R35","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1177\/107155769400100303","article-title":"Changes in oxytocin receptor messenger RNA in the endometrium, myometrium, mesometrium, and cervix of sheep in late gestation and during spontaneous and cortisol-induced labor","volume":"1","year":"1994","journal-title":"J Soc Gynecol Investig"},{"key":"key\n\t\t\t\t20170224171025_R36","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.1210\/endo.139.8.6147","article-title":"Induction of oxytocin receptor gene expression in rabbit amnion cells","volume":"139","year":"1998","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224171025_R37","first-page":"987","article-title":"The effect of steroid hormone on oxytocin receptor expression in primary human uterine myometrium cell culture","volume":"45","year":"1993","journal-title":"Acta Obstet Gynaecol Jpn"},{"key":"key\n\t\t\t\t20170224171025_R38","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1677\/joe.0.0660061","article-title":"Mechanism of action of glucocorticoids in induction of ovine parturition: effect of placental steroid metabolism","volume":"66","year":"1975","journal-title":"J Endocrinol"},{"key":"key\n\t\t\t\t20170224171025_R39","first-page":"2104","article-title":"Medroxyprogesterone acetate and dexamethasone are competitive inhibitors of different human steroidogenic enzymes","volume":"84","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20170224171025_R40","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.8755-8920.2000.430204.x","article-title":"Interleukin-1\u03b2 down-regulates the oxytocin receptor in cultured uterine smooth muscle cells","volume":"43","year":"2000","journal-title":"Am J Reprod Immunol"},{"key":"key\n\t\t\t\t20170224171025_R41","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1210\/endo.142.4.8107","article-title":"Transcriptional regulation of oxytocin receptor by interleukin-1\u03b2 and interleukin-6","volume":"142","year":"2001","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224171025_R42","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S1071-5576(01)00142-3","article-title":"Production of oxytocin receptor and cytokines in primary uterine smooth muscle cells cultured under inflammatory conditions","volume":"9","year":"2002","journal-title":"J Soc Gynecol Investig"},{"key":"key\n\t\t\t\t20170224171025_R43","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1677\/joe.0.1540007","article-title":"The desensitization of oxytocin receptors in human myometrial cells is accompanied by down-regulation of oxytocin receptor messenger RNA","volume":"154","year":"1997","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224171025_R44","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1093\/humupd\/4.5.625","article-title":"Desensitization of oxytocin receptors in human myometrium","volume":"4","year":"1998","journal-title":"Hum Reprod Update"},{"key":"key\n\t\t\t\t20170224171025_R45","first-page":"65","article-title":"Effects of LPS and IL-6 on oxytocin receptor in non-pregnant and pregnant rat uterus","volume":"44","year":"200","journal-title":"Am J Reprod Immunol"},{"key":"key\n\t\t\t\t20170224171025_R46","first-page":"E477","article-title":"Effect of chronic hypoxia on myometrial responsiveness in the pregnant rat","volume":"270","year":"1996","journal-title":"Am J Physiol"},{"key":"key\n\t\t\t\t20170224171025_R47","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0002-9378(97)70158-3","article-title":"Suppression of myometrial contractile response to oxytocin after different durations of chronic hypoxia in the near-term pregnant rat","volume":"177","year":"1997","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t20170224171025_R48","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0014-2999(98)00504-4","article-title":"Functional determination of oxytocin affinity in near-term pregnant rat myometrium: effect of chronic hypoxia","volume":"356","year":"1998","journal-title":"Eur J Pharmacol"},{"key":"key\n\t\t\t\t20170224171025_R49","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3109\/03602539109029754","article-title":"Metabolism of nicotine","volume":"23","year":"1991","journal-title":"Drug Metab Rev"},{"key":"key\n\t\t\t\t20170224171025_R50","first-page":"125","article-title":"Pharmacokinetics of nicotine and 12 metabolites in the rat. Application of a new radiometric high performance liquid chromatography assay","volume":"16","year":"1988","journal-title":"Drug Metab Dispos"},{"key":"key\n\t\t\t\t20170224171025_R51","first-page":"173","article-title":"Disposition of nicotine in the rat after intravenous administration","volume":"13","year":"1976","journal-title":"Res Commun Chem Pathol Pharmacol"},{"key":"key\n\t\t\t\t20170224171025_R52","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/BF00543327","article-title":"Steady-state concentration of cotinine as a measure of nicotine intake by smokers","volume":"28","year":"1985","journal-title":"Eur J Clin Pharmacol"},{"key":"key\n\t\t\t\t20170224171025_R53","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/BF00606635","article-title":"Kinetics of cotinine after oral and intravenous administration to man","volume":"31","year":"1987","journal-title":"Eur J Clin Pharmacol"},{"key":"key\n\t\t\t\t20170224171025_R54","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/BF00315031","article-title":"The pharmacokinetics of cotinine in plasma and saliva from non-smoking healthy volunteers","volume":"38","year":"1990","journal-title":"Eur J Clin Pharmacol"},{"key":"key\n\t\t\t\t20170224171025_R55","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/S0002-9378(99)70521-1","article-title":"Nicotine patch use in pregnant smokers: Nicotine and cotinine levels and fetal effects","volume":"181","year":"1999","journal-title":"Am J Obstet Gynecol"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/biolreprod\/article-pdf\/68\/6\/2274\/10562578\/biolreprod2274.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,29]],"date-time":"2023-04-29T16:36:37Z","timestamp":1682786197000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-lookup\/doi\/10.1095\/biolreprod.102.010785"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,6,1]]},"references-count":55,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2003,6,1]]}},"URL":"https:\/\/doi.org\/10.1095\/biolreprod.102.010785","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,6,1]]}}}