{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T21:54:56Z","timestamp":1783634096146,"version":"3.55.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,1,1]]},"DOI":"10.1095\/biolreprod.103.019232","type":"journal-article","created":{"date-parts":[[2004,10,20]],"date-time":"2004-10-20T18:30:50Z","timestamp":1098297050000},"page":"168-177","source":"Crossref","is-referenced-by-count":33,"title":["Expression of Platelet-Derived Growth Factor (PDGF) in the Epididymis and Analysis of the Epididymal Development in PDGF-A, PDGF-B, and PDGF Receptor \u03b2 Deficient Mice"],"prefix":"10.1093","volume":"70","author":[{"given":"Sabrina","family":"Basciani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Mariani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Arizzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Brama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Ricci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christer","family":"Betsholtz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Bondjers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Ricci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Catizone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Galdieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Spera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucio","family":"Gnessi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"key\n\t\t\t\t20170224170700_R1","first-page":"284","article-title":"New members of the platelet-derived growth factor family of mitogens.","volume":"15","year":"2002","journal-title":"Arch Biochem Biophys"},{"key":"key\n\t\t\t\t20170224170700_R2","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1002\/bies.1069","article-title":"Developmental roles of platelet derived growth factor.","volume":"23","year":"2001","journal-title":"Bioessays"},{"key":"key\n\t\t\t\t20170224170700_R3","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/S0958-1669(99)00024-5","article-title":"Current biology of VEGF-B and VEGF-C.","volume":"10","year":"1999","journal-title":"Curr Opin Biotechnol"},{"key":"key\n\t\t\t\t20170224170700_R4","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1152\/physrev.1999.79.4.1283","article-title":"Mechanism of action and in vivo role of platelet derived growth factor.","volume":"79","year":"1999","journal-title":"Physiol Rev"},{"key":"key\n\t\t\t\t20170224170700_R5","first-page":"1875","article-title":"Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities.","volume":"15","year":"1994","journal-title":"Genes Dev"},{"key":"key\n\t\t\t\t20170224170700_R6","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1101\/gad.8.16.1888","article-title":"Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice.","volume":"8","year":"1994","journal-title":"Genes Dev"},{"key":"key\n\t\t\t\t20170224170700_R7","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1126\/science.277.5323.242","article-title":"Pericyte loss and microaneurysm formation in PDGF-B-deficient mice.","volume":"277","year":"1997","journal-title":"Science"},{"key":"key\n\t\t\t\t20170224170700_R8","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1242\/dev.125.17.3313","article-title":"Paracrine PDGF-B\/PDGF-R\u03b2 signaling controls mesangial cell development in kidney glomeruli.","volume":"125","year":"1998","journal-title":"Development"},{"key":"key\n\t\t\t\t20170224170700_R9","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/S0092-8674(00)81270-2","article-title":"PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis.","volume":"85","year":"1996","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170224170700_R10","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1242\/dev.126.12.2611","article-title":"Roles of PDGF-A and sonic hedgehog in development of mesenchymal components of the hair follicle.","volume":"126","year":"1999","journal-title":"Development"},{"key":"key\n\t\t\t\t20170224170700_R11","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1242\/dev.126.3.457","article-title":"Defective oligodendrocyte development and severe hypomyelination in PDGF-A knockout mice.","volume":"126","year":"1999","journal-title":"Development"},{"key":"key\n\t\t\t\t20170224170700_R12","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1083\/jcb.149.5.1019","article-title":"Leydig cell loss and spermatogenic arrest in platelet-derived growth factor (PDGF)-A-deficient mice.","volume":"149","year":"2000","journal-title":"J Cell Biol"},{"key":"key\n\t\t\t\t20170224170700_R13","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1242\/dev.124.14.2691","article-title":"The PDGF-\u03b1 receptor is required for neural crest cell development and for normal patterning of the somites.","volume":"124","year":"1997","journal-title":"Development"},{"key":"key\n\t\t\t\t20170224170700_R14","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1101\/gad.1052503","article-title":"PDGFR-\u03b1 mediates testis cord organization and fetal Leydig cell development in the XY gonad.","volume":"17","year":"2003","journal-title":"Genes Dev"},{"key":"key\n\t\t\t\t20170224170700_R15","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/35010579","article-title":"PDGF-C is a new protease-activated ligand for the PDGF \u03b1-receptor.","volume":"2","year":"2000","journal-title":"Nat Cell Biol"},{"key":"key\n\t\t\t\t20170224170700_R16","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/35074588","article-title":"PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor.","volume":"3","year":"2001","journal-title":"Nat Cell Biol"},{"key":"key\n\t\t\t\t20170224170700_R17","first-page":"301","article-title":"Temporal and spatial specificity of PDGF alpha receptor promoter in transgenic mice.","volume":"6","year":"1997","journal-title":"Gene Expr"},{"key":"key\n\t\t\t\t20170224170700_R18","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/ki.1992.300","article-title":"Developmental patterns of PDGF B-chain, PDGF-receptor, and alpha-actin expression in human glomerulogenesis.","volume":"42","year":"1992","journal-title":"Kidney Int"},{"key":"key\n\t\t\t\t20170224170700_R19","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/ki.1995.278","article-title":"Platelet-derived growth factor A-chain expression in developing and mature human kidneys and in Wilms\u2019 tumor.","volume":"48","year":"1995","journal-title":"Kidney Int"},{"key":"key\n\t\t\t\t20170224170700_R20","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0925-4773(01)00560-3","article-title":"Expression analysis of PDGF-C in adult and developing mouse tissues.","volume":"110","year":"2002","journal-title":"Mech Dev"},{"key":"key\n\t\t\t\t20170224170700_R21","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1083\/jcb.131.4.1105","article-title":"Testicular development involves the spatiotemporal control of PDGFs and PDGF receptors gene expression and action.","volume":"131","year":"1995","journal-title":"J Cell Biol"},{"key":"key\n\t\t\t\t20170224170700_R22","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/mrd.1080360406","article-title":"Identification of receptor tyrosine kinases in the rat testis.","volume":"36","year":"1993","journal-title":"Mol Reprod Dev"},{"key":"key\n\t\t\t\t20170224170700_R23","first-page":"87","article-title":"Growth factor expression during rat development: a comparison of TGF-\u03b23, TGF-\u03b1, bFGF, PDGF and PDGF-R.","volume":"74","year":"1993","journal-title":"Int J Exp Pathol"},{"key":"key\n\t\t\t\t20170224170700_R24","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0303-7207(93)90218-9","article-title":"Discrete stimulatory effects of platelet-derived growth factor (PDGF-BB) on Leydig cell steroidogenesis.","volume":"97","year":"1993","journal-title":"Mol Cell Endocrinol"},{"key":"key\n\t\t\t\t20170224170700_R25","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0303-7207(94)03471-5","article-title":"Platelet-derived growth factor ligand and receptor subunit mRNA in the Sertoli and Leydig cells of the rat testis.","volume":"108","year":"1995","journal-title":"Mol Cell Endocrinol"},{"key":"key\n\t\t\t\t20170224170700_R26","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1210\/endo.133.4.8404630","article-title":"Platelet-derived growth factor effects on purified testicular peritubular myoid cells: binding, cytosolic Ca2+ increase, mitogenic activity, and extracellular matrix production enhancement.","volume":"133","year":"1993","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224170700_R27","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/jcp.1041330214","article-title":"Ornithine decarboxylase activity during rat spermatogenesis in vivo and in vitro: selective effect of hormones and growth factors.","volume":"133","year":"1987","journal-title":"J Cell Physiol"},{"key":"key\n\t\t\t\t20170224170700_R28","first-page":"2219","article-title":"Rat Leydig cells bind platelet-derived growth factor through specific receptors and produce platelet-derived growth factor-like molecules.","volume":"130","year":"1992","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224170700_R29","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1002\/jcp.1041460308","article-title":"Transforming growth factor-\u03b2 and platelet-derived growth factor synergistically stimulate contraction by testicular peritubular cells in culture in serum-free medium.","volume":"146","year":"1991","journal-title":"J Cell Physiol"},{"key":"key\n\t\t\t\t20170224170700_R30","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/jcp.1041330214","article-title":"Ornitine decarboxylase activity during rat spermatogenesis in vivo and in vitro: selective effect of hormones and growth factors.","volume":"133","year":"1987","journal-title":"J Cell Physiol"},{"key":"key\n\t\t\t\t20170224170700_R31","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1210\/endo.138.3.5021","article-title":"Regulation of rat testis gonocyte proliferation by platelet-derived growth factor and estradiol: identification of signaling mechanisms involved.","volume":"138","year":"1997","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224170700_R32","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1095\/biolreprod66.3.745","article-title":"Inhibition of platelet-derived growth factor actions in the embryonic testis influences normal cord development and morphology.","volume":"66","year":"2002","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224170700_R33","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1046\/j.1523-1755.1998.00046.x","article-title":"Expression of platelet-derived growth factor and its receptors in the developing and adult mouse kidney.","volume":"54","year":"1998","journal-title":"Kidney Int"},{"key":"key\n\t\t\t\t20170224170700_R34","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1002\/j.1939-4640.2000.tb03392.x","article-title":"Immunolocalization of CA II and H+V-ATPase in epithelial cells of the mouse and rat epididymis.","volume":"21","year":"2000","journal-title":"J Androl"},{"key":"key\n\t\t\t\t20170224170700_R35","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1095\/biolreprod61.4.973","article-title":"Immunolocalization of AE2 anion exchanger in rat and mouse epididymis.","volume":"61","year":"1999","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224170700_R36","first-page":"999","article-title":"Efferent ducts, epididymis and vas deferens: structure, functions, and their regulation.","volume-title":"The Physiology of Reproduction","year":"1988"},{"key":"key\n\t\t\t\t20170224170700_R37","first-page":"319","article-title":"Endocrine control of the development and maintenance of sperm fertilizing ability in the epididymis.","volume-title":"Handbook of Physiology, Section 7, vol. 5, Male Reproductive System","year":"1975"},{"key":"key\n\t\t\t\t20170224170700_R38","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1159\/000147611","article-title":"Effects of androgen deprivation in the goat epididymis.","volume":"150","year":"1994","journal-title":"Acta Anat"},{"key":"key\n\t\t\t\t20170224170700_R39","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0303-7207(81)90017-4","article-title":"The organ culture of human epididymal tubules and their response to androgens.","volume":"21","year":"1981","journal-title":"Mol Cell Endocrinol"},{"key":"key\n\t\t\t\t20170224170700_R40","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s002329900219","article-title":"Angiotensin II receptors: localization of type I and type II in rat epididymides of different developmental stages.","volume":"157","year":"1997","journal-title":"J Membr Biol"},{"key":"key\n\t\t\t\t20170224170700_R41","first-page":"461","article-title":"Differential gene expression of angiotensin II receptor subtypes in the epididymides of mature and immature rats.","volume":"62","year":"1998","journal-title":"Life Sci"},{"key":"key\n\t\t\t\t20170224170700_R42","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0303-7207(99)00107-0","article-title":"Angiotensinogen expression by rat epididymis: evidence for an intrinsic, angiotensin-generating system.","volume":"155","year":"1999","journal-title":"Mol Cell Endocrinol"},{"key":"key\n\t\t\t\t20170224170700_R43","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1023\/A:1007153025897","article-title":"Mechanisms of angiotensin II-induced platelet-derived growth factor gene expression.","volume":"212","year":"2000","journal-title":"Mol Cell Biochem"},{"key":"key\n\t\t\t\t20170224170700_R44","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1161\/01.RES.80.5.607","article-title":"Angiotensin II signal transduction in vascular smooth muscle: role of tyrosine kinases.","volume":"80","year":"1997","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170224170700_R45","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1677\/joe.0.1250457","article-title":"The role of angiotensin-converting enzyme in the rat epididymis.","volume":"125","year":"1990","journal-title":"J Endocrinol"},{"key":"key\n\t\t\t\t20170224170700_R46","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/jemt.1070300106","article-title":"Epididymal epithelium: its contribution to the formation of a luminal fluid microenvironment.","volume":"30","year":"1995","journal-title":"Microsc Res Tech"},{"key":"key\n\t\t\t\t20170224170700_R47","first-page":"221","article-title":"Direct evidence for the elevated synthesis and secretion of procathepsin L in the distal caput epididymis of boar.","volume":"19","year":"1995","journal-title":"Biochim Biophys Acta"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/biolreprod\/article-pdf\/70\/1\/168\/10588059\/biolreprod0168.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T02:32:04Z","timestamp":1734575524000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article\/2712661\/Expression"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1,1]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,1,1]]}},"URL":"https:\/\/doi.org\/10.1095\/biolreprod.103.019232","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,1,1]]}}}