{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:28:54Z","timestamp":1790616534857,"version":"4.1.0"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,4,1]]},"DOI":"10.1095\/biolreprod.103.024950","type":"journal-article","created":{"date-parts":[[2004,10,20]],"date-time":"2004-10-20T18:30:50Z","timestamp":1098297050000},"page":"1206-1212","source":"Crossref","is-referenced-by-count":52,"title":["Ataxia Telangiectasia Mutated Expression and Activation in the Testis1"],"prefix":"10.1093","volume":"70","author":[{"given":"Geert","family":"Hamer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henk B.","family":"Kal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph H.","family":"Westphal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry","family":"Ashley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk G.","family":"de Rooij","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"key\n\t\t\t\t20170224180018_R1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/nrc1011","article-title":"ATM and related protein kinases: safeguarding genome integrity.","volume":"3","year":"2003","journal-title":"Nat Rev Cancer"},{"key":"key\n\t\t\t\t20170224180018_R2","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nature01368","article-title":"DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation.","volume":"421","year":"2003","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170224180018_R3","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/421486a","article-title":"DNA repair: damage alert.","volume":"421","year":"2003","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170224180018_R4","doi-asserted-by":"crossref","first-page":"3867","DOI":"10.1038\/sj.onc.1206649","article-title":"Electron microscopy and 3D reconstructions reveal that human ATM kinase uses an arm-like domain to clamp around double-stranded DNA.","volume":"22","year":"2003","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t20170224180018_R5","doi-asserted-by":"crossref","first-page":"5858","DOI":"10.1074\/jbc.273.10.5858","article-title":"DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139.","volume":"273","year":"1998","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170224180018_R6","doi-asserted-by":"crossref","first-page":"38224","DOI":"10.1074\/jbc.M102986200","article-title":"Nuclear retention of ATM at sites of DNA double strand breaks.","volume":"276","year":"2001","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170224180018_R7","doi-asserted-by":"crossref","first-page":"42462","DOI":"10.1074\/jbc.C100466200","article-title":"ATM phosphorylates histone H2AX in response to DNA double-strand breaks.","volume":"276","year":"2001","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170224180018_R8","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1083\/jcb.146.5.905","article-title":"Megabase chromatin domains involved in DNA double-strand breaks in vivo.","volume":"146","year":"1999","journal-title":"J Cell Biol"},{"key":"key\n\t\t\t\t20170224180018_R9","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/S0960-9822(00)00610-2","article-title":"A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage.","volume":"10","year":"2000","journal-title":"Curr Biol"},{"key":"key\n\t\t\t\t20170224180018_R10","doi-asserted-by":"crossref","first-page":"R229","DOI":"10.1016\/S0960-9822(01)00112-9","article-title":"DNA repair: spot(light)s on chromatin.","volume":"11","year":"2001","journal-title":"Curr Biol"},{"key":"key\n\t\t\t\t20170224180018_R11","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1083\/jcb.153.3.613","article-title":"Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways.","volume":"153","year":"2001","journal-title":"J Cell Biol"},{"key":"key\n\t\t\t\t20170224180018_R12","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/ncb1004","article-title":"Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks.","volume":"5","year":"2003","journal-title":"Nat Cell Biol"},{"key":"key\n\t\t\t\t20170224180018_R13","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1126\/science.281.5383.1674","article-title":"Enhanced phosphorylation of p53 by ATM in response to DNA damage.","volume":"281","year":"1998","journal-title":"Science"},{"key":"key\n\t\t\t\t20170224180018_R14","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1126\/science.281.5383.1677","article-title":"Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.","volume":"281","year":"1998","journal-title":"Science"},{"key":"key\n\t\t\t\t20170224180018_R15","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/3882","article-title":"ATM associates with and phosphorylates p53: mapping the region of interaction.","volume":"20","year":"1998","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20170224180018_R16","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1101\/gad.886901","article-title":"ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage.","volume":"15","year":"2001","journal-title":"Genes Dev"},{"key":"key\n\t\t\t\t20170224180018_R17","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/sj.cdd.4400396","article-title":"The role of the tumor suppressor p53 in spermatogenesis.","volume":"5","year":"1998","journal-title":"Cell Death Differ"},{"key":"key\n\t\t\t\t20170224180018_R18","doi-asserted-by":"crossref","first-page":"263","DOI":"10.2307\/3579959","article-title":"Resistance of differentiating spermatogonia to radiation-induced apoptosis and loss in p53-deficient mice.","volume":"149","year":"1998","journal-title":"Radiat Res"},{"key":"key\n\t\t\t\t20170224180018_R19","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/35077232","article-title":"Genome maintenance mechanisms for preventing cancer.","volume":"411","year":"2001","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170224180018_R20","first-page":"259","article-title":"Partners and pathways repairing a double-strand break.","volume":"16","year":"2000","journal-title":"Trends Genet"},{"key":"key\n\t\t\t\t20170224180018_R21","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0955-0674(00)00091-0","article-title":"The MRE11 complex and ATM: collaborating to navigate S phase.","volume":"12","year":"2000","journal-title":"Curr Opin Cell Biol"},{"key":"key\n\t\t\t\t20170224180018_R22","doi-asserted-by":"crossref","first-page":"17276","DOI":"10.1074\/jbc.M011681200","article-title":"Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of BRCA1 at distinct and overlapping sites.","volume":"276","year":"2001","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170224180018_R23","first-page":"3299","article-title":"Role for ATM in DNA damage-induced phosphorylation of BRCA1.","volume":"60","year":"2000","journal-title":"Cancer Res"},{"key":"key\n\t\t\t\t20170224180018_R24","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/35018134","article-title":"Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response.","volume":"406","year":"2000","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170224180018_R25","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1126\/science.286.5442.1162","article-title":"Requirement of ATM-dependent phosphorylation of BRCA1 in the DNA damage response to double-strand breaks.","volume":"286","year":"1999","journal-title":"Science"},{"key":"key\n\t\t\t\t20170224180018_R26","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/85830","article-title":"Recombinational DNA double-strand breaks in mice precede synapsis.","volume":"27","year":"2001","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20170224180018_R27","doi-asserted-by":"crossref","first-page":"R253","DOI":"10.1016\/S0960-9822(01)00131-2","article-title":"Meiotic recombination: breaking the genome to save it.","volume":"11","year":"2001","journal-title":"Curr Biol"},{"key":"key\n\t\t\t\t20170224180018_R28","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/ng1297-457","article-title":"ATM and RPA in meiotic chromosome synapsis and recombination.","volume":"17","year":"1997","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20170224180018_R29","doi-asserted-by":"crossref","first-page":"13084","DOI":"10.1073\/pnas.93.23.13084","article-title":"Pleiotropic defects in ataxia-telangiectasia protein-deficient mice.","volume":"93","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170224180018_R30","doi-asserted-by":"crossref","first-page":"4007","DOI":"10.1242\/dev.125.20.4007","article-title":"ATM deficiency results in severe meiotic disruption as early as leptonema of prophase I.","volume":"125","year":"1998","journal-title":"Development"},{"key":"key\n\t\t\t\t20170224180018_R31","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0092-8674(00)80086-0","article-title":"ATM-deficient mice: a paradigm of ataxia telangiectasia.","volume":"86","year":"1996","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170224180018_R32","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1101\/gad.10.19.2411","article-title":"Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma.","volume":"10","year":"1996","journal-title":"Genes Dev"},{"key":"key\n\t\t\t\t20170224180018_R33","doi-asserted-by":"crossref","first-page":"5096","DOI":"10.1128\/MCB.19.7.5096","article-title":"ATM inactivation results in aberrant telomere clustering during meiotic prophase.","volume":"19","year":"1999","journal-title":"Mol Cell Biol"},{"key":"key\n\t\t\t\t20170224180018_R34","doi-asserted-by":"crossref","first-page":"4298","DOI":"10.1038\/sj.onc.1204568","article-title":"Role for c-Abl and p73 in the radiation response of male germ cells.","volume":"20","year":"2001","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t20170224180018_R35","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1095\/biolreprod.102.008672","article-title":"DNA double-strand breaks and \u03b3-H2AX signaling in the testis.","volume":"68","year":"2003","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224180018_R36","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1095\/biolreprod.102.008920","article-title":"Function of DNA-PKcs during the early meiotic prophase without Ku70 and Ku86.","volume":"68","year":"2003","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224180018_R37","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4.","volume":"227","year":"1970","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170224180018_R38","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1101\/gad.10.19.2423","article-title":"The ATR and ATM protein kinases associate with different sites along meiotically pairing chromosomes.","volume":"10","year":"1996","journal-title":"Genes Dev"},{"key":"key\n\t\t\t\t20170224180018_R39","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/S0960-9822(06)00417-9","article-title":"ATM-dependent interactions of a mammalian Chk1 homolog with meiotic chromosomes.","volume":"7","year":"1997","journal-title":"Curr Biol"},{"key":"key\n\t\t\t\t20170224180018_R40","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/35043058","article-title":"The many substrates and functions of ATM.","volume":"1","year":"2000","journal-title":"Nat Rev Mol Cell Biol"},{"key":"key\n\t\t\t\t20170224180018_R41","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0065-230X(01)83007-4","article-title":"ATM: genome stability, neuronal development, and cancer cross paths.","volume":"83","year":"2001","journal-title":"Adv Cancer Res"},{"key":"key\n\t\t\t\t20170224180018_R42","doi-asserted-by":"crossref","first-page":"7883","DOI":"10.1038\/sj.onc.1203283","article-title":"DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis.","volume":"18","year":"1999","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t20170224180018_R43","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/35056049","article-title":"Chromosomal stability and the DNA double-stranded break connection.","volume":"2","year":"2001","journal-title":"Nat Rev Genet"},{"key":"key\n\t\t\t\t20170224180018_R44","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/85798","article-title":"DNA double-strand breaks: signaling, repair and the cancer connection.","volume":"27","year":"2001","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20170224180018_R45","first-page":"8885","article-title":"DNA repair.","volume":"21","year":"2002","journal-title":"Oncogene Rev"},{"key":"key\n\t\t\t\t20170224180018_R46","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S1383-5742(02)00009-1","article-title":"DNA repair\/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis.","volume":"511","year":"2002","journal-title":"Mutat Res"},{"key":"key\n\t\t\t\t20170224180018_R47","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1126\/science.1074740","article-title":"Interfaces between the detection, signaling, and repair of DNA damage.","volume":"297","year":"2002","journal-title":"Science"},{"key":"key\n\t\t\t\t20170224180018_R48","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nature01408","article-title":"DNA damage and repair.","volume":"421","year":"2003","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170224180018_R49","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nature01407","article-title":"DNA replication and recombination.","volume":"421","year":"2003","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170224180018_R50","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/nrm1101","article-title":"Who\u2019s on first in the cellular response to DNA damage?.","volume":"4","year":"2003","journal-title":"Nat Rev Mol Cell Biol"},{"key":"key\n\t\t\t\t20170224180018_R51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-662-05066-8_1","article-title":"Multiple guardians of the epithelial stage IV meiotic checkpoint.","volume-title":"Testicular Tangrams","year":"2002"},{"key":"key\n\t\t\t\t20170224180018_R52","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1101\/gad.13.5.523","article-title":"Mouse MutS-like protein MSH5 is required for proper chromosome synapsis in male and female meiosis.","volume":"13","year":"1999","journal-title":"Genes Dev"},{"key":"key\n\t\t\t\t20170224180018_R53","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/ng0398-257","article-title":"The meiotic checkpoint monitoring synapsis eliminates spermatocytes via p53-independent apoptosis.","volume":"18","year":"1998","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20170224180018_R54","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1126\/science.1069398","article-title":"Genomic instability in mice lacking histone H2AX.","volume":"296","year":"2002","journal-title":"Science"},{"key":"key\n\t\t\t\t20170224180018_R55","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S1534-5807(03)00093-5","article-title":"H2AX is required for chromatin remodeling and inactivation of sex chromosomes in male mouse meiosis.","volume":"4","year":"2003","journal-title":"Dev Cell"},{"key":"key\n\t\t\t\t20170224180018_R56","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1242\/dev.00410","article-title":"Impaired meiotic DNA-damage repair and lack of crossing-over during spermatogenesis in BRCA1 full-length isoform deficient mice.","volume":"130","year":"2003","journal-title":"Development"},{"key":"key\n\t\t\t\t20170224180018_R57","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0092-8674(02)01052-8","article-title":"BRCA1 supports XIST RNA concentration on the inactive X chromosome.","volume":"111","year":"2002","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170224180018_R58","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/13821","article-title":"MRE11 and Ku70 interact in somatic cells, but are differentially expressed in early meiosis.","volume":"23","year":"1999","journal-title":"Nat Genet"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/biolreprod\/article-pdf\/70\/4\/1206\/10591358\/biolreprod1206.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T18:44:01Z","timestamp":1624733041000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-lookup\/doi\/10.1095\/biolreprod.103.024950"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4,1]]},"references-count":58,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,4,1]]}},"URL":"https:\/\/doi.org\/10.1095\/biolreprod.103.024950","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,4,1]]}}}