{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:49:34Z","timestamp":1789649374627,"version":"4.0.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,7,1]]},"DOI":"10.1095\/biolreprod.103.026062","type":"journal-article","created":{"date-parts":[[2004,10,20]],"date-time":"2004-10-20T14:30:50Z","timestamp":1098282650000},"page":"217-223","source":"Crossref","is-referenced-by-count":88,"title":["Tissue-Specific Elevated Genomic Cytosine Methylation Levels Are Associated with an Overgrowth Phenotype of Bovine Fetuses Derived by In Vitro Techniques1"],"prefix":"10.1093","volume":"71","author":[{"given":"Stefan","family":"Hiendleder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cora","family":"Mund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horst-Dieter","family":"Reichenbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik","family":"Wenigerkind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gottfried","family":"Brem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeri","family":"Zakhartchenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Lyko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eckhard","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"key\n\t\t\t\t20170224035440_R1","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/nrg887","article-title":"Chromatin modification and epigenetic reprogramming in mammalian development","volume":"3","year":"2002","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20170224035440_R2","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1126\/science.1086887","article-title":"Heterochromatin and epigenetic control of gene expression","volume":"301","year":"2003","journal-title":"Science"},{"key":"key\n\t\t\t\t20170224035440_R3","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S1084-9521(02)00137-4","article-title":"DNA methylation in animal development","volume":"14","year":"2003","journal-title":"Semin Cell Dev Biol"},{"key":"key\n\t\t\t\t20170224035440_R4","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1126\/science.1063206","article-title":"Nuclear cloning and epigenetic reprogramming of the genome","volume":"293","year":"2001","journal-title":"Science"},{"key":"key\n\t\t\t\t20170224035440_R5","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1046\/j.1432-0436.2002.690406.x","article-title":"Epigenetics by DNA methylation for development of normal and cloned animals","volume":"69","year":"2002","journal-title":"Differentiation"},{"key":"key\n\t\t\t\t20170224035440_R6","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S1084-9521(02)00141-6","article-title":"Epigenetic reprogramming in early mammalian development and following somatic nuclear transfer","volume":"14","year":"2003","journal-title":"Semin Cell Dev Biol"},{"key":"key\n\t\t\t\t20170224035440_R7","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/S0955-0674(03)00031-0","article-title":"Reprogramming DNA methylation in the preimplantation stage: peeping with Dolly\u2019s eyes","volume":"15","year":"2003","journal-title":"Curr Opin Cell Biol"},{"key":"key\n\t\t\t\t20170224035440_R8","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1046\/j.1432-0436.2003.710201.x","article-title":"Epigenetic reprogramming in mammalian nuclear transfer","volume":"71","year":"2003","journal-title":"Differentiation"},{"key":"key\n\t\t\t\t20170224035440_R9","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1530\/ror.0.0030155","article-title":"Large offspring syndrome in cattle and sheep","volume":"3","year":"1998","journal-title":"Rev Reprod"},{"key":"key\n\t\t\t\t20170224035440_R10","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1093\/humrep\/15.suppl_5.68","article-title":"In-utero overgrowth in ruminants following embryo culture: lessons from mice and a warning to men","volume":"15","year":"2000","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20170224035440_R11","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0093-691X(00)00452-0","article-title":"Influence of in vitro systems on embryo survival and fetal development in cattle","volume":"55","year":"2001","journal-title":"Theriogenology"},{"key":"key\n\t\t\t\t20170224035440_R12","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1093\/humupd\/7.4.419","article-title":"Culture of preimplantation embryos and its long-term effects on gene expression and phenotype","volume":"7","year":"2001","journal-title":"Hum Reprod Update"},{"key":"key\n\t\t\t\t20170224035440_R13","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/S0093-691X(02)00935-4","article-title":"Morphology and morphometry of in vivo- and in vitro-produced bovine concepti from early pregnancy to term and association with high birth weights","volume":"58","year":"2002","journal-title":"Theriogenology"},{"key":"key\n\t\t\t\t20170224035440_R14","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1016\/S0140-6736(03)13592-1","article-title":"Rare congenital disorders, imprinted genes, and assisted reproductive technology","volume":"361","year":"2003","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170224035440_R15","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1126\/science.1063443","article-title":"Epigenetic reprogramming in mammalian development","volume":"293","year":"2001","journal-title":"Science"},{"key":"key\n\t\t\t\t20170224035440_R16","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/ng1158","article-title":"The role of DNA methylation in setting up chromatin structure during development","volume":"34","year":"2003","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20170224035440_R17","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/88903","article-title":"Aberrant methylation of donor genome in cloned bovine embryos","volume":"28","year":"2001","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20170224035440_R18","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1093\/emboj\/21.5.1092","article-title":"Limited demethylation leaves mosaic-type methylation states in cloned bovine pre-implantation embryos","volume":"21","year":"2002","journal-title":"EMBO J"},{"key":"key\n\t\t\t\t20170224035440_R19","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1016\/S0960-9822(01)00480-8","article-title":"Delayed and incomplete reprogramming of chromosome methylation patterns in bovine cloned embryos","volume":"11","year":"2001","journal-title":"Curr Biol"},{"key":"key\n\t\t\t\t20170224035440_R20","doi-asserted-by":"crossref","first-page":"13734","DOI":"10.1073\/pnas.241522698","article-title":"Conservation of methylation reprogramming in mammalian development: aberrant reprogramming in cloned embryos","volume":"98","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170224035440_R21","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/S0960-9822(03)00419-6","article-title":"Epigenetic marking correlates with developmental potential in cloned bovine preimplantation embryos","volume":"13","year":"2003","journal-title":"Curr Biol"},{"key":"key\n\t\t\t\t20170224035440_R22","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/84769","article-title":"Epigenetic change in IGF2R is associated with fetal overgrowth after sheep embryo culture","volume":"27","year":"2001","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20170224035440_R23","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1095\/biolreprod.102.010181","article-title":"Genome-wide epigenetic alterations in cloned bovine fetuses","volume":"68","year":"2003","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224035440_R24","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/0005-2787(81)90156-8","article-title":"Methylation of reiterated sequences in mammalian DNAs. Effects of the tissue type, age, malignancy and hormonal induction","volume":"653","year":"1981","journal-title":"Biochim Biophys Acta"},{"key":"key\n\t\t\t\t20170224035440_R25","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/0167-4781(83)90079-9","article-title":"Tissue-specific differences in DNA methylation in various mammals","volume":"740","year":"1983","journal-title":"Biochim Biophys Acta"},{"key":"key\n\t\t\t\t20170224035440_R26","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.1093\/nar\/gng002","article-title":"Capillary electrophoretic analysis of genomic DNA methylation levels","volume":"31","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"key\n\t\t\t\t20170224035440_R27","doi-asserted-by":"crossref","unstructured":"FarinCE, FarinPW, BlondinP, CrosierAE. Fetal development of in vitro-produced embryos: possible association with uterine function. Proc Am Soc Anim Sci 1999; http:\/\/www.asas.org\/jas\/symposia\/proceedings","DOI":"10.2527\/jas2000.77E-Suppl1p"},{"key":"key\n\t\t\t\t20170224035440_R28","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/0012-1606(86)90325-8","article-title":"Undermethylation of structural gene sequences in extraembryonic lineages of the mouse","volume":"117","year":"1986","journal-title":"Dev Biol"},{"key":"key\n\t\t\t\t20170224035440_R29","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1242\/dev.99.3.371","article-title":"Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development","volume":"99","year":"1987","journal-title":"Development"},{"key":"key\n\t\t\t\t20170224035440_R30","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0093-691X(99)00263-0","article-title":"Improving the safety of embryo technologies: possible role of genomic imprinting","volume":"53","year":"2000","journal-title":"Theriogenology"},{"key":"key\n\t\t\t\t20170224035440_R31","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0093-691X(02)01271-2","article-title":"Nuclear reprogramming of cloned embryos produced in vitro","volume":"59","year":"2003","journal-title":"Theriogenology"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/biolreprod\/article-pdf\/71\/1\/217\/10561377\/biolreprod0217.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T14:38:05Z","timestamp":1624718285000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-lookup\/doi\/10.1095\/biolreprod.103.026062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,7,1]]}},"URL":"https:\/\/doi.org\/10.1095\/biolreprod.103.026062","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,7,1]]}}}