{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T03:59:49Z","timestamp":1788321589863,"version":"build-2803163510"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,7,1]]},"DOI":"10.1095\/biolreprod.103.026708","type":"journal-article","created":{"date-parts":[[2004,10,20]],"date-time":"2004-10-20T14:30:50Z","timestamp":1098282650000},"page":"156-162","source":"Crossref","is-referenced-by-count":7,"title":["Long-Term Hypoxia Alters Calcium Regulation in Near-Term Ovine Myometrium1"],"prefix":"10.1093","volume":"71","author":[{"given":"T.K.","family":"Arakawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Mlynarczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.M.","family":"Kaushal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.A.","family":"Ducsay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"key\n\t\t\t\t20170224043105_R1","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1113\/expphysiol.1992.sp003590","article-title":"The effects of metabolic inhibition and acidification on force production in the rat uterus","volume":"77","year":"1992","journal-title":"Exp Physiol"},{"key":"key\n\t\t\t\t20170224043105_R2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1113\/jphysiol.1993.sp019665","article-title":"Effects of metabolic inhibition and changes of intracellular pH on potassium permeability and contraction of rat uterus","volume":"465","year":"1993","journal-title":"J Physiol"},{"key":"key\n\t\t\t\t20170224043105_R3","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1113\/jphysiol.1994.sp020136","article-title":"An in vivo study of the effects of ischemia on uterine contraction, intracellular pH and metabolites in the rat","volume":"476","year":"1994","journal-title":"J Physiol"},{"key":"key\n\t\t\t\t20170224043105_R4","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/BF00373847","article-title":"The effect of metabolic inhibition on rat uterine intracellular pH and its role in contractile failure","volume":"430","year":"1995","journal-title":"Pflugers Arch"},{"key":"key\n\t\t\t\t20170224043105_R5","first-page":"E477","article-title":"Effect of chronic hypoxia on myometrial responsiveness in the pregnant rat","volume":"270","year":"1996","journal-title":"Am J Physiol"},{"key":"key\n\t\t\t\t20170224043105_R6","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0002-9378(97)70158-3","article-title":"Suppression of myometrial contractile responses to oxytocin after different durations of chronic hypoxia in the near-term pregnant rat","volume":"177","year":"1997","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t20170224043105_R7","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0014-2999(98)00504-4","article-title":"Functional determination of oxytocin affinity in near-term pregnant rat myometrium: effect of chronic hypoxia","volume":"356","year":"1998","journal-title":"Eur J Pharmacol"},{"key":"key\n\t\t\t\t20170224043105_R8","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1095\/biolreprod.103.018556","article-title":"Long-term hypoxia changes myometrial responsiveness and oxytocin receptors in the pregnant ewe: differential effects on longitudinal versus circular smooth muscle","volume":"69","year":"2003","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224043105_R9","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1097\/00006250-199404000-00024","article-title":"Nifedipine and its indications in obstetrics and gynecology","volume":"83","year":"1994","journal-title":"Obstet Gynecol"},{"key":"key\n\t\t\t\t20170224043105_R10","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/1043-6618(90)90707-K","article-title":"Characterization of the spontaneous motor activity of the isolated human pregnant myometrium","volume":"22","year":"1990","journal-title":"Pharmacol Res"},{"key":"key\n\t\t\t\t20170224043105_R11","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1177\/107155769700400204","article-title":"Effects of sodium and calcium channel blockade on cytosolic calcium oscillations and phasic contractions of myometrial tissue","volume":"4","year":"1997","journal-title":"J Soc Gynecol Investig"},{"key":"key\n\t\t\t\t20170224043105_R12","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0002-9378(87)80373-3","article-title":"The effects of aminophylline and nifedipine on contractility of isolated pregnant human myometrium","volume":"157","year":"1987","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t20170224043105_R13","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1006\/bbrc.1996.0652","article-title":"The effects of ruthenium red, an inhibitor of calcium-induced calcium release, on phasic myometrial contractions","volume":"221","year":"1996","journal-title":"Biochem Biophys Res Commun"},{"key":"key\n\t\t\t\t20170224043105_R14","doi-asserted-by":"crossref","first-page":"6300","DOI":"10.1016\/S0021-9258(19)84563-5","article-title":"Ryanodine activation and inhibition of the Ca2+ release channel of sarcoplasmic reticulum","volume":"261","year":"1986","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170224043105_R15","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.1471-0528.2002.01110.x","article-title":"Effect of inhibiting the sarcoplasmic reticulum on spontaneous and oxytocin-induced contractions of human myometrium","volume":"109","year":"2002","journal-title":"Br J Obstet Gynaecol"},{"key":"key\n\t\t\t\t20170224043105_R16","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1210\/jcem-71-5-1243","article-title":"Regulation of intracellular free calcium in human myometrial cells by prostaglandin F2\u03b1: comparison with oxytocin","volume":"71","year":"1990","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20170224043105_R17","doi-asserted-by":"crossref","first-page":"6024","DOI":"10.1016\/S0021-9258(18)43692-7","article-title":"Serine esterase inhibitors block stimulus-induced mobilization of arachidonic acid and phosphatidylinositide-specific phospholipase C activity in platelets","volume":"255","year":"1980","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170224043105_R18","doi-asserted-by":"crossref","first-page":"153","DOI":"10.2170\/jjphysiol.25.153","article-title":"Physiological comparison of the longitudinal and circular muscles of the pregnant rat uterus","volume":"25","year":"1975","journal-title":"Jpn J Physiol"},{"key":"key\n\t\t\t\t20170224043105_R19","doi-asserted-by":"crossref","first-page":"403","DOI":"10.2170\/jjphysiol.26.403","article-title":"Comparative investigations of \u03b1- and \u03b2-effects on the longitudinal and circular muscles of the pregnant rat myometrium","volume":"26","year":"1976","journal-title":"Jpn J Physiol"},{"key":"key\n\t\t\t\t20170224043105_R20","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0014-2999(81)90497-0","article-title":"Effects of catecholamines on circular and longitudinal uterine muscle of the rat","volume":"76","year":"1981","journal-title":"Eur J Pharmacol"},{"key":"key\n\t\t\t\t20170224043105_R21","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1095\/biolreprod37.2.348","article-title":"Comparison of effects of oxytocin and prostaglandin F2\u03b1 on circular and longitudinal myometrium from the pregnant rat","volume":"37","year":"1987","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224043105_R22","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1113\/jphysiol.1988.sp017065","article-title":"Gestational changes in the utilization of intracellularly stored calcium in the myometrium of guinea pigs","volume":"399","year":"1988","journal-title":"J Physiol"},{"key":"key\n\t\t\t\t20170224043105_R23","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1139\/y87-124","article-title":"The sensitivity of the longitudinal and circular muscle layers of the rat\u2019s myometrium to oxytocin in vitro during pregnancy","volume":"65","year":"1987","journal-title":"Can J Physiol Pharmacol"},{"key":"key\n\t\t\t\t20170224043105_R24","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/S0196-9781(01)00402-8","article-title":"Muscle layer- and region-dependent distributions of oxytocin receptors in the porcine myometrium","volume":"22","year":"2001","journal-title":"Peptides"},{"key":"key\n\t\t\t\t20170224043105_R25","first-page":"101","article-title":"Direct measurement of intracellular free calcium in cultured human puerperal myometrial cells stimulated by oxytocin: effects of extracellular calcium and calcium channel blockers","volume":"77","year":"1991","journal-title":"Obstet Gynecol"},{"key":"key\n\t\t\t\t20170224043105_R26","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/S1071-5576(03)00089-3","article-title":"Calcium signaling and uterine contractility","volume":"10","year":"2003","journal-title":"J Soc Gynecol Investig"},{"key":"key\n\t\t\t\t20170224043105_R27","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1053\/gast.2001.21167","article-title":"Down-regulation of L-type calcium channels in inflamed circular smooth muscle cells of the canine colon","volume":"120","year":"2001","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t20170224043105_R28","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1095\/biolreprod51.5.993","article-title":"Changes in the expression of the L-type voltage-dependent calcium channel during pregnancy and parturition in the rat","volume":"51","year":"1994","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224043105_R29","first-page":"H1196","article-title":"Activator calcium and myocardial contractility in fetal sheep exposed to long-term high-altitude hypoxia","volume":"272","year":"1997","journal-title":"Am J Physiol"},{"key":"key\n\t\t\t\t20170224043105_R30","doi-asserted-by":"crossref","first-page":"C1743","DOI":"10.1152\/ajpcell.2001.281.6.C1743","article-title":"Regulation of cardiac and smooth muscle Ca2+ channels (CaV1.2a,b) by protein kinases","volume":"281","year":"2001","journal-title":"Am J Physiol Cell Physiol"},{"key":"key\n\t\t\t\t20170224043105_R31","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1139\/y94-187","article-title":"Protein kinase C stimulates Ca2+ current in pregnant rat myometrial cells","volume":"72","year":"1994","journal-title":"Can J Physiol Pharmacol"},{"key":"key\n\t\t\t\t20170224043105_R32","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1096\/fasebj.10.11.8836045","article-title":"PACAP modulates L-type Ca2+ channel currents in vascular smooth muscle cells: involvement of PKC and PKA","volume":"10","year":"1996","journal-title":"FASEB J"},{"key":"key\n\t\t\t\t20170224043105_R33","doi-asserted-by":"crossref","first-page":"C535","DOI":"10.1152\/ajpcell.1998.275.2.C535","article-title":"PKC activity modulates availability and long openings of L-type Ca2+ channels in A7r5 cells","volume":"275","year":"1998","journal-title":"Am J Physiol"},{"key":"key\n\t\t\t\t20170224043105_R34","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1095\/biolreprod50.4.855","article-title":"Protein kinase C, an inhibitor of oxytocin-stimulated phasic myometrial contractions","volume":"50","year":"1994","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224043105_R35","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0014-5793(86)80561-0","article-title":"Carbachol and oxytocin stimulate the generation of inositol phosphates in the guinea pig myometrium","volume":"201","year":"1986","journal-title":"FEBS Lett"},{"key":"key\n\t\t\t\t20170224043105_R36","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/S0002-9378(88)80182-0","article-title":"A role for phosphoinositide hydrolysis in human uterine smooth muscle during parturition","volume":"159","year":"1988","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t20170224043105_R37","doi-asserted-by":"crossref","first-page":"C1","DOI":"10.1152\/ajpcell.1993.264.1.C1","article-title":"Uterine contraction and physiological mechanisms of modulation","volume":"264","year":"1993","journal-title":"Am J Physiol"},{"key":"key\n\t\t\t\t20170224043105_R38","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/1071-5576(96)00006-8","article-title":"The mechanisms underlying Bay K 8644-stimulated phasic myometrial contractions","volume":"3","year":"1996","journal-title":"J Soc Gynecol Investig"},{"key":"key\n\t\t\t\t20170224043105_R39","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1113\/eph8602114","article-title":"The physiological basis of uterine contractility: a short review","volume":"86","year":"2001","journal-title":"Exp Physiol"},{"key":"key\n\t\t\t\t20170224043105_R40","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1469-7793.1998.133bi.x","article-title":"Contribution of sarcoplasmic reticular calcium to smooth muscle contractile activation: gestational dependence in isolated rat uterus","volume":"511","year":"1998","journal-title":"J Physiol"},{"key":"key\n\t\t\t\t20170224043105_R41","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1042\/bj3220777","article-title":"Differential expression of ryanodine receptor RyR2 mRNA in the non-pregnant and pregnant human myometrium","volume":"322","year":"1997","journal-title":"Biochem J"},{"key":"key\n\t\t\t\t20170224043105_R42","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0014-5793(95)00771-Z","article-title":"The modulation and characterization of the Ca2+-induced Ca2+ release mechanism in cultured human myometrial smooth muscle cells","volume":"369","year":"1995","journal-title":"FEBS Lett"},{"key":"key\n\t\t\t\t20170224043105_R43","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1067\/mob.2001.113872","article-title":"The mechanism of propagation of intracellular calcium waves in cultured human uterine myocytes","volume":"184","year":"2001","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t20170224043105_R44","first-page":"1447","article-title":"Block by ruthenium red of cloned neuronal voltage-gated calcium channels","volume":"289","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"key\n\t\t\t\t20170224043105_R45","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/0005-2736(90)90138-E","article-title":"Ruthenium red and compound 48\/80 inhibit the smooth-muscle plasma-membrane Ca2+ pump via interaction with associated polyphosphoinositides","volume":"1023","year":"1990","journal-title":"Biochim Biophys Acta"},{"key":"key\n\t\t\t\t20170224043105_R46","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0003-2697(90)90539-L","article-title":"Interaction of ruthenium red with Ca2+-binding proteins","volume":"188","year":"1990","journal-title":"Anal Biochem"},{"key":"key\n\t\t\t\t20170224043105_R47","doi-asserted-by":"crossref","first-page":"21518","DOI":"10.1016\/S0021-9258(19)36640-2","article-title":"Ruthenium red inhibits the binding of calcium to calmodulin required for enzyme activation","volume":"267","year":"1992","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170224043105_R48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0143-4160(88)90032-2","article-title":"Ryanodine sensitivity of the calcium release channel of sarcoplasmic reticulum","volume":"9","year":"1988","journal-title":"Cell Calcium"},{"key":"key\n\t\t\t\t20170224043105_R49","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/351751a0","article-title":"Bell-shaped calcium-response curves of Ins(1,4,5)P3- and calcium-gated channels from endoplasmic reticulum of cerebellum","volume":"351","year":"1991","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170224043105_R50","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/0470853050.ch2","article-title":"Role of the sarcoplasmic reticulum in uterine smooth muscle","volume":"246","year":"2002","journal-title":"Novartis Found Symp"},{"key":"key\n\t\t\t\t20170224043105_R51","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1067\/mob.2001.118143","article-title":"Protein expression of phospholipase C in pregnant and nonpregnant rat uterine tissue","volume":"185","year":"2001","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t20170224043105_R52","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/S0002-9378(98)70502-2","article-title":"Phosphatidylinositol-specific phospholipase C isoform expression in pregnant and nonpregnant rat myometrial tissue","volume":"178","year":"1998","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t20170224043105_R53","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1177\/107155769400100110","article-title":"The relationship between oxytocin, phosphoinositide-specific phospholipase C, and phasic myometrial contractions","volume":"1","year":"1994","journal-title":"J Soc Gynecol"},{"key":"key\n\t\t\t\t20170224043105_R54","first-page":"2098","article-title":"Multiple G proteins and phospholipase C isoforms in human myometrial cells: implication for oxytocin action","volume":"81","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20170224043105_R55","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1042\/bj3310283","article-title":"Phospholipase C-\u03b41 and oxytocin receptor signaling: evidence of its role as an effector","volume":"331","year":"1998","journal-title":"Biochem J"},{"key":"key\n\t\t\t\t20170224043105_R56","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/978-1-4615-4871-3_35","article-title":"Molecular mechanisms regulating the effects of oxytocin on myometrial intracellular calcium","volume":"449","year":"1998","journal-title":"Adv Exp Med Biol"},{"key":"key\n\t\t\t\t20170224043105_R57","first-page":"R669","article-title":"High altitude-induced changes in \u03b11-adrenergic receptors and Ins(1,4,5)P3 responses in cerebral arteries","volume":"272","year":"1997","journal-title":"Am J Physiol"},{"key":"key\n\t\t\t\t20170224043105_R58","first-page":"977","article-title":"Effect of chronic hypoxia on \u03b11-adrenoceptor-mediated inositol 1,4,5-trisphosphate signaling in ovine uterine artery","volume":"288","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"key\n\t\t\t\t20170224043105_R59","doi-asserted-by":"crossref","first-page":"C976","DOI":"10.1152\/ajpcell.1993.265.4.C976","article-title":"Calcium-activated K+ channels as modulators of human myometrial contractile activity","volume":"265","year":"1993","journal-title":"Am J Physiol"},{"key":"key\n\t\t\t\t20170224043105_R60","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1098\/rspb.1993.0002","article-title":"Properties of large-conductance K+ channels in human myometrium during pregnancy and labor","volume":"251","year":"1993","journal-title":"Proc R Soc Lond B Biol Sci"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/biolreprod\/article-pdf\/71\/1\/156\/10560450\/biolreprod0156.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T14:38:16Z","timestamp":1624718296000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-lookup\/doi\/10.1095\/biolreprod.103.026708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7,1]]},"references-count":60,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,7,1]]}},"URL":"https:\/\/doi.org\/10.1095\/biolreprod.103.026708","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,7,1]]}}}