{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T08:29:26Z","timestamp":1774686566549,"version":"3.50.1"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,7,1]]},"DOI":"10.1095\/biolreprod.103.026989","type":"journal-article","created":{"date-parts":[[2004,10,20]],"date-time":"2004-10-20T18:30:50Z","timestamp":1098297050000},"page":"348-358","source":"Crossref","is-referenced-by-count":26,"title":["The Ability of a Gonadotropin-Releasing Hormone Antagonist, Acyline, to Prevent Irreversible Infertility Induced by the Indenopyridine, CDB-4022, in Adult Male Rats: The Role of Testosterone1"],"prefix":"10.1093","volume":"71","author":[{"given":"Sheri Ann","family":"Hild","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara J.","family":"Attardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerry R.","family":"Reel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","reference":[{"key":"key\n\t\t\t\t20170224033740_R1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1095\/biolreprod65.1.165","article-title":"Lupron Depot prevention of antispermatogenic\/antifertility activity of the indenopyridine, CDB-4022, in the rat","volume":"65","year":"2001","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224033740_R2","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1095\/biolreprod65.6.1771","article-title":"Disruption of spermatogenesis and Sertoli cell structure and function by the indenopyridine CDB-4022 in rats","volume":"65","year":"2001","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224033740_R3","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1021\/jm00005a003","article-title":"Lee Y-W, Fail PA, Anderson SA, Gu Y-Q, Petrow V. Structure-activity studies of 2,3,4,4a,5,9b-hexahydroindeno[1,2-c]pyridines as antispermatogenic agents for male contraception","volume":"38","year":"1995","journal-title":"J Med Chem"},{"key":"key\n\t\t\t\t20170224033740_R4","first-page":"552","volume-title":"The Sertoli Cell","year":"1993"},{"key":"key\n\t\t\t\t20170224033740_R5","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1210\/endo.141.1.7272","article-title":"Enhancement of a spermatogonial proliferation and differentiation in irradiated rats by gonadotropin-releasing hormone antagonist administration","volume":"141","year":"2000","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224033740_R6","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1210\/endo.141.5.7446","article-title":"Gonadotropin-releasing hormone analogs stimulate and testosterone inhibits the recovery of spermatogenesis in irradiated rats","volume":"141","year":"2000","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224033740_R7","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1210\/endo.136.7.7789313","article-title":"Rapid protection of rat spermatogenic stem cells against procarbazine by treatment with a gonadotropin-releasing hormone antagonist (Nal-Glu) and an antiandrogen (flutamide)","volume":"136","year":"1995","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224033740_R8","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1002\/j.1939-4640.1995.tb00538.x","article-title":"Hormonal protection from cyclophosphamide-induced inactivation of rat stem spermatogonia","volume":"16","year":"1995","journal-title":"J Androl"},{"key":"key\n\t\t\t\t20170224033740_R9","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1093\/toxsci\/kfg237","article-title":"Restoration of spermatogenesis in dibromochloropropane (DBCP)-treated rats by hormone suppression","volume":"76","year":"2003","journal-title":"Toxicol Sci"},{"key":"key\n\t\t\t\t20170224033740_R10","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1210\/endo.139.1.5678","article-title":"Luprolide, a gonadotropin-releasing hormone agonist, reestablishes spermatogenesis after 2,5-hexanedione-induced irreversible testicular injury in the rat, resulting in a normalized stem cell factor expression","volume":"139","year":"1998","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224033740_R11","volume-title":"Guide for the Care and Use of Laboratory Animals","author":"National Research Council","year":"1996"},{"key":"key\n\t\t\t\t20170224033740_R12","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1210\/endo-117-4-1380","article-title":"The ontogeny of biologically active androgen-binding protein in rat plasma, testis, and epididymis","volume":"117","year":"1985","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224033740_R13","first-page":"106","volume-title":"Methods in Toxicology, vol. 3, Part A: Male Reproductive Toxicology.","year":"1993"},{"key":"key\n\t\t\t\t20170224033740_R14","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/j.1939-4640.2003.tb02652.x","article-title":"Inhibition of spermatogonial differentiation by testosterone","volume":"24","year":"2003","journal-title":"J Androl"},{"key":"key\n\t\t\t\t20170224033740_R15","doi-asserted-by":"crossref","first-page":"3385","DOI":"10.1210\/en.2002-220206","article-title":"Inhibition of recovery of spermatogenesis in irradiated rats by different androgens","volume":"143","year":"2002","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224033740_R16","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1210\/mend.13.3.0255","article-title":"Distinguishing androgen receptor agonists and antagonists: distinct mechanism of activation by medroxyprogesterone acetate and dihydrotestosterone","volume":"13","year":"1999","journal-title":"Mol Endocrinol"},{"key":"key\n\t\t\t\t20170224033740_R17","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1093\/toxsci\/66.1.82","article-title":"Gray LE Jr. Development of two androgen receptor assays using adenoviral transduction of MMTV-luc reporter and\/or hAR for endocrine screening","volume":"66","year":"2002","journal-title":"Toxicol Sci"},{"key":"key\n\t\t\t\t20170224033740_R18","doi-asserted-by":"crossref","first-page":"3180","DOI":"10.1210\/endo-127-6-3180","article-title":"Immunohistochemical localization of the androgen receptor in rat and human tissues","volume":"127","year":"1990","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224033740_R19","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1677\/joe.0.1260017","article-title":"Immunohistochemical localization of androgen receptors with mono- and polyclonal antibodies to androgen receptor","volume":"126","year":"1990","journal-title":"J Endocrinol"},{"key":"key\n\t\t\t\t20170224033740_R20","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1677\/joe.0.1650359","article-title":"Localization of oestrogen receptor alpha, oestrogen receptor beta and androgen receptors in the rat reproductive organs","volume":"165","year":"2000","journal-title":"J Endocrinol"},{"key":"key\n\t\t\t\t20170224033740_R21","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1046\/j.1365-2605.2000.00229.x","article-title":"Regulation of inhibin production in the human male and its clinical applications","volume":"23","year":"2000","journal-title":"Int J Androl"},{"key":"key\n\t\t\t\t20170224033740_R22","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1210\/edrv.22.6.0446","article-title":"The functional significance of FSH in spermatogenesis and the control of its secretion in male primates","volume":"22","year":"2001","journal-title":"Endocr Rev"},{"key":"key\n\t\t\t\t20170224033740_R23","doi-asserted-by":"crossref","first-page":"5618","DOI":"10.1210\/jc.2002-020737","article-title":"Inhibin B: a marker for the functional state of the seminiferous epithelium in patients with azoospermia factor c microdeletions","volume":"87","year":"2002","journal-title":"J Clin Endocinol Metab"},{"key":"key\n\t\t\t\t20170224033740_R24","article-title":"Antispermatogenic activity of the purified enantiomers of the indenopyridine CDB-4022: potential interactions of the isomers in vivo and in vitro.","year":"2003","journal-title":"Program of the 36th annual meeting of the Society for the Study of Reproduction"},{"key":"key\n\t\t\t\t20170224033740_R25","first-page":"421","article-title":"Spermatogenesis by sisyphus: proliferating stem germ cells fail to repopulate the testes after \u2018irreversible\u2019 injury","volume":"VI","year":"2001","journal-title":"Biol React Intermed"},{"key":"key\n\t\t\t\t20170224033740_R26","first-page":"726","article-title":"Divergent actions of testosterone on follicle stimulating hormone-\u03b2 and glycoprotein hormone \u03b1-subunit messenger RNAs","volume":"130","year":"1992","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224033740_R27","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0303-7207(93)90116-2","article-title":"Biphasic effect of exogenous testosterone on follicle-stimulating hormone gene expression and synthesis in the male rat","volume":"93","year":"1993","journal-title":"Mol Cell Endocrinol"},{"key":"key\n\t\t\t\t20170224033740_R28","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1046\/j.1365-2605.2003.00400.x","article-title":"Suppression of testosterone stimulates recovery of spermatogenesis after cancer treatment","volume":"26","year":"2003","journal-title":"Int J Androl"},{"key":"key\n\t\t\t\t20170224033740_R29","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1210\/er.2002-0002","article-title":"Male contraception","volume":"23","year":"2002","journal-title":"Endocr Rev"},{"key":"key\n\t\t\t\t20170224033740_R30","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/S0165-6147(03)00141-X","article-title":"Advancing toward a male contraceptive: a novel approach from an unexpected direction","volume":"24","year":"2003","journal-title":"TRENDS Pharmacol Sci"},{"key":"key\n\t\t\t\t20170224033740_R31","doi-asserted-by":"crossref","first-page":"17173","DOI":"10.1073\/pnas.262586099","article-title":"Reversible infertility in male mice after oral administration of alkylated imino sugars: a nonhormonal approach to male contraception","volume":"99","year":"2002","journal-title":"PNAS"},{"key":"key\n\t\t\t\t20170224033740_R32","first-page":"810","article-title":"Antispermatogenic activity of an indenopyridine derivative","volume":"33","year":"1977","journal-title":"Experientia"},{"key":"key\n\t\t\t\t20170224033740_R33","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/978-3-642-66896-8_67","article-title":"Reversible inhibition of spermatogenesis with an indenopyridine (20-438)","volume":"1","year":"1978","journal-title":"Toxicol Aspects Food Safety Arch Toxicol Suppl"},{"key":"key\n\t\t\t\t20170224033740_R34","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0165-1218(79)90055-7","article-title":"Actions of an antispermatogenic, but not mutagenic, indenopyridine derivative in mice and Salmonella typhimurium","volume":"66","year":"1979","journal-title":"Mutat Res"},{"key":"key\n\t\t\t\t20170224033740_R35","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0890-6238(00)00077-0","article-title":"28-Day toxicology test: indenopyridine RTI 4587-056 in male Sprague-Dawley rats","volume":"14","year":"2000","journal-title":"Reprod Toxicol"},{"key":"key\n\t\t\t\t20170224033740_R36","first-page":"48","article-title":"Contraceptive potency of two indenopyridine analogs of Sandoz 20-438 test in Swiss mice","volume":"15","year":"1995","journal-title":"J Androl"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/biolreprod\/article-pdf\/71\/1\/348\/10563751\/biolreprod0348.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,14]],"date-time":"2024-01-14T18:03:11Z","timestamp":1705255391000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-lookup\/doi\/10.1095\/biolreprod.103.026989"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7,1]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,7,1]]}},"URL":"https:\/\/doi.org\/10.1095\/biolreprod.103.026989","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,7,1]]}}}