{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:22:04Z","timestamp":1791249724963,"version":"4.1.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,6,1]]},"DOI":"10.1095\/biolreprod.105.040386","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T01:43:38Z","timestamp":1109209418000},"page":"1429-1436","source":"Crossref","is-referenced-by-count":78,"title":["Cell-Cycle Inhibitors p27Kip1 and p21Cip1 Regulate Murine Sertoli Cell Proliferation1"],"prefix":"10.1093","volume":"72","author":[{"given":"Denise R.","family":"Holsberger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory M.","family":"Buchold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Castro","family":"Leal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Kiesewetter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah A.","family":"O\u2019Brien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rex A.","family":"Hess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz R.","family":"Franc\u0327a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Kiyokawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul S.","family":"Cooke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"key\n\t\t\t\t20170224035305_R1","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1002\/ar.1092030408","article-title":"Proliferation of Sertoli cells in fetal and postnatal rats: a quantitative autoradiographic study","volume":"203","year":"1982","journal-title":"Anat Rec"},{"key":"key\n\t\t\t\t20170224035305_R2","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1002\/j.1939-4640.1993.tb03261.x","article-title":"Neonatal goitrogen treatment increases adult testis size and sperm production in the mouse","volume":"14","year":"1993","journal-title":"J Androl"},{"key":"key\n\t\t\t\t20170224035305_R3","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1210\/endo-122-3-787","article-title":"Evidence from Sertoli cell-depleted rats indicates that spermatid number in adults depends on numbers of Sertoli cells produced during perinatal development","volume":"122","year":"1988","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224035305_R4","first-page":"559","article-title":"Developmental hormonal profiles accompanying the neonatal hypothyroidism-induced increase in adult testicular size and sperm production in the rat","volume":"131","year":"1992","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224035305_R5","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1095\/biolreprod51.5.1000","article-title":"Triiodothyronine inhibits proliferation and stimulates differentiation of cultured neonatal Sertoli cells: possible mechanism for increased adult testis weight and sperm production induced by neonatal goitrogen treatment","volume":"51","year":"1994","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224035305_R6","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0303-7207(77)90064-8","article-title":"Stimulation by follicle-stimulating hormone of DNA synthesis and of mitosis in cultured Sertoli cells prepared from testes of immature rats","volume":"7","year":"1977","journal-title":"Mol Cell Endocrinol"},{"key":"key\n\t\t\t\t20170224035305_R7","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1210\/en.2003-1055","article-title":"Regulation of Sertoli cell number and activity by follicle-stimulating hormone and androgen during postnatal development in the mouse","volume":"145","year":"2004","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224035305_R8","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1677\/joe.1.05884","article-title":"Evidence that androgens and oestrogens, as well as follicle-stimulating hormone, can alter Sertoli cell number in the neonatal rat","volume":"184","year":"2005","journal-title":"J Endocrinol"},{"key":"key\n\t\t\t\t20170224035305_R9","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1073\/pnas.0308114100","article-title":"A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis","volume":"101","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170224035305_R10","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1210\/endo-129-1-237","article-title":"Early hypothyroidism in rats causes increased adult testis and reproductive organ size but does not change testosterone levels","volume":"129","year":"1991","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224035305_R11","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1210\/endo-129-1-244","article-title":"Increased sperm production in adult rats after transient neonatal hypothyroidism","volume":"129","year":"1991","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224035305_R12","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1210\/endo.132.6.8504761","article-title":"Adult testicular enlargement induced by neonatal hypothyroidism is accompanied by increased Sertoli and germ cell numbers","volume":"132","year":"1993","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224035305_R13","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1210\/endo.131.3.1505485","article-title":"The effect of hypothyroidism on Sertoli cell proliferation and differentiation and hormone levels during testicular development in the rat","volume":"131","year":"1992","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224035305_R14","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1210\/endo.133.2.8344214","article-title":"High neonatal triiodothyronine levels reduce the period of Sertoli cell proliferation and accelerate tubular lumen formation in the rat testis, and increase serum inhibin levels","volume":"133","year":"1993","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224035305_R15","doi-asserted-by":"crossref","first-page":"3732","DOI":"10.1210\/en.2003-0389","article-title":"Thyroid hormone regulates the cell cycle inhibitor p27Kip1 in postnatal murine Sertoli cells","volume":"144","year":"2003","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224035305_R16","doi-asserted-by":"crossref","first-page":"3722","DOI":"10.1210\/en.2003-0379","article-title":"Thyroid hormone, retinoic acid, and testosterone suppress proliferation and induce markers of differentiation in cultured rat Sertoli cells","volume":"144","year":"2003","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224035305_R17","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1210\/endo.140.4.6638","article-title":"Regulatory role of p27kip1 in the mouse and human testis","volume":"140","year":"1999","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224035305_R18","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1210\/mend.15.6.0650","article-title":"Inhibin and p27 interact to regulate gonadal tumorigenesis","volume":"15","year":"2001","journal-title":"Mol Endocrinol"},{"key":"key\n\t\t\t\t20170224035305_R19","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/0092-8674(95)90039-X","article-title":"Mice lacking p21CIP1\/WAF1 undergo normal development, but are defective in G1 checkpoint control","volume":"82","year":"1995","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170224035305_R20","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S0092-8674(00)81238-6","article-title":"Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1)","volume":"85","year":"1996","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170224035305_R21","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S0092-8674(00)81239-8","article-title":"A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice","volume":"85","year":"1996","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170224035305_R22","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S0092-8674(00)81237-4","article-title":"Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors","volume":"85","year":"1996","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170224035305_R23","doi-asserted-by":"crossref","first-page":"17021","DOI":"10.1074\/jbc.M301206200","article-title":"The cyclin-dependent kinase inhibitors p27Kip1 and p21Cip1 cooperate to restrict proliferative life span in differentiating ovarian cells","volume":"278","year":"2003","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170224035305_R24","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1095\/biolreprod.102.010652","article-title":"Testis morphometry, seminiferous epithelium cycle length, and daily sperm production in domestic cats (Felis catus)","volume":"68","year":"2003","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224035305_R25","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1096\/fj.04-2631fje","article-title":"Loss of cyclin-dependent kinase inhibitors produces adipocyte hyperplasia and obesity","volume":"18","year":"2004","journal-title":"FASEB J"},{"key":"key\n\t\t\t\t20170224035305_R26","doi-asserted-by":"crossref","first-page":"2916","DOI":"10.1210\/endo.142.7.8230","article-title":"Analysis of the testicular phenotype of the follicle-stimulating hormone beta-subunit knockout and the activin type II receptor knockout mice by stereological analysis","volume":"142","year":"2001","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224035305_R27","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1210\/me.2003-0038","article-title":"Cyclin D2 and p27 are tissue-specific regulators of tumorigenesis in inhibin alpha knockout mice","volume":"17","year":"2003","journal-title":"Mol Endocrinol"},{"key":"key\n\t\t\t\t20170224035305_R28","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/384470a0","article-title":"Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis","volume":"384","year":"1996","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170224035305_R29","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.ydbio.2003.07.001","article-title":"Cki-1 links cell division and cell fate acquisition in the C. elegans somatic gonad","volume":"263","year":"2003","journal-title":"Dev Biol"},{"key":"key\n\t\t\t\t20170224035305_R30","doi-asserted-by":"crossref","first-page":"6147","DOI":"10.1128\/MCB.20.16.6147-6158.2000","article-title":"Functional collaboration between different cyclin-dependent kinase inhibitors suppresses tumor growth with distinct tissue specificity","volume":"20","year":"2000","journal-title":"Mol Cell Biol"},{"key":"key\n\t\t\t\t20170224035305_R31","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1093\/humrep\/deg273","article-title":"Human \u2018testicular dysgenesis syndrome\u2019: a possible model using in-utero exposure of the rat to dibutyl phthalate","volume":"18","year":"2003","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20170224035305_R32","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1210\/en.2003-1164","article-title":"Complete Sertoli cell proliferation induced by follicle-stimulating hormone (FSH) independently of luteinizing hormone activity: evidence from genetic models of isolated FSH action","volume":"145","year":"2004","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224035305_R33","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1095\/biolreprod51.5.945","article-title":"Effects of testosterone on spermatogenic cell populations in the adult rat","volume":"51","year":"1994","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224035305_R34","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1002\/(SICI)1098-2795(199707)47:3<240::AID-MRD2>3.0.CO;2-L","article-title":"P21(Cip1\/WAF1) expression in the mouse testis before and after X irradiation","volume":"47","year":"1997","journal-title":"Mol Reprod Dev"},{"key":"key\n\t\t\t\t20170224035305_R35","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1126\/science.7863329","article-title":"P53-independent expression of p21Cip1 in muscle and other terminally differentiating cells","volume":"267","year":"1995","journal-title":"Science"},{"key":"key\n\t\t\t\t20170224035305_R36","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1101\/gad.9.8.935","article-title":"P53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage","volume":"9","year":"1995","journal-title":"Genes Dev"},{"key":"key\n\t\t\t\t20170224035305_R37","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1210\/endo.143.7.8878","article-title":"Role of systemic and local IGF-I in the effects of estrogen on growth and epithelial proliferation of mouse uterus","volume":"143","year":"2002","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224035305_R38","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1210\/endo.142.5.8148","article-title":"Roberts CT Jr. Minireview: tissue-specific versus generalized gene targeting of the igf1 and igf1r genes and their roles in insulin-like growth factor physiology","volume":"142","year":"2001","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224035305_R39","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1158\/1055-9965.EPI-130-3","article-title":"Association between insulin-like growth factor-I: insulin-like growth factor-binding protein-1 ratio and metabolic and anthropometric factors in men and women","volume":"13","year":"2004","journal-title":"Cancer Epidemiol Biomarkers Prev"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/biolreprod\/article-pdf\/72\/6\/1429\/10563911\/biolreprod1429.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T18:21:49Z","timestamp":1706034109000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-lookup\/doi\/10.1095\/biolreprod.105.040386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6,1]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,6,1]]}},"URL":"https:\/\/doi.org\/10.1095\/biolreprod.105.040386","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,6,1]]}}}