{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T15:55:39Z","timestamp":1793202939248,"version":"4.5.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,5,1]]},"DOI":"10.1095\/biolreprod.105.046896","type":"journal-article","created":{"date-parts":[[2006,1,26]],"date-time":"2006-01-26T02:03:21Z","timestamp":1138241001000},"page":"954-958","source":"Crossref","is-referenced-by-count":59,"title":["Mechanism of Action of L-arginine on the Vitality of Spermatozoa is Primarily Through Increased Biosynthesis of Nitric Oxide"],"prefix":"10.1093","volume":"74","author":[{"given":"Sudha","family":"Srivastava","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashant","family":"Desai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evans","family":"Coutinho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Girjesh","family":"Govil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"key\n\t\t\t\t20170224035838_R1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0015-0282(16)37384-8","article-title":"Effect of arginine on oligospermia. Fertil","volume":"21","year":"1970","journal-title":"Steril"},{"key":"key\n\t\t\t\t20170224035838_R2","first-page":"143","article-title":"Observation of amino acids deficiencies in man. Trans. Assoc. Am","volume":"58","year":"1944","journal-title":"Physicians"},{"key":"key\n\t\t\t\t20170224035838_R3","first-page":"199","article-title":"The role of arginine indomethacin and kallikrein in the treatment of oligospermia. Int. Urol","volume":"27","year":"1995","journal-title":"Nephrol"},{"key":"key\n\t\t\t\t20170224035838_R4","first-page":"251","article-title":"Arginine and male infertility. Minerva Urol","volume":"46","year":"1994","journal-title":"Nefrol"},{"key":"key\n\t\t\t\t20170224035838_R5","first-page":"770","article-title":"Arginine uptake by rabbit spermatozoa. Arch. Biochem","volume":"210","year":"1981","journal-title":"Biophys"},{"key":"key\n\t\t\t\t20170224035838_R6","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1016\/S0006-3495(98)74071-8","article-title":"Arginine activates glycolysis of goat epididymal spermatozoa: An NMR study","volume":"75","year":"1998","journal-title":"Biophys J"},{"key":"key\n\t\t\t\t20170224035838_R7","first-page":"29","article-title":"Arginine acts as a protective and reversal agent against glycolytic inhibitors in spermatozoa","volume":"31","year":"1999","journal-title":"Physiol Chem Phys Med NMR"},{"key":"key\n\t\t\t\t20170224035838_R8","first-page":"213","volume-title":"Male reproductive function and semen.","year":"1981"},{"key":"key\n\t\t\t\t20170224035838_R9","first-page":"122","volume-title":"Aging gametes Ed.","year":"1975"},{"key":"key\n\t\t\t\t20170224035838_R10","first-page":"27","volume-title":"Lipid soluble antioxidants: Biochemistry and clinical applications","year":"1992"},{"key":"key\n\t\t\t\t20170224035838_R11","first-page":"127","article-title":"Protective effect of l-arginine against lipid peroxidation in goat epididymal spermatozoa","volume":"32","year":"2000","journal-title":"Physiol. Chem. Phys. & Med"},{"key":"key\n\t\t\t\t20170224035838_R12","first-page":"664","article-title":"Vascular endothelial cells synthesize nitric oxide from l-arginine","volume":"33","year":"1988","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170224035838_R13","first-page":"109","article-title":"Nitric oxide: physiology pathophysiology and pharmacology","volume":"43","year":"1992","journal-title":"Pharmacol. Rev"},{"key":"key\n\t\t\t\t20170224035838_R14","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1071\/RD9930639","article-title":"Lipids and calcium uptake of sperm in relation to cold shock and preservation: a review","volume":"5","year":"1993","journal-title":"Reprod. Fertil. Dev"},{"key":"key\n\t\t\t\t20170224035838_R15","first-page":"302","article-title":"Methods","volume":"52","year":"1978","journal-title":"Enzymol"},{"key":"key\n\t\t\t\t20170224035838_R16","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1095\/biolreprod13.2.154","article-title":"l-arginine stimulation of human sperm motility in-vitro.","volume":"13","year":"1975","journal-title":"Biol. Reprod"},{"key":"key\n\t\t\t\t20170224035838_R17","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/j.1939-4640.1995.tb00558.x","article-title":"Low levels of nitric oxide promote human sperm capacitation in vitro","volume":"16","year":"1995","journal-title":"J Androl"},{"key":"key\n\t\t\t\t20170224035838_R18","first-page":"433","article-title":"Evidence that nitric oxide synthase is involved in progesterone-induced acrosomal exocytosis in mouse spermatozoa. Reprod. Fertil","volume":"9","year":"1997","journal-title":"Dev"},{"key":"key\n\t\t\t\t20170224035838_R19","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/S0015-0282(97)00537-2","article-title":"Effects of low concentrations of nitric oxide on the zona pellucida binding ability of human spermatozoa. Fertil","volume":"69","year":"1998","journal-title":"Steril"},{"key":"key\n\t\t\t\t20170224035838_R20","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1095\/biolreprod64.6.1708","article-title":"Signaling pathway of nitric oxide-induced acrosome reaction in human spermatozoa. Biol","volume":"64","year":"2001","journal-title":"Reprod"},{"key":"key\n\t\t\t\t20170224035838_R21","first-page":"29","article-title":"Effect of sodium nitroprusside on mouse sperm migration in vitro. Arch","volume":"45","year":"2000","journal-title":"Androl"},{"key":"key\n\t\t\t\t20170224035838_R22","first-page":"344","article-title":"Artificial stimulation of cryopreserved human spermatozoa by sodium nitroprusside 2-chloroadenosine and 2-deoxyadenosine. Eur","volume":"32","year":"1997","journal-title":"Urol"},{"key":"key\n\t\t\t\t20170224035838_R23","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/S0015-0282(16)56766-1","article-title":"Effect of sodium nitroprusside on sperm motility viability and lipid peroxidation. Fertil","volume":"61","year":"1994","journal-title":"Steril"},{"key":"key\n\t\t\t\t20170224035838_R24","first-page":"692","article-title":"Martinez SPDe, Gimeno MF, Analysis of the effect of nitric oxide synthase inhibition on mouse sperm employing a modified staining method for assessment of the acrosome reaction. J","volume":"17","year":"1996","journal-title":"Androl"},{"key":"key\n\t\t\t\t20170224035838_R25","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1042\/bj2980249","article-title":"Nitric oxide synthases in mammals","volume":"298","year":"1994","journal-title":"Biochem J"},{"key":"key\n\t\t\t\t20170224035838_R26","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1111\/j.1476-5381.1990.tb14151.x","article-title":"Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo","volume":"101","year":"1990","journal-title":"Br J Pharmacol"},{"key":"key\n\t\t\t\t20170224035838_R27","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0005-2728(99)00025-0","article-title":"Nitric oxide and mitochondrial respiration","volume":"1411","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"key\n\t\t\t\t20170224035838_R28","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/sj.cdd.4400580","article-title":"Neuronal protection and destruction by NO","volume":"6","year":"1999","journal-title":"Cell Death Differ"},{"key":"key\n\t\t\t\t20170224035838_R29","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1007\/s00240-004-0401-2","article-title":"Testicular tissue nitric oxide and thiobarbituric acid reactive substance levels: evaluation with respect to the pathogenesis of varicocele","volume":"32","year":"2004","journal-title":"Urol Res"},{"key":"key\n\t\t\t\t20170224035838_R30","first-page":"185","volume":"64","year":"1998","journal-title":"Interactive role of nitric oxide and superoxide anion in neutrophil-mediated endothelial cell injury Journal of Leukocyte Biology"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/biolreprod\/article-pdf\/74\/5\/954\/10567744\/biolreprod0954.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T15:31:40Z","timestamp":1706887900000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article\/2667057\/Mechanism"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5,1]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,5,1]]}},"URL":"https:\/\/doi.org\/10.1095\/biolreprod.105.046896","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5,1]]}}}