{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:36:45Z","timestamp":1791221805280,"version":"4.1.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,6,1]]},"DOI":"10.1095\/biolreprod.106.057810","type":"journal-article","created":{"date-parts":[[2008,1,24]],"date-time":"2008-01-24T20:13:15Z","timestamp":1201205595000},"page":"1127-1138","source":"Crossref","is-referenced-by-count":92,"title":["A Novel Potent Indazole Carboxylic Acid Derivative Blocks Spermatogenesis and Is Contraceptive in Rats after a Single Oral Dose1"],"prefix":"10.1093","volume":"78","author":[{"given":"Joseph S.","family":"Tash","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Attardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheri A.","family":"Hild","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramappa","family":"Chakrasali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudhakar R.","family":"Jakkaraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunda I.","family":"Georg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"key\n\t\t\t\t20170224041140_R1","doi-asserted-by":"crossref","DOI":"10.30875\/8466f5ca-en","volume-title":"The World Health Report 2005: Make every mother and child count","author":"World Health Organization.","year":"2005"},{"issue":"(suppl A):","key":"key\n\t\t\t\t20170224041140_R2","first-page":"11","article-title":"The costs of unintended pregnancy","volume":"19","year":"2006","journal-title":"Manag Care Interface"},{"key":"key\n\t\t\t\t20170224041140_R3","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S1043-2760(99)00220-9","article-title":"Male contraception: Views to the 21st Century, Bethesda, MD, USA, 9\u201310 September 1999","volume":"11","year":"2000","journal-title":"Trends Endocrinol Metab"},{"key":"key\n\t\t\t\t20170224041140_R4","volume-title":"New Frontiers in Contraceptive Research: A Blueprint for Action","year":"2004"},{"key":"key\n\t\t\t\t20170224041140_R5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0015-0282(03)00577-6","article-title":"Development of methods of male contraception: impact of the World Health Organization Task Force","volume":"80","year":"2003","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20170224041140_R6","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1126\/science.1099743","article-title":"Reversible immunocontraception in male monkeys immunized with eppin","volume":"306","year":"2004","journal-title":"Science"},{"key":"key\n\t\t\t\t20170224041140_R7","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1095\/biolreprod59.5.1029","article-title":"Potential contraceptive use of epididymal proteins: immunization of male rats with epididymal protein DE inhibits sperm fusion ability","volume":"59","year":"1998","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224041140_R8","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0010-7824(01)00227-X","article-title":"Immune response of male baboons to testis-specific LDH-C(4)","volume":"64","year":"2001","journal-title":"Contraception"},{"key":"key\n\t\t\t\t20170224041140_R9","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1095\/biolreprod.104.036053","article-title":"Alkylated imino sugars, reversible male infertility-inducing agents, do not affect the genetic integrity of male mouse germ cells during short-term treatment despite induction of sperm deformities","volume":"72","year":"2005","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224041140_R10","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/0014-4800(75)90029-5","article-title":"Reversible inhibition of spermatogenesis in rats and monkeys with a new class of indazole-carboxylic acids","volume":"23","year":"1975","journal-title":"Exp Mol Pathol"},{"issue":"(suppl 2):","key":"key\n\t\t\t\t20170224041140_R11","first-page":"27","article-title":"Effects of AF 1312 TS and lonidamine on mammalian testis. A morphological study","volume":"27","year":"1981","journal-title":"Chemotherapy"},{"issue":"(suppl 2):","key":"key\n\t\t\t\t20170224041140_R12","first-page":"91","article-title":"Toxicological studies on 1-substituted indazole-3-carboxylic acids","volume":"27","year":"1981","journal-title":"Chemotherapy"},{"key":"key\n\t\t\t\t20170224041140_R13","first-page":"18","article-title":"Toxicity and clinical tolerance of lonidamine","volume":"18","year":"1991","journal-title":"Semin Oncol"},{"key":"key\n\t\t\t\t20170224041140_R14","first-page":"751","article-title":"Phase II study of lonidamine in patients with metastatic renal cell carcinoma: a National Cancer Institute of Canada Clinical Trials Group Study","volume":"70","year":"1986","journal-title":"Cancer Treat Rep"},{"issue":"(suppl 1):","key":"key\n\t\t\t\t20170224041140_R15","first-page":"60","article-title":"Phase I and clinical pharmacologic evaluation of lonidamine in patients with advanced cancer","volume":"41","year":"1984","journal-title":"Oncology"},{"key":"key\n\t\t\t\t20170224041140_R16","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1023\/A:1023756707900","article-title":"Phase II study of lonidamine and diazepam in the treatment of recurrent glioblastoma multiforme","volume":"63","year":"2003","journal-title":"J Neurooncol"},{"key":"key\n\t\t\t\t20170224041140_R17","first-page":"1","article-title":"The benefits of investing in sexual and reproductive health","volume-title":"Issues Brief (Alan Guttmacher Inst","author":"Alan Guttmacher Institute.","year":"2004"},{"key":"key\n\t\t\t\t20170224041140_R18","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1021\/jm00005a003","article-title":"Structure-activity studies of 2,3,4,4a,5,9b-hexahydroindeno[1,2-c]pyridines as antispermatogenic agents for male contraception","volume":"38","year":"1995","journal-title":"J Med Chem"},{"key":"key\n\t\t\t\t20170224041140_R19","doi-asserted-by":"crossref","first-page":"353","DOI":"10.3109\/01485017908987337","article-title":"1-(2,4-Dichlorobenzyl)-1H-indazole-3-carboxylic acid (DICA), an exfoliative antispermatogenic agent in the rat","volume":"2","year":"1979","journal-title":"Arch Androl"},{"key":"key\n\t\t\t\t20170224041140_R20","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1152\/japplphysiol.00931.2001","article-title":"Long-term (6-wk) hindlimb suspension inhibits spermatogenesis in adult male rats","volume":"92","year":"2002","journal-title":"J Appl Physiol"},{"key":"key\n\t\t\t\t20170224041140_R21","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1530\/jrf.0.0720277","article-title":"Effect of transitional photoperiods on testicular development and puberty in male deer mice (Peromyscus maniculatus)","volume":"72","year":"1984","journal-title":"J Reprod Fertil"},{"key":"key\n\t\t\t\t20170224041140_R22","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1095\/biolreprod.103.026989","article-title":"The ability of a gonadotropin-releasing hormone antagonist, acyline, to prevent irreversible infertility induced by the indenopyridine, CDB-4022, in adult male rats: the role of testosterone","volume":"71","year":"2004","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224041140_R23","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1095\/biolreprod65.6.1771","article-title":"Disruption of spermatogenesis and Sertoli cell structure and function by the indenopyridine CDB-4022 in rats","volume":"65","year":"2001","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224041140_R24","doi-asserted-by":"crossref","first-page":"35607","DOI":"10.1074\/jbc.274.50.35607","article-title":"NF-\u03baB induces cAMP-response element-binding protein gene transcription in Sertoli cells","volume":"274","year":"1999","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170224041140_R25","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1210\/mend.14.11.0557","article-title":"The USF proteins regulate transcription of the follicle-stimulating hormone receptor but are insufficient for cell-specific expression","volume":"14","year":"2000","journal-title":"Mol Endocrinol"},{"key":"key\n\t\t\t\t20170224041140_R26","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1095\/biolreprod65.2.449","article-title":"Two new male contraceptives exert their effects by depleting germ cells prematurely from the testis","volume":"65","year":"2001","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224041140_R27","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1095\/biolreprod64.5.1500","article-title":"Reversible inhibition of spermatogenesis in rats using a new male contraceptive, 1-(2,4-dichlorobenzyl)-indazole-3-carbohydrazide","volume":"64","year":"2001","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224041140_R28","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0010-7824(98)00031-6","article-title":"Long-term sequelae of tolnidamine on male reproduction and general body metabolism in rabbits","volume":"57","year":"1998","journal-title":"Contraception"},{"key":"key\n\t\t\t\t20170224041140_R29","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0014-4800(75)90028-3","article-title":"Antispermatogenic activity of 1-p-chlorobenzyl-1H indazol-3-carboxylic acid (AF 1312\/TS) in rats. III. A light and electron microscopic study after single oral doses","volume":"23","year":"1975","journal-title":"Exp Mol Pathol"},{"key":"key\n\t\t\t\t20170224041140_R30","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/0010-7824(91)90138-6","article-title":"Antispermatogenic effects of tolnidamine in langur (Presbytis entellus)","volume":"43","year":"1991","journal-title":"Contraception"},{"issue":"(suppl 2):","key":"key\n\t\t\t\t20170224041140_R31","first-page":"9","article-title":"Basic and applied research in the study of indazole carboxylic acids","volume":"27","year":"1981","journal-title":"Chemotherapy"},{"key":"key\n\t\t\t\t20170224041140_R32","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0010-7824(02)00289-5","article-title":"Recent studies on lonidamine, the lead compound of the antispermatogenic indazol-carboxylic acids","volume":"65","year":"2002","journal-title":"Contraception"},{"key":"key\n\t\t\t\t20170224041140_R33","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1210\/er.2003-0022","article-title":"Sertoli-Sertoli and Sertoli-germ cell interactions and their significance in germ cell movement in the seminiferous epithelium during spermatogenesis","volume":"25","year":"2004","journal-title":"Endocr Rev"},{"key":"key\n\t\t\t\t20170224041140_R34","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.contraception.2004.10.001","article-title":"Steroid hormones for contraception in men: systematic review of randomized controlled trials","volume":"71","year":"2005","journal-title":"Contraception"},{"key":"key\n\t\t\t\t20170224041140_R35","volume-title":"Histological and histopathological evaluation of the testis","year":"1990"},{"key":"key\n\t\t\t\t20170224041140_R36","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1095\/biolreprod63.4.977","article-title":"Regulation of Leydig cell steroidogenic function during aging","volume":"63","year":"2000","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224041140_R37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mce.2005.04.009","article-title":"The decline in testosterone biosynthesis during male aging: a consequence of multiple alterations","volume":"238","year":"2005","journal-title":"Mol Cell Endocrinol"},{"key":"key\n\t\t\t\t20170224041140_R38","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1093\/humrep\/13.4.920","article-title":"Inhibin B in seminal plasma: testicular origin and relationship to spermatogenesis","volume":"13","year":"1998","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20170224041140_R39","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1046\/j.1365-2605.2000.00229.x","article-title":"Regulation of inhibin production in the human male and its clinical applications","volume":"23","year":"2000","journal-title":"Int J Androl"},{"key":"key\n\t\t\t\t20170224041140_R40","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1095\/biolreprod.107.062679","article-title":"Gamendazole, an orally active indazole carboxylic acid male contraceptive agent, targets HSP90AB1 (HSP90BETA) and EEF1A1 (eEF1A), and stimulates Il1a transcription in rat Sertoli cells","volume":"78","year":"2008","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224041140_R41","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1210\/edrv.22.6.0446","article-title":"The functional significance of FSH in spermatogenesis and the control of its secretion in male primates","volume":"22","year":"2001","journal-title":"Endocr Rev"},{"key":"key\n\t\t\t\t20170224041140_R42","doi-asserted-by":"crossref","first-page":"5618","DOI":"10.1210\/jc.2002-020737","article-title":"Inhibin B: a marker for the functional state of the seminiferous epithelium in patients with azoospermia factor C microdeletions","volume":"87","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20170224041140_R43","first-page":"1","article-title":"Chemical and biological characterization of the inhibin family of protein hormones","volume":"44","year":"1988","journal-title":"Recent Prog Horm Res"},{"key":"key\n\t\t\t\t20170224041140_R44","doi-asserted-by":"crossref","first-page":"7934","DOI":"10.1074\/jbc.M209710200","article-title":"Inhibin is an antagonist of bone morphogenetic protein signaling","volume":"278","year":"2003","journal-title":"J Biol Chem"},{"issue":"(suppl 1):","key":"key\n\t\t\t\t20170224041140_R45","first-page":"S26","article-title":"Hormonal contraception: recent advances and controversies.","volume":"82","author":"Practice Committee of the American Society for Reproductive Medicine.","year":"2004","journal-title":"Fertil Steril"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/biolreprod\/article-pdf\/78\/6\/1127\/10571284\/biolreprod1127.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T06:09:19Z","timestamp":1557209359000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-lookup\/doi\/10.1095\/biolreprod.106.057810"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6,1]]},"references-count":45,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,6,1]]}},"URL":"https:\/\/doi.org\/10.1095\/biolreprod.106.057810","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6,1]]}}}