{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T23:01:26Z","timestamp":1774911686079,"version":"3.50.1"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,5,1]]},"DOI":"10.1095\/biolreprod.106.059089","type":"journal-article","created":{"date-parts":[[2007,2,3]],"date-time":"2007-02-03T01:00:19Z","timestamp":1170464419000},"page":"892-899","source":"Crossref","is-referenced-by-count":31,"title":["Calcitonin Gene-Related Peptide (CALCA) Is a Proangiogenic Growth Factor in the Human Placental Development1"],"prefix":"10.1093","volume":"76","author":[{"given":"Yuan-Lin","family":"Dong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepti M.","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kortney E.","family":"Green","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madhu S.","family":"Chauhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Qun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manubai","family":"Nagamani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary D.V.","family":"Hankins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandra","family":"Yallampalli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","reference":[{"key":"key\n\t\t\t\t20170224025335_R1","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.semnephrol.2004.07.003","article-title":"Angiogenic imbalance in the pathophysiology of preeclampsia: newer insights","volume":"24","year":"2004","journal-title":"Semin Nephrol"},{"key":"key\n\t\t\t\t20170224025335_R2","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF00707305","article-title":"The fetal vascularisation of term human placental villi. I. Peripheral stem villi","volume":"173","year":"1985","journal-title":"Anat Embryol (Berl)"},{"key":"key\n\t\t\t\t20170224025335_R3","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1172\/JCI119387","article-title":"Human cytotrophoblasts adopt a vascular phenotype as they differentiate. A strategy for successful endovascular invasion?","volume":"99","year":"1997","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20170224025335_R4","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1172\/JCI200422991","article-title":"Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interface","volume":"114","year":"2004","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20170224025335_R5","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1111\/j.1471-0528.1994.tb13182.x","article-title":"A study of placental bed spiral arteries and trophoblast invasion in normal and severe pre-eclamptic pregnancies","volume":"101","year":"1994","journal-title":"Br J Obstet Gynaecol"},{"key":"key\n\t\t\t\t20170224025335_R6","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/304129a0","article-title":"Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing","volume":"304","year":"1983","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170224025335_R7","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1210\/edrv-17-5-533","article-title":"Calcitonin gene-related peptide and its receptors: molecular genetics, physiology, pathophysiology and therapeutic potentials","volume":"17","year":"1996","journal-title":"Endocr Rev"},{"key":"key\n\t\t\t\t20170224025335_R8","doi-asserted-by":"crossref","first-page":"4383","DOI":"10.1210\/jc.2002-020138","article-title":"Calcitonin gene-related peptide (CGRP) and CGRP receptor expression at the human implantation site","volume":"87","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20170224025335_R9","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0143-4004(96)90023-5","article-title":"Localization and distribution of vasoactive neuropeptides in the human placenta","volume":"17","year":"1996","journal-title":"Placenta"},{"key":"key\n\t\t\t\t20170224025335_R10","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0301-2115(01)00519-X","article-title":"Adrenomedullin, calcitonin gene-related peptide and their receptors: evidence for a decreased placental mRNA content in preeclampsia and HELLP syndrome","volume":"101","year":"2002","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"key\n\t\t\t\t20170224025335_R11","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1002\/(SICI)1097-4644(19970301)64:3<447::AID-JCB11>3.0.CO;2-D","article-title":"Retinoic acid abolishes the calcitonin gene-related peptide autocrine system in F9 teratocarcinoma cells","volume":"64","year":"1997","journal-title":"J Cell Biochem"},{"key":"key\n\t\t\t\t20170224025335_R12","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1046\/j.1442-2042.2001.00250.x","article-title":"Effect of prostatic neuropeptides on migration of prostate cancer cell lines","volume":"8","year":"2001","journal-title":"Int J Urol"},{"key":"key\n\t\t\t\t20170224025335_R13","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/0196-9781(92)90071-A","article-title":"CGRP stimulates the adhesion of leukocytes to vascular endothelial cells","volume":"13","year":"1992","journal-title":"Peptides"},{"key":"key\n\t\t\t\t20170224025335_R14","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/30666","article-title":"RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor","volume":"393","year":"1998","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170224025335_R15","doi-asserted-by":"crossref","first-page":"7264","DOI":"10.1074\/jbc.M305332200","article-title":"Intermedin is a calcitonin\/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor\/receptor activity-modifying protein receptor complexes","volume":"279","year":"2004","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170224025335_R16","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1128\/MCB.26.7.2511-2518.2006","article-title":"Hydrops fetalis, cardiovascular defects, and embryonic lethality in mice lacking the calcitonin receptor-like receptor gene","volume":"26","year":"2006","journal-title":"Mol Cell Biol"},{"key":"key\n\t\t\t\t20170224025335_R17","first-page":"423","article-title":"Diagnosis of preeclampsia","volume":"65","year":"1985","journal-title":"Obstet Gynecol"},{"key":"key\n\t\t\t\t20170224025335_R18","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","year":"1983","journal-title":"J Immunol Methods"},{"key":"key\n\t\t\t\t20170224025335_R19","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1126\/science.1111726","article-title":"Latest advances in understanding preeclampsia","volume":"308","year":"2005","journal-title":"Science"},{"key":"key\n\t\t\t\t20170224025335_R20","first-page":"239","article-title":"Vascularization of the placenta.","volume-title":"Cardiovascular Molecular Morphogenesis: Assembly of the Vasculature and Its Regulation","year":"2002"},{"key":"key\n\t\t\t\t20170224025335_R21","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/0002-9378(95)90625-8","article-title":"Plasma and placental calcitonin gene-related peptide in pregnancies complicated by severe preeclampsia","volume":"173","year":"1995","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t20170224025335_R22","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1432-1033.1987.tb13710.x","article-title":"Isolation and characterisation of a human calcitonin-gene-related-peptide receptor","volume":"170","year":"1987","journal-title":"Eur J Biochem"},{"key":"key\n\t\t\t\t20170224025335_R23","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0143-4004(97)90091-6","article-title":"Calcitonin gene-related peptide receptor in human placental syncytiotrophoblast brush-border and basal plasma membranes","volume":"18","year":"1997","journal-title":"Placenta"},{"key":"key\n\t\t\t\t20170224025335_R24","doi-asserted-by":"crossref","first-page":"21052","DOI":"10.1016\/S0021-9258(19)36796-1","article-title":"Calcitonin gene-related peptide inhibits interleukin 2 production by murine T lymphocytes","volume":"267","year":"1992","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170224025335_R25","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1165\/ajrcmb\/8.6.592","article-title":"Proliferation of guinea pig tracheal epithelial cells induced by calcitonin gene-related peptide","volume":"8","year":"1993","journal-title":"Am J Respir Cell Mol Biol"},{"key":"key\n\t\t\t\t20170224025335_R26","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1083\/jcb.129.3.789","article-title":"Calcitonin gene-related peptide promotes Schwann cell proliferation","volume":"129","year":"1995","journal-title":"J Cell Biol"},{"key":"key\n\t\t\t\t20170224025335_R27","first-page":"23","article-title":"Granin-A, parathyroid hormone-related protein, and calcitonin gene products in neuroendocrine prostate cancer","volume":"8","year":"1998","journal-title":"Prostate Suppl"},{"key":"key\n\t\t\t\t20170224025335_R28","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.1073\/pnas.87.9.3299","article-title":"Calcitonin gene-related peptide stimulates proliferation of human endothelial cells","volume":"87","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170224025335_R29","doi-asserted-by":"crossref","first-page":"203","DOI":"10.2174\/0929867053363478","article-title":"Gastric mucosal protection: from prostaglandins to gene-therapy","volume":"12","year":"2005","journal-title":"Curr Med Chem"},{"key":"key\n\t\t\t\t20170224025335_R30","first-page":"97","article-title":"Development of extraembryonic cell lineages in the mouse embryo.","volume-title":"Experimental Approaches to Mammalian Embryonic Development","year":"1986"},{"key":"key\n\t\t\t\t20170224025335_R31","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1095\/biolreprod.105.045997","article-title":"New insights into the biology of preeclampsia","volume":"74","year":"2006","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224025335_R32","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/0002-9378(89)90665-0","article-title":"Preeclampsia: an endothelial cell disorder","volume":"161","year":"1989","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t20170224025335_R33","first-page":"1657","article-title":"Circulating calcitonin gene-related peptide and its placental origins in normotensive and preeclamptic pregnancies","volume-title":"Am J Obstet Gynecol.","year":"2006"},{"key":"key\n\t\t\t\t20170224025335_R34","first-page":"893","article-title":"Calcitonin gene- and parathyroid hormone-related peptides in preeclampsia: effects of magnesium sulfate","volume":"97","year":"2001","journal-title":"Obstet Gynecol"},{"key":"key\n\t\t\t\t20170224025335_R35","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/0140-6736(92)93207-4","article-title":"Plasma calcitonin gene-related peptide during gestation","volume":"340","year":"1992","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170224025335_R36","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1111\/j.1471-0528.2006.00882.x","article-title":"Morphometric placental villous and vascular abnormalities in early- and late-onset pre-eclampsia with and without fetal growth restriction","volume":"113","year":"2006","journal-title":"BJOG"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/biolreprod\/article-pdf\/76\/5\/892\/10567899\/biolreprod0892.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,8]],"date-time":"2021-08-08T07:34:29Z","timestamp":1628408069000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-lookup\/doi\/10.1095\/biolreprod.106.059089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5,1]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,5,1]]}},"URL":"https:\/\/doi.org\/10.1095\/biolreprod.106.059089","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,5,1]]}}}