{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:21:47Z","timestamp":1790612507532,"version":"4.1.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,10,1]]},"DOI":"10.1095\/biolreprod.107.060442","type":"journal-article","created":{"date-parts":[[2007,7,5]],"date-time":"2007-07-05T23:29:28Z","timestamp":1183678168000},"page":"671-680","source":"Crossref","is-referenced-by-count":46,"title":["Developmental Expression and Gene Regulation of Insulin-like 3 Receptor RXFP2 in Mouse Male Reproductive Organs1"],"prefix":"10.1093","volume":"77","author":[{"given":"Shu","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia V.","family":"Bogatcheva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Truong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borys","family":"Korchin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin E.","family":"Bishop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Klonisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina U.","family":"Agoulnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander I.","family":"Agoulnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"key\n\t\t\t\t20170224043907_R1","first-page":"259","article-title":"Anatomical and functional aspects of testicular descent and cryptorchidism","volume":"18","year":"1997","journal-title":"Endocr Rev"},{"key":"key\n\t\t\t\t20170224043907_R2","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/10364","article-title":"Cryptorchidism in mice mutant for Insl3","volume":"22","year":"1999","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20170224043907_R3","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1210\/mend.13.5.0272","article-title":"Targeted disruption of the Insl3 gene causes bilateral cryptorchidism","volume":"13","year":"1999","journal-title":"Mol Endocrinol"},{"key":"key\n\t\t\t\t20170224043907_R4","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1210\/mend.16.2.0772","article-title":"The overexpression of the insl3 in female mice causes descent of the ovaries","volume":"16","year":"2002","journal-title":"Mol Endocrinol"},{"key":"key\n\t\t\t\t20170224043907_R5","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0022-5347(06)00519-2","article-title":"Over expression of insulin-like 3 does not prevent cryptorchidism in GNRHR or HOXA10 deficient mice","volume":"176","year":"2006","journal-title":"J Urol"},{"key":"key\n\t\t\t\t20170224043907_R6","doi-asserted-by":"crossref","first-page":"2960","DOI":"10.1210\/endo.139.6.6046","article-title":"Relaxin-like factor expression as a marker of differentiation in the mouse testis and ovary","volume":"139","year":"1998","journal-title":"Endocrinology"},{"issue":"(suppl)","key":"key\n\t\t\t\t20170224043907_R7","first-page":"28","article-title":"Transgenic and knockout mouse models for aberrant pituitary-testicular function: relevance to the pathogenesis of cryptorchidism","volume":"46","year":"2004","journal-title":"Turk J Pediatr"},{"key":"key\n\t\t\t\t20170224043907_R8","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1210\/endo.141.2.7379","article-title":"Involvement of insulin-like factor 3 (Insl3) in diethylstilbestrol-induced cryptorchidism","volume":"141","year":"2000","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224043907_R9","doi-asserted-by":"crossref","first-page":"4536","DOI":"10.1210\/en.2005-0676","article-title":"Expression of insulin-like factor 3 protein in the rat testis during fetal and postnatal development and in relation to cryptorchidism induced by in utero exposure to di (n-Butyl) phthalate","volume":"146","year":"2005","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224043907_R10","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1365-2605.2005.00563.x","article-title":"Disruption of reproductive development in male rat offspring following in utero exposure to phthalate esters","volume":"29","year":"2006","journal-title":"Int J Androl"},{"key":"key\n\t\t\t\t20170224043907_R11","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.toxlet.2003.09.012","article-title":"Phthalate ester-induced gubernacular lesions are associated with reduced insl3 gene expression in the fetal rat testis","volume":"146","year":"2004","journal-title":"Toxicol Lett"},{"key":"key\n\t\t\t\t20170224043907_R12","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/gene.1029","article-title":"A transgenic insertion causing cryptorchidism in mice","volume":"30","year":"2001","journal-title":"Genesis"},{"key":"key\n\t\t\t\t20170224043907_R13","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1093\/hmg\/11.19.2309","article-title":"Mutations of the GREAT gene cause cryptorchidism","volume":"11","year":"2002","journal-title":"Hum Mol Genet"},{"key":"key\n\t\t\t\t20170224043907_R14","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1126\/science.1065654","article-title":"Activation of orphan receptors by the hormone relaxin","volume":"295","year":"2002","journal-title":"Science"},{"key":"key\n\t\t\t\t20170224043907_R15","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1124\/pr.58.1.9","article-title":"International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides","volume":"58","year":"2006","journal-title":"Pharmacol Rev"},{"key":"key\n\t\t\t\t20170224043907_R16","doi-asserted-by":"crossref","first-page":"411","DOI":"10.2174\/156801305774322420","article-title":"Mouse mutants of relaxin, insulin-like 3 peptide and their receptors","volume":"5","year":"2005","journal-title":"Curr Med Chem Immunol Endocr Metab Agents"},{"key":"key\n\t\t\t\t20170224043907_R17","doi-asserted-by":"crossref","first-page":"7323","DOI":"10.1073\/pnas.0307061101","article-title":"Paracrine regulation of mammalian oocyte maturation and male germ cell survival","volume":"101","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170224043907_R18","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1196\/annals.1282.077","article-title":"Detection, localization, and action of the INSL3 receptor, LGR8, in rat kidney","volume":"1041","year":"2005","journal-title":"Ann N Y Acad Sci"},{"key":"key\n\t\t\t\t20170224043907_R19","first-page":"307","article-title":"INSL3 in the benign hyperplastic and neoplastic human prostate gland","volume":"27","year":"2005","journal-title":"Int J Oncol"},{"key":"key\n\t\t\t\t20170224043907_R20","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1196\/annals.1282.069","article-title":"Human medullary thyroid carcinoma: a source and potential target for relaxin-like hormones","volume":"1041","year":"2005","journal-title":"Ann N Y Acad Sci"},{"key":"key\n\t\t\t\t20170224043907_R21","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1095\/biolreprod.105.048165","article-title":"Expression of the insulin-like peptide 3 (INSL3) hormone-receptor (LGR8) system in the testis","volume":"74","year":"2006","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224043907_R22","doi-asserted-by":"crossref","first-page":"4712","DOI":"10.1210\/en.2004-0515","article-title":"Genetic targeting of relaxin and insulin-like factor 3 receptors in mice","volume":"145","year":"2004","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224043907_R23","doi-asserted-by":"crossref","first-page":"31283","DOI":"10.1074\/jbc.C200398200","article-title":"INSL3\/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent","volume":"277","year":"2002","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170224043907_R24","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1095\/biolreprod.103.019166","article-title":"Isolation and expression analysis of the canine insulin-like factor 3 gene","volume":"69","year":"2003","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224043907_R25","doi-asserted-by":"crossref","first-page":"5718","DOI":"10.1093\/emboj\/17.19.5718","article-title":"A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene","volume":"17","year":"1998","journal-title":"EMBO J"},{"key":"key\n\t\t\t\t20170224043907_R26","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1128\/MCB.17.4.2336","article-title":"SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene","volume":"17","year":"1997","journal-title":"Mol Cell Biol"},{"key":"key\n\t\t\t\t20170224043907_R27","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1095\/biolreprod.104.031757","article-title":"Differential oocyte-specific expression of Cre recombinase activity in GDF-9-iCre, Zp3cre, and Msx2Cre transgenic mice","volume":"71","year":"2004","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224043907_R28","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/gene.10023","article-title":"Codon-improved Cre recombinase (iCre) expression in the mouse","volume":"32","year":"2002","journal-title":"Genesis"},{"key":"key\n\t\t\t\t20170224043907_R29","doi-asserted-by":"crossref","first-page":"W217","DOI":"10.1093\/nar\/gkh383","article-title":"rVISTA 2.0: evolutionary analysis of transcription factor binding sites","volume":"32","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"key\n\t\t\t\t20170224043907_R30","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1006\/mgme.2000.3081","article-title":"Molecular mechanisms of SOX9 action","volume":"71","year":"2000","journal-title":"Mol Genet Metab"},{"key":"key\n\t\t\t\t20170224043907_R31","doi-asserted-by":"crossref","first-page":"4149","DOI":"10.1128\/MCB.20.11.4149-4158.2000","article-title":"Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase A enhances SOX9\u2032s ability to transactivate a Col2a1 chondrocyte-specific enhancer","volume":"20","year":"2000","journal-title":"Mol Cell Biol"},{"key":"key\n\t\t\t\t20170224043907_R32","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1210\/me.2003-0096","article-title":"GREAT\/LGR8 is the only receptor for insulin-like 3 peptide","volume":"17","year":"2003","journal-title":"Mol Endocrinol"},{"key":"key\n\t\t\t\t20170224043907_R33","doi-asserted-by":"crossref","first-page":"E138","DOI":"10.1152\/ajpendo.00228.2006","article-title":"T222P mutation of the insulin-like 3 hormone receptor LGR8 is associated with testicular maldescent and hinders receptor expression on the cell surface membrane","volume":"292","year":"2007","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"key\n\t\t\t\t20170224043907_R34","doi-asserted-by":"crossref","first-page":"5952","DOI":"10.1210\/jc.2004-0575","article-title":"A novel circulating hormone of testis origin in humans","volume":"89","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20170224043907_R35","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1196\/annals.1282.076","article-title":"Restricted expression of LGR8 in intralaminar thalamic nuclei of rat brain suggests a role in sensorimotor systems","volume":"1041","year":"2005","journal-title":"Ann N Y Acad Sci"},{"key":"key\n\t\t\t\t20170224043907_R36","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.mce.2005.03.017","article-title":"Constitutive regulation of the Insl3 gene in rat Leydig cells","volume":"241","year":"2005","journal-title":"Mol Cell Endocrinol"},{"key":"key\n\t\t\t\t20170224043907_R37","first-page":"175","article-title":"Paracrine regulation of mammalian oocyte maturation and male germ cell survival","volume":"15","year":"2005","journal-title":"Eur J Pediatr Surg"},{"key":"key\n\t\t\t\t20170224043907_R38","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1093\/molehr\/5.2.104","article-title":"Expression of relaxin-like factor is down-regulated in human testicular Leydig cell neoplasia","volume":"5","year":"1999","journal-title":"Mol Hum Reprod"},{"key":"key\n\t\t\t\t20170224043907_R39","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1016\/S0022-5347(05)64412-6","article-title":"Effects of orchiopexy on congenitally cryptorchid insulin-3 knockout mice","volume":"168","year":"2002","journal-title":"J Urol"},{"key":"key\n\t\t\t\t20170224043907_R40","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1210\/mend.12.5.0107","article-title":"Transcription of the Leydig insulin-like gene is mediated by steroidogenic factor-1","volume":"12","year":"1998","journal-title":"Mol Endocrinol"},{"key":"key\n\t\t\t\t20170224043907_R41","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1210\/endo.143.3.8683","article-title":"Murine relaxin-like factor promoter: functional characterization and regulation by transcription factors steroidogenic factor 1 and DAX-1","volume":"143","year":"2002","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224043907_R42","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0022-5347(17)35553-2","article-title":"Calcitonin gene-related peptide stimulates motility of the gubernaculum via cyclic adenosine monophosphate","volume":"150","year":"1993","journal-title":"J Urol"},{"key":"key\n\t\t\t\t20170224043907_R43","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.tig.2005.05.006","article-title":"Sex determination: a tale of two Sox genes","volume":"21","year":"2005","journal-title":"Trends Genet"},{"key":"key\n\t\t\t\t20170224043907_R44","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1093\/hmg\/ddi133","article-title":"Sox9 is sufficient for functional testis development producing fertile male mice in the absence of Sry","volume":"14","year":"2005","journal-title":"Hum Mol Genet"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/biolreprod\/article-pdf\/77\/4\/671\/10568436\/biolreprod0671.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T00:14:58Z","timestamp":1556583298000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-lookup\/doi\/10.1095\/biolreprod.107.060442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10,1]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,10,1]]}},"URL":"https:\/\/doi.org\/10.1095\/biolreprod.107.060442","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10,1]]}}}