{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:21:03Z","timestamp":1792632063647,"version":"4.5.0"},"reference-count":90,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,12,1]]},"DOI":"10.1095\/biolreprod.108.069930","type":"journal-article","created":{"date-parts":[[2008,8,13]],"date-time":"2008-08-13T21:59:02Z","timestamp":1218664742000},"page":"1135-1147","source":"Crossref","is-referenced-by-count":71,"title":["Activation of Toll-Like Receptor 4 (TLR4) by In Vivo and In Vitro Exposure of Rat Epididymis to Lipopolysaccharide from Escherichia Coli1"],"prefix":"10.1093","volume":"79","author":[{"given":"Alexandre","family":"Rodrigues","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel B.C.","family":"Queir\u00f3z","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Honda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erick Jos\u00e9 R.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan H.","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Christina W.","family":"Avellar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"key\n\t\t\t\t20170224020404_R01","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/216816a0","article-title":"Sperm maturation in rabbit epididymis","volume":"216","year":"1967","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170224020404_R02","first-page":"999","article-title":"Efferent ducts, epididymis and vas deferens: structure, functions and their regulation.","volume-title":"The Physiology of Reproduction, vol. 1","year":"1988"},{"key":"key\n\t\t\t\t20170224020404_R03","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1128\/MMBR.65.2.208-231.2001","article-title":"Viruses in the mammalian male genital tract and their effects on the reproductive system","volume":"65","year":"2001","journal-title":"Microbiol Mol Biol Rev"},{"key":"key\n\t\t\t\t20170224020404_R04","first-page":"101","article-title":"Inflammation of the testis, epididymis, peritesticular membranes, and scrotum","volume":"17","year":"1982","journal-title":"Pathol Annu"},{"key":"key\n\t\t\t\t20170224020404_R05","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2605.1993.tb01146.x","article-title":"Infection in the male reproductive tract. Impact, diagnosis and treatment in relation to male infertility","volume":"16","year":"1993","journal-title":"Int J Androl"},{"key":"key\n\t\t\t\t20170224020404_R06","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1097\/01.ju.0000102160.55494.1f","article-title":"Acute epididymitis in boys: evidence of a post-infectious etiology","volume":"171","year":"2004","journal-title":"J Urol"},{"key":"key\n\t\t\t\t20170224020404_R07","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ucl.2007.09.013","article-title":"Diagnosis and management of epididymitis","volume":"35","year":"2008","journal-title":"Urol Clin North Am"},{"key":"key\n\t\t\t\t20170224020404_R08","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1126\/science.1056545","article-title":"An antimicrobial peptide gene found in the male reproductive system of rats","volume":"291","year":"2001","journal-title":"Science"},{"key":"key\n\t\t\t\t20170224020404_R09","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.4049\/jimmunol.169.5.2516","article-title":"Identification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice","volume":"169","year":"2002","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170224020404_R10","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1095\/biolreprod.104.031740","article-title":"Differential expression and antibacterial activity of epididymis protein 2 isoforms in the male reproductive tract of human and rhesus monkey (Macaca mulatta)","volume":"71","year":"2004","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224020404_R11","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1126\/science.1099743","article-title":"Reversible immunocontraception in male monkeys immunized with eppin","volume":"306","year":"2004","journal-title":"Science"},{"key":"key\n\t\t\t\t20170224020404_R12","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1152\/physiolgenomics.00104.2005","article-title":"Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract","volume":"23","year":"2005","journal-title":"Physiol Genomics"},{"key":"key\n\t\t\t\t20170224020404_R13","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1002\/j.1939-4640.2002.tb02295.x","article-title":"Host defense proteins of the male reproductive tract","volume":"23","year":"2002","journal-title":"J Androl"},{"key":"key\n\t\t\t\t20170224020404_R14","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/j.1745-7262.2007.00298.x","article-title":"Characterization and functions of beta defensins in the epididymis","volume":"9","year":"2007","journal-title":"Asian J Androl"},{"key":"key\n\t\t\t\t20170224020404_R15","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri1391","article-title":"Toll-like receptor signalling","volume":"4","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"key\n\t\t\t\t20170224020404_R16","doi-asserted-by":"crossref","first-page":"9577","DOI":"10.1073\/pnas.0502272102","article-title":"The evolution of vertebrate Toll-like receptors","volume":"102","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170224020404_R17","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1126\/science.1094351","article-title":"A toll-like receptor that prevents infection by uropathogenic bacteria","volume":"303","year":"2004","journal-title":"Science"},{"key":"key\n\t\t\t\t20170224020404_R18","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.4049\/jimmunol.170.8.3977","article-title":"Strategic compartmentalization of Toll-like receptor 4 in the mouse gut","volume":"170","year":"2003","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170224020404_R19","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.1074\/jbc.M305790200","article-title":"Response of human pulmonary epithelial cells to lipopolysaccharide involves Toll-like receptor 4 (TLR4)-dependent signaling pathways: evidence for an intracellular compartmentalization of TLR4","volume":"279","year":"2004","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170224020404_R20","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.4049\/jimmunol.168.3.1286","article-title":"In vivo expression of Toll-like receptor 2 and 4 by renal epithelial cells: IFN-gamma and TNF-alpha mediated up-regulation during inflammation","volume":"168","year":"2002","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170224020404_R21","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jri.2007.03.014","article-title":"Toll-like receptors in female reproductive tract and their menstrual cycle dependent expression","volume":"77","year":"2008","journal-title":"J Reprod Immunol"},{"key":"key\n\t\t\t\t20170224020404_R22","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1093\/humrep\/deh775","article-title":"Characterization of Toll-like receptors in the female reproductive tract in humans","volume":"20","year":"2005","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20170224020404_R23","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1128\/IAI.72.6.3179-3186.2004","article-title":"Toll-like receptor 4 expression and cytokine responses in the human urinary tract mucosa","volume":"72","year":"2004","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20170224020404_R24","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/S1071-5576(00)00054-X","article-title":"Lipopolysaccharide induces expression of genes encoding pro-inflammatory cytokines and the elastin-degrading enzyme, cathepsin S, in human cervical smooth-muscle cells","volume":"7","year":"2000","journal-title":"J Soc Gynecol Investig"},{"key":"key\n\t\t\t\t20170224020404_R25","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1164\/rccm.200403-406OC","article-title":"Agonists of toll-like receptors 2 and 4 activate airway smooth muscle via mononuclear leukocytes","volume":"171","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"key\n\t\t\t\t20170224020404_R26","doi-asserted-by":"crossref","first-page":"H1069","DOI":"10.1152\/ajpheart.00143.2005","article-title":"Proinflammatory phenotype of vascular smooth muscle cells: role of efficient Toll-like receptor 4 signaling","volume":"289","year":"2005","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key\n\t\t\t\t20170224020404_R27","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/sj.icb.7100086","article-title":"Toll-like receptors in the gonads and reproductive tract: emerging roles in reproductive physiology and pathology","volume":"85","year":"2007","journal-title":"Immunol Cell Biol"},{"key":"key\n\t\t\t\t20170224020404_R28","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1095\/biolreprod.106.059410","article-title":"Members of the Toll-like receptor family of innate immunity pattern-recognition receptors are abundant in the male rat reproductive tract","volume":"76","year":"2007","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224020404_R29","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1095\/biolreprod.106.053967","article-title":"Toll-like receptor 4 in rat prostate: modulation by testosterone and acute bacterial infection in epithelial and stromal cells","volume":"75","year":"2006","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224020404_R30","doi-asserted-by":"crossref","first-page":"5537","DOI":"10.4049\/jimmunol.180.8.5537","article-title":"Uropathogenic Escherichia coli block MyD88-dependent and activate MyD88-independent signaling pathways in rat testicular cells","volume":"180","year":"2008","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170224020404_R31","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1189\/jlb.1005597","article-title":"Prostate epithelial cells can act as early sensors of infection by up-regulating TLR4 expression and proinflammatory mediators upon LPS stimulation","volume":"79","year":"2006","journal-title":"J Leukoc Biol"},{"key":"key\n\t\t\t\t20170224020404_R32","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jri.2005.01.005","article-title":"Lipopolysaccharide-binding protein is produced in the epididymis and associated with spermatozoa and prostasomes","volume":"66","year":"2005","journal-title":"J Reprod Immunol"},{"key":"key\n\t\t\t\t20170224020404_R33","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/j.1939-4640.2002.tb02259.x","article-title":"Inflammatory conditions of the male excurrent ductal system. Part I","volume":"23","year":"2002","journal-title":"J Androl"},{"key":"key\n\t\t\t\t20170224020404_R34","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1128\/IAI.60.6.2324-2328.1992","article-title":"Experimental epididymitis due to Chlamydia trachomatis in rats","volume":"60","year":"1992","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20170224020404_R35","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1046\/j.1464-410x.2001.02216.x","article-title":"Acute epididymitis","volume":"87","year":"2001","journal-title":"BJU Int"},{"key":"key\n\t\t\t\t20170224020404_R36","first-page":"1411","article-title":"Diagnosis and treatment of Chlamydia trachomatis infection","volume":"73","year":"2006","journal-title":"Am Fam Physician"},{"key":"key\n\t\t\t\t20170224020404_R37","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/S0028-3908(03)00279-X","article-title":"MK-801 and 7-Ni attenuate the activation of brain NF-kappa B induced by LPS","volume":"45","year":"2003","journal-title":"Neuropharmacology"},{"key":"key\n\t\t\t\t20170224020404_R38","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.reprotox.2006.03.003","article-title":"Bacterial lipopolysaccharide-induced oxidative stress in the impairment of steroidogenesis and spermatogenesis in rats","volume":"22","year":"2006","journal-title":"Reprod Toxicol"},{"key":"key\n\t\t\t\t20170224020404_R39","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.imbio.2006.05.015","article-title":"The rat macrophage scavenger receptor CD163: expression, regulation and role in inflammatory mediator production","volume":"211","year":"2006","journal-title":"Immunobiology"},{"key":"key\n\t\t\t\t20170224020404_R40","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/sj.bjp.0703846","article-title":"Molecular and pharmacological evidence for modulation of kinin B(1) receptor expression by endogenous glucocorticoids hormones in rats","volume":"132","year":"2001","journal-title":"Br J Pharmacol"},{"key":"key\n\t\t\t\t20170224020404_R41","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1084\/jem.186.2.247","article-title":"Neisseria gonorrhoeae epithelial cell interaction leads to the activation of the transcription factors nuclear factor kappaB and activator protein 1 and the induction of inflammatory cytokines","volume":"186","year":"1997","journal-title":"J Exp Med"},{"key":"key\n\t\t\t\t20170224020404_R42","first-page":"354","article-title":"Synergistic effect of 5-hydroxytryptamine on the response of rats's seminal vesicles to adrenaline and noradrenaline","volume":"138","year":"1962","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"key\n\t\t\t\t20170224020404_R43","doi-asserted-by":"crossref","first-page":"17623","DOI":"10.1074\/jbc.272.28.17623","article-title":"Androgen-dependent protein interactions within an intron 1 regulatory region of the 20-kDa protein gene","volume":"272","year":"1997","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170224020404_R44","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s00441-005-0108-x","article-title":"Cells positive for microtubule-associated protein 1B (MAP 1B) are present along rat and human efferent ductules and epididymis","volume":"325","year":"2006","journal-title":"Cell Tissue Res"},{"key":"key\n\t\t\t\t20170224020404_R45","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1046\/j.1471-4159.1999.0730309.x","article-title":"Effects of systemic immunogenic insults and circulating proinflammatory cytokines on the transcription of the inhibitory factor kappaB alpha within specific cellular populations of the rat brain","volume":"73","year":"1999","journal-title":"J Neurochem"},{"key":"key\n\t\t\t\t20170224020404_R46","doi-asserted-by":"crossref","first-page":"6473","DOI":"10.1523\/JNEUROSCI.20-17-06473.2000","article-title":"Induction of IkappaBalpha mRNA expression in the brain by glucocorticoids: a negative feedback mechanism for immune-to-brain signaling","volume":"20","year":"2000","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170224020404_R47","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1136\/bmj.1.6121.1177","article-title":"Pituitary-testicular interrelationships in mumps orchitis and other viral infections","volume":"1","year":"1978","journal-title":"Br Med J"},{"key":"key\n\t\t\t\t20170224020404_R48","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/S0015-0282(16)54262-9","article-title":"Variation in sperm penetration assay related to viral illness","volume":"55","year":"1991","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20170224020404_R49","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1002\/art.1780311015","article-title":"Sex hormone status of male patients with rheumatoid arthritis: evidence of low serum concentrations of testosterone at baseline and after human chorionic gonadotropin stimulation","volume":"31","year":"1988","journal-title":"Arthritis Rheum"},{"key":"key\n\t\t\t\t20170224020404_R50","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1210\/endo.141.1.7240","article-title":"Bacterial lipopolysaccharide-induced inflammation compromises testicular function at multiple levels in vivo","volume":"141","year":"2000","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224020404_R51","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1210\/endo.132.3.8382598","article-title":"Relationship between antigen-induced immune stimulation and activation of the hypothalamic-pituitary-adrenal axis in the rat","volume":"132","year":"1993","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224020404_R52","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1093\/infdis\/128.Supplement_1.S259","article-title":"Biological effects of bacterial endotoxins in man","volume":"128","year":"1973","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20170224020404_R53","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1146\/annurev.immunol.16.1.225","article-title":"NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses","volume":"16","year":"1998","journal-title":"Annu Rev Immunol"},{"key":"key\n\t\t\t\t20170224020404_R54","doi-asserted-by":"crossref","first-page":"7826","DOI":"10.1128\/MCB.13.12.7826","article-title":"A novel NF-kappa B complex containing p65 homodimers: implications for transcriptional control at the level of subunit dimerization","volume":"13","year":"1993","journal-title":"Mol Cell Biol"},{"key":"key\n\t\t\t\t20170224020404_R55","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1074\/jbc.270.2.933","article-title":"Transcriptional regulation of the intercellular adhesion molecule-1 gene by inflammatory cytokines in human endothelial cells. Essential roles of a variant NF-kappa B site and p65 homodimers","volume":"270","year":"1995","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170224020404_R56","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0165-2427(01)00329-4","article-title":"p65 Homodimer activity in distal airway cells determines lung dysfunction in equine heaves","volume":"80","year":"2001","journal-title":"Vet Immunol Immunopathol"},{"key":"key\n\t\t\t\t20170224020404_R57","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1096\/fj.14.11.1471","article-title":"Yersinia enterocolitica invasin protein triggers IL-8 production in epithelial cells via activation of Rel p65-p65 homodimers","volume":"14","year":"2000","journal-title":"FASEB J"},{"key":"key\n\t\t\t\t20170224020404_R58","doi-asserted-by":"crossref","first-page":"6876","DOI":"10.4049\/jimmunol.163.12.6876","article-title":"Activation of eotaxin gene transcription by NF-kappa B and STAT6 in human airway epithelial cells","volume":"163","year":"1999","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170224020404_R59","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1002\/eji.1830220650","article-title":"Lipopolysaccharide induces up-regulation of CD14 molecule on monocytes in human whole blood","volume":"22","year":"1992","journal-title":"Eur J Immunol"},{"key":"key\n\t\t\t\t20170224020404_R60","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1084\/jem.179.5.1671","article-title":"Upregulation of mouse CD14 expression in Kupffer cells by lipopolysaccharide","volume":"179","year":"1994","journal-title":"J Exp Med"},{"key":"key\n\t\t\t\t20170224020404_R61","doi-asserted-by":"crossref","first-page":"44715","DOI":"10.1074\/jbc.M202524200","article-title":"Molecular mechanisms for lipopolysaccharide-induced biphasic activation of nuclear factor-kappa B (NF-kappa B)","volume":"277","year":"2002","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170224020404_R62","first-page":"G1402","article-title":"Early NF-kappaB activation is associated with hormone-induced pancreatitis","volume":"275","year":"1998","journal-title":"Am J Physiol"},{"key":"key\n\t\t\t\t20170224020404_R63","doi-asserted-by":"crossref","first-page":"5391","DOI":"10.1128\/JVI.69.9.5391-5400.1995","article-title":"Human cytomegalovirus upregulates NF-kappa B activity by transactivating the NF-kappa B p105\/p50 and p65 promoters","volume":"69","year":"1995","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170224020404_R64","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1042\/bj3550029","article-title":"Alpha-melanocyte-related tripeptide, Lys-d-Pro-Val, ameliorates endotoxin-induced nuclear factor kappaB translocation and activation: evidence for involvement of an interleukin-1beta193\u2013195 receptor antagonism in the alveolar epithelium","volume":"355","year":"2001","journal-title":"Biochem J"},{"key":"key\n\t\t\t\t20170224020404_R65","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1055\/s-0038-1657543","article-title":"Molecular mechanisms of early inflammation","volume":"78","year":"1997","journal-title":"Thromb Haemost"},{"key":"key\n\t\t\t\t20170224020404_R66","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1097\/00003246-199701000-00023","article-title":"Comparative effects of lipopolysaccharide on newborn versus adult rat hepatocyte and nonparenchymal cell cocultures","volume":"25","year":"1997","journal-title":"Crit Care Med"},{"key":"key\n\t\t\t\t20170224020404_R67","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1677\/joe.1.06266","article-title":"Regulation of activin A and inhibin B secretion by inflammatory mediators in adult rat Sertoli cell cultures","volume":"187","year":"2005","journal-title":"J Endocrinol"},{"key":"key\n\t\t\t\t20170224020404_R68","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.4049\/jimmunol.171.3.1473","article-title":"Injury primes the innate immune system for enhanced Toll-like receptor reactivity","volume":"171","year":"2003","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170224020404_R69","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/j.1365-2567.2004.01898.x","article-title":"Toll-like receptor (TLR) expression and TLR-mediated cytokine\/chemokine production by human uterine epithelial cells","volume":"112","year":"2004","journal-title":"Immunology"},{"key":"key\n\t\t\t\t20170224020404_R70","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1084\/jem.20022194","article-title":"Intracellular recognition of lipopolysaccharide by toll-like receptor 4 in intestinal epithelial cells","volume":"198","year":"2003","journal-title":"J Exp Med"},{"key":"key\n\t\t\t\t20170224020404_R71","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/1465-9921-6-116","article-title":"Respiratory epithelial cells require Toll-like receptor 4 for induction of human beta-defensin 2 by lipopolysaccharide","volume":"6","year":"2005","journal-title":"Respir Res"},{"key":"key\n\t\t\t\t20170224020404_R72","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1099\/0022-1317-51-8-626","article-title":"Priming of human oral epithelial cells by interferon-gamma to secrete cytokines in response to lipopolysaccharides, lipoteichoic acids and peptidoglycans","volume":"51","year":"2002","journal-title":"J Med Microbiol"},{"key":"key\n\t\t\t\t20170224020404_R73","doi-asserted-by":"crossref","first-page":"47834","DOI":"10.1074\/jbc.M207873200","article-title":"Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction","volume":"277","year":"2002","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170224020404_R74","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1530\/jrf.0.1040193","article-title":"Total number of immunocompetent cells in the normal rat epididymis and after vasectomy","volume":"104","year":"1995","journal-title":"J Reprod Fertil"},{"key":"key\n\t\t\t\t20170224020404_R75","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1365-2605.1993.tb01152.x","article-title":"Immuno-competent cells in the murine epididymis following infection with Escherichia coli","volume":"16","year":"1993","journal-title":"Int J Androl"},{"key":"key\n\t\t\t\t20170224020404_R76","first-page":"517","article-title":"Intraepithelial lymphocytes and macrophages in the human epididymis","volume":"233","year":"1983","journal-title":"Cell Tissue Res"},{"key":"key\n\t\t\t\t20170224020404_R77","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0165-0378(02)00016-5","article-title":"Macrophages and the immune responsiveness of the testis","volume":"57","year":"2002","journal-title":"J Reprod Immunol"},{"key":"key\n\t\t\t\t20170224020404_R78","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1095\/biolreprod61.3.705","article-title":"Distribution of immune cells in the epididymis of the aging Brown Norway rat is segment-specific and related to the luminal content","volume":"61","year":"1999","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224020404_R79","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1095\/biolreprod50.4.917","article-title":"Basal cells of the human epididymis\u2014antigenic and ultrastructural similarities to tissue-fixed macrophages","volume":"50","year":"1994","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224020404_R80","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/S0021-9975(03)00043-4","article-title":"Macrophage populations in L-cysteine-induced rat sperm granulomas","volume":"129","year":"2003","journal-title":"J Comp Pathol"},{"key":"key\n\t\t\t\t20170224020404_R81","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1742-4690-4-7","article-title":"The testis and epididymis are productively infected by SIV and SHIV in juvenile macaques during the post-acute stage of infection","volume":"4","year":"2007","journal-title":"Retrovirology"},{"key":"key\n\t\t\t\t20170224020404_R82","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s00441-005-0129-5","article-title":"Identification of a dendritic cell population in normal testis and in chronically inflamed testis of rats with autoimmune orchitis","volume":"324","year":"2006","journal-title":"Cell Tissue Res"},{"key":"key\n\t\t\t\t20170224020404_R83","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0165-0378(02)00060-8","article-title":"Cytokines and the immune-testicular axis","volume":"58","year":"2003","journal-title":"J Reprod Immunol"},{"key":"key\n\t\t\t\t20170224020404_R84","first-page":"589","article-title":"The heterogeneity of mononuclear phagocytes in lymphoid organs: distinct macrophage subpopulations in the rat recognized by monoclonal antibodies ED1, ED2 and ED3","volume":"54","year":"1985","journal-title":"Immunology"},{"key":"key\n\t\t\t\t20170224020404_R85","first-page":"298","article-title":"Cell-surface marker analysis of rat thymic dendritic cells","volume":"79","year":"1993","journal-title":"Immunology"},{"key":"key\n\t\t\t\t20170224020404_R86","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1095\/biolreprod59.2.371","article-title":"Local regulation of macrophage subsets in the adult rat testis: examination of the roles of the seminiferous tubules, testosterone, and macrophage-migration inhibitory factor","volume":"59","year":"1998","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224020404_R87","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1095\/biolreprod51.3.551","article-title":"Leukocyte populations of the adult rat testis following removal of the Leydig cells by treatment with ethane dimethane sulfonate and subcutaneous testosterone implants","volume":"51","year":"1994","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224020404_R88","doi-asserted-by":"crossref","first-page":"R1744","DOI":"10.1152\/ajpregu.00651.2004","article-title":"Cytokine profiles in the testes of rats treated with lipopolysaccharide reveal localized suppression of inflammatory responses","volume":"288","year":"2005","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"key\n\t\t\t\t20170224020404_R89","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s00441-002-0547-6","article-title":"The response of testicular leukocytes to lipopolysaccharide-induced inflammation: further evidence for heterogeneity of the testicular macrophage population","volume":"308","year":"2002","journal-title":"Cell Tissue Res"},{"key":"key\n\t\t\t\t20170224020404_R90","doi-asserted-by":"crossref","first-page":"5252","DOI":"10.4049\/jimmunol.168.10.5252","article-title":"Regulation of Toll-like receptor 4 expression in the lung following hemorrhagic shock and lipopolysaccharide","volume":"168","year":"2002","journal-title":"J Immunol"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/biolreprod\/article-pdf\/79\/6\/1135\/10571031\/biolreprod1135.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T04:18:09Z","timestamp":1709180289000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-lookup\/doi\/10.1095\/biolreprod.108.069930"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12,1]]},"references-count":90,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,12,1]]}},"URL":"https:\/\/doi.org\/10.1095\/biolreprod.108.069930","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,12,1]]}}}