{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T23:16:43Z","timestamp":1789600603903,"version":"build-2803163510"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,5,1]]},"DOI":"10.1095\/biolreprod.108.073551","type":"journal-article","created":{"date-parts":[[2009,1,22]],"date-time":"2009-01-22T02:58:38Z","timestamp":1232593118000},"page":"965-972","source":"Crossref","is-referenced-by-count":55,"title":["Compartmentalization of Proteins in Epididymosomes Coordinates the Association of Epididymal Proteins with the Different Functional Structures of Bovine Spermatozoa1"],"prefix":"10.1093","volume":"80","author":[{"given":"Julie","family":"Girouard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Frenette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"key\n\t\t\t\t20170224020823_R01","first-page":"999","article-title":"Efferens ducts, epididymis, and vas deferens: structure, functions, and their regulation.","volume-title":"The Physiology of Reproduction, 1st ed","year":"1988"},{"key":"key\n\t\t\t\t20170224020823_R02","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1095\/biolreprod52.2.226","article-title":"Regulation of epididymal epithelial cell functions","volume":"52","year":"1995","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224020823_R03","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1095\/biolreprod52.5.1012","article-title":"Protein synthesis and secretion by the rat caput epididymidis in vivo: influence of the luminal microenvironment","volume":"52","year":"1995","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224020823_R04","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/j.1939-4640.1999.tb02536.x","article-title":"Cell- and region-specific localization of lysosomal and secretory proteins and endocytic receptors in epithelial cells of the cauda epididymidis and vas deferens of the adult rat","volume":"20","year":"1999","journal-title":"J Androl"},{"key":"key\n\t\t\t\t20170224020823_R05","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1071\/RD9950731","article-title":"The epididymis as protector of maturing spermatozoa","volume":"7","year":"1995","journal-title":"Reprod Fertil Dev"},{"key":"key\n\t\t\t\t20170224020823_R06","first-page":"197","article-title":"The specificity of epididymal secretory proteins","volume":"53","year":"1998","journal-title":"J Reprod Fertil Suppl"},{"key":"key\n\t\t\t\t20170224020823_R07","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1071\/RD9960553","article-title":"Regulation of the motility and metabolism of spermatozoa for storage in the epididymis of eutherian and marsupial mammals","volume":"8","year":"1996","journal-title":"Reprod Fertil Dev"},{"key":"key\n\t\t\t\t20170224020823_R08","first-page":"119","article-title":"Interactions between epididymal secretions and spermatozoa","volume":"53","year":"1998","journal-title":"J Reprod Fertil Suppl"},{"key":"key\n\t\t\t\t20170224020823_R09","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0074-7696(08)62442-0","article-title":"Membrane heterogeneity in the mammalian spermatozoon","volume":"87","year":"1984","journal-title":"Int Rev Cytol"},{"key":"key\n\t\t\t\t20170224020823_R10","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1093\/molehr\/2.3.177","article-title":"Cell-to-cell transfer of glycosylphosphatidylinositol-anchored membrane proteins during sperm maturation","volume":"2","year":"1996","journal-title":"Mol Hum Reprod"},{"key":"key\n\t\t\t\t20170224020823_R11","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1093\/molehr\/gah075","article-title":"Influence of macrophage migration inhibitory factor (MIF) on the zinc content and redox state of protein-bound sulphydryl groups in rat sperm: indications for a new role of MIF in sperm maturation","volume":"10","year":"2004","journal-title":"Mol Hum Reprod"},{"key":"key\n\t\t\t\t20170224020823_R12","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/BF03401836","article-title":"Purification and characterization of macrophage migration inhibitory factor as a secretory protein from rat epididymis: evidences for alternative release and transfer to spermatozoa","volume":"7","year":"2001","journal-title":"Mol Med"},{"key":"key\n\t\t\t\t20170224020823_R13","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1093\/molehr\/gah197","article-title":"Macrophage migration inhibitory factor in the human epididymis and semen","volume":"11","year":"2005","journal-title":"Mol Hum Reprod"},{"key":"key\n\t\t\t\t20170224020823_R14","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/mrd.1013","article-title":"Prostasome-like particles are involved in the transfer of P25b from the bovine epididymal fluid to the sperm surface","volume":"59","year":"2001","journal-title":"Mol Reprod Dev"},{"key":"key\n\t\t\t\t20170224020823_R15","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/(SICI)1098-2795(199902)52:2<225::AID-MRD14>3.0.CO;2-M","article-title":"Hamster sperm antigen P26h is a phosphatidylinositol-anchored protein","volume":"52","year":"1999","journal-title":"Mol Reprod Dev"},{"key":"key\n\t\t\t\t20170224020823_R16","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1093\/molehr\/7.7.617","article-title":"Changes of the major sperm maturation-associated epididymal protein HE5 (CD52) on human ejaculated spermatozoa during incubation","volume":"7","year":"2001","journal-title":"Mol Hum Reprod"},{"key":"key\n\t\t\t\t20170224020823_R17","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1126\/science.3381102","article-title":"Restricted lateral diffusion of PH-20, a PI-anchored sperm membrane protein","volume":"240","year":"1988","journal-title":"Science"},{"key":"key\n\t\t\t\t20170224020823_R18","doi-asserted-by":"crossref","first-page":"7788","DOI":"10.1021\/bi00024a002","article-title":"Biochemical characterization of a glycosylphosphatidylinositol-linked hyaluronidase on mouse sperm","volume":"34","year":"1995","journal-title":"Biochemistry"},{"key":"key\n\t\t\t\t20170224020823_R19","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/j.1939-4640.2003.tb02640.x","article-title":"Mouse epididymal Spam1 (pH-20) is released in the luminal fluid with its lipid anchor","volume":"24","year":"2003","journal-title":"J Androl"},{"key":"key\n\t\t\t\t20170224020823_R20","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/978-1-4615-5913-9_39","article-title":"The role of apocrine released proteins in the post-testicular regulation of human sperm function","volume":"424","year":"1997","journal-title":"Adv Exp Med Biol"},{"key":"key\n\t\t\t\t20170224020823_R21","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0940-9602(99)80020-X","article-title":"Apocrine secretion\u2013fact or artifact?","volume":"181","year":"1999","journal-title":"Ann Anat"},{"key":"key\n\t\t\t\t20170224020823_R22","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1002\/mrd.90023","article-title":"Nature's ingenuity: bypassing the classical secretory route via apocrine secretion","volume":"63","year":"2002","journal-title":"Mol Reprod Dev"},{"key":"key\n\t\t\t\t20170224020823_R23","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1095\/biolreprod.105.049304","article-title":"Lipid remodeling of murine epididymosomes and spermatozoa during epididymal maturation","volume":"74","year":"2006","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224020823_R24","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1095\/biolreprod.104.036426","article-title":"Identification, proteomic profiling, and origin of ram epididymal fluid exosome-like vesicles","volume":"72","year":"2005","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224020823_R25","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1095\/biolreprod67.2.393","article-title":"Prion protein is secreted in soluble forms in the epididymal fluid and proteolytically processed and transported in seminal plasma","volume":"67","year":"2002","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224020823_R26","first-page":"1","article-title":"Morphological and enzymatic study of membrane-bound vesicles from the lumen of the rat epididymis","volume":"27","year":"1995","journal-title":"Andrologia"},{"key":"key\n\t\t\t\t20170224020823_R27","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/aja.1001720406","article-title":"Maturation of spermatozoa in the epididymis of the Chinese hamster","volume":"172","year":"1985","journal-title":"Am J Anat"},{"key":"key\n\t\t\t\t20170224020823_R28","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1095\/biolreprod.106.054692","article-title":"Comparison between epididymosomes collected in the intraluminal compartment of the bovine caput and cauda epididymidis","volume":"75","year":"2006","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224020823_R29","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1095\/biolreprod67.1.308","article-title":"Selected proteins of \u201cprostasome-like particles\u201d from epididymal cauda fluid are transferred to epididymal caput spermatozoa in bull","volume":"67","year":"2002","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224020823_R30","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1095\/biolreprod.103.019216","article-title":"Aldose reductase and macrophage migration inhibitory factor are associated with epididymosomes and spermatozoa in the bovine epididymis","volume":"69","year":"2003","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224020823_R31","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1095\/biolreprod.107.066514","article-title":"Seminal plasma proteins regulate the association of lipids and proteins within detergent-resistant membrane domains of bovine spermatozoa","volume":"78","year":"2008","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224020823_R32","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","year":"1976","journal-title":"Anal Biochem"},{"key":"key\n\t\t\t\t20170224020823_R33","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1095\/biolreprod29.4.987","article-title":"Purification and partial characterization of plasma membranes from bovine spermatozoa","volume":"29","year":"1983","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224020823_R34","doi-asserted-by":"crossref","first-page":"7099","DOI":"10.1074\/jbc.M211566200","article-title":"Lipid raft-dependent and -independent signaling through HLA-DR molecules","volume":"278","year":"2003","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170224020823_R35","doi-asserted-by":"crossref","first-page":"4336","DOI":"10.1182\/blood-2003-03-0871","article-title":"Lipid raft-associated protein sorting in exosomes","volume":"102","year":"2003","journal-title":"Blood"},{"key":"key\n\t\t\t\t20170224020823_R36","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1046\/j.1365-2605.2001.00309.x","article-title":"Membrane fluidity and lipid content of human spermatozoa selected by swim-up method","volume":"24","year":"2001","journal-title":"Int J Androl"},{"key":"key\n\t\t\t\t20170224020823_R37","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1093\/clinchem\/20.7.794","article-title":"Mechanisms of the Liebermann-Burchard and Zak color reactions for cholesterol","volume":"20","year":"1974","journal-title":"Clin Chem"},{"key":"key\n\t\t\t\t20170224020823_R38","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S0021-9673(00)95654-1","article-title":"Thin-layer chromatography of phospholipids","volume":"166","year":"1978","journal-title":"J Chromatogr"},{"key":"key\n\t\t\t\t20170224020823_R39","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1574-6968.2006.00545.x","article-title":"Rafting with cholera toxin: endocytosis and trafficking from plasma membrane to ER","volume":"266","year":"2007","journal-title":"FEMS Microbiol Lett"},{"key":"key\n\t\t\t\t20170224020823_R40","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1095\/biolreprod.104.030502","article-title":"Reorganization of lipid rafts during capacitation of human sperm","volume":"71","year":"2004","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224020823_R41","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0003-2697(84)90782-6","article-title":"A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids","volume":"138","year":"1984","journal-title":"Anal Biochem"},{"key":"key\n\t\t\t\t20170224020823_R42","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","year":"1970","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170224020823_R43","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/(SICI)1098-2795(199901)52:1<57::AID-MRD8>3.0.CO;2-U","article-title":"Bull subfertility is associated with low levels of a sperm membrane antigen","volume":"52","year":"1999","journal-title":"Mol Reprod Dev"},{"key":"key\n\t\t\t\t20170224020823_R44","doi-asserted-by":"crossref","first-page":"11205","DOI":"10.1074\/jbc.M208318200","article-title":"An aldose reductase with 20 alpha-hydroxysteroid dehydrogenase activity is most likely the enzyme responsible for the production of prostaglandin f2 alpha in the bovine endometrium","volume":"278","year":"2003","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170224020823_R45","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.ydbio.2005.11.030","article-title":"Sperm capacitation induces an increase in lipid rafts having zona pellucida binding ability and containing sulfogalactosylglycerolipid","volume":"290","year":"2006","journal-title":"Dev Biol"},{"key":"key\n\t\t\t\t20170224020823_R46","doi-asserted-by":"crossref","first-page":"6771","DOI":"10.1074\/jbc.M210758200","article-title":"T cell receptor can be recruited to a subset of plasma membrane rafts, independently of cell signaling and attendantly to raft clustering","volume":"278","year":"2003","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170224020823_R47","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1530\/jrf.0.0700541","article-title":"Addition of androgens to cultured hamster epididymis increases zona recognition by immature spermatozoa","volume":"70","year":"1984","journal-title":"J Reprod Fertil"},{"key":"key\n\t\t\t\t20170224020823_R48","first-page":"73","article-title":"Plasma membrane structure and remodelling during sperm maturation in the epididymis","volume":"53","year":"1998","journal-title":"J Reprod Fertil Suppl"},{"key":"key\n\t\t\t\t20170224020823_R49","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1095\/biolreprod51.6.1255","article-title":"Inhibition of in vivo fertilization by active immunization of male hamsters against a 26-kDa sperm glycoprotein","volume":"51","year":"1994","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224020823_R50","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1093\/molehr\/4.5.447","article-title":"Epididymal secretion of CD52 as measured in human seminal plasma by a fluorescence immunoassay","volume":"4","year":"1998","journal-title":"Mol Hum Reprod"},{"key":"key\n\t\t\t\t20170224020823_R51","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1002\/1098-2795(200011)57:3<280::AID-MRD10>3.0.CO;2-5","article-title":"Maturational changes of the CD52-like epididymal glycoprotein on cynomolgus monkey sperm and their apparent reversal in capacitation conditions","volume":"57","year":"2000","journal-title":"Mol Reprod Dev"},{"key":"key\n\t\t\t\t20170224020823_R52","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.mce.2005.12.033","article-title":"Epididymal SPAM1 and its impact on sperm function","volume":"250","author":"Martin-DeLeon PA.","year":"2006","journal-title":"Mol Cell Endocrinol"},{"key":"key\n\t\t\t\t20170224020823_R53","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.semcdb.2007.07.010","article-title":"Lipid rafts, fluid\/fluid phase separation, and their relevance to plasma membrane structure and function","volume":"18","year":"2007","journal-title":"Semin Cell Dev Biol"},{"key":"key\n\t\t\t\t20170224020823_R54","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/35036052","article-title":"Lipid rafts and signal transduction","volume":"1","year":"2000","journal-title":"Nat Rev Mol Cell Biol"},{"key":"key\n\t\t\t\t20170224020823_R55","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1007\/PL00000831","article-title":"The GPI-anchor and protein sorting","volume":"58","year":"2001","journal-title":"Cell Mol Life Sci"},{"key":"key\n\t\t\t\t20170224020823_R56","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1095\/biolreprod.105.046219","article-title":"Visualization of GM1 with cholera toxin B in live epididymal versus ejaculated bull, mouse, and human spermatozoa","volume":"74","year":"2006","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224020823_R57","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1002\/jcp.20504","article-title":"Segregation of micron-scale membrane sub-domains in live murine sperm","volume":"206","year":"2006","journal-title":"J Cell Physiol"},{"key":"key\n\t\t\t\t20170224020823_R58","first-page":"130","article-title":"Interaction between sperm and epididymal secretory proteins.","volume-title":"The Male Gamete: From Basic to Clinical Applications","year":"1999"},{"key":"key\n\t\t\t\t20170224020823_R59","first-page":"341","article-title":"Male fertility markers, myth or reality","volume":"82\u201383","year":"2004","journal-title":"Anim Reprod Sci"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/biolreprod\/article-pdf\/80\/5\/965\/10572941\/biolreprod0965.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,9]],"date-time":"2024-03-09T09:53:01Z","timestamp":1709977981000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-lookup\/doi\/10.1095\/biolreprod.108.073551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5,1]]},"references-count":59,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,5,1]]}},"URL":"https:\/\/doi.org\/10.1095\/biolreprod.108.073551","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5,1]]}}}