{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T21:01:53Z","timestamp":1790974913491,"version":"4.1.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,11,1]]},"DOI":"10.1095\/biolreprod.110.083931","type":"journal-article","created":{"date-parts":[[2010,8,6]],"date-time":"2010-08-06T00:18:52Z","timestamp":1281053932000},"page":"818-824","source":"Crossref","is-referenced-by-count":20,"title":["Decreased Expression of the Rat Myometrial Relaxin Receptor (RXFP1) in Late Pregnancy Is Partially Mediated by the Presence of the Conceptus1"],"prefix":"10.1093","volume":"83","author":[{"given":"Lenka A.","family":"Vodstrcil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oksana","family":"Shynlova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill W.","family":"Verlander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E.","family":"Wlodek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura J.","family":"Parry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"key\n\t\t\t\t20170224011531_R01","first-page":"514","article-title":"Endocrine and paracrine regulation of birth at term and preterm","volume":"21","year":"2000","journal-title":"Endocr Rev"},{"key":"key\n\t\t\t\t20170224011531_R02","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1159\/000061025","article-title":"Role of mechanical signals in the onset of term and preterm labor","volume":"27","year":"2001","journal-title":"Front Horm Res"},{"key":"key\n\t\t\t\t20170224011531_R03","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1016\/0002-9378(89)90942-3","article-title":"The antagonistic effect of oxytocin and relaxin on rat uterine segment contractility","volume":"161","year":"1989","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t20170224011531_R04","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1530\/jrf.0.0990275","article-title":"Action of relaxin on uterine contractions\u2014a review","volume":"99","year":"1993","journal-title":"J Reprod Fertil"},{"key":"key\n\t\t\t\t20170224011531_R05","first-page":"43","article-title":"Effect of porcine relaxin and progesterone on rat, pig and human myometrial activity in vitro","volume":"31","year":"1986","journal-title":"J Reprod Med"},{"key":"key\n\t\t\t\t20170224011531_R06","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1067\/mob.2003.454","article-title":"Effects of recombinant human relaxin on pregnant rat uterine artery and myometrium in vitro","volume":"188","year":"2003","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t20170224011531_R07","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1677\/joe.0.0830183","article-title":"Relaxin inhibits spontaneous and prostaglandin-driven myometrial activity in anesthetized rats","volume":"83","year":"1979","journal-title":"J Endocrinol"},{"key":"key\n\t\t\t\t20170224011531_R08","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1530\/jrf.0.0760205","article-title":"Relaxin and progesterone are myometrial inhibitors in the ovariectomized nonpregnant mini-pig","volume":"76","year":"1986","journal-title":"J Reprod Fertil"},{"key":"key\n\t\t\t\t20170224011531_R09","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1210\/endo-116-3-1206","article-title":"The physiological role of relaxin in the pregnant rat. II. The influence of relaxin on uterine contractile activity","volume":"116","year":"1985","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224011531_R10","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1095\/biolreprod27.3.673","article-title":"Localization of relaxin binding sites in the rat uterus and cervix by autoradiography","volume":"27","year":"1982","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224011531_R11","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1095\/biolreprod26.1.120","article-title":"Relaxin receptors in the myometrium and cervix of the pig","volume":"26","year":"1982","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224011531_R12","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/sj.bjp.0702517","article-title":"Quantitative autoradiographic studies of relaxin binding in rat atria, uterus and cerebral cortex: characterization and effects of estrogen treatment","volume":"127","year":"1999","journal-title":"Br J Pharmacol"},{"key":"key\n\t\t\t\t20170224011531_R13","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1095\/biolreprod59.4.991","article-title":"Identification of specific relaxin-binding cells in the human female","volume":"59","year":"1998","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224011531_R14","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1093\/molehr\/7.10.963","article-title":"Characterization of relaxin binding in the uterus of the marmoset monkey","volume":"7","year":"2001","journal-title":"Mol Hum Reprod"},{"key":"key\n\t\t\t\t20170224011531_R15","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1126\/science.1065654","article-title":"Activation of orphan receptors by the hormone relaxin","volume":"295","year":"2002","journal-title":"Science"},{"key":"key\n\t\t\t\t20170224011531_R16","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1124\/pr.58.1.9","article-title":"International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides","volume":"58","year":"2006","journal-title":"Pharmacol Rev"},{"key":"key\n\t\t\t\t20170224011531_R17","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1128\/MCB.24.2.687-696.2004","article-title":"Impaired nipple development and parturition in LGR7 knockout mice","volume":"24","year":"2004","journal-title":"Mol Cell Biol"},{"key":"key\n\t\t\t\t20170224011531_R18","doi-asserted-by":"crossref","first-page":"4272","DOI":"10.1210\/en.2003-0548","article-title":"Inhibition of oxytocin receptor and estrogen receptor-a, but not relaxin receptors (LGR7), in the myometrium of late pregnant relaxin gene knockout mice","volume":"144","year":"2003","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224011531_R19","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1071\/RD07007","article-title":"Effects of uteroplacental restriction on the relaxin-family receptors, Lgr7 and Lgr8, in the uterus of late pregnant rats","volume":"19","year":"2007","journal-title":"Reprod Fertil Dev"},{"key":"key\n\t\t\t\t20170224011531_R20","doi-asserted-by":"crossref","first-page":"5398","DOI":"10.1210\/endo.138.12.5624","article-title":"Expression of connexin-43 and connexin-26 in the rat myometrium during pregnancy and labor is differentially regulated by mechanical and hormonal signals","volume":"138","year":"1997","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224011531_R21","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1095\/biolreprod59.5.1055","article-title":"Increased expression of the rat myometrial oxytocin receptor messenger ribonucleic acid during labor requires both mechanical and hormonal signals","volume":"59","year":"1998","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224011531_R22","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1095\/biolreprod.107.062356","article-title":"Uterine stretch regulates temporal and spatial expression of fibronectin protein and its alpha 5 integrin receptor in myometrium of unilaterally pregnant rats","volume":"77","year":"2007","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224011531_R23","doi-asserted-by":"crossref","first-page":"5712","DOI":"10.1210\/endo.140.12.7201","article-title":"Differential expression of myometrial oxytocin receptor and prostaglandin H synthase 2, but not estrogen receptor alpha and heat shock protein 90 messenger ribonucleic acid in the gravid horn and nongravid horn in sheep during betamethasone-induced labor","volume":"140","year":"1999","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224011531_R24","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1095\/biolreprod56.1.200","article-title":"Evidence for a local fetal influence on myometrial oxytocin receptors during pregnancy in the tammar wallaby (Macropus eugenii)","volume":"56","year":"1997","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224011531_R25","doi-asserted-by":"crossref","first-page":"34942","DOI":"10.1074\/jbc.M602728200","article-title":"Characterization of novel splice variants of LGR7 and LGR8 reveals that receptor signaling is mediated by their unique low density lipoprotein class A modules","volume":"281","year":"2006","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170224011531_R26","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1210\/en.2006-1086","article-title":"The low-density lipoprotein class A module of the relaxin receptor (leucine-rich repeat containing G-protein coupled receptor 7): its role in signaling and trafficking to the cell membrane","volume":"148","year":"2007","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224011531_R27","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1210\/en.2008-1385","article-title":"Characterization of relaxin receptor (RXFP1) desensitization and internalization in primary human decidual cells and RXFP1-transfected HEK293 cells","volume":"150","year":"2009","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224011531_R28","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.1096\/fj.06-6263com","article-title":"Evidence for local relaxin ligand-receptor expression and function in arteries","volume":"20","year":"2006","journal-title":"FASEB J"},{"key":"key\n\t\t\t\t20170224011531_R29","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1196\/annals.1282.014","article-title":"Oxytocin and estrogen receptor expression in the myometrium of pregnant relaxin-deficient (Rlx\u2212\/\u2212) mice","volume":"1041","year":"2005","journal-title":"Ann N Y Acad Sci"},{"key":"key\n\t\t\t\t20170224011531_R30","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1196\/annals.1282.013","article-title":"Mechanisms of relaxin action in the reproductive tract: studies in the relaxin-deficient (Rlx\u2212\/\u2212) mouse","volume":"1041","year":"2005","journal-title":"Ann N Y Acad Sci"},{"key":"key\n\t\t\t\t20170224011531_R31","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1210\/endo-119-1-435","article-title":"Relaxin increases calcium efflux from rat myometrial cells in culture","volume":"119","year":"1986","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224011531_R32","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1210\/endo-118-2-499","article-title":"Relaxin treatment alters the kinetic properties of myosin light chain kinase activity in rat myometrial cells in culture","volume":"118","year":"1986","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224011531_R33","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1095\/biolreprod43.5.851","article-title":"Involvement of protein kinase A in the regulation of intracellular free calcium and phosphoinositide turnover in rat myometrium","volume":"43","year":"1990","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224011531_R34","doi-asserted-by":"crossref","first-page":"C312","DOI":"10.1152\/ajpcell.1995.269.2.C312","article-title":"Relaxin stimulates myometrial calcium-activated potassium channel activity via protein kinase A","volume":"269","year":"1995","journal-title":"Am J Physiol"},{"key":"key\n\t\t\t\t20170224011531_R35","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1095\/biolreprod.107.064485","article-title":"Multiple signals regulate phospholipase Cbeta3 in human myometrial cells","volume":"78","year":"2008","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224011531_R36","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.jsgi.2005.07.002","article-title":"Molecular signaling through G-protein-coupled receptors and the control of intracellular calcium in myometrium","volume":"12","year":"2005","journal-title":"J Soc Gynecol Investig"},{"key":"key\n\t\t\t\t20170224011531_R37","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1093\/molehr\/gan051","article-title":"Relaxin signaling in primary cultures of human myometrial cells","volume":"14","year":"2008","journal-title":"Mol Hum Reprod"},{"key":"key\n\t\t\t\t20170224011531_R38","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1113\/jphysiol.1984.sp015321","article-title":"Relaxin inhibits the plateau component of the action potential in the circular myometrium of the rat","volume":"353","year":"1984","journal-title":"J Physiol"},{"key":"key\n\t\t\t\t20170224011531_R39","doi-asserted-by":"crossref","first-page":"5322","DOI":"10.1210\/endo.136.12.7588277","article-title":"Differential expression and regulation of connexin-43 and cell-cell coupling in myocytes from the circular and longitudinal layers of bovine myometrium","volume":"136","year":"1995","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224011531_R40","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1095\/biolreprod.105.040006","article-title":"Expression and localization of alpha-smooth muscle and gamma-actins in the pregnant rat myometrium","volume":"73","year":"2005","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224011531_R41","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1210\/endo-104-4-893","article-title":"Development of a homologous radioimmunoassay for rat relaxin","volume":"104","year":"1979","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224011531_R42","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1530\/REP-08-0014","article-title":"Relaxin (RLX) and estrogen affect estrogen receptor alpha, vascular endothelial growth factor and RLX receptor expression in the neonatal porcine uterus and cervix","volume":"135","year":"2008","journal-title":"Reproduction"},{"key":"key\n\t\t\t\t20170224011531_R43","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1210\/endo-110-1-220","article-title":"Relaxin receptor in the rat myometrium: regulation by estrogen and relaxin","volume":"110","year":"1982","journal-title":"Endocrinology"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T10:57:48Z","timestamp":1559386668000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-lookup\/doi\/10.1095\/biolreprod.110.083931"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,1]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,11,1]]}},"URL":"https:\/\/doi.org\/10.1095\/biolreprod.110.083931","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,1]]}}}