{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T04:54:50Z","timestamp":1774414490166,"version":"3.50.1"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,12,1]]},"DOI":"10.1095\/biolreprod.110.085282","type":"journal-article","created":{"date-parts":[[2010,8,6]],"date-time":"2010-08-06T00:18:52Z","timestamp":1281053932000},"page":"929-937","source":"Crossref","is-referenced-by-count":103,"title":["Inhibition of Class IIb Histone Deacetylase Significantly Improves Cloning Efficiency in Mice1"],"prefix":"10.1093","volume":"83","author":[{"given":"Tetsuo","family":"Ono","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiji","family":"Mizutani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukari","family":"Terashita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Yamagata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teruhiko","family":"Wakayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","reference":[{"key":"key\n\t\t\t\t20170224011423_R01","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/385810a0","article-title":"Viable offspring derived from fetal and adult mammalian cells","volume":"385","year":"1997","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170224011423_R02","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/28615","article-title":"Full-term development of mice from enucleated oocytes injected with cumulus cell nuclei","volume":"394","year":"1998","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170224011423_R03","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/nbt0102-13","article-title":"The health profile of cloned animals","volume":"20","year":"2002","journal-title":"Nat Biotechnol"},{"key":"key\n\t\t\t\t20170224011423_R04","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1095\/biolreprod65.6.1813","article-title":"Placentomegaly in cloned mouse concepti caused by expansion of the spongiotrophoblast layer","volume":"65","year":"2001","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224011423_R05","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/9632","article-title":"Cloning of male mice from adult tail-tip cells","volume":"22","year":"1999","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20170224011423_R06","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/nm0302-262","article-title":"Cloned mice have an obese phenotype not transmitted to their offspring","volume":"8","year":"2002","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t20170224011423_R07","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1095\/biolreprod63.1.328","article-title":"Postnatal growth and behavioral development of mice cloned from adult cumulus cells","volume":"63","year":"2000","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224011423_R08","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1262\/jrd.09-221A","article-title":"How to improve the success rate of mouse cloning technology","volume":"56","year":"2010","journal-title":"J Reprod Dev"},{"key":"key\n\t\t\t\t20170224011423_R09","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/ng841","article-title":"Early death of mice cloned from somatic cells","volume":"30","year":"2002","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20170224011423_R10","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1262\/jrd.18120","article-title":"Production of cloned mice and ES cells from adult somatic cells by nuclear transfer: how to improve cloning efficiency?","volume":"53","year":"2007","journal-title":"J Reprod Dev"},{"key":"key\n\t\t\t\t20170224011423_R11","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1530\/rep.0.1220049","article-title":"Effect of cytokinesis inhibitors, DMSO and the timing of oocyte activation on mouse cloning using cumulus cell nuclei","volume":"122","year":"2001","journal-title":"Reproduction"},{"key":"key\n\t\t\t\t20170224011423_R12","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1089\/153623003769645848","article-title":"Effect of timing of the removal of oocyte chromosomes before or after injection of somatic nucleus on development of NT embryos","volume":"5","year":"2003","journal-title":"Cloning Stem Cells"},{"key":"key\n\t\t\t\t20170224011423_R13","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1095\/biolreprod.103.017954","article-title":"Epigenetic characteristics and development of embryos cloned from donor cells treated by trichostatin A or 5-aza-2\u2032-deoxycytidine","volume":"69","year":"2003","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224011423_R14","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1262\/jrd.17061","article-title":"Mice cloned by nuclear transfer from somatic and ntES cells derived from the same individuals","volume":"51","year":"2005","journal-title":"J Reprod Dev"},{"key":"key\n\t\t\t\t20170224011423_R15","doi-asserted-by":"crossref","first-page":"5304","DOI":"10.1093\/emboj\/cdg507","article-title":"Pluripotency deficit in clones overcome by clone-clone aggregation: epigenetic complementation?","volume":"22","year":"2003","journal-title":"EMBO J"},{"key":"key\n\t\t\t\t20170224011423_R16","doi-asserted-by":"crossref","first-page":"13734","DOI":"10.1073\/pnas.241522698","article-title":"Conservation of methylation reprogramming in mammalian development: aberrant reprogramming in cloned embryos","volume":"98","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170224011423_R17","doi-asserted-by":"crossref","first-page":"12889","DOI":"10.1073\/pnas.192433399","article-title":"Abnormal gene expression in cloned mice derived from embryonic stem cell and cumulus cell nuclei","volume":"99","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170224011423_R18","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1126\/science.295.5553.297","article-title":"Faithful expression of imprinted genes in cloned mice","volume":"295","year":"2002","journal-title":"Science"},{"key":"key\n\t\t\t\t20170224011423_R19","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/88903","article-title":"Aberrant methylation of donor genome in cloned bovine embryos","volume":"28","year":"2001","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20170224011423_R20","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/j.1356-9597.2004.00720.x","article-title":"The Sall3 locus is an epigenetic hotspot of aberrant DNA methylation associated with placentomegaly of cloned mice","volume":"9","year":"2004","journal-title":"Genes Cells"},{"key":"key\n\t\t\t\t20170224011423_R21","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/S0960-9822(03)00419-6","article-title":"Epigenetic marking correlates with developmental potential in cloned bovine preimplantation embryos","volume":"13","year":"2003","journal-title":"Curr Biol"},{"key":"key\n\t\t\t\t20170224011423_R22","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1006\/dbio.2002.0870","article-title":"Expression profiling of placentomegaly associated with nuclear transplantation of mouse ES cells","volume":"253","year":"2003","journal-title":"Dev Biol"},{"key":"key\n\t\t\t\t20170224011423_R23","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1095\/biolreprod.107.063149","article-title":"Dynamic reprogramming of histone acetylation and methylation in the first cell cycle of cloned mouse embryos","volume":"77","year":"2007","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224011423_R24","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1262\/jrd.18098","article-title":"Successful mouse cloning of an outbred strain by trichostatin A treatment after somatic nuclear transfer","volume":"53","year":"2007","journal-title":"J Reprod Dev"},{"key":"key\n\t\t\t\t20170224011423_R25","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.bbrc.2005.11.164","article-title":"Significant improvement of mouse cloning technique by treatment with trichostatin A after somatic nuclear transfer","volume":"340","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"key\n\t\t\t\t20170224011423_R26","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1095\/biolreprod.105.047456","article-title":"Role of histone acetylation in reprogramming of somatic nuclei following nuclear transfer","volume":"74","year":"2006","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224011423_R27","first-page":"3137","article-title":"A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library","volume":"60","year":"2000","journal-title":"Cancer Res"},{"key":"key\n\t\t\t\t20170224011423_R28","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1530\/REP-08-0299","article-title":"The histone deacetylase inhibitor scriptaid enhances nascent mRNA production and rescues full-term development in cloned inbred mice","volume":"138","year":"2009","journal-title":"Reproduction"},{"key":"key\n\t\t\t\t20170224011423_R29","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1095\/biolreprod.109.077016","article-title":"Significant improvement in cloning efficiency of an inbred miniature pig by histone deacetylase inhibitor treatment after somatic cell nuclear transfer","volume":"81","year":"2009","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224011423_R30","first-page":"97","article-title":"Effects of sirtinol on early development of the cloned murine embryos","volume":"23","year":"2008","journal-title":"Yamanashi Med J"},{"key":"key\n\t\t\t\t20170224011423_R31","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1095\/biolreprod.109.083337","article-title":"Effect of trichostatin A on chromatin remodeling, histone modifications, DNA replication and transcriptional activity in cloned mouse embryos","volume":"83","year":"2010","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224011423_R32","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/j.lfs.2008.03.004","article-title":"The use of diversity profiling to characterize chemical modulators of the histone deacetylases","volume":"82","year":"2008","journal-title":"Life Sci"},{"key":"key\n\t\t\t\t20170224011423_R33","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1042\/bj20021321","article-title":"Histone deacetylases (HDACs): characterization of the classical HDAC family","volume":"370","year":"2003","journal-title":"Biochem J"},{"key":"key\n\t\t\t\t20170224011423_R34","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.tins.2009.06.002","article-title":"Multiple roles of HDAC inhibition in neurodegenerative conditions","volume":"32","year":"2009","journal-title":"Trends Neurosci"},{"key":"key\n\t\t\t\t20170224011423_R35","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.biocel.2008.05.026","article-title":"Zn(II)-dependent histone deacetylase inhibitors: suberoylanilide hydroxamic acid and trichostatin A","volume":"41","year":"2009","journal-title":"Int J Biochem Cell Biol"},{"key":"key\n\t\t\t\t20170224011423_R36","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1261\/rna.1332609","article-title":"Stalling of spliceosome assembly at distinct stages by small-molecule inhibitors of protein acetylation and deacetylation","volume":"15","year":"2009","journal-title":"RNA"},{"key":"key\n\t\t\t\t20170224011423_R37","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/j.athoracsur.2005.06.059","article-title":"Effectiveness of trichostatin A as a potential candidate for anticancer therapy in non-small-cell lung cancer","volume":"81","year":"2006","journal-title":"Ann Thorac Surg"},{"key":"key\n\t\t\t\t20170224011423_R38","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1021\/jm021070e","article-title":"3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-alkylamides as a new class of synthetic histone deacetylase inhibitors. 1. Design, synthesis, biological evaluation, and binding mode studies performed through three different docking procedures","volume":"46","year":"2003","journal-title":"J Med Chem"},{"key":"key\n\t\t\t\t20170224011423_R39","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/S1471-4892(03)00084-5","article-title":"Histone deacetylases","volume":"3","year":"2003","journal-title":"Curr Opin Pharmacol"},{"key":"key\n\t\t\t\t20170224011423_R40","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1002\/jcb.20615","article-title":"Histone modifying enzymes and cancer: going beyond histones","volume":"96","year":"2005","journal-title":"J Cell Biochem"},{"key":"key\n\t\t\t\t20170224011423_R41","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/nbt1418","article-title":"Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds","volume":"26","year":"2008","journal-title":"Nat Biotechnol"},{"key":"key\n\t\t\t\t20170224011423_R42","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1095\/biolreprod52.4.709","article-title":"Intracytoplasmic sperm injection in the mouse","volume":"52","year":"1995","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224011423_R43","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1262\/jrd.19067","article-title":"Efficient strontium-induced activation of mouse oocytes in standard culture media by chelating calcium","volume":"53","year":"2007","journal-title":"J Reprod Dev"},{"key":"key\n\t\t\t\t20170224011423_R44","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1073\/pnas.0408548102","article-title":"Propagation of an infertile hermaphrodite mouse lacking germ cells by using nuclear transfer and embryonic stem cell technology","volume":"102","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170224011423_R45","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1095\/biolreprod.104.035105","article-title":"Establishment of male and female nuclear transfer embryonic stem cell lines from different mouse strains and tissues","volume":"72","year":"2005","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224011423_R46","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1126\/science.1059399","article-title":"Differentiation of embryonic stem cell lines generated from adult somatic cells by nuclear transfer","volume":"292","year":"2001","journal-title":"Science"},{"key":"key\n\t\t\t\t20170224011423_R47","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1262\/jrd.20112","article-title":"Nuclear transfer preserves the nuclear genome of freeze-dried mouse cells","volume":"54","year":"2008","journal-title":"J Reprod Dev"},{"key":"key\n\t\t\t\t20170224011423_R48","doi-asserted-by":"crossref","first-page":"e6753","DOI":"10.1371\/journal.pone.0006753","article-title":"Detrimental effects of microgravity on mouse preimplantation development in vitro","volume":"4","year":"2009","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170224011423_R49","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1262\/jrd.20166","article-title":"Long-term, six-dimensional live-cell imaging for the mouse preimplantation embryo that does not affect full-term development","volume":"55","year":"2009","journal-title":"J Reprod Dev"},{"key":"key\n\t\t\t\t20170224011423_R50","doi-asserted-by":"crossref","first-page":"17318","DOI":"10.1073\/pnas.0806166105","article-title":"Production of healthy cloned mice from bodies frozen at \u221220 degrees C for 16 years","volume":"105","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170224011423_R51","doi-asserted-by":"crossref","first-page":"4868","DOI":"10.1073\/pnas.96.9.4868","article-title":"Three proteins define a class of human histone deacetylases related to yeast Hda1p","volume":"96","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170224011423_R52","doi-asserted-by":"crossref","first-page":"3350","DOI":"10.1074\/jbc.M109861200","article-title":"Molecular cloning and characterization of a novel histone deacetylase HDAC10","volume":"277","year":"2002","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170224011423_R53","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nbt1068","article-title":"A small molecule-kinase interaction map for clinical kinase inhibitors","volume":"23","year":"2005","journal-title":"Nat Biotechnol"},{"key":"key\n\t\t\t\t20170224011423_R54","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1146\/annurev.biochem.70.1.81","article-title":"Histone acetyltransferases","volume":"70","year":"2001","journal-title":"Annu Rev Biochem"},{"key":"key\n\t\t\t\t20170224011423_R55","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/417455a","article-title":"HDAC6 is a microtubule-associated deacetylase","volume":"417","year":"2002","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170224011423_R56","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.molcel.2005.04.021","article-title":"HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor","volume":"18","year":"2005","journal-title":"Mol Cell"},{"key":"key\n\t\t\t\t20170224011423_R57","doi-asserted-by":"crossref","first-page":"7187","DOI":"10.1074\/jbc.M109.061861","article-title":"Histone deacetylase 10 relieves repression on the melanogenic program by maintaining the deacetylation status of repressors","volume":"285","year":"2010","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170224011423_R58","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1095\/biolreprod56.5.1088","article-title":"Apoptosis during mouse blastocyst formation: evidence for a role for survival factors including transforming growth factor alpha","volume":"56","year":"1997","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224011423_R59","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1017\/S0967199408005133","article-title":"The developmental potential of mouse somatic cell nuclear-transferred oocytes treated with trichostatin A and 5-aza-2\u2032-deoxycytidine","volume":"17","year":"2009","journal-title":"Zygote"},{"key":"key\n\t\t\t\t20170224011423_R60","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1387\/ijdb.082654rf","article-title":"Epigenetic asymmetry in the zygote and mammalian development","volume":"53","year":"2009","journal-title":"Int J Dev Biol"},{"key":"key\n\t\t\t\t20170224011423_R61","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/35000656","article-title":"Demethylation of the zygotic paternal genome","volume":"403","year":"2000","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170224011423_R62","first-page":"376","article-title":"Harmful or not: trichostatin A treatment of embryos generated by ICSI or ROSI","volume":"1","year":"2006","journal-title":"Cent Eur J Biol"},{"key":"key\n\t\t\t\t20170224011423_R63","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1095\/biolreprod64.6.1713","article-title":"Regulation of zygotic gene activation in the preimplantation mouse embryo: global activation and repression of gene expression","volume":"64","year":"2001","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224011423_R64","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ydbio.2005.10.026","article-title":"Epigenetic abnormalities of the mouse paternal zygotic genome associated with microinsemination of round spermatids","volume":"289","year":"2006","journal-title":"Dev Biol"},{"key":"key\n\t\t\t\t20170224011423_R65","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1017\/S0967199408004620","article-title":"Effect of volume of oocyte cytoplasm on embryo development after parthenogenetic activation, intracytoplasmic sperm injection, or somatic cell nuclear transfer","volume":"16","year":"2008","journal-title":"Zygote"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T17:05:08Z","timestamp":1685725508000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-lookup\/doi\/10.1095\/biolreprod.110.085282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,1]]},"references-count":65,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,12,1]]}},"URL":"https:\/\/doi.org\/10.1095\/biolreprod.110.085282","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,1]]}}}