{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:22:41Z","timestamp":1779236561734,"version":"3.51.4"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,5,1]]},"DOI":"10.1095\/biolreprod.111.094904","type":"journal-article","created":{"date-parts":[[2012,2,23]],"date-time":"2012-02-23T07:05:50Z","timestamp":1329980750000},"source":"Crossref","is-referenced-by-count":11,"title":["The Forkhead Transcription Factor, FOXP3, Is Required for Normal Pituitary Gonadotropin Expression in Mice1"],"prefix":"10.1093","volume":"86","author":[{"given":"Deborah O.","family":"Jung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jake S.","family":"Jasurda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noboru","family":"Egashira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Buffy S.","family":"Ellsworth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","reference":[{"key":"key\n\t\t\t\t20170224025624_R01","volume-title":"Physiology","year":"1993"},{"key":"key\n\t\t\t\t20170224025624_R02","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0303-7207(98)00187-7","article-title":"Role of cyclic nucleotide phosphodiesterases in resumption of meiosis","volume":"145","year":"1998","journal-title":"Mol Cell Endocrinol"},{"key":"key\n\t\t\t\t20170224025624_R03","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0303-7207(98)00168-3","article-title":"Molecular mechanisms of ovulation and luteinization","volume":"145","year":"1998","journal-title":"Mol Cell Endocrinol"},{"key":"key\n\t\t\t\t20170224025624_R04","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1210\/er.2003-0029","article-title":"Multiple and overlapping combinatorial codes orchestrate hormonal responsiveness and dictate cell-specific expression of the genes encoding luteinizing hormone","volume":"25","year":"2004","journal-title":"Endocr Rev"},{"key":"key\n\t\t\t\t20170224025624_R05","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0025-7125(03)00150-0","article-title":"Male factor infertility: evaluation and management","volume":"88","year":"2004","journal-title":"Med Clin North Am"},{"key":"key\n\t\t\t\t20170224025624_R06","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.fertnstert.2005.08.066","article-title":"International disparities in access to infertility services","volume":"85","year":"2006","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20170224025624_R07","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0303-7207(01)00698-0","article-title":"Transgenic and knockout mouse models for the study of luteinizing hormone and luteinizing hormone receptor function","volume":"187","year":"2002","journal-title":"Mol Cell Endocrinol"},{"key":"key\n\t\t\t\t20170224025624_R08","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1042\/BJ20060387","article-title":"In control of biology: of mice, men and Foxes","volume":"397","year":"2006","journal-title":"Biochem J"},{"key":"key\n\t\t\t\t20170224025624_R09","first-page":"1432","article-title":"FOXP3 actively represses transcription by recruiting the HAT\/HDAC complex","volume":"6","year":"2007","journal-title":"Cell Cycle"},{"key":"key\n\t\t\t\t20170224025624_R10","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/S0022-3476(82)80573-8","article-title":"An X-linked syndrome of diarrhea, polyendocrinopathy, and fatal infection in infancy","volume":"100","year":"1982","journal-title":"J Pediatr"},{"key":"key\n\t\t\t\t20170224025624_R11","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1126\/science.1079490","article-title":"Control of regulatory T cell development by the transcription factor Foxp3","volume":"299","year":"2003","journal-title":"Science"},{"key":"key\n\t\t\t\t20170224025624_R12","doi-asserted-by":"crossref","first-page":"5163","DOI":"10.4049\/jimmunol.180.8.5163","article-title":"Cutting edge: broad expression of the FoxP3 locus in epithelial cells: a caution against early interpretation of fatal inflammatory diseases following in vivo depletion of FoxP3-expressing cells","volume":"180","year":"2008","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170224025624_R13","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/83784","article-title":"Disruption of a new forkhead\/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse","volume":"27","year":"2001","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20170224025624_R14","first-page":"93","article-title":"Hypogonadism in scurfy (sf) males","volume":"74","year":"1986","journal-title":"Mouse News Lett"},{"key":"key\n\t\t\t\t20170224025624_R15","doi-asserted-by":"crossref","first-page":"5528","DOI":"10.1073\/pnas.88.13.5528","article-title":"Fatal lymphoreticular disease in the scurfy (sf) mouse requires T cells that mature in a sf thymic environment: potential model for thymic education","volume":"88","year":"1991","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170224025624_R16","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","year":"2001","journal-title":"Methods"},{"key":"key\n\t\t\t\t20170224025624_R17","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","year":"2008","journal-title":"Nat Protoc"},{"key":"key\n\t\t\t\t20170224025624_R18","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1210\/endo.141.3.7391","article-title":"Responsiveness of the ovine gonadotropin-releasing hormone receptor gene to estradiol and gonadotropin-releasing hormone is not detectable in vitro but is revealed in transgenic mice","volume":"141","year":"2000","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224025624_R19","first-page":"89017","article-title":"IPEX as a result of mutations in FOXP3","volume":"2007","year":"2007","journal-title":"Clin Dev Immunol"},{"key":"key\n\t\t\t\t20170224025624_R20","first-page":"752","article-title":"Early growth response protein 1 binds to the luteinizing hormone-beta promoter and mediates gonadotropin-releasing hormone-stimulated gene expression","volume":"13","year":"1999","journal-title":"Mol Endocrinol"},{"key":"key\n\t\t\t\t20170224025624_R21","doi-asserted-by":"crossref","first-page":"14712","DOI":"10.1074\/jbc.273.24.14712","article-title":"Steroidogenic factor-1 and early growth response protein 1 act through two composite DNA binding sites to regulate luteinizing hormone beta-subunit gene expression","volume":"273","year":"1998","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170224025624_R22","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1128\/MCB.19.4.2567","article-title":"Egr-1 is a downstream effector of GnRH and synergizes by direct interaction with Ptx1 and SF-1 to enhance luteinizing hormone beta gene transcription","volume":"19","year":"1999","journal-title":"Mol Cell Biol"},{"key":"key\n\t\t\t\t20170224025624_R23","first-page":"734","article-title":"A single Pitx1 binding site is essential for activity of the LHbeta promoter in transgenic mice","volume":"15","year":"2001","journal-title":"Mol Endocrinol"},{"key":"key\n\t\t\t\t20170224025624_R24","doi-asserted-by":"crossref","first-page":"4643","DOI":"10.1242\/dev.126.20.4643","article-title":"Dosage requirement of Pitx2 for development of multiple organs","volume":"126","year":"1999","journal-title":"Development"},{"key":"key\n\t\t\t\t20170224025624_R25","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1242\/dev.129.2.329","article-title":"Pitx2 is required at multiple stages of pituitary organogenesis: pituitary primordium formation and cell specification","volume":"129","year":"2002","journal-title":"Development"},{"key":"key\n\t\t\t\t20170224025624_R26","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.ydbio.2007.10.006","article-title":"Mechanisms underlying pituitary hypoplasia and failed cell specification in Lhx3-deficient mice","volume":"313","year":"2008","journal-title":"Dev Biol"},{"key":"key\n\t\t\t\t20170224025624_R27","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1126\/science.272.5264.1004","article-title":"Specification of pituitary cell lineages by the LIM homeobox gene Lhx3","volume":"272","year":"1996","journal-title":"Science"},{"key":"key\n\t\t\t\t20170224025624_R28","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0303-7207(03)00235-1","article-title":"The gonadotropin releasing hormone (GnRH) receptor activating sequence (GRAS) is a composite regulatory element that interacts with multiple classes of transcription factors including Smads, AP-1 and a forkhead DNA binding protein","volume":"206","year":"2003","journal-title":"Mol Cell Endocrinol"},{"key":"key\n\t\t\t\t20170224025624_R29","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.1210\/me.2005-0303","article-title":"FOXL2 in the pituitary: molecular, genetic, and developmental analysis","volume":"20","year":"2006","journal-title":"Mol Endocrinol"},{"key":"key\n\t\t\t\t20170224025624_R30","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.tem.2010.05.006","article-title":"FoxL in the Smad house: activin regulation of FSH","volume":"21","year":"2010","journal-title":"Trends Endocrinol Metab"},{"key":"key\n\t\t\t\t20170224025624_R31","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1210\/me.2010-0480","article-title":"SMADs and FOXL2 synergistically regulate murine FSHbeta transcription via a conserved proximal promoter element","volume":"25","year":"2011","journal-title":"Mol Endocrinol"},{"key":"key\n\t\t\t\t20170224025624_R32","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1210\/me.2011-0093","article-title":"Impaired FSH{beta} expression in the pituitaries of Foxl2 mutant animals","volume":"25","year":"2011","journal-title":"Mol Endocrinol"},{"key":"key\n\t\t\t\t20170224025624_R33","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1084\/jem.20061852","article-title":"Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease","volume":"204","year":"2007","journal-title":"J Exp Med"},{"key":"key\n\t\t\t\t20170224025624_R34","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1146\/annurev.immunol.24.021605.090547","article-title":"FOXP3: of mice and men","volume":"24","year":"2006","journal-title":"Annu Rev Immunol"},{"key":"key\n\t\t\t\t20170224025624_R35","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/s12026-007-0022-2","article-title":"FOXP3 and regulatory T-cells: a model for autoimmunity","volume":"38","year":"2007","journal-title":"Immunol Res"},{"key":"key\n\t\t\t\t20170224025624_R36","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/83707","article-title":"X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy","volume":"27","year":"2001","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20170224025624_R37","doi-asserted-by":"crossref","first-page":"3212","DOI":"10.4049\/jimmunol.0804355","article-title":"X-linked Foxp3 (Scurfy) mutation dominantly inhibits submandibular gland development and inflammation respectively through adaptive and innate immune mechanisms","volume":"183","year":"2009","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170224025624_R38","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.cmet.2010.06.010","article-title":"Rescue of obesity-induced infertility in female mice due to a pituitary-specific knockout of the insulin receptor","volume":"12","year":"2010","journal-title":"Cell Metab"},{"issue":"(suppl)","key":"key\n\t\t\t\t20170224025624_R39","first-page":"56","article-title":"and FOXP3: clinical and research perspectives","volume":"25","year":"2005","journal-title":"J Autoimmun"},{"key":"key\n\t\t\t\t20170224025624_R40","first-page":"443","article-title":"Thyroid hormone and male gonadal function","volume":"16","year":"1995","journal-title":"Endocr Rev"},{"key":"key\n\t\t\t\t20170224025624_R41","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/j.jaci.2005.08.046","article-title":"Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice","volume":"116","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"key\n\t\t\t\t20170224025624_R42","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s12035-011-8224-y","article-title":"Signaling of cytokines is important in regulation of GnRH neurons","volume":"45","year":"2012","journal-title":"Mol Neurobiol"},{"key":"key\n\t\t\t\t20170224025624_R43","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1159\/000026372","article-title":"Immunoneuroendocrine connectivity: the paradigm of the thymus-hypothalamus\/pituitary axis","volume":"6","year":"1999","journal-title":"Neuroimmunomodulation"},{"key":"key\n\t\t\t\t20170224025624_R44","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1210\/endo-127-1-101","article-title":"Tumor necrosis factor alpha inhibits the hormonal response of the pituitary gland to hypothalamic releasing factors","volume":"127","year":"1990","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224025624_R45","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1210\/endo-113-2-535","article-title":"The effects of daily administration of single and multiple injections of gonadotropin-releasing hormone on pituitary and gonadal function in the hypogonadal (hpg) mouse","volume":"113","year":"1983","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224025624_R46","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1210\/endo-122-3-959","article-title":"Gonadotropin-releasing hormone increases the amount of messenger ribonucleic acid for gonadotropins in ovariectomized ewes after hypothalamic-pituitary disconnection","volume":"122","year":"1988","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224025624_R47","first-page":"E652","article-title":"Pituitary and gonadal responsiveness is enhanced during GnRH-induced puberty","volume":"254","year":"1988","journal-title":"Am J Physiol"},{"key":"key\n\t\t\t\t20170224025624_R48","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1210\/edrv-11-1-177","article-title":"Molecular biology of the pituitary gonadotropins","volume":"11","year":"1990","journal-title":"Endocr Rev"},{"key":"key\n\t\t\t\t20170224025624_R49","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1126\/science.3024317","article-title":"A deletion truncating the gonadotropin-releasing hormone gene is responsible for hypogonadism in the hpg mouse","volume":"234","year":"1986","journal-title":"Science"},{"key":"key\n\t\t\t\t20170224025624_R50","doi-asserted-by":"crossref","first-page":"3154","DOI":"10.1210\/endo.138.8.5306","article-title":"Expression of a murine gonadotropin-releasing hormone receptor-luciferase fusion gene in transgenic mice is diminished by immunoneutralization of gonadotropin-releasing hormone","volume":"138","year":"1997","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224025624_R51","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1210\/endo-110-4-1108","article-title":"Hypothalamic regulation of pituitary gonadotropin-releasing hormone receptors: effects of hypothalamic lesions and a gonadotropin-releasing hormone antagonist","volume":"110","year":"1982","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224025624_R52","doi-asserted-by":"crossref","first-page":"3902","DOI":"10.4049\/jimmunol.0802124","article-title":"Aire-deficient C57BL\/6 mice mimicking the common human 13-base pair deletion mutation present with only a mild autoimmune phenotype","volume":"182","year":"2009","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170224025624_R53","doi-asserted-by":"crossref","first-page":"R743","DOI":"10.1152\/ajpregu.90751.2008","article-title":"Defects in the regulatory clearance mechanisms favor the breakdown of self-tolerance during spontaneous autoimmune orchitis","volume":"296","year":"2009","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"key\n\t\t\t\t20170224025624_R54","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/BF00711545","article-title":"Thymocytes express a mRNA that is identical to hypothalamic luteinizing hormone-releasing hormone mRNA","volume":"12","year":"1992","journal-title":"Cell Mol Neurobiol"},{"key":"key\n\t\t\t\t20170224025624_R55","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1111\/j.1749-6632.2000.tb05434.x","article-title":"Gender, neuroendocrine-immune interactions and neuron-glial plasticity. Role of luteinizing hormone-releasing hormone (LHRH)","volume":"917","year":"2000","journal-title":"Ann N Y Acad Sci"},{"key":"key\n\t\t\t\t20170224025624_R56","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0739-7240(03)00043-2","article-title":"The reproductive system at the neuroendocrine-immune interface: focus on LHRH, estrogens and growth factors in LHRH neuron-glial interactions","volume":"25","year":"2003","journal-title":"Domest Anim Endocrinol"},{"key":"key\n\t\t\t\t20170224025624_R57","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1006\/brbi.2000.0595","article-title":"Gomez Dumm CL, Dardenne M. Altered functional responses with preserved morphology of gonadotrophic cells in congenitally athymic mice","volume":"15","year":"2001","journal-title":"Brain Behav Immun"},{"key":"key\n\t\t\t\t20170224025624_R58","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1159\/000096948","article-title":"Morphometric assessment of the impact of serum thymulin immunoneutralization on pituitary cell populations in peripubertal mice","volume":"184","year":"2006","journal-title":"Cells Tissues Organs"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/biolreprod\/article-pdf\/86\/5\/144","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,20]],"date-time":"2024-04-20T08:02:03Z","timestamp":1713600123000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-lookup\/doi\/10.1095\/biolreprod.111.094904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,1]]},"references-count":58,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,5,1]]}},"URL":"https:\/\/doi.org\/10.1095\/biolreprod.111.094904","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,1]]}}}