{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:01:37Z","timestamp":1792040497703,"version":"4.4.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,4,1]]},"DOI":"10.1095\/biolreprod.111.097501","type":"journal-article","created":{"date-parts":[[2012,1,6]],"date-time":"2012-01-06T01:14:01Z","timestamp":1325812441000},"source":"Crossref","is-referenced-by-count":47,"title":["The Autoimmune Regulator Prevents Premature Reproductive Senescence in Female Mice1"],"prefix":"10.1093","volume":"86","author":[{"given":"Susmita","family":"Jasti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryce D.","family":"Warren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynda K.","family":"McGinnis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William H.","family":"Kinsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian K.","family":"Petroff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret G.","family":"Petroff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"key\n\t\t\t\t20170224014305_R01","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1093\/humupd\/dmh014","article-title":"Autoimmunity and antigenic targets in ovarian pathology","volume":"10","year":"2004","journal-title":"Hum Reprod Update"},{"key":"key\n\t\t\t\t20170224014305_R02","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0015-0282(16)58095-9","article-title":"Characterization of idiopathic premature ovarian failure","volume":"65","year":"1996","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20170224014305_R03","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1146\/annurev.immunol.23.021704.115601","article-title":"A central role for central tolerance","volume":"24","year":"2006","journal-title":"Annu Rev Immunol"},{"key":"key\n\t\t\t\t20170224014305_R04","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1146\/annurev.immunol.21.120601.141107","article-title":"Positive and negative selection of T cells","volume":"21","year":"2003","journal-title":"Annu Rev Immunol"},{"key":"key\n\t\t\t\t20170224014305_R05","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1093\/intimm\/9.9.1355","article-title":"Pancreatic gene expression in rare cells of thymic medulla: evidence for functional contribution to T cell tolerance","volume":"9","year":"1997","journal-title":"Int Immunol"},{"key":"key\n\t\t\t\t20170224014305_R06","doi-asserted-by":"crossref","first-page":"6707","DOI":"10.1073\/pnas.91.14.6707","article-title":"T-cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous pancreatic genes in thymus","volume":"91","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170224014305_R07","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1038\/ni723","article-title":"Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self","volume":"2","year":"2001","journal-title":"Nat Immunol"},{"key":"key\n\t\t\t\t20170224014305_R08","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.1038\/emboj.2009.212","article-title":"Thymus-specific deletion of insulin induces autoimmune diabetes","volume":"28","year":"2009","journal-title":"EMBO J"},{"key":"key\n\t\t\t\t20170224014305_R09","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.1084\/jem.20061864","article-title":"Spontaneous autoimmunity prevented by thymic expression of a single self-antigen","volume":"203","year":"2006","journal-title":"J Exp Med"},{"key":"key\n\t\t\t\t20170224014305_R10","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1126\/science.1075958","article-title":"Projection of an immunological self shadow within the thymus by the aire protein","volume":"298","year":"2002","journal-title":"Science"},{"key":"key\n\t\t\t\t20170224014305_R11","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.cell.2009.12.030","article-title":"Aire's partners in the molecular control of immunological tolerance","volume":"140","year":"2010","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170224014305_R12","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1084\/jem.20050471","article-title":"Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels","volume":"202","year":"2005","journal-title":"J Exp Med"},{"key":"key\n\t\t\t\t20170224014305_R13","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.immuni.2005.07.005","article-title":"The cellular mechanism of aire control of T cell tolerance","volume":"23","year":"2005","journal-title":"Immunity"},{"key":"key\n\t\t\t\t20170224014305_R14","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1084\/jem.20040581","article-title":"Gene dosage-limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity","volume":"200","year":"2004","journal-title":"J Exp Med"},{"key":"key\n\t\t\t\t20170224014305_R15","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/ni906","article-title":"Aire regulates negative selection of organ-specific T cells","volume":"4","year":"2003","journal-title":"Nat Immunol"},{"key":"key\n\t\t\t\t20170224014305_R16","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/ng1297-399","article-title":"An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger proteins","volume":"17","year":"1997","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20170224014305_R17","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1093\/hmg\/7.10.1547","article-title":"Gene defect behind APECED: a new clue to autoimmunity","volume":"7","year":"1998","journal-title":"Hum Mol Genet"},{"key":"key\n\t\t\t\t20170224014305_R18","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1210\/jc.2005-2611","article-title":"Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy","volume":"91","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20170224014305_R19","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1146\/annurev.immunol.25.022106.141532","article-title":"Aire","volume":"27","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"key\n\t\t\t\t20170224014305_R20","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/hmg\/11.4.397","article-title":"Aire deficient mice develop multiple features of APECED phenotype and show altered immune response","volume":"11","year":"2002","journal-title":"Hum Mol Genet"},{"key":"key\n\t\t\t\t20170224014305_R21","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1084\/jem.20050693","article-title":"Modifier loci condition autoimmunity provoked by Aire deficiency","volume":"202","year":"2005","journal-title":"J Exp Med"},{"key":"key\n\t\t\t\t20170224014305_R22","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1477-7827-1-11","article-title":"Ovarian follicle counts\u2014not as simple as 1, 2, 3","volume":"1","year":"2003","journal-title":"Reprod Biol Endocrinol"},{"key":"key\n\t\t\t\t20170224014305_R23","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.ydbio.2007.03.024","article-title":"Localized activation of Src-family protein kinases in the mouse egg","volume":"306","year":"2007","journal-title":"Dev Biol"},{"key":"key\n\t\t\t\t20170224014305_R24","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1095\/biolreprod.105.046581","article-title":"Trophoblast CD274 (B7-H1) is differentially expressed across gestation: influence of oxygen concentration","volume":"74","year":"2006","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224014305_R25","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1177\/002215540104900207","article-title":"Subcellular location and expression pattern of autoimmune regulator (Aire), the mouse orthologue for human gene defective in autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED)","volume":"49","year":"2001","journal-title":"J Histochem Cytochem"},{"key":"key\n\t\t\t\t20170224014305_R26","doi-asserted-by":"crossref","first-page":"4363","DOI":"10.4049\/jimmunol.166.7.4363","article-title":"Endogenous oocyte antigens are required for rapid induction and progression of autoimmune ovarian disease following day-3 thymectomy","volume":"166","year":"2001","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170224014305_R27","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/j.1600-0897.1995.tb00929.x","article-title":"Murine experimental autoimmune oophoritis develops independently of gonadotropin stimulation and is primarily localized in the stroma and theca","volume":"34","year":"1995","journal-title":"Am J Reprod Immunol"},{"key":"key\n\t\t\t\t20170224014305_R28","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1186\/1471-2164-9-307","article-title":"Expression profiling of a high-fertility mouse line by microarray analysis and qPCR","volume":"9","year":"2008","journal-title":"BMC Genomics"},{"key":"key\n\t\t\t\t20170224014305_R29","first-page":"1871","article-title":"Rees Smith B, Furmaniak J. Autoantibodies to steroidogenic enzymes in autoimmune polyglandular syndrome, Addison's disease, and premature ovarian failure","volume":"81","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20170224014305_R30","first-page":"323","article-title":"Autoantibodies to cytochrome P450 enzymes P450scc, P450c17, and P450c21 in autoimmune polyglandular disease types I and II and in isolated Addison's disease","volume":"78","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20170224014305_R31","doi-asserted-by":"crossref","first-page":"5446","DOI":"10.1210\/en.2010-0629","article-title":"Development and hormonal regulation of the ovarian lymphatic vasculature","volume":"151","year":"2010","journal-title":"Endocrinology"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","deposited":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T12:17:17Z","timestamp":1497961037000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-lookup\/doi\/10.1095\/biolreprod.111.097501"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,1]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4,1]]}},"URL":"https:\/\/doi.org\/10.1095\/biolreprod.111.097501","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,1]]}}}