{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T03:29:19Z","timestamp":1793071759179,"version":"4.5.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,12,1]]},"DOI":"10.1095\/biolreprod.112.103382","type":"journal-article","created":{"date-parts":[[2012,10,25]],"date-time":"2012-10-25T00:40:41Z","timestamp":1351125641000},"source":"Crossref","is-referenced-by-count":57,"title":["Insulin-Like 3 Signaling Is Important for Testicular Descent but Dispensable for Spermatogenesis and Germ Cell Survival in Adult Mice1"],"prefix":"10.1093","volume":"87","author":[{"given":"Zaohua","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Rivas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander I.","family":"Agoulnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"key\n\t\t\t\t20170224051154_R01","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1053\/j.sempedsurg.2010.04.001","article-title":"Cryptorchidism","volume":"19","year":"2010","journal-title":"Semin Pediatr Surg"},{"issue":"(III\u2013X)","key":"key\n\t\t\t\t20170224051154_R02","first-page":"1","article-title":"The testicular descent in human. Origin, development and fate of the gubernaculum Hunteri, processus vaginalis peritonei, and gonadal ligaments","volume":"156","year":"2000","journal-title":"Adv Anat Embryol Cell Biol"},{"key":"key\n\t\t\t\t20170224051154_R03","first-page":"419","article-title":"A biphasic model for the hormonal control of testicular descent","volume":"2","year":"1985","journal-title":"Lancet"},{"issue":"(Pt 1)","key":"key\n\t\t\t\t20170224051154_R04","first-page":"97","article-title":"Towards a rational terminology in the study of the gubernaculum testis: arguments in support of the notion that the cremasteric sac should be considered the gubernaculum in postnatal rats and other mammals","volume":"189","year":"1996","journal-title":"J Anat"},{"key":"key\n\t\t\t\t20170224051154_R05","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.1365-2605.2004.00481.x","article-title":"Insulin-like 3 signalling in testicular descent","volume":"27","year":"2004","journal-title":"Int J Androl"},{"key":"key\n\t\t\t\t20170224051154_R06","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S1472-6483(10)60803-6","article-title":"INSL3\/LGR8 role in testicular descent and cryptorchidism","volume":"10","year":"2005","journal-title":"Reprod Biomed Online"},{"key":"key\n\t\t\t\t20170224051154_R07","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1002\/(SICI)1098-2795(199705)47:1<30::AID-MRD5>3.0.CO;2-R","article-title":"Mouse Leydig insulin-like (Ley I-L) gene: structure and expression during testis and ovary development","volume":"47","year":"1997","journal-title":"Mol Reprod Dev"},{"key":"key\n\t\t\t\t20170224051154_R08","doi-asserted-by":"crossref","first-page":"411","DOI":"10.2174\/156801305774322420","article-title":"Mouse mutants of relaxin, insulin-like 3 peptide and their receptors","volume":"5","year":"2005","journal-title":"Curr Med Chem Immunol Endocr Metab Agents"},{"key":"key\n\t\t\t\t20170224051154_R09","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1093\/hmg\/11.19.2309","article-title":"Mutations of the GREAT gene cause cryptorchidism","volume":"11","year":"2002","journal-title":"Hum Mol Genet"},{"key":"key\n\t\t\t\t20170224051154_R10","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/gene.1029","article-title":"A transgenic insertion causing cryptorchidism in mice","volume":"30","year":"2001","journal-title":"Genesis"},{"key":"key\n\t\t\t\t20170224051154_R11","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1210\/mend.13.5.0272","article-title":"Targeted disruption of the Insl3 gene causes bilateral cryptorchidism","volume":"13","year":"1999","journal-title":"Mol Endocrinol"},{"key":"key\n\t\t\t\t20170224051154_R12","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/10364","article-title":"Cryptorchidism in mice mutant for Insl3","volume":"22","year":"1999","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20170224051154_R13","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1210\/mend.16.2.0772","article-title":"The overexpression of the insl3 in female mice causes descent of the ovaries","volume":"16","year":"2002","journal-title":"Mol Endocrinol"},{"key":"key\n\t\t\t\t20170224051154_R14","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1095\/biolreprod.107.060442","article-title":"Developmental expression and gene regulation of insulin-like 3 receptor RXFP2 in mouse male reproductive organs","volume":"77","year":"2007","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224051154_R15","doi-asserted-by":"crossref","first-page":"7323","DOI":"10.1073\/pnas.0307061101","article-title":"Paracrine regulation of mammalian oocyte maturation and male germ cell survival","volume":"101","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170224051154_R16","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1477-7827-5-29","article-title":"Relaxin family peptide receptors Rxfp1 and Rxfp2: mapping of the mRNA and protein distribution in the reproductive tract of the male rat","volume":"5","year":"2007","journal-title":"Reprod Biol Endocrinol"},{"key":"key\n\t\t\t\t20170224051154_R17","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1095\/biolreprod.105.048165","article-title":"Expression of the insulin-like peptide 3 (INSL3) hormone-receptor (LGR8) system in the testis","volume":"74","year":"2006","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224051154_R18","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1016\/S0022-5347(05)64412-6","article-title":"Effects of orchiopexy on congenitally cryptorchid insulin-3 knockout mice","volume":"168","year":"2002","journal-title":"J Urol"},{"key":"key\n\t\t\t\t20170224051154_R19","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/1526-968X(200011\/12)28:3\/4<106::AID-GENE30>3.0.CO;2-T","article-title":"Widespread recombinase expression using FLPeR (flipper) mice","volume":"28","year":"2000","journal-title":"Genesis"},{"key":"key\n\t\t\t\t20170224051154_R20","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1242\/dev.01858","article-title":"Distinct and sequential tissue-specific activities of the LIM-class homeobox gene Lim1 for tubular morphogenesis during kidney development","volume":"132","year":"2005","journal-title":"Development"},{"key":"key\n\t\t\t\t20170224051154_R21","doi-asserted-by":"crossref","first-page":"e27","DOI":"10.1093\/nar\/27.19.e27","article-title":"Gene targeting restricted to mouse striated muscle lineage","volume":"27","year":"1999","journal-title":"Nucleic Acids Res"},{"key":"key\n\t\t\t\t20170224051154_R22","doi-asserted-by":"crossref","first-page":"7142","DOI":"10.1073\/pnas.102650499","article-title":"Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure","volume":"99","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170224051154_R23","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1002\/dvg.20437","article-title":"Cre recombinase activity specific to postnatal, premeiotic male germ cells in transgenic mice","volume":"46","year":"2008","journal-title":"Genesis"},{"key":"key\n\t\t\t\t20170224051154_R24","doi-asserted-by":"crossref","first-page":"4712","DOI":"10.1210\/en.2004-0515","article-title":"Genetic targeting of relaxin and insulin-like factor 3 receptors in mice","volume":"145","year":"2004","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224051154_R25","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1210\/me.2011-1283","article-title":"Cryptorchidism in mice with an androgen receptor ablation in gubernaculum testis","volume":"26","year":"2012","journal-title":"Mol Endocrinol"},{"key":"key\n\t\t\t\t20170224051154_R26","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1210\/me.2010-0330","article-title":"Suppression of insulin-like3 receptor reveals the role of beta-catenin and Notch signaling in gubernaculum development","volume":"25","year":"2011","journal-title":"Mol Endocrinol"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/biolreprod\/article-pdf\/87\/6\/143","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,24]],"date-time":"2017-08-24T06:58:49Z","timestamp":1503557929000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-lookup\/doi\/10.1095\/biolreprod.112.103382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,1]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,12,1]]}},"URL":"https:\/\/doi.org\/10.1095\/biolreprod.112.103382","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,1]]}}}