{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:44:20Z","timestamp":1790264660704,"version":"4.1.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,1,1]]},"DOI":"10.1095\/biolreprod.112.105460","type":"journal-article","created":{"date-parts":[[2012,12,14]],"date-time":"2012-12-14T01:49:21Z","timestamp":1355449761000},"source":"Crossref","is-referenced-by-count":42,"title":["Profiling Lgals9 Splice Variant Expression at the Fetal-Maternal Interface: Implications in Normal and Pathological Human Pregnancy1"],"prefix":"10.1093","volume":"88","author":[{"given":"Roy","family":"Heusschen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Freitag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Tirado-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Barrientos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Moschansky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Mu\u00f1oz-Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ester","family":"Leno-Dur\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burghard F.","family":"Klapp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor L.J.L.","family":"Thijssen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra M.","family":"Blois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"key\n\t\t\t\t20170224015534_R01","doi-asserted-by":"crossref","first-page":"6078","DOI":"10.1074\/jbc.272.9.6078","article-title":"Identification and characterization of galectin-9, a novel beta-galactoside-binding mammalian lectin","volume":"272","year":"1997","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170224015534_R02","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/nri2536","article-title":"Turning \u2018sweet' on immunity: galectin-glycan interactions in immune tolerance and inflammation","volume":"9","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"key\n\t\t\t\t20170224015534_R03","article-title":"Therapeutic potential of galectin-9 in human disease","year":"2013","journal-title":"Med Res Rev"},{"key":"key\n\t\t\t\t20170224015534_R04","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/nrc1527","article-title":"Galectins as modulators of tumor progression","volume":"5","year":"2005","journal-title":"Nat Rev Cancer"},{"key":"key\n\t\t\t\t20170224015534_R05","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1038\/ni1271","article-title":"The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity","volume":"6","year":"2005","journal-title":"Nat Immunol"},{"key":"key\n\t\t\t\t20170224015534_R06","doi-asserted-by":"crossref","first-page":"3631","DOI":"10.4049\/jimmunol.170.7.3631","article-title":"Galectin-9 induces apoptosis through the calcium-calpain-caspase-1 pathway","volume":"170","year":"2003","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170224015534_R07","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.clim.2009.04.012","article-title":"Stable form of galectin-9, a Tim-3 ligand, inhibits contact hypersensitivity and psoriatic reactions: a potent therapeutic tool for Th1- and\/or Th17-mediated skin inflammation","volume":"132","year":"2009","journal-title":"Clin Immunol"},{"key":"key\n\t\t\t\t20170224015534_R08","doi-asserted-by":"crossref","first-page":"2974","DOI":"10.4049\/jimmunol.175.5.2974","article-title":"Galectin-9 induces maturation of human monocyte-derived dendritic cells","volume":"175","year":"2005","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170224015534_R09","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.trim.2008.01.008","article-title":"Activation of Tim-3-Galectin-9 pathway improves survival of fully allogeneic skin grafts","volume":"19","year":"2008","journal-title":"Transpl Immunol"},{"key":"key\n\t\t\t\t20170224015534_R10","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.clim.2008.01.006","article-title":"Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis","volume":"127","year":"2008","journal-title":"Clin Immunol"},{"key":"key\n\t\t\t\t20170224015534_R11","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1038\/nm1680","article-title":"A pivotal role for galectin-1 in fetomaternal tolerance","volume":"13","year":"2007","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t20170224015534_R12","doi-asserted-by":"crossref","first-page":"6170","DOI":"10.1210\/jc.2004-2529","article-title":"Galectin-9: a new endometrial epithelial marker for the mid- and late-secretory and decidual phases in humans","volume":"90","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20170224015534_R13","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1507\/endocrj.K08E-111","article-title":"Expression and localization of galectin-9 in the human uterodome","volume":"55","year":"2008","journal-title":"Endocr J"},{"key":"key\n\t\t\t\t20170224015534_R14","doi-asserted-by":"crossref","first-page":"545","DOI":"10.2353\/ajpath.2008.070938","article-title":"The galectin profile of the endothelium: altered expression and localization in activated and tumor endothelial cells","volume":"172","year":"2008","journal-title":"Am J Pathol"},{"key":"key\n\t\t\t\t20170224015534_R15","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.placenta.2011.12.016","article-title":"Galectin fingerprinting detects differences in expression profiles between bovine endometrium and placentomes as well as early and late gestational stages","volume":"33","year":"2012","journal-title":"Placenta"},{"key":"key\n\t\t\t\t20170224015534_R16","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S0300-9084(01)01335-9","article-title":"Molecular and functional characterization of galectin 9 mRNA isoforms in porcine and human cells and tissues","volume":"83","year":"2001","journal-title":"Biochimie"},{"key":"key\n\t\t\t\t20170224015534_R17","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1093\/glycob\/12.2.111","article-title":"Regulation of galectin-9 expression and release in Jurkat T cell line cells","volume":"12","year":"2002","journal-title":"Glycobiology"},{"key":"key\n\t\t\t\t20170224015534_R18","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1007\/s11033-008-9251-2","article-title":"Different roles of galectin-9 isoforms in modulating E-selectin expression and adhesion function in LoVo colon carcinoma cells","volume":"36","year":"2009","journal-title":"Mol Biol Rep"},{"key":"key\n\t\t\t\t20170224015534_R19","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1600-0897.1993.tb00579.x","article-title":"Stress-triggered abortion in mice prevented by alloimmunization","volume":"29","year":"1993","journal-title":"Am J Reprod Immunol"},{"key":"key\n\t\t\t\t20170224015534_R20","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1600-0897.1999.tb00071.x","article-title":"Why did your mother reject you? Immunogenetic determinants of the response to environmental selective pressure expressed at the uterine level","volume":"41","year":"1999","journal-title":"Am J Reprod Immunol"},{"key":"key\n\t\t\t\t20170224015534_R21","doi-asserted-by":"crossref","first-page":"4562","DOI":"10.4049\/jimmunol.151.9.4562","article-title":"Synthesis of T helper 2-type cytokines at the maternal-fetal interface","volume":"151","year":"1993","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170224015534_R22","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1038\/2006","article-title":"Defective production of both leukemia inhibitory factor and type 2 T-helper cytokines by decidual T cells in unexplained recurrent abortions","volume":"4","year":"1998","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t20170224015534_R23","doi-asserted-by":"crossref","first-page":"5893","DOI":"10.4049\/jimmunol.172.10.5893","article-title":"Depletion of CD8+ cells abolishes the pregnancy protective effect of progesterone substitution with dydrogesterone in mice by altering the Th1\/Th2 cytokine profile","volume":"172","year":"2004","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170224015534_R24","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1034\/j.1600-0897.2003.00045.x","article-title":"MD-1 is a critical part of the mechanism causing Th1-cytokine-triggered murine fetal loss syndrome","volume":"49","year":"2003","journal-title":"Am J Reprod Immunol"},{"key":"key\n\t\t\t\t20170224015534_R25","doi-asserted-by":"crossref","first-page":"15C","DOI":"10.1093\/glycob\/cwl028","article-title":"Galectin-8 and galectin-9 are novel substrates for thrombin","volume":"16","year":"2006","journal-title":"Glycobiology"},{"issue":"(suppl 1)","key":"key\n\t\t\t\t20170224015534_R26","first-page":"95","article-title":"Involvement of galectin-9 in guinea pig allergic airway inflammation","volume":"143","year":"2007","journal-title":"Int Arch Allergy Immunol"},{"key":"key\n\t\t\t\t20170224015534_R27","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.molimm.2010.11.011","article-title":"The N- and C-terminal carbohydrate recognition domains of galectin-9 contribute differently to its multiple functions in innate immunity and adaptive immunity","volume":"48","year":"2011","journal-title":"Mol Immunol"},{"key":"key\n\t\t\t\t20170224015534_R28","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1210\/er.2003-0020","article-title":"Molecular cues to implantation","volume":"25","year":"2004","journal-title":"Endocr Rev"},{"key":"key\n\t\t\t\t20170224015534_R29","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.clim.2011.11.006","article-title":"Galectin-9 signaling prolongs survival in murine lung-cancer by inducing macrophages to differentiate into plasmacytoid dendritic cell-like macrophages","volume":"142","year":"2012","journal-title":"Clin Immunol"},{"key":"key\n\t\t\t\t20170224015534_R30","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1093\/glycob\/cwn062","article-title":"Galectin-9 suppresses tumor metastasis by blocking adhesion to endothelium and extracellular matrices","volume":"18","year":"2008","journal-title":"Glycobiology"},{"key":"key\n\t\t\t\t20170224015534_R31","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1002\/ijc.10436","article-title":"Possible role of galectin-9 in cell aggregation and apoptosis of human melanoma cell lines and its clinical significance","volume":"99","year":"2002","journal-title":"Int J Cancer"},{"key":"key\n\t\t\t\t20170224015534_R32","doi-asserted-by":"crossref","first-page":"S196","DOI":"10.1111\/j.1075-122X.2006.00334.x","article-title":"Galectin-9, a novel prognostic factor with antimetastatic potential in breast cancer","volume":"12","year":"2006","journal-title":"Breast J"},{"key":"key\n\t\t\t\t20170224015534_R33","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1095\/biolreprod52.4.885","article-title":"Expression of collagen alpha 1(VI), alpha 2(VI), and alpha 3(VI) chains in the pregnant mouse uterus","volume":"52","year":"1995","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224015534_R34","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1095\/biolreprod56.1.169","article-title":"Absence of natural killer cells during murine pregnancy is associated with reproductive compromise in TgE26 mice","volume":"56","year":"1997","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224015534_R35","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1006\/dbio.2002.0773","article-title":"Interactions between trophoblast cells and the maternal and fetal circulation in the mouse placenta","volume":"250","year":"2002","journal-title":"Dev Biol"},{"key":"key\n\t\t\t\t20170224015534_R36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/cmi.2010.38","article-title":"Natural killer cell-triggered vascular transformation: maternal care before birth?","volume":"8","year":"2011","journal-title":"Cell Mol Immunol"},{"key":"key\n\t\t\t\t20170224015534_R37","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1084\/jem.20061022","article-title":"Complement activation induces dysregulation of angiogenic factors and causes fetal rejection and growth restriction","volume":"203","year":"2006","journal-title":"J Exp Med"},{"key":"key\n\t\t\t\t20170224015534_R38","first-page":"491","article-title":"Galectin 9 is the sugar-regulated urate transporter\/channel UAT","volume":"19","year":"2004","journal-title":"Glycoconj J"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/biolreprod\/article-pdf\/88\/1\/22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T20:25:13Z","timestamp":1687897513000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-lookup\/doi\/10.1095\/biolreprod.112.105460"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,1]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1,1]]}},"URL":"https:\/\/doi.org\/10.1095\/biolreprod.112.105460","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,1]]}}}