{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:17:53Z","timestamp":1790803073677,"version":"4.1.0"},"reference-count":81,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,7,1]]},"DOI":"10.1095\/biolreprod.113.110056","type":"journal-article","created":{"date-parts":[[2013,6,6]],"date-time":"2013-06-06T00:59:39Z","timestamp":1370480379000},"source":"Crossref","is-referenced-by-count":79,"title":["NOD1 and NOD2 Regulate Proinflammatory and Prolabor Mediators in Human Fetal Membranes and Myometrium via Nuclear Factor-Kappa B1"],"prefix":"10.1093","volume":"89","author":[{"given":"Martha","family":"Lappas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"issue":"(4)","key":"key\n\t\t\t\t20170224025524_R01","first-page":"1566","article-title":"The contribution of preterm birth to infant mortality rates in the United States","volume":"118","year":"2006","journal-title":"Pediatrics"},{"issue":"(9608)","key":"key\n\t\t\t\t20170224025524_R02","first-page":"261","article-title":"An overview of mortality and sequelae of preterm birth from infancy to adulthood","volume":"371","year":"2008","journal-title":"Lancet"},{"issue":"(1)","key":"key\n\t\t\t\t20170224025524_R03","first-page":"9","article-title":"Neurologic and developmental disability at six years of age after extremely preterm birth","volume":"352","year":"2005","journal-title":"N Engl J Med"},{"issue":"(5)","key":"key\n\t\t\t\t20170224025524_R04","first-page":"e1109","article-title":"Group ftPPIS. Impact of very preterm birth on health care costs at five years of age","volume":"125","year":"2010","journal-title":"Pediatrics"},{"issue":"(1)","key":"key\n\t\t\t\t20170224025524_R05","first-page":"6","article-title":"Measuring economic consequences of preterm birth\u2014methodological recommendations for the evaluation of personal burden on children and their caregivers","volume":"1","year":"2011","journal-title":"Health Econ Rev"},{"issue":"(3)","key":"key\n\t\t\t\t20170224025524_R06","first-page":"467","article-title":"Infection and the role of inflammation in preterm premature rupture of the membranes","volume":"21","year":"2007","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"key\n\t\t\t\t20170224025524_R07","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1159\/000061023","article-title":"Cytokines and the initiation of parturition","volume":"27","year":"2001","journal-title":"Front Horm Res"},{"issue":"(2)","key":"key\n\t\t\t\t20170224025524_R08","first-page":"87","article-title":"Phospholipase A2 isozymes in pregnancy and parturition","volume":"70","year":"2004","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"issue":"(4)","key":"key\n\t\t\t\t20170224025524_R09","first-page":"257","article-title":"Cytokines of the placenta and extra-placental membranes: roles and regulation during human pregnancy and parturition","volume":"23","year":"2002","journal-title":"Placenta"},{"issue":"(1)","key":"key\n\t\t\t\t20170224025524_R10","first-page":"50","article-title":"Inflammatory processes in preterm and term parturition","volume":"79","year":"2008","journal-title":"J Reprod Immunol"},{"issue":"(5)","key":"key\n\t\t\t\t20170224025524_R11","first-page":"717","article-title":"The role of prostaglandins in the initiation of parturition","volume":"17","year":"2003","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"issue":"(1)","key":"key\n\t\t\t\t20170224025524_R12","first-page":"77","article-title":"Cellular turnover and extracellular matrix remodeling in female reproductive tissues: functions of metalloproteinases and their inhibitors","volume":"57","year":"2000","journal-title":"Cell Mol Life Sci"},{"issue":"(5\u20136)","key":"key\n\t\t\t\t20170224025524_R13","first-page":"543","article-title":"The role and regulation of the nuclear factor kappa B signalling pathway in human labour","volume":"28","year":"2007","journal-title":"Placenta"},{"issue":"(suppl A)","key":"key\n\t\t\t\t20170224025524_R14","first-page":"S90","article-title":"Transcriptional regulation of the processes of human labour and delivery","volume":"30","year":"2009","journal-title":"Placenta"},{"issue":"(5)","key":"key\n\t\t\t\t20170224025524_R15","first-page":"569","article-title":"The role of nuclear factor kappa B in human labour","volume":"130","year":"2005","journal-title":"Reproduction"},{"issue":"(1)","key":"key\n\t\t\t\t20170224025524_R16","first-page":"106","article-title":"Function of Nod-like receptors in microbial recognition and host defense","volume":"227","year":"2009","journal-title":"Immunol Rev"},{"issue":"(7)","key":"key\n\t\t\t\t20170224025524_R17","first-page":"702","article-title":"An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid","volume":"4","year":"2003","journal-title":"Nat Immunol"},{"issue":"(11)","key":"key\n\t\t\t\t20170224025524_R18","first-page":"8869","article-title":"Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection","volume":"278","year":"2003","journal-title":"J Bioll Chem"},{"issue":"(7)","key":"key\n\t\t\t\t20170224025524_R19","first-page":"4812","article-title":"Nod2, a Nod1\/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB","volume":"276","year":"2001","journal-title":"J Biol Chem"},{"issue":"(5625)","key":"key\n\t\t\t\t20170224025524_R20","first-page":"1584","article-title":"Nod1 detects a unique muropeptide from Gram-negative bacterial peptidoglycan","volume":"300","year":"2003","journal-title":"Science"},{"issue":"(1)","key":"key\n\t\t\t\t20170224025524_R21","first-page":"1","article-title":"Intracellular NOD-like receptors in innate immunity, infection and disease","volume":"10","year":"2008","journal-title":"Cell Microbiol"},{"issue":"(pt 6)","key":"key\n\t\t\t\t20170224025524_R22","first-page":"1479","article-title":"Nod1 and Nod2 in innate immunity and human inflammatory disorders","volume":"35","year":"2007","journal-title":"Biochem Soc Trans"},{"issue":"(12)","key":"key\n\t\t\t\t20170224025524_R23","first-page":"1250","article-title":"Nod-like proteins in immunity, inflammation and disease","volume":"7","year":"2006","journal-title":"Nat Immunol"},{"issue":"(5)","key":"key\n\t\t\t\t20170224025524_R24","first-page":"371","article-title":"NODs: Intracellular proteins involved in inflammation and apoptosis","volume":"3","year":"2003","journal-title":"Nat Rev Immunol"},{"issue":"(1)","key":"key\n\t\t\t\t20170224025524_R25","first-page":"9","article-title":"Signalling pathways and molecular interactions of NOD1 and NOD2","volume":"6","year":"2006","journal-title":"Nat Rev Immunol"},{"issue":"(6)","key":"key\n\t\t\t\t20170224025524_R26","first-page":"1047","article-title":"Stimulation of the cytosolic receptor for peptidoglycan, Nod1, by infection with Chlamydia trachomatis or Chlamydia muridarum","volume":"8","year":"2006","journal-title":"Cell Microbiol"},{"issue":"(3)","key":"key\n\t\t\t\t20170224025524_R27","first-page":"1487","article-title":"Nod1 is an essential signal transducer in intestinal epithelial cells infected with bacteria that avoid recognition by Toll-like receptors","volume":"72","year":"2004","journal-title":"Infect Immun"},{"issue":"(44)","key":"key\n\t\t\t\t20170224025524_R28","first-page":"36714","article-title":"Nod1 participates in the innate immune response to Pseudomonas aeruginosa","volume":"280","year":"2005","journal-title":"J Biol Chem"},{"issue":"(7)","key":"key\n\t\t\t\t20170224025524_R29","first-page":"3150","article-title":"The cytosolic pattern recognition receptor NOD1 induces inflammatory interleukin-8 during Chlamydia trachomatis infection","volume":"76","year":"2008","journal-title":"Infect Immun"},{"issue":"(9)","key":"key\n\t\t\t\t20170224025524_R30","first-page":"2499","article-title":"Nod1 and Nod2 induce CCL5\/RANTES through the NF-kappaB pathway","volume":"37","year":"2007","journal-title":"Eur J Immunol"},{"issue":"(1)","key":"key\n\t\t\t\t20170224025524_R31","first-page":"203","article-title":"Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo","volume":"203","year":"2006","journal-title":"J Exp Med"},{"issue":"(8)","key":"key\n\t\t\t\t20170224025524_R32","first-page":"762","article-title":"Roles of TLR2, TLR4, Nod2, and Nod1 in pulp dibroblasts","volume":"88","year":"2009","journal-title":"J Dent Res"},{"issue":"(12)","key":"key\n\t\t\t\t20170224025524_R33","first-page":"1351","article-title":"Activation of Nod1 and Nod2 induces innate immune responses of prostate epithelial cells","volume":"72","year":"2012","journal-title":"Prostate"},{"issue":"(5)","key":"key\n\t\t\t\t20170224025524_R34","first-page":"717","article-title":"Dual roles of NOD2 in TLR4-mediated signal transduction and -induced inflammatory gene expression in macrophages","volume":"13","year":"2011","journal-title":"Cell Microbiol"},{"issue":"(2)","key":"key\n\t\t\t\t20170224025524_R35","first-page":"355","article-title":"regulation, and signaling of the pattern-recognition receptor nucleotide-binding oligomerization domain 2 in rheumatoid arthritis synovial fibroblasts","volume":"60","year":"2009","journal-title":"Arthritis Rheum"},{"issue":"(2)","key":"key\n\t\t\t\t20170224025524_R36","first-page":"135","article-title":"The inflammasomes in health and disease: from genetics to molecular mechanisms of autoinflammation and beyond","volume":"8","year":"2011","journal-title":"Cell Mol Immunol"},{"key":"key\n\t\t\t\t20170224025524_R37","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1146\/annurev-cellbio-101011-155745","article-title":"Inflammasomes and their roles in health and disease","volume":"28","year":"2012","journal-title":"Annu Rev Cell Dev Biol"},{"issue":"(3)","key":"key\n\t\t\t\t20170224025524_R38","first-page":"471","article-title":"Nod-like receptors in intestinal homeostasis, inflammation, and cancer","volume":"90","year":"2011","journal-title":"J Leukoc Biol"},{"issue":"(4)","key":"key\n\t\t\t\t20170224025524_R39","first-page":"343","article-title":"Inflammasomes in carcinogenesis and anticancer immune responses","volume":"13","year":"2012","journal-title":"Nat Immunol"},{"issue":"(1)","key":"key\n\t\t\t\t20170224025524_R40","first-page":"67","article-title":"NOD protein expression and function in first trimester trophoblast cells","volume":"57","year":"2007","journal-title":"Am J Reprod Immunol"},{"issue":"(4)","key":"key\n\t\t\t\t20170224025524_R41","first-page":"294","article-title":"Regulation of Nod1 and Nod2 in first trimester trophoblast cells","volume":"61","year":"2009","journal-title":"Am J Reprod Immunol"},{"issue":"(2)","key":"key\n\t\t\t\t20170224025524_R42","first-page":"980","article-title":"Nod1 activation by bacterial iE-DAP induces maternal-fetal inflammation and preterm labor","volume":"187","year":"2011","journal-title":"J Immunol"},{"issue":"(2)","key":"key\n\t\t\t\t20170224025524_R43","first-page":"235","article-title":"Nod1, but not the ASC inflammasome, contributes to induction of IL-1beta secretion in human trophoblasts after sensing of Chlamydia trachomatis","volume":"6","year":"2013","journal-title":"Mucosal Immunol"},{"issue":"(1)","key":"key\n\t\t\t\t20170224025524_R44","first-page":"17","article-title":"SIRT6 is decreased with preterm labor and regulates key terminal effector pathways of human labor in fetal membranes","volume":"88","year":"2013","journal-title":"Biol Reprod"},{"issue":"(2)","key":"key\n\t\t\t\t20170224025524_R45","first-page":"176","article-title":"Peroxisome proliferator-activated receptors and retinoid X receptor-alpha in term human gestational tissues: tissue specific and labour-associated changes","volume":"30","year":"2009","journal-title":"Placenta"},{"issue":"(8\u20139)","key":"key\n\t\t\t\t20170224025524_R46","first-page":"936","article-title":"Mitogen-activated protein kinase proteins regulate LPS-stimulated release of pro-inflammatory cytokines and prostaglandins from human gestational tissues","volume":"28","year":"2007","journal-title":"Placenta"},{"issue":"(7)","key":"key\n\t\t\t\t20170224025524_R47","first-page":"354","article-title":"Nuclear factor-kappaB mediates placental growth factor induced pro-labour mediators in human placenta","volume":"18","year":"2012","journal-title":"Mol Hum Reprod"},{"issue":"(35)","key":"key\n\t\t\t\t20170224025524_R48","first-page":"23818","article-title":"Girardin SE. pH-dependent internalization of muramyl peptides from early endosomes enables Nod1 and Nod2 signaling","volume":"284","year":"2009","journal-title":"J Biol Chem"},{"issue":"(3)","key":"key\n\t\t\t\t20170224025524_R49","first-page":"448","article-title":"Distinct intracellular signaling pathways control the synthesis of IL-8 and RANTES in TLR1\/TLR2, TLR3 or NOD1 activated human airway epithelial cells","volume":"21","year":"2009","journal-title":"Cell Signal"},{"key":"key\n\t\t\t\t20170224025524_R50","article-title":"Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium","year":"2013","journal-title":"Mol Hum Reprod"},{"issue":"(1)","key":"key\n\t\t\t\t20170224025524_R51","first-page":"52","article-title":"Human labour is associated with decreased cytoplasmic FoxO4","volume":"33","year":"2012","journal-title":"Placenta"},{"key":"key\n\t\t\t\t20170224025524_R52","article-title":"Apelin is decreased with human preterm and term labor and regulates prolabor mediators in human primary amnion cells","year":"2013","journal-title":"Reprod Sci"},{"issue":"(11\u201312)","key":"key\n\t\t\t\t20170224025524_R53","first-page":"1060","article-title":"15-Deoxy-Delta(12,14)-prostaglandin J(2) and troglitazone regulation of the release of phospholipid metabolites, inflammatory cytokines and proteases from human gestational tissues","volume":"27","year":"2006","journal-title":"Placenta"},{"issue":"(1)","key":"key\n\t\t\t\t20170224025524_R54","first-page":"195","article-title":"Stretch and interleukin 1 beta: pro-labour factors with similar mitogen-activated protein kinase effects but differential patterns of transcription factor activation and gene expression","volume":"212","year":"2007","journal-title":"J Cell Physiol"},{"issue":"(6)","key":"key\n\t\t\t\t20170224025524_R55","first-page":"3517","article-title":"The mitogen-activated protein kinase dependent expression of prostaglandin H synthase-2 and interleukin-8 messenger ribonucleic acid by myometrial cells: the differential effect of stretch and interleukin-1{beta}","volume":"90","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"issue":"(4)","key":"key\n\t\t\t\t20170224025524_R56","first-page":"549","article-title":"Intracellular NOD-like receptors in host defense and disease","volume":"27","year":"2007","journal-title":"Immunity"},{"issue":"(2)","key":"key\n\t\t\t\t20170224025524_R57","first-page":"269","article-title":"Advanced glycation endproducts mediate pro-inflammatory actions in human gestational tissues via nuclear factor-kappaB and extracellular signal-regulated kinase 1\/2","volume":"193","year":"2007","journal-title":"J Endocrinol"},{"issue":"(12)","key":"key\n\t\t\t\t20170224025524_R58","first-page":"1016","article-title":"and AP-1 proteins are increased in term pre-labour fetal membranes overlying the cervix: regulation of enzymes involved in the degradation of fetal membranes","volume":"32","year":"2011","journal-title":"Placenta"},{"issue":"(9606)","key":"key\n\t\t\t\t20170224025524_R59","first-page":"75","article-title":"Epidemiology and causes of preterm birth","volume":"371","year":"2008","journal-title":"Lancet"},{"issue":"(2)","key":"key\n\t\t\t\t20170224025524_R60","first-page":"85","article-title":"Recognition of pathogen-associated molecular patterns by TLR family","volume":"85","year":"2003","journal-title":"Immunol Lett"},{"issue":"(3)","key":"key\n\t\t\t\t20170224025524_R61","first-page":"319","article-title":"Nod1-mediated endothelial cell activation by Chlamydophila pneumoniae","volume":"96","year":"2005","journal-title":"Circ Res"},{"issue":"(44)","key":"key\n\t\t\t\t20170224025524_R62","first-page":"41701","article-title":"Induction of Nod2 in myelomonocytic and intestinal epithelial cells via nuclear factor-kappa B activation","volume":"277","year":"2002","journal-title":"J Biol Chem"},{"issue":"(4)","key":"key\n\t\t\t\t20170224025524_R63","first-page":"1001","article-title":"TNF-alpha and IFN-gamma regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells","volume":"124","year":"2003","journal-title":"Gastroenterology"},{"issue":"(4 pt 1)","key":"key\n\t\t\t\t20170224025524_R64","first-page":"969","article-title":"Systemic administration of interleukin-1 induces preterm parturition in mice","volume":"165","year":"1991","journal-title":"Am J Obstet Gynecol"},{"issue":"(6)","key":"key\n\t\t\t\t20170224025524_R65","first-page":"1578","article-title":"Preterm labor is induced by intraamniotic infusions of interleukin-1beta and tumor necrosis factor-alpha but not by interleukin-6 or interleukin-8 in a nonhuman primate model","volume":"195","year":"2006","journal-title":"Am J Obstet Gynecol"},{"issue":"(4 pt 1)","key":"key\n\t\t\t\t20170224025524_R66","first-page":"1041","article-title":"The natural interleukin-1 receptor antagonist prevents interleukin-1-induced preterm delivery in mice","volume":"167","year":"1992","journal-title":"Am J Obstet Gynecol"},{"issue":"(5)","key":"key\n\t\t\t\t20170224025524_R67","first-page":"471","article-title":"Up-regulation of NOD1 and NOD2 through TLR4 and TNF-alpha in LPS-treated murine macrophages","volume":"68","year":"2006","journal-title":"J Vet Med Sci"},{"issue":"(1)","key":"key\n\t\t\t\t20170224025524_R68","first-page":"229","article-title":"Leukocytes infiltrate the myometrium during human parturition: further evidence that labour is an inflammatory process","volume":"14","year":"1999","journal-title":"Hum Reprod"},{"issue":"(7)","key":"key\n\t\t\t\t20170224025524_R69","first-page":"841","article-title":"Intrauterine inflammation at term: a histopathologic study","volume":"31","year":"2000","journal-title":"Hum Pathol"},{"issue":"(5)","key":"key\n\t\t\t\t20170224025524_R70","first-page":"317","article-title":"Inflammation in preterm and term labour and delivery","volume":"11","year":"2006","journal-title":"Semin Fetal Neonatal Med"},{"issue":"(suppl A)","key":"key\n\t\t\t\t20170224025524_R71","first-page":"S33","article-title":"Cytokines, prostaglandins and parturition\u2014a review","volume":"24","year":"2003","journal-title":"Placenta"},{"key":"key\n\t\t\t\t20170224025524_R72","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1159\/000061023","article-title":"Cytokines and the initiation of parturition","volume":"27","year":"2001","journal-title":"Front Horm Res"},{"issue":"(3)","key":"key\n\t\t\t\t20170224025524_R73","first-page":"262","article-title":"Long-term medical and social consequences of preterm birth","volume":"359","year":"2008","journal-title":"N Engl J Med"},{"issue":"(36)","key":"key\n\t\t\t\t20170224025524_R74","first-page":"27823","article-title":"An induced proximity model for NF-kappa B activation in the Nod1\/RICK and RIP signaling pathways","volume":"275","year":"2000","journal-title":"J Biol Chem"},{"issue":"(21)","key":"key\n\t\t\t\t20170224025524_R75","first-page":"14560","article-title":"Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB","volume":"274","year":"1999","journal-title":"J Biol Chem"},{"issue":"(4)","key":"key\n\t\t\t\t20170224025524_R76","first-page":"693","article-title":"Hepatocytes express functional NOD1 and NOD2 receptors: a role for NOD1 in hepatocyte CC and CXC chemokine production","volume":"53","year":"2010","journal-title":"J Hepatol"},{"issue":"(2)","key":"key\n\t\t\t\t20170224025524_R77","first-page":"668","article-title":"Nuclear factor kappa B regulation of proinflammatory cytokines in human gestational tissues in vitro","volume":"67","year":"2002","journal-title":"Biol Reprod"},{"issue":"(5)","key":"key\n\t\t\t\t20170224025524_R78","first-page":"2365","article-title":"Regulation of phospholipase isozymes by nuclear factor-kappaB in human gestational tissues in vitro","volume":"89","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"issue":"(4)","key":"key\n\t\t\t\t20170224025524_R79","first-page":"1723","article-title":"N-acetyl-cysteine inhibits phospholipid metabolism, proinflammatory cytokine release, protease activity, and nuclear factor-kappaB deoxyribonucleic acid-binding activity in human fetal membranes in vitro","volume":"88","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"issue":"(6877)","key":"key\n\t\t\t\t20170224025524_R80","first-page":"194","article-title":"RICK\/Rip2\/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems","volume":"416","year":"2002","journal-title":"Nature"},{"issue":"(4)","key":"key\n\t\t\t\t20170224025524_R81","first-page":"2380","article-title":"RICK\/RIP2 mediates innate immune responses induced through Nod1 and Nod2 but not TLRs","volume":"178","year":"2007","journal-title":"J Immunol"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/biolreprod\/article-pdf\/89\/1\/14","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,14]],"date-time":"2019-07-14T15:57:46Z","timestamp":1563119866000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-lookup\/doi\/10.1095\/biolreprod.113.110056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,1]]},"references-count":81,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,7,1]]}},"URL":"https:\/\/doi.org\/10.1095\/biolreprod.113.110056","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718070398.793481917","asserted-by":"object"}]},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,1]]}}}