{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:50:14Z","timestamp":1790016614490,"version":"4.0.1"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,12,1]]},"DOI":"10.1095\/biolreprod.115.131664","type":"journal-article","created":{"date-parts":[[2015,10,29]],"date-time":"2015-10-29T03:34:57Z","timestamp":1446089697000},"source":"Crossref","is-referenced-by-count":35,"title":["Anti-M\u00fcllerian Hormone Is Required for Chicken Embryonic Urogenital System Growth but Not Sexual Differentiation1"],"prefix":"10.1093","volume":"93","author":[{"given":"Luke S.","family":"Lambeth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Ayers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Cutting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J.","family":"Doran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew H.","family":"Sinclair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig A.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"key\n\t\t\t\t20170224011152_CIT0001","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1152\/physrev.1986.66.4.1038","article-title":"Anti-Mullerian hormone","volume":"66","year":"1986","journal-title":"Physiol Rev"},{"key":"key\n\t\t\t\t20170224011152_CIT0002","first-page":"1","article-title":"Anti-M\u00fcllerian hormone: the Jost factor","volume":"48","year":"1993","journal-title":"Recent Prog Horm Res"},{"key":"key\n\t\t\t\t20170224011152_CIT0003","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1530\/jrf.0.0690207","article-title":"Mesnil du Buisson du F, Heyman Y, Josso N. Use of monoclonal antibody techniques to study the ontogeny of bovine anti-M\u00fcllerian hormone","volume":"69","year":"1983","journal-title":"J Reprod Fertil"},{"key":"key\n\t\t\t\t20170224011152_CIT0004","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0303-7207(01)00467-1","article-title":"Anti-M\u00fcllerian hormone and its receptors","volume":"179","year":"2001","journal-title":"Mol Cell Endocrinol"},{"key":"key\n\t\t\t\t20170224011152_CIT0005","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1242\/dev.113.2.613","article-title":"Expression of the mouse anti-m\u00fcllerian hormone gene suggests a role in both male and female sexual differentiation","volume":"113","year":"1991","journal-title":"Development"},{"key":"key\n\t\t\t\t20170224011152_CIT0006","doi-asserted-by":"crossref","first-page":"6653","DOI":"10.1128\/MCB.18.11.6653","article-title":"Direct interaction of SRY-related protein SOX9 and steroidogenic factor 1 regulates transcription of the human anti-M\u00fcllerian hormone gene","volume":"18","year":"1998","journal-title":"Mol Cell Biol"},{"key":"key\n\t\t\t\t20170224011152_CIT0007","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1242\/dev.124.9.1799","article-title":"The nuclear receptor SF-1 mediates sexually dimorphic expression of Mullerian inhibiting substance, in vivo","volume":"124","year":"1997","journal-title":"Development"},{"key":"key\n\t\t\t\t20170224011152_CIT0008","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0092-8674(00)81527-5","article-title":"Targeted mutagenesis of the endogenous mouse Mis gene promoter: in vivo definition of genetic pathways of vertebrate sexual development","volume":"99","year":"1999","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170224011152_CIT0009","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0092-8674(00)81172-1","article-title":"Wilms' tumor 1 and Dax-1 modulate the orphan nuclear receptor SF-1 in sex-specific gene expression","volume":"93","year":"1998","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170224011152_CIT0010","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1095\/biolreprod.107.061879","article-title":"Expression and regulation of anti-mullerian hormone in an oviparous species, the hen","volume":"78","year":"2008","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224011152_CIT0011","first-page":"1","article-title":"Regulation of anti-M\u00fcllerian hormone production in domestic animals","volume":"25","year":"2012","journal-title":"Reprod Fertil Dev"},{"key":"key\n\t\t\t\t20170224011152_CIT0012","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/0092-8674(94)90050-7","article-title":"Nuclear receptor steroidogenic factor 1 regulates the m\u00fcllerian inhibiting substance gene: a link to the sex determination cascade","volume":"77","year":"1994","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170224011152_CIT0013","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1242\/dev.125.14.2665","article-title":"Transcription factor GATA-4 is expressed in a sexually dimorphic pattern during mouse gonadal development and is a potent activator of the M\u00fcllerian inhibiting substance promoter","volume":"125","year":"1998","journal-title":"Development"},{"key":"key\n\t\t\t\t20170224011152_CIT0014","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1159\/000334854","article-title":"Abdel Hamid MS, El-Gammal M, Aref A, Amr K. AMH gene mutations in two Egyptian families with persistent m\u00fcllerian duct syndrome","volume":"5","year":"2011","journal-title":"Sex Dev"},{"key":"key\n\t\t\t\t20170224011152_CIT0015","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1093\/humupd\/dmi014","article-title":"and AMH receptor defects in persistent M\u00fcllerian duct syndrome","volume":"11","year":"2005","journal-title":"Hum Reprod Update"},{"key":"key\n\t\t\t\t20170224011152_CIT0016","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/0092-8674(94)90251-8","article-title":"M\u00fcllerian-inhibiting substance function during mammalian sexual development","volume":"79","year":"1994","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170224011152_CIT0017","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/345167a0","article-title":"Abnormal sexual development in transgenic mice chronically expressing m\u00fcllerian inhibiting substance","volume":"345","year":"1990","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170224011152_CIT0018","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/dvdy.10153","article-title":"Different patterns of anti-Mullerian hormone expression, as related to DMRT1, SF-1, WT1, GATA-4, Wnt-4, and Lhx9 expression, in the chick differentiating gonads","volume":"225","year":"2002","journal-title":"Dev Dyn"},{"key":"key\n\t\t\t\t20170224011152_CIT0019","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1002\/(SICI)1097-0177(199808)212:4<522::AID-AJA5>3.0.CO;2-J","article-title":"Early expression of AMH in chicken embryonic gonads precedes testicular SOX9 expression","volume":"212","year":"1998","journal-title":"Dev Dyn"},{"key":"key\n\t\t\t\t20170224011152_CIT0020","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0378-1119(99)00179-1","article-title":"Gene expression during gonadogenesis in the chicken embryo","volume":"234","year":"1999","journal-title":"Gene"},{"key":"key\n\t\t\t\t20170224011152_CIT0021","doi-asserted-by":"crossref","first-page":"2955","DOI":"10.1073\/pnas.1018392109","article-title":"Y-linked anti-Mullerian hormone duplication takes over a critical role in sex determination","volume":"109","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170224011152_CIT0022","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1242\/dev.076307","article-title":"Hyperproliferation of mitotically active germ cells due to defective anti-Mullerian hormone signaling mediates sex reversal in medaka","volume":"139","year":"2012","journal-title":"Development"},{"key":"key\n\t\t\t\t20170224011152_CIT0023","doi-asserted-by":"crossref","first-page":"9691","DOI":"10.1073\/pnas.0611379104","article-title":"The hotei mutation of medaka in the anti-Mullerian hormone receptor causes the dysregulation of germ cell and sexual development","volume":"104","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170224011152_CIT0024","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1530\/jrf.0.0700473","article-title":"Origin of anti-M\u00fcllerian hormone in bovine freemartin fetuses","volume":"70","year":"1984","journal-title":"J Reprod Fertil"},{"key":"key\n\t\t\t\t20170224011152_CIT0025","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1242\/dev.100.1.43","article-title":"Purified bovine AMH induces a characteristic freemartin effect in fetal rat prospective ovaries exposed to it in vitro","volume":"100","year":"1987","journal-title":"Development"},{"key":"key\n\t\t\t\t20170224011152_CIT0026","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.1073\/pnas.86.10.3684","article-title":"Anti-M\u00fcllerian hormone produces endocrine sex reversal of fetal ovaries","volume":"86","year":"1989","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170224011152_CIT0027","first-page":"81","article-title":"Influence of a temporary embryonic testis graft on the regression of M\u00fcllerian ducts in female chick embryo","volume":"67","year":"1982","journal-title":"J Embryol Exp Morphol"},{"key":"key\n\t\t\t\t20170224011152_CIT0028","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1095\/biolreprod29.5.1221","article-title":"Development of the testes in female domestic fowls submitted to an experimental sex reversal during embryonic life","volume":"29","year":"1983","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224011152_CIT0029","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nature08298","article-title":"The avian Z-linked gene DMRT1 is required for male sex determination in the chicken","volume":"461","year":"2009","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170224011152_CIT0030","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1002\/(SICI)1097-0177(199912)216:4\/5<411::AID-DVDY9>3.0.CO;2-Y","article-title":"Temperature-dependent sex determination in the American alligator: AMH precedes SOX9 expression","volume":"216","year":"1999","journal-title":"Dev Dyn"},{"key":"key\n\t\t\t\t20170224011152_CIT0031","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/S0022-3468(81)80827-5","article-title":"The ontogeny of Mullerian inhibiting substance in the gonads of the chicken","volume":"16","year":"1981","journal-title":"J Pediatr Surg"},{"key":"key\n\t\t\t\t20170224011152_CIT0032","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/S0022-3468(82)80474-0","article-title":"Estrogen inhibition of Mullerian inhibiting substance in the chick embryo","volume":"17","year":"1982","journal-title":"J Pediatr Surg"},{"key":"key\n\t\t\t\t20170224011152_CIT0033","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1095\/biolreprod16.2.267","article-title":"Relationship between avian and mammalian anti-Mulllerian hormones","volume":"16","year":"1977","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224011152_CIT0034","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0091-679X(08)60379-9","article-title":"Retroviral gene delivery","volume":"52","year":"1997","journal-title":"Methods Cell Biol"},{"key":"key\n\t\t\t\t20170224011152_CIT0035","doi-asserted-by":"crossref","first-page":"2604","DOI":"10.1128\/MCB.13.4.2604","article-title":"Replication-competent retroviral vectors encoding alkaline phosphatase reveal spatial restriction of viral gene expression\/transduction in the chick embryo","volume":"13","year":"1993","journal-title":"Mol Cell Biol"},{"key":"key\n\t\t\t\t20170224011152_CIT0036","doi-asserted-by":"crossref","first-page":"3728","DOI":"10.1128\/JVI.65.7.3728-3737.1991","article-title":"Replication-competent retrovirus vectors for the transfer and expression of gene cassettes in avian cells","volume":"65","year":"1991","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170224011152_CIT0037","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1080\/10495390600867515","article-title":"Characterization and comparison of chicken U6 promoters for the expression of short hairpin RNAs","volume":"18","year":"2007","journal-title":"Anim Biotechnol"},{"key":"key\n\t\t\t\t20170224011152_CIT0038","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/978-1-62703-119-6_12","article-title":"Short hairpin RNA-mediated gene silencing","volume":"942","year":"2013","journal-title":"Methods Mol Biol"},{"key":"key\n\t\t\t\t20170224011152_CIT0039","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.diff.2009.02.001","article-title":"Robust and ubiquitous GFP expression in a single generation of chicken embryos using the avian retroviral vector, RCASBP","volume":"77","year":"2009","journal-title":"Differentiation"},{"key":"key\n\t\t\t\t20170224011152_CIT0040","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/aja.1001950404","article-title":"A series of normal stages in the development of the chick embryo. 1951","volume":"195","year":"1992","journal-title":"Dev Dyn"},{"key":"key\n\t\t\t\t20170224011152_CIT0041","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1080\/713655025","article-title":"Sexing chick embryos: a rapid and simple protocol","volume":"42","year":"2001","journal-title":"Br Poult Sci"},{"key":"key\n\t\t\t\t20170224011152_CIT0042","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1095\/biolreprod.102.007294","article-title":"DMRT1 is upregulated in the gonads during female-to-male sex reversal in ZW chicken embryos","volume":"68","year":"2003","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224011152_CIT0043","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","year":"2012","journal-title":"Nat Meth"},{"key":"key\n\t\t\t\t20170224011152_CIT0044","doi-asserted-by":"crossref","first-page":"R26","DOI":"10.1186\/gb-2013-14-3-r26","article-title":"RNA sequencing reveals sexually dimorphic gene expression before gonadal differentiation in chicken and allows comprehensive annotation of the W-chromosome","volume":"14","year":"2013","journal-title":"Genome Biol"},{"key":"key\n\t\t\t\t20170224011152_CIT0045","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1006\/gcen.1997.6978","article-title":"Sites of estrogen receptor and aromatase expression in the chicken embryo","volume":"108","year":"1997","journal-title":"Gen Comp Endocrinol"},{"key":"key\n\t\t\t\t20170224011152_CIT0046","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1095\/biolreprod.113.116491","article-title":"Identification, expression, and regulation of anti-Mullerian hormone type-II receptor in the embryonic chicken gonad","volume":"90","year":"2014","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224011152_CIT0047","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0960-0760(96)00196-3","article-title":"Gonadal sex differentiation in chicken embryos: expression of estrogen receptor and aromatase genes","volume":"60","year":"1997","journal-title":"J Steroid Biochem Mol Biol"},{"key":"key\n\t\t\t\t20170224011152_CIT0048","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1677\/jme.0.0200193","article-title":"Differential expression of genes for aromatase and estrogen receptor during the gonadal development in chicken embryos","volume":"20","year":"1998","journal-title":"J Mol Endocrinol"},{"key":"key\n\t\t\t\t20170224011152_CIT0049","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ydbio.2014.02.012","article-title":"Over-expression of DMRT1 induces the male pathway in embryonic chicken gonads","volume":"389","year":"2014","journal-title":"Dev Biol"},{"key":"key\n\t\t\t\t20170224011152_CIT0050","doi-asserted-by":"crossref","first-page":"e68362","DOI":"10.1371\/journal.pone.0068362","article-title":"Overexpression of aromatase alone is sufficient for ovarian development in genetically male chicken embryos","volume":"8","year":"2013","journal-title":"PLoS ONE"},{"key":"key\n\t\t\t\t20170224011152_CIT0051","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1210\/er.2003-0030","article-title":"Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones","volume":"25","year":"2004","journal-title":"Endocr Rev"},{"key":"key\n\t\t\t\t20170224011152_CIT0052","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1530\/rep.1.01075","article-title":"All in the family: TGF-beta family action in testis development","volume":"132","year":"2006","journal-title":"Reproduction"},{"key":"key\n\t\t\t\t20170224011152_CIT0053","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mce.2003.09.021","article-title":"AMH induces mesonephric cell migration in XX gonads","volume":"211","year":"2003","journal-title":"Mol Cell Endocrinol"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/biolreprod\/article-pdf\/93\/6\/138","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T18:28:37Z","timestamp":1653416917000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-lookup\/doi\/10.1095\/biolreprod.115.131664"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,1]]},"references-count":53,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,12,1]]}},"URL":"https:\/\/doi.org\/10.1095\/biolreprod.115.131664","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,1]]}}}