{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T02:51:00Z","timestamp":1777517460218,"version":"3.51.4"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,2,1]]},"DOI":"10.1095\/biolreprod.115.136358","type":"journal-article","created":{"date-parts":[[2016,1,14]],"date-time":"2016-01-14T05:57:32Z","timestamp":1452751052000},"source":"Crossref","is-referenced-by-count":13,"title":["Ggnbp2 Is Essential for Pregnancy Success via Regulation of Mouse Trophoblast Stem Cell Proliferation and Differentiation1"],"prefix":"10.1093","volume":"94","author":[{"given":"Shengqiang","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew K.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huaxin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengying","family":"Xing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangbin","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry C.","family":"Bohler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jixiang","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Austin J.","family":"Cooney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zijian","family":"Lan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenmin","family":"Lei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","reference":[{"key":"key\n\t\t\t\t20170224011050_CIT0001","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1172\/JCI41211","article-title":"The placenta: transcriptional, epigenetic, and physiological integration during development","volume":"120","year":"2010","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20170224011050_CIT0002","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1152\/physiol.00001.2005","article-title":"Development of structures and transport functions in the mouse placenta","volume":"20","year":"2005","journal-title":"Physiology (Bethesda)"},{"key":"key\n\t\t\t\t20170224011050_CIT0003","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1242\/dev.020099","article-title":"Early patterning of the chorion leads to the trilaminar trophoblast cell structure in the placental labyrinth","volume":"135","year":"2008","journal-title":"Development"},{"key":"key\n\t\t\t\t20170224011050_CIT0004","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0303-7207(01)00703-1","article-title":"Trophoblast functions, angiogenesis and remodeling of the maternal vasculature in the placenta","volume":"187","year":"2002","journal-title":"Mol Cell Endocrinol"},{"key":"key\n\t\t\t\t20170224011050_CIT0005","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1095\/biolreprod.108.073312","article-title":"Csf2 null mutation alters placental gene expression and trophoblast glycogen cell and giant cell abundance in mice","volume":"81","year":"2009","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224011050_CIT0006","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/35080570","article-title":"Placental development: lessons from mouse mutants","volume":"2","year":"2001","journal-title":"Nat Rev Genet"},{"key":"key\n\t\t\t\t20170224011050_CIT0007","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1101\/gr.101469.109","article-title":"Examination of transcriptional networks reveals an important role for TCFAP2C, SMARCA4, and EOMES in trophoblast stem cell maintenance","volume":"20","year":"2010","journal-title":"Genome Res"},{"key":"key\n\t\t\t\t20170224011050_CIT0008","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mod.2009.09.004","article-title":"Genes and signals regulating murine trophoblast cell development","volume":"127","year":"2010","journal-title":"Mech Dev"},{"issue":"(Suppl)","key":"key\n\t\t\t\t20170224011050_CIT0009","first-page":"S81","article-title":"Review: the transcriptional and signalling networks of mouse trophoblast stem cells","volume":"35","year":"2014","journal-title":"Placenta"},{"key":"key\n\t\t\t\t20170224011050_CIT0010","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1053\/plac.2002.0887","article-title":"Genes, development and evolution of the placenta","volume":"24","year":"2003","journal-title":"Placenta"},{"key":"key\n\t\t\t\t20170224011050_CIT0011","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1089\/scd.2005.14.535","article-title":"Identification of committed placental stem cell lines for studies of differentiation","volume":"14","year":"2005","journal-title":"Stem Cells Dev"},{"key":"key\n\t\t\t\t20170224011050_CIT0012","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1387\/ijdb.082768dh","article-title":"Development and function of trophoblast giant cells in the rodent placenta","volume":"54","year":"2010","journal-title":"Int J Dev Biol"},{"key":"key\n\t\t\t\t20170224011050_CIT0013","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1530\/REP-11-0374","article-title":"Trophoblast development","volume":"143","year":"2012","journal-title":"Reproduction"},{"key":"key\n\t\t\t\t20170224011050_CIT0014","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1095\/biolreprod.110.088724","article-title":"Trophoblast stem cells","volume":"84","year":"2011","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224011050_CIT0015","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.devcel.2013.10.019","article-title":"c-Met-dependent multipotent labyrinth trophoblast progenitors establish placental exchange interface","volume":"27","year":"2013","journal-title":"Dev Cell"},{"issue":"(Suppl 1)","key":"key\n\t\t\t\t20170224011050_CIT0016","first-page":"188","article-title":"Hepatocyte growth factor twenty years on: Much more than a growth factor","volume":"26","year":"2011","journal-title":"J Gastroenterol Hepatol"},{"key":"key\n\t\t\t\t20170224011050_CIT0017","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.1038\/onc.2011.84","article-title":"HGF-independent potentiation of EGFR action by c-Met","volume":"30","year":"2011","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t20170224011050_CIT0018","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.molmed.2005.04.005","article-title":"Cancer therapy: can the challenge be MET?","volume":"11","year":"2005","journal-title":"Trends Mol Med"},{"key":"key\n\t\t\t\t20170224011050_CIT0019","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/nrm3012","article-title":"MET signalling: principles and functions in development, organ regeneration and cancer","volume":"11","year":"2010","journal-title":"Nat Rev Mol Cell Biol"},{"key":"key\n\t\t\t\t20170224011050_CIT0020","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0014-5793(01)03039-3","article-title":"Dioxin induces a novel nuclear factor, DIF-3, that is implicated in spermatogenesis","volume":"508","year":"2001","journal-title":"FEBS Lett"},{"key":"key\n\t\t\t\t20170224011050_CIT0021","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.cub.2013.12.040","article-title":"NANOG amplifies STAT3 activation and they synergistically induce the naive pluripotent program","volume":"24","year":"2014","journal-title":"Curr Biol"},{"key":"key\n\t\t\t\t20170224011050_CIT0022","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.febslet.2004.10.112","article-title":"Yeast two-hybrid screens imply that GGNBP1, GGNBP2 and OAZ3 are potential interaction partners of testicular germ cell-specific protein GGN1","volume":"579","year":"2005","journal-title":"FEBS Lett"},{"key":"key\n\t\t\t\t20170224011050_CIT0023","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1097\/01.mlg.0000191470.71454.a1","article-title":"Comparative proteomics analysis of the proteins associated with laryngeal carcinoma-related gene 1","volume":"116","year":"2006","journal-title":"Laryngoscope"},{"key":"key\n\t\t\t\t20170224011050_CIT0024","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s11010-012-1262-6","article-title":"Knockdown of ZNF403 inhibits cell proliferation and induces G2\/M arrest by modulating cell-cycle mediators","volume":"365","year":"2012","journal-title":"Mol Cell Biochem"},{"key":"key\n\t\t\t\t20170224011050_CIT0025","first-page":"468","article-title":"Screening the effective target sequences of laryngeal carcinoma related gene LCRG1 [in Chinese]","volume":"33","year":"2008","journal-title":"Zhong Nan Da Xue Xue Bao Yi Xue Ban"},{"key":"key\n\t\t\t\t20170224011050_CIT0026","doi-asserted-by":"crossref","first-page":"12127","DOI":"10.1073\/pnas.0902925106","article-title":"Syncytin-A knockout mice demonstrate the critical role in placentation of a fusogenic, endogenous retrovirus-derived, envelope gene","volume":"106","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170224011050_CIT0027","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1128\/MCB.24.1.228-244.2004","article-title":"Cited1 is required in trophoblasts for placental development and for embryo growth and survival","volume":"24","year":"2004","journal-title":"Mol Cell Biol"},{"key":"key\n\t\t\t\t20170224011050_CIT0028","article-title":"Derivation of mouse trophoblast stem cells from blastocysts","year":"2010","journal-title":"J Vis Exp"},{"key":"key\n\t\t\t\t20170224011050_CIT0029","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1128\/MCB.00662-09","article-title":"The imprinted Phlda2 gene regulates extraembryonic energy stores","volume":"30","year":"2010","journal-title":"Mol Cell Biol"},{"key":"key\n\t\t\t\t20170224011050_CIT0030","doi-asserted-by":"crossref","first-page":"9173","DOI":"10.1038\/sj.onc.1208146","article-title":"Regulation of c-Met-dependent gene expression by PTEN","volume":"23","year":"2004","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t20170224011050_CIT0031","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/labinvest.3700702","article-title":"Functional and molecular interactions between the HGF\/c-Met pathway and c-Myc in large-cell medulloblastoma","volume":"88","year":"2008","journal-title":"Lab Invest"},{"key":"key\n\t\t\t\t20170224011050_CIT0032","doi-asserted-by":"crossref","first-page":"9951","DOI":"10.1073\/pnas.1016912108","article-title":"c-Met signaling induces a reprogramming network and supports the glioblastoma stem-like phenotype","volume":"108","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170224011050_CIT0033","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ydbio.2005.05.010","article-title":"Determinants of trophoblast lineage and cell subtype specification in the mouse placenta","volume":"284","year":"2005","journal-title":"Dev Biol"},{"key":"key\n\t\t\t\t20170224011050_CIT0034","doi-asserted-by":"crossref","first-page":"24065","DOI":"10.1074\/jbc.M701380200","article-title":"HOP\/NECC1, a novel regulator of mouse trophoblast differentiation","volume":"282","year":"2007","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170224011050_CIT0035","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.placenta.2010.05.001","article-title":"New insights for Ets2 function in trophoblast using lentivirus-mediated gene knockdown in trophoblast stem cells","volume":"31","year":"2010","journal-title":"Placenta"},{"key":"key\n\t\t\t\t20170224011050_CIT0036","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1074\/jbc.M111.287128","article-title":"SATB homeobox proteins regulate trophoblast stem cell renewal and differentiation","volume":"287","year":"2012","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170224011050_CIT0037","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.ydbio.2011.07.036","article-title":"Ablation of Tpbpa-positive trophoblast precursors leads to defects in maternal spiral artery remodeling in the mouse placenta","volume":"358","year":"2011","journal-title":"Dev Biol"},{"key":"key\n\t\t\t\t20170224011050_CIT0038","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1095\/biolreprod.113.109868","article-title":"Role of LIN28A in mouse and human trophoblast cell differentiation","volume":"89","year":"2013","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224011050_CIT0039","doi-asserted-by":"crossref","first-page":"e89451","DOI":"10.1371\/journal.pone.0089451","article-title":"The ubiquitin ligase ASB4 promotes trophoblast differentiation through the degradation of ID2","volume":"9","year":"2014","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170224011050_CIT0040","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1172\/JCI0215650","article-title":"What does Stat3 do?","volume":"109","year":"2002","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20170224011050_CIT0041","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.stem.2010.06.022","article-title":"Stat3 activation is limiting for reprogramming to ground state pluripotency","volume":"7","year":"2010","journal-title":"Cell Stem Cell"},{"key":"key\n\t\t\t\t20170224011050_CIT0042","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1042\/BJ20102152","article-title":"Regulation of embryonic stem cell self-renewal and pluripotency by leukaemia inhibitory factor","volume":"438","year":"2011","journal-title":"Biochem J"},{"key":"key\n\t\t\t\t20170224011050_CIT0043","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.ccr.2011.03.004","article-title":"Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3","volume":"19","year":"2011","journal-title":"Cancer Cell"},{"key":"key\n\t\t\t\t20170224011050_CIT0044","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/nrm909","article-title":"Stats: transcriptional control and biological impact","volume":"3","year":"2002","journal-title":"Nat Rev Mol Cell Biol"},{"key":"key\n\t\t\t\t20170224011050_CIT0045","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1126\/science.1066355","article-title":"Signal transduction and the control of gene expression","volume":"295","year":"2002","journal-title":"Science"},{"issue":"(Suppl)","key":"key\n\t\t\t\t20170224011050_CIT0046","first-page":"S121","article-title":"Cytokine signaling in 2002: new surprises in the Jak\/Stat pathway","volume":"109","year":"2002","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170224011050_CIT0047","doi-asserted-by":"crossref","first-page":"8017","DOI":"10.1038\/sj.onc.1208159","article-title":"Role of STATs as downstream signal transducers in Src family kinase-mediated tumorigenesis","volume":"23","year":"2004","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t20170224011050_CIT0048","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1177\/1758834011422556","article-title":"An overview of the c-MET signaling pathway","volume":"3","year":"2011","journal-title":"Ther Adv Med Oncol"},{"key":"key\n\t\t\t\t20170224011050_CIT0049","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.biocel.2014.01.009","article-title":"Met endosomal signalling: in the right place, at the right time","volume":"49","year":"2014","journal-title":"Int J Biochem Cell Biol"},{"key":"key\n\t\t\t\t20170224011050_CIT0050","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.brainres.2007.02.045","article-title":"Hepatocyte growth factor (HGF) promotes oligodendrocyte progenitor cell proliferation and inhibits its differentiation during postnatal development in the rat","volume":"1147","year":"2007","journal-title":"Brain Res"},{"key":"key\n\t\t\t\t20170224011050_CIT0051","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1002\/jcb.10239","article-title":"Constitutive activation of met kinase in non-small-cell lung carcinomas correlates with anchorage-independent cell survival","volume":"86","year":"2002","journal-title":"J Cell Biochem"},{"key":"key\n\t\t\t\t20170224011050_CIT0052","article-title":"Only a subset of Met-activated pathways are required to sustain oncogene addiction","year":"2009","journal-title":"Sci Signal"},{"key":"key\n\t\t\t\t20170224011050_CIT0053","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1186\/1471-2407-12-198","article-title":"Constitutively active c-Met kinase in PC-3 cells is autocrine-independent and can be blocked by the Met kinase inhibitor BMS-777607","volume":"12","year":"2012","journal-title":"BMC Cancer"},{"key":"key\n\t\t\t\t20170224011050_CIT0054","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1038\/onc.2012.154","article-title":"Met signaling regulates growth, repopulating potential and basal cell-fate commitment of mammary luminal progenitors: implications for basal-like breast cancer","volume":"32","year":"2013","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t20170224011050_CIT0055","first-page":"553","article-title":"Comoglio PM. c-met is amplified but not mutated in a cell line with an activated met tyrosine kinase","volume":"6","year":"1991","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t20170224011050_CIT0056","doi-asserted-by":"crossref","first-page":"521","DOI":"10.2174\/157016109789043982","article-title":"The role of trophoblast nutrient and ion transporters in the development of pregnancy complications and adult disease","volume":"7","year":"2009","journal-title":"Curr Vasc Pharmacol"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/biolreprod\/article-pdf\/94\/2\/41","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T16:50:58Z","timestamp":1567529458000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article\/2434449\/Ggnbp2-Is-Essential-for-Pregnancy-Success-via"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,1]]},"references-count":56,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2,1]]}},"URL":"https:\/\/doi.org\/10.1095\/biolreprod.115.136358","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,1]]}}}