{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T10:57:36Z","timestamp":1790161056745,"version":"4.1.0"},"reference-count":98,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1095\/biolreprod.116.144998","type":"journal-article","created":{"date-parts":[[2017,2,28]],"date-time":"2017-02-28T08:24:44Z","timestamp":1488270284000},"page":"617-634","source":"Crossref","is-referenced-by-count":22,"title":["Relationship of neuropeptide FF receptors with pubertal maturation of gilts \u2020"],"prefix":"10.1093","volume":"96","author":[{"given":"Jennifer F.","family":"Thorson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neely L.","family":"Heidorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitaly","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Czaja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny J.","family":"Nonneman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Richard","family":"Barb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary J.","family":"Hausman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary A.","family":"Rohrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ligia D.","family":"Prezotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard B.","family":"McCosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elane C.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett R.","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley A.","family":"Freking","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William T.","family":"Oliver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley M.","family":"Hileman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clay A.","family":"Lents","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,1,28]]},"reference":[{"key":"key\n\t\t\t\t20170320092508_bib1","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.theriogenology.2011.05.004","article-title":"Ovarian activity and uterus organometry in delayed puberty gilts","volume":"76","year":"2011","journal-title":"Theriogenology"},{"key":"key\n\t\t\t\t20170320092508_bib2","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.anireprosci.2010.10.006","article-title":"Luteinizing hormone secretion as influenced by age and estradiol in the prepubertal gilt","volume":"122","year":"2010","journal-title":"Anim Reprod Sci"},{"key":"key\n\t\t\t\t20170320092508_bib3","doi-asserted-by":"crossref","first-page":"686","DOI":"10.2527\/jas1984.583686x","article-title":"Serum luteinizing hormone and estrogen profiles before puberty in the gilt","volume":"58","year":"1984","journal-title":"J Anim Sci"},{"key":"key\n\t\t\t\t20170320092508_bib4","doi-asserted-by":"crossref","first-page":"165","DOI":"10.2527\/jas1984.581165x","article-title":"Luteinizing hormone secretion in ovariectomized gilts: Effects of age, reproductive state and estrogen replacement","volume":"58","year":"1984","journal-title":"J Anim Sci"},{"key":"key\n\t\t\t\t20170320092508_bib5","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0739-7240(85)90027-X","article-title":"Induction of ovulation in the prepubertal gilt by pulsatile administration of gonadotropin releasing hormone","volume":"2","year":"1985","journal-title":"Domest Anim Endocrinol"},{"key":"key\n\t\t\t\t20170320092508_bib6","first-page":"3","article-title":"Hypothalamic control of gonadotrophin and prolactin secretion in pigs","volume":"40","year":"1990","journal-title":"J Reprod Fertil Suppl"},{"key":"key\n\t\t\t\t20170320092508_bib7","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.2527\/jas1985.6051308x","article-title":"Plasma prolactin, LH, FSH and estrogen excretion patterns in gilts during sexual development","volume":"60","year":"1985","journal-title":"J Anim Sci"},{"key":"key\n\t\t\t\t20170320092508_bib8","doi-asserted-by":"crossref","first-page":"139","DOI":"10.2527\/jas1983.561139x","article-title":"Serum profiles of LH, FSH and prolactin from 10 weeks of age until puberty in gilts","volume":"56","year":"1983","journal-title":"J Anim Sci"},{"key":"key\n\t\t\t\t20170320092508_bib9","first-page":"82","article-title":"Current concepts of the onset of puberty in the gilt","volume-title":"Reprod Domest Anim Suppl","year":"1999"},{"key":"key\n\t\t\t\t20170320092508_bib10","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1111\/j.1365-2826.2010.02018.x","article-title":"Discovery and evolutionary history of gonadotrophin-inhibitory hormone and kisspeptin: new key neuropeptides controlling reproduction","volume":"22","year":"2010","journal-title":"J Neuroendocrinol"},{"key":"key\n\t\t\t\t20170320092508_bib11","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s00441-010-1116-z","article-title":"Molecular evolution and functional characterization of the orexigenic peptide 26RFa and its receptor in vertebrates","volume":"343","year":"2011","journal-title":"Cell Tissue Res"},{"key":"key\n\t\t\t\t20170320092508_bib12","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1113\/jphysiol.2006.106856","article-title":"Novel role of 26RFa, a hypothalamic RFamide orexigenic peptide, as putative regulator of the gonadotropic axis","volume":"573","year":"2006","journal-title":"J Physiol"},{"key":"key\n\t\t\t\t20170320092508_bib13","doi-asserted-by":"crossref","first-page":"11349","DOI":"10.1523\/JNEUROSCI.3328-05.2005","article-title":"Activation of gonadotropin-releasing hormone neurons by kisspeptin as a neuroendocrine switch for the onset of puberty","volume":"25","year":"2005","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170320092508_bib14","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1073\/pnas.0409330102","article-title":"Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54","volume":"102","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170320092508_bib15","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1530\/REP-07-0502","article-title":"Central and peripheral administration of kisspeptin activates gonadotropin but not somatotropin secretion in prepubertal gilts","volume":"135","year":"2008","journal-title":"Reproduction"},{"key":"key\n\t\t\t\t20170320092508_bib16","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1111\/j.1365-2826.2011.02177.x","article-title":"Developmental changes in hypothalamic Kiss1 expression during activation of the pulsatile release of luteinising hormone in maturing ewe lambs","volume":"23","year":"2011","journal-title":"J Neuroendocrinol"},{"key":"key\n\t\t\t\t20170320092508_bib17","doi-asserted-by":"crossref","first-page":"4565","DOI":"10.1210\/en.2004-0413","article-title":"Developmental and hormonally regulated messenger ribonucleic acid expression of KiSS-1 and its putative receptor, GPR54, in rat hypothalamus and potent luteinizing hormone-releasing activity of KiSS-1 peptide","volume":"145","year":"2004","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170320092508_bib18","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0014-5793(02)02275-5","article-title":"A novel rat hypothalamic RFamide-related peptide identified by immunoaffinity chromatography and mass spectrometry","volume":"512","year":"2002","journal-title":"FEBS Lett"},{"key":"key\n\t\t\t\t20170320092508_bib19","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1002\/mas.20031","article-title":"A new member of the hypothalamic RF-amide peptide family, LPXRF-amide peptides: structure, localization, and function","volume":"24","year":"2005","journal-title":"Mass Spectrom Rev"},{"key":"key\n\t\t\t\t20170320092508_bib20","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1073\/pnas.0511003103","article-title":"Identification and characterization of a gonadotropin-inhibitory system in the brains of mammals","volume":"103","year":"2006","journal-title":"Proc Nat Acad Sci USA"},{"key":"key\n\t\t\t\t20170320092508_bib21","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.yfrne.2009.04.001","article-title":"Evidence that RF-amide related peptides are inhibitors of reproduction in mammals","volume":"30","year":"2009","journal-title":"Front Neuroendocrinol"},{"key":"key\n\t\t\t\t20170320092508_bib22","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1006\/bbrc.2000.3350","article-title":"A novel avian hypothalamic peptide inhibiting gonadotropin release","volume":"275","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"key\n\t\t\t\t20170320092508_bib23","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1210\/en.2005-1178","article-title":"Gonadotropin-inhibitory hormone inhibits gonadal development and maintenance by decreasing gonadotropin synthesis and release in male quail","volume":"147","year":"2006","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170320092508_bib24","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1677\/joe.0.1820033","article-title":"Gonadotropin-inhibitory hormone in Gambel's white-crowned sparrow (Zonotrichia leucophrys gambelii): cDNA identification, transcript localization and functional effects in laboratory and field experiments","volume":"182","year":"2004","journal-title":"J Endocrinol"},{"key":"key\n\t\t\t\t20170320092508_bib25","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.yfrne.2010.03.001","article-title":"Gonadotropin-inhibitory hormone (GnIH) and its control of central and peripheral reproductive function","volume":"31","year":"2010","journal-title":"Front Neuroendocrinol"},{"key":"key\n\t\t\t\t20170320092508_bib26","doi-asserted-by":"crossref","first-page":"5811","DOI":"10.1210\/en.2008-0575","article-title":"Potent action of RFRP-3 on pituitary gonadotropes indicative of an hypophysiotropic role in the negative regulation of gonadotropin secretion","volume":"149","year":"2008","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170320092508_bib27","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1677\/JOE-08-0197","article-title":"Hypophysiotropic role of RFamide-related peptide-3 in the inhibition of LH secretion in female rats","volume":"199","year":"2008","journal-title":"J Endocrinol"},{"key":"key\n\t\t\t\t20170320092508_bib28","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.domaniend.2009.02.001","article-title":"Bovine C-terminal octapeptide of RFamide-related peptide-3 suppresses luteinizing hormone (LH) secretion from the piuitary as well as pulsatile LH secretion in bovines","volume":"36","year":"2009","journal-title":"Domest Anim Endocrinol"},{"key":"key\n\t\t\t\t20170320092508_bib29","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.mce.2013.03.015","article-title":"The effects of RFRP-3, the mammalian ortholog of GnIH, on the female pig reproductive axis in vitro","volume":"372","year":"2013","journal-title":"Mol Cell Endocrinol"},{"key":"key\n\t\t\t\t20170320092508_bib30","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.yhbeh.2006.09.009","article-title":"Rat RFamide-related peptide-3 stimulates GH secretion, inhibits LH secretion, and has variable effects on sex behavior in the adult male rat","volume":"51","year":"2007","journal-title":"Horm Behav"},{"key":"key\n\t\t\t\t20170320092508_bib31","doi-asserted-by":"crossref","first-page":"5770","DOI":"10.1210\/en.2008-0581","article-title":"Variation in kisspeptin and gonadotropin-inhibitory hormone expression and terminal connections to GnRH neurons in the brain: a novel medium for seasonal breeding in the sheep","volume":"149","year":"2008","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170320092508_bib32","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1046\/j.1365-2826.2003.01062.x","article-title":"Gonadotropin-inhibitory peptide in song sparrows (Melospiza melodia) in different reproductive conditions, and in house sparrows (Passer domesticus) relative to chicken-gonadotropin-releasing hormone","volume":"15","year":"2003","journal-title":"J Neuroendocrinol"},{"key":"key\n\t\t\t\t20170320092508_bib33","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1210\/en.2008-1359","article-title":"Central and peripheral effects of RFamide-related peptide-3 on luteinizing hormone and prolactin secretion in rats","volume":"150","year":"2009","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170320092508_bib34","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1113\/jphysiol.2008.166447","article-title":"Gonadotropin inhibitory hormone inhibits basal forebrain vGlutT2-gonadotropin-releasing hormone neurons via a direct postsynaptic mechanism","volume":"587","year":"2009","journal-title":"J Physiol"},{"key":"key\n\t\t\t\t20170320092508_bib35","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1210\/en.2008-1623","article-title":"RFamide-related peptide-3 (RFRP-3), a mammalian gonadotropin-inhibitory hormone ortholog, regulates gonadotropin-releasing hormone (GnRH) neuron firing in the mouse","volume":"150","year":"2009","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170320092508_bib36","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.anireprosci.2015.05.013","article-title":"The role of RFamide-related peptide 3 (RFRP3) in regulation of the neuroendocrine reproductive and growth axes of the boar","volume":"159","year":"2015","journal-title":"Anim Reprod Sci"},{"key":"key\n\t\t\t\t20170320092508_bib37","first-page":"1","article-title":"Genome-wide association and identification of candidate genes for age at puberty in swine","volume":"17","year":"2016","journal-title":"BMC Genetics"},{"key":"key\n\t\t\t\t20170320092508_bib38","doi-asserted-by":"crossref","first-page":"39324","DOI":"10.1074\/jbc.M004385200","article-title":"Identification and characterization of two G protein-coupled receptors for neuropeptide FF","volume":"275","year":"2000","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170320092508_bib39","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.peptides.2005.06.031","article-title":"Recent advances in mammalian RFamide peptides: the discovery and functional analyses of PrRP, RFRPs and QRFP","volume":"27","year":"2006","journal-title":"Peptides"},{"key":"key\n\t\t\t\t20170320092508_bib40","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/35036326","article-title":"New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals","volume":"2","year":"2000","journal-title":"Nat Cell Biol"},{"key":"key\n\t\t\t\t20170320092508_bib41","article-title":"Guide for the Care and Use of Agricultural Animals in Research and Teaching","author":"FASS","year":"2010","edition":"3rd ed"},{"key":"key\n\t\t\t\t20170320092508_bib42","volume-title":"Nutrient Requirements of Swine","author":"NRC","year":"1998","edition":"10th rev. ed."},{"key":"key\n\t\t\t\t20170320092508_bib43","article-title":"Guidelines for the Euthanasia of Animals: 2013 Edition","author":"AVMA","year":"2015"},{"key":"key\n\t\t\t\t20170320092508_bib44","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1095\/biolreprod21.3.715","article-title":"Ovarian development in fetal and prepubertal pigs","volume":"21","year":"1979","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170320092508_bib45","doi-asserted-by":"crossref","first-page":"5245","DOI":"10.1158\/0008-5472.CAN-04-0496","article-title":"Normalization of real-time quantitative reverse transcription-PCR data: A model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets","volume":"64","year":"2004","journal-title":"Cancer Res"},{"key":"key\n\t\t\t\t20170320092508_bib46","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1023\/B:BILE.0000019559.84305.47","article-title":"Determination of stable housekeeping genes, differentially regulated target genes and sample integrity: BestKeeper \u2013 Excel-based tool using pair-wise correlations","volume":"26","year":"2004","journal-title":"Biotechnol Lett"},{"key":"key\n\t\t\t\t20170320092508_bib47","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT Method","volume":"25","year":"2001","journal-title":"Methods"},{"key":"key\n\t\t\t\t20170320092508_bib48","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.peptides.2005.07.026","article-title":"Prediction of neuropeptide prohormone cleavages with application to RFamides","volume":"27","year":"2006","journal-title":"Peptides"},{"key":"key\n\t\t\t\t20170320092508_bib49","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1210\/en.2009-0908","article-title":"Melatonin stimulates the release of gonadotropin-inhibitory hormone by the avian hypothalamus","volume":"151","year":"2010","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170320092508_bib50","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3181\/00379727-193-43007A","article-title":"Gonadotropin and prolactin secretion following intraventricular administration of morphine in gilts","volume":"193","year":"1990","journal-title":"Proc Soc Exp Biol Med"},{"key":"key\n\t\t\t\t20170320092508_bib51","first-page":"1","article-title":"Technique for cannulation of the lateral ventricle of the brain in swine","volume":"35","year":"1993","journal-title":"Kopf Carrier"},{"key":"key\n\t\t\t\t20170320092508_bib52","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1210\/endo-121-5-1862","article-title":"Absence of an estradiol-induced surge of luteinizing hormone in pigs receiving unvarying pulsatile gonadotropin-releasing hormone stimulation","volume":"121","year":"1987","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170320092508_bib53","first-page":"E310","article-title":"Algorithms for the study of episodic hormone secretion","volume":"243","year":"1982","journal-title":"Am J Physiol"},{"key":"key\n\t\t\t\t20170320092508_bib54","doi-asserted-by":"crossref","first-page":"5918","DOI":"10.1210\/en.2012-1611","article-title":"Evidence that dopamine acts via kisspeptin to hold GnRH pulse frequency in check in anestrous ewes","volume":"153","year":"2012","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170320092508_bib55","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.peptides.2012.05.008","article-title":"Gonadotropin-inhibitory hormone (GnIH) and its receptor in the female pig: cDNA cloning, expression in tissues and expression pattern in the reproductive axis during the estrous cycle","volume":"36","year":"2012","journal-title":"Peptides"},{"key":"key\n\t\t\t\t20170320092508_bib56","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0167-0115(02)00220-3","article-title":"Characterization of the NPGP receptor and identification of a novel short mRNA isoform in human hypothalamus","volume":"111","year":"2003","journal-title":"Regul Pep"},{"key":"key\n\t\t\t\t20170320092508_bib57","doi-asserted-by":"crossref","first-page":"6955","DOI":"10.1016\/j.febslet.2006.11.063","article-title":"Alternative splicing of human and mouse NPFF2 receptor genes: Implications to receptor expression","volume":"580","year":"2006","journal-title":"FEBS Lett"},{"key":"key\n\t\t\t\t20170320092508_bib58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/gb-2006-7-s1-s1","article-title":"AceView: a comprehensive cDNA-supported gene and transcripts annotation","volume":"7","year":"2006","journal-title":"Genome Biol"},{"key":"key\n\t\t\t\t20170320092508_bib59","doi-asserted-by":"crossref","first-page":"472","DOI":"10.2527\/2004.822472x","article-title":"Lack of an association between plasma follicle-stimulating hormone concentrations and ovarian weight in prepubertal gilts","volume":"82","year":"2004","journal-title":"J Anim Sci"},{"key":"key\n\t\t\t\t20170320092508_bib60","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1111\/j.1365-2826.2008.01765.x","article-title":"Gonadotrophin-inhibitory hormone receptor expression in the chicken pituitary gland: potential influence of sexual maturation and ovarian steroids","volume":"20","year":"2008","journal-title":"J Neuroendocrinol"},{"key":"key\n\t\t\t\t20170320092508_bib61","doi-asserted-by":"crossref","first-page":"15060","DOI":"10.1523\/JNEUROSCI.2200-14.2014","article-title":"Development of gonadotropin-releasing hormone secretion and pituitary response","volume":"34","year":"2014","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20170320092508_bib62","doi-asserted-by":"crossref","first-page":"5549","DOI":"10.1210\/en.2009-0775","article-title":"Effect of RF-amide-related peptide-3 on luteinizing hormone and follicle-stimulating hormone synthesis and secretion in ovine pituitary gonadotropes","volume":"150","year":"2009","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170320092508_bib63","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1095\/biolreprod64.6.1614","article-title":"Developmental changes in the long form leptin receptor and related neuropeptide gene expression in the pig brain","volume":"64","year":"2001","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170320092508_bib64","first-page":"33","article-title":"Gene expression in the brain-pituitary adipose tissue axis and luteinising hormone secretion during pubertal development in the gilt","volume":"62","year":"2006","journal-title":"Soc Reprod Fertil Suppl"},{"key":"key\n\t\t\t\t20170320092508_bib65","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1210\/en.2010-0022","article-title":"Minireview: Kisspeptin\/neurokinin B\/dynorphin (KNDy) cells of the arcuate nucleus: a central node in the control of gonadotropin-releasing hormone secretion","volume":"151","year":"2010","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170320092508_bib66","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.1210\/en.2011-2009","article-title":"Evidence of a role for kisspeptin and neurokinin B in puberty of female sheep","volume":"153","year":"2012","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170320092508_bib67","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1530\/rep.1.01108","article-title":"The role of neuropeptide Y and interaction with leptin in regulating feed intake and luteinizing hormone and growth hormone secretion in the pig","volume":"131","year":"2006","journal-title":"Reproduction"},{"key":"key\n\t\t\t\t20170320092508_bib68","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/0739-7240(94)90009-4","article-title":"Opioid modulation of gonadotropin releasing hormone release from the hypothalamic preoptic area in the pig","volume":"11","year":"1994","journal-title":"Domest Anim Endocrinol"},{"key":"key\n\t\t\t\t20170320092508_bib69","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1210\/en.2009-1259","article-title":"Characterization of the potent gonadotropin-releasing activity of RF9, a selective antagonist of RF-amide-related peptides and neuropeptide FF receptors: physiological and pharmacological implications","volume":"151","year":"2010","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170320092508_bib70","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1111\/j.1365-2826.2012.02283.x","article-title":"RF9 powerfully stimulates gonadotrophin secretion in the ewe: evidence for a seasonal threshold of sensitivity","volume":"24","year":"2012","journal-title":"J Neuroendocrinol"},{"key":"key\n\t\t\t\t20170320092508_bib71","first-page":"28","article-title":"Hypothalamic distribution, adenohypophyseal receptor expression, and ligand functionality of RFamide-related peptide 3 in the mare during the breeding and nonbreeding seasons","volume":"90","year":"2014","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170320092508_bib72","doi-asserted-by":"crossref","first-page":"3770","DOI":"10.1210\/en.2012-1133","article-title":"RFamide-related peptide-3 receptor gene expression in GnRH and kisspeptin neurons and GnRH-dependent mechanism of action","volume":"153","year":"2012","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170320092508_bib73","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1021\/ml1002053","article-title":"Activation of neuropeptide FF receptors by kisspeptin receptor ligands","volume":"2","year":"2011","journal-title":"ACS Med Chem Lett"},{"key":"key\n\t\t\t\t20170320092508_bib74","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1073\/pnas.0502090103","article-title":"RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia","volume":"103","year":"2006","journal-title":"Proc Nat Acad Sci USA"},{"key":"key\n\t\t\t\t20170320092508_bib75","doi-asserted-by":"crossref","first-page":"4639","DOI":"10.1210\/en.2015-1635","article-title":"RF9 Acts as a KISS1R agonist in vivo and in vitro","volume":"156","year":"2015","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170320092508_bib76","doi-asserted-by":"crossref","first-page":"4915","DOI":"10.1210\/en.2014-1517","article-title":"RF9 excitation of GnRH neurons is dependent upon Kiss1r in the adult male and female mouse","volume":"155","year":"2014","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170320092508_bib77","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1530\/REP-14-0683","article-title":"Kisspeptin antagonist prevents RF9-induced reproductive changes in female rats","volume":"149","year":"2015","journal-title":"Reproduction"},{"key":"key\n\t\t\t\t20170320092508_bib78","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1210\/en.2015-1854","article-title":"No evidence that RFamide-related peptide 3 directly modulates LH secretion in the ewe","volume":"157","year":"2016","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170320092508_bib79","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.npep.2007.06.004","article-title":"Modulatory role of neuropeptide FF system in nociception and opiate analgesia","volume":"42","year":"2008","journal-title":"Neuropeptides"},{"key":"key\n\t\t\t\t20170320092508_bib80","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0739-7240(85)90009-8","article-title":"Opioid inhibition stimulates luteinizing hormone and prolactin secretion in the gilt","volume":"2","year":"1985","journal-title":"Domest Anim Endocrinol"},{"key":"key\n\t\t\t\t20170320092508_bib81","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1095\/biolreprod35.5.1162","article-title":"Influence of stage of the estrous cycle on endogenous opioid modulation of luteinizing hormone, prolactin, and cortisol secretion in the gilt","volume":"35","year":"1986","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170320092508_bib82","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1095\/biolreprod39.3.603","article-title":"Absence of brain opioid peptide modulation of luteinizing hormone secretion in the prepubertal gilt","volume":"39","year":"1988","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170320092508_bib83","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0167-4889(02)00389-0","article-title":"Molecular properties of endogenous RFamide-related peptide-3 and its interaction with receptors","volume":"1593","year":"2003","journal-title":"Biochim Biophys Acta"},{"key":"key\n\t\t\t\t20170320092508_bib84","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1002\/cne.22191","article-title":"Gonadotropin-inhibitory hormone identification, cDNA cloning, and distribution in rhesus macaque brain","volume":"517","year":"2009","journal-title":"J Comp Neurol"},{"key":"key\n\t\t\t\t20170320092508_bib85","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1042\/bj3540379","article-title":"Characterization of a cDNA encoding a novel avian hypothalamic neuropeptide exerting an inhibitory effect on gonadotropin release","volume":"354","year":"2001","journal-title":"Biochem J"},{"key":"key\n\t\t\t\t20170320092508_bib86","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.ygcen.2006.10.005","article-title":"The general and comparative biology of gonadotropin-inhibitory hormone (GnIH)","volume":"153","year":"2007","journal-title":"Gen Comp Endocrinol"},{"key":"key\n\t\t\t\t20170320092508_bib87","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.pneurobio.2009.02.003","article-title":"A new key neurohormone controlling reproduction, gonadotropin-inhibitory hormone (GnIH): Biosynthesis, mode of action and functional significance","volume":"88","year":"2009","journal-title":"Prog Neurobiol"},{"key":"key\n\t\t\t\t20170320092508_bib88","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1111\/j.1365-2826.2009.01886.x","article-title":"Projections of RFamide-related peptide-3 neurons in the ovine hypothalamus, with special reference to regions regulating energy balance and reproduction","volume":"21","year":"2009","journal-title":"J Neuroendocrinol"},{"key":"key\n\t\t\t\t20170320092508_bib89","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1210\/en.2008-1287","article-title":"Cells expressing RFamide-related peptide-1\/3, the mammalian gonadotropin-inhibitory hormone orthologs, are not hypophysiotropic neuroendocrine neurons in the rat","volume":"150","year":"2009","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170320092508_bib90","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.npep.2008.11.001","article-title":"Distribution and genesis of the RFRP-producing neurons in the rat brain: Comparison with melanin-concentrating hormone- and hypocretin-containing neurons","volume":"43","year":"2009","journal-title":"Neuropeptides"},{"key":"key\n\t\t\t\t20170320092508_bib91","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0304-3940(01)01583-X","article-title":"Distribution of novel RFamide-related peptide-like immunoreactivity in the mouse central nervous system","volume":"300","year":"2001","journal-title":"Neurosci Lett"},{"key":"key\n\t\t\t\t20170320092508_bib92","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/S0006-8993(03)02877-4","article-title":"Localization and neuronal response of RFamide related peptides in the rat central nervous system","volume":"982","year":"2003","journal-title":"Brain Res"},{"key":"key\n\t\t\t\t20170320092508_bib93","first-page":"1252\u20131259","article-title":"RFamide-related peptide and its cognate receptor in the sheep: cDNA cloning, mRNA distribution in the hypothalamus and the effect of photoperiod","volume":"20","year":"2008","journal-title":"J Neuroendocrinol"},{"key":"key\n\t\t\t\t20170320092508_bib94","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1159\/000332822","article-title":"Gonadotropin-inhibitory hormone is a hypothalamic peptide that provides a molecular switch between reproduction and feeding","volume":"95","year":"2012","journal-title":"Neuroendocrinol"},{"key":"key\n\t\t\t\t20170320092508_bib95","doi-asserted-by":"crossref","first-page":"E39","DOI":"10.1152\/ajpendo.00108.2010","article-title":"Characterization of the inhibitory roles of RFRP3, the mammalian ortholog of GnIH, in the control of gonadotropin secretion in the rat: in vivo and in vitro studies","volume":"299","year":"2010","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"key\n\t\t\t\t20170320092508_bib96","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1210\/en.2011-1622","article-title":"Stimulatory effect of RFRP-3 on the gonadotrophic axis in the male Syrian hamster: the exception proves the rule","volume":"153","year":"2012","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170320092508_bib97","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.1152\/jn.00712.2012","article-title":"Neuropeptide RFRP inhibits the pacemaker activity of terminal nerve GnRH neurons","volume":"109","year":"2013","journal-title":"J Neurophysiol"},{"key":"key\n\t\t\t\t20170320092508_bib98","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1262\/jrd.20252","article-title":"Follicular size is associated with the levels of transcripts and proteins of selected molecules responsible for the fertilization ability of oocytes of puberal gilts","volume":"55","year":"2009","journal-title":"J Reprod Dev"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T20:58:21Z","timestamp":1750021101000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-lookup\/doi\/10.1095\/biolreprod.116.144998"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,28]]},"references-count":98,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,1,28]]},"published-print":{"date-parts":[[2017,3]]}},"URL":"https:\/\/doi.org\/10.1095\/biolreprod.116.144998","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,28]]}}}