{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:43:37Z","timestamp":1762865017933},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,2,1]]},"DOI":"10.1095\/biolreprod60.2.322","type":"journal-article","created":{"date-parts":[[2005,10,31]],"date-time":"2005-10-31T23:08:20Z","timestamp":1130800100000},"page":"322-329","source":"Crossref","is-referenced-by-count":25,"title":["Effect of Oxytocin Receptor and \u03b22-Adrenoceptor Blockade on Myometrial Oxytocin Receptors in Parturient Rats1"],"prefix":"10.1093","volume":"60","author":[{"given":"T.","family":"Engstr\u00f8m","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Bratholm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Vilhardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels J.","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","reference":[{"key":"key\n\t\t\t\t20170224183359_R1","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/0002-9378(84)90677-X","article-title":"Oxytocin receptors in the human uterus during pregnancy and parturition","volume":"150","year":"1984","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t20170224183359_R2","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1095\/biolreprod55.3.575","article-title":"Characterization of porcine endometrial, myometrial, and mammary oxytocin binding sites during gestation and labor","volume":"55","year":"1996","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224183359_R3","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1126\/science.221972","article-title":"Oxytocin receptors: triggers for parturition and lactation?","volume":"204","year":"1979","journal-title":"Science"},{"key":"key\n\t\t\t\t20170224183359_R4","first-page":"385","article-title":"Sex steroid modulation of neurohypophysial hormone receptors in human nonpregnant myometrium","volume":"74","year":"1992","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20170224183359_R5","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1095\/biolreprod54.3.700","article-title":"Oxytocin receptors in bovine cervix: distribution and gene expression during the estrous cycle","volume":"54","year":"1996","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224183359_R6","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1139\/o83-077","article-title":"Systemic and local regulation of oxytocin receptors in the rat uterus, and their functional significance","volume":"61","year":"1983","journal-title":"Can J Biochem Cell Biol"},{"key":"key\n\t\t\t\t20170224183359_R7","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1210\/endo-113-2-742","article-title":"Correlation between oxytocin receptor concentration and responsiveness to oxytocin in pregnant rat myometrium: effects of ovarian steroids","volume":"113","year":"1983","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224183359_R8","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1210\/endo-106-3-730","article-title":"Oxytocin receptors and parturition. I. Control of oxytocin receptor concentration in the rat myometrium at term","volume":"106","year":"1980","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224183359_R9","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0167-0115(88)90058-4","article-title":"Oxytocin receptors and contractile response of the myometrium after long term infusion of prostaglandin F2 alpha, indomethacin, oxytocin and an oxytocin antagonist in rats","volume":"20","year":"1988","journal-title":"Regul Pept"},{"key":"key\n\t\t\t\t20170224183359_R10","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1071\/RD9920505","article-title":"Effect of continuous infusion of oxytocin on ovarian function and uterine oxytocin receptor concentration in the cyclic ewe","volume":"4","year":"1992","journal-title":"Reprod Fertil Dev"},{"key":"key\n\t\t\t\t20170224183359_R11","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1677\/jme.0.0200261","article-title":"\u03b22-Desensitization in non-pregnant estrogen primed rat myometrium involves modulation of oxytocin receptor gene expression","volume":"20","year":"1998","journal-title":"J Mol Endocrinol"},{"key":"key\n\t\t\t\t20170224183359_R12","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1095\/biolreprod53.5.1051","article-title":"Effectors of cyclic adenosine 5\u2032-monophosphate up-regulating-oxytocin receptors in rabbit amnion cells: isoproterenol, parathyroid hormone-related protein, and potentiation by cortisol","volume":"53","year":"1995","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224183359_R13","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1210\/endo.132.1.8380370","article-title":"Up-regulation of oxytocin receptors in rabbit amnion by adenosine 3\u2032,5\u2032-monophosphate","volume":"132","year":"1993","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224183359_R14","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/S0169-328X(97)00287-8","article-title":"NGF, cyclic AMP, and phorbol esters regulate oxytocin receptor gene transcription in SK-N-SH and MCF7 cells","volume":"53","year":"1998","journal-title":"Mol Brain Res"},{"key":"key\n\t\t\t\t20170224183359_R15","first-page":"389","article-title":"Estrogen reduces beta-adrenoceptor-mediated cAMP production and the concentration of the guanyl nucleotide-regulatory protein, Gs, in rabbit myometrium","volume":"33","year":"1988","journal-title":"Mol Pharmacol"},{"key":"key\n\t\t\t\t20170224183359_R16","first-page":"E410","article-title":"Myometrial desensitization after ritodrine infusion","volume":"253","year":"1987","journal-title":"Am J Physiol"},{"key":"key\n\t\t\t\t20170224183359_R17","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/jmr.300080303","article-title":"Changes in kinetic properties of oxytocin receptors in longitudinal muscle membranes of rat uterus during gestation","volume":"8","year":"1995","journal-title":"J Mol Recognit"},{"key":"key\n\t\t\t\t20170224183359_R18","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1111\/j.1471-0528.1987.tb02287.x","article-title":"Inhibition of uterine contractions of premature labour with an oxytocin analogue. Results from a pilot study","volume":"94","year":"1987","journal-title":"Br J Obstet Gynaecol"},{"key":"key\n\t\t\t\t20170224183359_R19","first-page":"449","article-title":"Effects of clenbuterol, ICI118551 and sotalol on the growth of cardiac and skeletal muscle and on beta 2-adrenoceptor density in female rats","volume":"344","year":"1991","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"key\n\t\t\t\t20170224183359_R20","first-page":"442","article-title":"Affinity of clenbuterol analogues for beta 2-adrenoceptors in bovine skeletal muscle and the effect of these compounds on urinary nitrogen excretion in female rats","volume":"344","year":"1991","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"key\n\t\t\t\t20170224183359_R21","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","article-title":"Basic local alignment search tool","volume":"215","year":"1990","journal-title":"J Mol Biol"},{"key":"key\n\t\t\t\t20170224183359_R22","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1677\/joe.0.1530393","article-title":"Effect of pregnancy on rat myometrial beta 2-adrenoceptor mRNA and isoproterenol-induced relaxation of isolated uterine strips","volume":"153","year":"1997","journal-title":"J Endocrinol"},{"key":"key\n\t\t\t\t20170224183359_R23","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1006\/bbrc.1995.2219","article-title":"Quantification of alpha-1-adrenoceptor subtypes in human tissues by competitive RT-PCR analysis","volume":"213","year":"1995","journal-title":"Biochem Biophys Res Commun"},{"key":"key\n\t\t\t\t20170224183359_R24","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1677\/joe.0.1180081","article-title":"Receptor-binding characteristics and contractile responsiveness of the myometrium following prolonged infusion of bradykinin and oxytocin in rats","volume":"118","year":"1988","journal-title":"J Endocrinol"},{"key":"key\n\t\t\t\t20170224183359_R25","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1210\/endo-66-3-451","article-title":"Effect of magnesium ion on the response of the rat uterus to neurohypophysial hormones and analogues","volume":"66","year":"1960","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224183359_R26","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","year":"1951","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170224183359_R27","first-page":"704","article-title":"Correlation between the levels of catecholamines (noradrenaline, adrenaline) and adrenal steroids (DHA-S, cortisol) in maternal and fetal blood during pregnancy and labor","volume":"65","year":"1989","journal-title":"Nippon Naibunpi Gakkai Zasshi"},{"key":"key\n\t\t\t\t20170224183359_R28","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1530\/jrf.0.0770559","article-title":"Comparison of nifedipine and diltiazem with salbutamol for prevention of preterm delivery in the ovariectomized, oestrogen-treated late pregnant rat","volume":"77","year":"1986","journal-title":"J Reprod Fertil"},{"key":"key\n\t\t\t\t20170224183359_R29","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/0002-9378(85)90310-2","article-title":"Beta-adrenergic receptors in human myometrium during pregnancy: changes in the number of receptors after beta-mimetic treatment","volume":"151","year":"1985","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t20170224183359_R30","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/S0002-9378(11)91725-6","article-title":"Failure of ritodrine to prevent preterm labor in the sheep","volume":"167","year":"1992","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t20170224183359_R31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3220001","article-title":"Regulatory mechanisms that modulate signalling by G-protein-coupled receptors","volume":"322","year":"1997","journal-title":"Biochem J"},{"key":"key\n\t\t\t\t20170224183359_R32","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1677\/joe.0.1520407","article-title":"Agonist-induced internalisation of the angiotensin II-binding sites from plasma membranes of isolated rat hepatocytes","volume":"152","year":"1997","journal-title":"J Endocrinol"},{"key":"key\n\t\t\t\t20170224183359_R33","first-page":"994","article-title":"Lactate dehydrogenase A subunit messenger RNA stability is synergistically regulated via the protein kinase A and C signal transduction pathways","volume":"9","year":"1995","journal-title":"Mol Endocrinol"},{"key":"key\n\t\t\t\t20170224183359_R34","doi-asserted-by":"crossref","first-page":"4772","DOI":"10.1016\/S0021-9258(19)67716-1","article-title":"The mechanism for synergism between phospholipase C- and adenylcyclase-linked hormones in liver. Cyclic AMP-dependent kinase augments inositol trisphosphate-mediated Ca2+ mobilization without increasing the cellular levels of inositol polyphosphates","volume":"266","year":"1991","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170224183359_R35","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/S0006-291X(05)81219-7","article-title":"Inositol 1,4,5-trisphosphate receptor is phosphorylated by cyclic AMP-dependent protein kinase at serines 1755 and 1589","volume":"175","year":"1991","journal-title":"Biochem Biophys Res Commun"},{"key":"key\n\t\t\t\t20170224183359_R36","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0005-2760(90)90298-C","article-title":"Vasopressin and norepinephrine stimulation of inositol phosphate accumulation in rat hepatocytes are modified differently by protein kinase C and protein kinase A","volume":"1043","year":"1990","journal-title":"Biochim Biophys Acta"},{"key":"key\n\t\t\t\t20170224183359_R37","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1210\/endo.138.5.5127","article-title":"Expression and region-specific regulation of the oxytocin receptor gene in rat brain","volume":"138","year":"1997","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224183359_R38","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1159\/000127160","article-title":"Effects of estrogen on oxytocin receptor messenger ribonucleic acid expression in the uterus, pituitary, and forebrain of the female rat","volume":"65","year":"1997","journal-title":"Neuroendocrinology"},{"key":"key\n\t\t\t\t20170224183359_R39","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1210\/endo.137.7.8770890","article-title":"Renal oxytocin receptor messenger ribonucleic acid: characterization and regulation during pregnancy and in response to ovarian steroid treatment","volume":"137","year":"1996","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224183359_R40","first-page":"329","article-title":"Oxytocin receptor gene expression in female rat kidney: the effect of estrogen","volume":"395","year":"1996","journal-title":"Adv Exp Med Biol"},{"key":"key\n\t\t\t\t20170224183359_R41","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1540\/jsmr.31.175","article-title":"The regulation of oxytocin receptor expression in human myometrial monolayer culture","volume":"31","year":"1995","journal-title":"J Smooth Muscle Res"},{"key":"key\n\t\t\t\t20170224183359_R42","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1016\/0002-9378(94)90414-6","article-title":"Effect of oxytocin antagonists on the activation of human myometrium in vitro: atosiban prevents oxytocin-induced desensitization","volume":"171","year":"1994","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t20170224183359_R43","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1677\/joe.0.1540007","article-title":"The desensitization of oxytocin receptors in human myometrial cells is accompanied by down-regulation of oxytocin receptor messenger RNA","volume":"154","year":"1997","journal-title":"J Endocrinol"},{"key":"key\n\t\t\t\t20170224183359_R44","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/356526a0","article-title":"Structure and expression of a human oxytocin receptor","volume":"356","year":"1992","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170224183359_R45","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1055\/s-2007-999568","article-title":"Pulsatile administration enhances the effect and reduces the dose of oxytocin required for induction of labor","volume":"6","year":"1989","journal-title":"Am J Perinatol"},{"key":"key\n\t\t\t\t20170224183359_R46","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1046\/j.1365-2826.1996.05266.x","article-title":"Deficiency in mouse oxytocin prevents milk ejection, but not fertility or parturition","volume":"8","year":"1996","journal-title":"J Neuroendocrinol"},{"key":"key\n\t\t\t\t20170224183359_R47","doi-asserted-by":"crossref","first-page":"11699","DOI":"10.1073\/pnas.93.21.11699","article-title":"Oxytocin is required for nursing but is not essential for parturition or reproductive behavior","volume":"93","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170224183359_R48","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1095\/biolreprod46.1.58","article-title":"Myometrial oxytocin receptors and prostaglandin in the parturition process in the rat","volume":"46","year":"1992","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224183359_R49","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1172\/JCI117629","article-title":"The effect of oxytocin receptor blockade on parturition in guinea pigs","volume":"95","year":"1995","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20170224183359_R50","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1055\/s-2007-999575","article-title":"Oxytocin receptor blockade: a new principle in the treatment of preterm labor?","volume":"6","year":"1989","journal-title":"Am J Perinatol"},{"key":"key\n\t\t\t\t20170224183359_R51","first-page":"1237","article-title":"Effect of ritodrine hydrochloride on fetal perfusion pressure in dually perfused human placenta","volume":"47","year":"1995","journal-title":"Nippon Sanka Fujinka Gakkai Zasshi"},{"key":"key\n\t\t\t\t20170224183359_R52","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S0029-7844(97)00056-2","article-title":"Oxytocin and its receptor in pregnancy and parturition: current concepts and clinical implications","volume":"89","year":"1997","journal-title":"Obstet Gynecol"},{"key":"key\n\t\t\t\t20170224183359_R53","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/0002-9378(93)90023-C","article-title":"Maternal and fetal cardiovascular effects and placental transfer of the oxytocin antagonist atosiban in late-gestation pregnant sheep","volume":"169","year":"1993","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t20170224183359_R54","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/0002-9378(95)91497-8","article-title":"Placental passage of the oxytocin antagonist atosiban","volume":"172","year":"1995","journal-title":"Am J Obstet Gynecol"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/biolreprod\/article-pdf\/60\/2\/322\/10589838\/biolreprod0322.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T00:22:48Z","timestamp":1626654168000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-lookup\/doi\/10.1095\/biolreprod60.2.322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,2,1]]},"references-count":54,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1999,2,1]]}},"URL":"https:\/\/doi.org\/10.1095\/biolreprod60.2.322","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,2,1]]}}}