{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T18:33:20Z","timestamp":1779129200733,"version":"3.51.4"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,1,1]]},"DOI":"10.1095\/biolreprod62.1.178","type":"journal-article","created":{"date-parts":[[2005,10,31]],"date-time":"2005-10-31T23:08:20Z","timestamp":1130800100000},"page":"178-185","source":"Crossref","is-referenced-by-count":45,"title":["Induction of Apoptosis in Placentas of Pregnant Mice Exposedto Lipopolysaccharides: Possible Involvement of Fas\/Fas Ligand System1"],"prefix":"10.1093","volume":"62","author":[{"given":"Kuniaki","family":"Ejima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehiko","family":"Koji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Tsuruta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Nanri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masamichi","family":"Kashimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaharu","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","reference":[{"key":"key\n\t\t\t\t20170224165732_R1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1471-0528.1995.tb09020.x","article-title":"Interleukin-6, tumor necrosis factor and soluble tumor necrosis factor receptors in women with preeclampsia.","volume":"102","year":"1995","journal-title":"Br J Obstet Gynecol"},{"key":"key\n\t\t\t\t20170224165732_R2","first-page":"93","article-title":"Murine experimental abortion by IL-2 administration is caused by activation of cytotoxic T-lymphocytes and placental apoptosis.","volume":"48","year":"1996","journal-title":"J Clin Lab Immunol"},{"key":"key\n\t\t\t\t20170224165732_R3","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/284555a0","article-title":"Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation.","volume":"284","year":"1980","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170224165732_R4","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1083\/jcb.119.3.493","article-title":"Identification of programmed cell death in situ via specific labeling of DNA fragmentation.","volume":"119","year":"1992","journal-title":"J Cell Biol"},{"key":"key\n\t\t\t\t20170224165732_R5","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1146\/annurev.cb.07.110191.003311","article-title":"Mechanism and functions of cell death.","volume":"7","year":"1991","journal-title":"Annu Rev Cell Biol"},{"key":"key\n\t\t\t\t20170224165732_R6","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/bies.950130805","article-title":"The role of cell death genes during development.","volume":"13","year":"1991","journal-title":"Bioessays"},{"key":"key\n\t\t\t\t20170224165732_R7","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1126\/science.7533326","article-title":"The Fas death factor.","volume":"267","year":"1995","journal-title":"Science"},{"key":"key\n\t\t\t\t20170224165732_R8","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.4049\/jimmunol.148.4.1274","article-title":"The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen.","volume":"148","year":"1992","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170224165732_R9","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1210\/endo.137.5.8612534","article-title":"Fas\/APO-1\/CD95 system as a mediator of granulosa cell apoptosis in ovarian follicle atresia.","volume":"137","year":"1996","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224165732_R10","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/j.1460-2075.1996.tb00351.x","article-title":"Involvement of Fas in regression of vaginal epithelia after ovariectomy and during an estrous cycle.","volume":"15","year":"1996","journal-title":"EMBO J"},{"key":"key\n\t\t\t\t20170224165732_R11","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1095\/biolreprod58.5.1250","article-title":"Autonomous cell death of mouse male germ cells during fetal and postnatal period.","volume":"58","year":"1998","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224165732_R12","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/(SICI)1096-9896(199610)180:2<152::AID-PATH649>3.0.CO;2-Y","article-title":"Apoptosis of crypt epithelial cells in ulcerative colitis.","volume":"180","year":"1996","journal-title":"J Pathol"},{"key":"key\n\t\t\t\t20170224165732_R13","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1126\/science.275.5302.960","article-title":"Potential involvement of Fas and its ligand in pathogenesis of Hashimoto's thyroiditis.","volume":"275","year":"1997","journal-title":"Science"},{"key":"key\n\t\t\t\t20170224165732_R14","doi-asserted-by":"crossref","first-page":"3646","DOI":"10.1210\/endo.139.8.6140","article-title":"Role of apoptosis of thyrocytes in a rat model of goiter. A possible involvement of Fas system.","volume":"139","year":"1998","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224165732_R15","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1681\/ASN.V94620","article-title":"Induction of apoptosis in ischemia-reperfusion model of mouse kidney: possible involvement of Fas.","volume":"9","year":"1998","journal-title":"J Am Soc Nephrol"},{"key":"key\n\t\t\t\t20170224165732_R16","first-page":"3119","article-title":"Expression of Fas ligand by human cytotrophoblasts: implications in placentation and fetal survival.","volume":"81","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20170224165732_R17","first-page":"387","article-title":"Apoptotic changes occur in syncytiotrophoblast of human placental villi where fibrin type fibrinoid is deposited at discontinuities in the villous trophoblast.","volume":"17","year":"1997","journal-title":"Placenta"},{"key":"key\n\t\t\t\t20170224165732_R18","first-page":"3173","article-title":"Expression of the apoptosis-inducing Fas ligand (Fas L) in human first and third trimester placenta and choriocarcinoma cells.","volume":"9","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20170224165732_R19","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/0891-5849(96)00171-2","article-title":"Fetal growth retardation in rats may result from apoptosis: role of peroxynitrite.","volume":"21","year":"1996","journal-title":"Free Radical Biol Med"},{"key":"key\n\t\t\t\t20170224165732_R20","first-page":"4112","article-title":"Fas ligand is positioned in mouse uterus and placenta to prevent trafficking of activated leukocytes between the mother and the conceptus.","volume":"158","year":"1997","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170224165732_R21","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0029-7844(97)00176-2","article-title":"Trophoblastic apoptosis in mice with preterm delivery and its suppression by urinary trypsin inhibitor.","volume":"90","year":"1997","journal-title":"Obstet Gynecol"},{"key":"key\n\t\t\t\t20170224165732_R22","doi-asserted-by":"crossref","first-page":"37","DOI":"10.4049\/jimmunol.138.1.37","article-title":"The immuno-stimulatory effect of T cells and T cell lymphokines on murine fetally derived placental cells.","volume":"138","year":"1987","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170224165732_R23","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/S0002-9378(12)80012-3","article-title":"Tumor necrosis factor-alpha in midtrimester amniotic fluid is associated with impaired intrauterine fetal growth.","volume":"167","year":"1992","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t20170224165732_R24","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/0002-9378(95)91358-0","article-title":"Amniotic fluid interleukin-10 concentrations increase through pregnancy and are elevated in patients with preterm labor associated with intrauterine infection.","volume":"173","year":"1995","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t20170224165732_R25","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/0002-9378(76)90579-2","article-title":"Immunologic aspects of preeclampsia.","volume":"125","year":"1976","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t20170224165732_R26","first-page":"223","article-title":"Immunological disorders of human pregnancy","volume":"8","year":"1986","journal-title":"Oxf Rev Reprod Biol"},{"key":"key\n\t\t\t\t20170224165732_R27","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1600-0897.1997.tb00195.x","article-title":"Immunology of preeclampsia.","volume":"37","year":"1997","journal-title":"Am J Reprod Immunol"},{"key":"key\n\t\t\t\t20170224165732_R28","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1095\/biolreprod57.3.616","article-title":"Interleukin-8 release from human gestational tissue explants: the effects of lipopolysaccharide and cytokines.","volume":"57","year":"1997","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224165732_R29","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0143-4004(97)80045-8","article-title":"Constitutive and induced cytokine production by human placenta and amniotic membrane at term.","volume":"18","year":"1997","journal-title":"Placenta"},{"key":"key\n\t\t\t\t20170224165732_R30","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1172\/JCI117842","article-title":"Involvement of reactive oxygen intermediates in cyclooxygenase-2 expression induced by interleukin-1, tumor necrosis factor-\u03b1, and lipopolysaccharide.","volume":"95","year":"1995","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20170224165732_R31","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/j.1460-2075.1996.tb00352.x","article-title":"Superoxide anion is a natural inhibitor of Fas-mediated cell death.","volume":"15","year":"1996","journal-title":"EMBO J"},{"key":"key\n\t\t\t\t20170224165732_R32","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0167-5699(94)90018-3","article-title":"Oxidative stress as a mediator of apoptosis.","volume":"15","year":"1994","journal-title":"Immunol Today"},{"key":"key\n\t\t\t\t20170224165732_R33","doi-asserted-by":"crossref","first-page":"4722","DOI":"10.4049\/jimmunol.156.12.4722","article-title":"Relation of oxidative stress and glutathione synthesis to CD95 (Fas\/Apo-1)-mediated apoptosis of adult T cell leukemia cells.","volume":"156","year":"1996","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170224165732_R34","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/0092-8674(94)90375-1","article-title":"Generalized lymphoproliferative disease in mice, caused by a point mutation in Fas ligand.","volume":"76","year":"1994","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170224165732_R35","first-page":"793","article-title":"Localization in situ of specific mRNA using thymine-thymine dimerized DNA probe: sensitive and reliable non-radioactive in situ hybridization.","volume":"40","year":"1990","journal-title":"Acta Pathol Jpn"},{"key":"key\n\t\t\t\t20170224165732_R36","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1083\/jcb.125.2.393","article-title":"Progesterone-dependent expression of keratinocytes growth factor mRNA in stromal cells of the primate endometrium: keratinocyte growth factor as a progestomedin.","volume":"125","year":"1994","journal-title":"J Cell Biol"},{"key":"key\n\t\t\t\t20170224165732_R37","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1177\/43.3.7532657","article-title":"In situ localization of ribosomal RNA is reliable reference for hybridizable RNA in tissue sections.","volume":"43","year":"1995","journal-title":"J Histochem Cytochem"},{"key":"key\n\t\t\t\t20170224165732_R38","doi-asserted-by":"crossref","first-page":"10709","DOI":"10.1016\/S0021-9258(19)50076-X","article-title":"Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor\/nerve growth factor receptor superfamily.","volume":"267","year":"1992","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170224165732_R39","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/0092-8674(93)90326-L","article-title":"Molecular cloning and expression of the Fas ligand, novel member of the tumor necrosis factor family.","volume":"75","year":"1993","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170224165732_R40","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.","volume":"72","year":"1976","journal-title":"Anal Biochem"},{"key":"key\n\t\t\t\t20170224165732_R41","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4.","volume":"227","year":"1970","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170224165732_R42","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1177\/29.6.7252134","article-title":"Heavy metal intensification of DAB-based HRP reaction product","volume":"29","year":"1981","journal-title":"J Histochem Cytochem"},{"key":"key\n\t\t\t\t20170224165732_R43","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1267\/ahc.27.459","article-title":"Immunohistochemical localization of Fas antigen paraffin sections with rabbit antibodies against human synthetic Fas peptides.","volume":"27","year":"1994","journal-title":"Acta Histochem Cytochem"},{"key":"key\n\t\t\t\t20170224165732_R44","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/S0891-5849(97)00388-2","article-title":"Oxidative stress developed during the reperfusion of ischemic myocardium induces apoptosis.","volume":"24","year":"1998","journal-title":"Free Radical Biol Med"},{"key":"key\n\t\t\t\t20170224165732_R45","first-page":"869","article-title":"Chemiluminescent real time imaging of post-ischemic oxygen free radical formation in livers isolated from young and old rats.","volume":"24","year":"1998","journal-title":"Free Radical Biol Med"},{"key":"key\n\t\t\t\t20170224165732_R46","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1038\/370650a0","article-title":"Cytolic T-cell cytotoxicity is mediated through perforin and Fas lytic pathway.","volume":"370","year":"1994","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170224165732_R47","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/0092-8674(94)90376-X","article-title":"Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogenic target cells.","volume":"76","year":"1994","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170224165732_R48","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1365-2184.1991.tb01150.x","article-title":"Dose-dependent induction of apoptosis in human tumor cell lines by widely diverging stimuli.","volume":"24","year":"1991","journal-title":"Cell Prolif"},{"key":"key\n\t\t\t\t20170224165732_R49","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1046\/j.1471-4159.1994.62010376.x","article-title":"Oxidative stress induces apoptosis in embryonic cortical neurons.","volume":"62","year":"1994","journal-title":"J Neurochem"},{"key":"key\n\t\t\t\t20170224165732_R50","doi-asserted-by":"crossref","first-page":"6384","DOI":"10.1073\/pnas.91.14.6384","article-title":"Down-regulation of copper\/zinc superoxide dismutase causes apoptotic death in PC 12 neuron cells.","volume":"91","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170224165732_R51","doi-asserted-by":"crossref","first-page":"4533","DOI":"10.1073\/pnas.90.10.4533","article-title":"Bcl-2 inhibits death of central cells induced by multiple agents.","volume":"90","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170224165732_R52","doi-asserted-by":"crossref","first-page":"8742","DOI":"10.1073\/pnas.90.18.8742","article-title":"Immunochemical detection of 4-hydroxynonenal protein adducts in oxidized hepatocytes.","volume":"90","year":"1993","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/biolreprod\/article-pdf\/62\/1\/178\/10594092\/biolreprod0178.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,5]],"date-time":"2025-01-05T07:57:41Z","timestamp":1736063861000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-lookup\/doi\/10.1095\/biolreprod62.1.178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,1,1]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,1,1]]}},"URL":"https:\/\/doi.org\/10.1095\/biolreprod62.1.178","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,1,1]]}}}