{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:06:05Z","timestamp":1791846365755,"version":"4.3.4"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,3,1]]},"DOI":"10.1095\/biolreprod62.3.739","type":"journal-article","created":{"date-parts":[[2005,10,31]],"date-time":"2005-10-31T23:08:20Z","timestamp":1130800100000},"page":"739-747","source":"Crossref","is-referenced-by-count":172,"title":["Extracellular Matrix Composition and Hypoxia Regulate the Expression of HLA-G and Integrins in a Human Trophoblast Cell Line1"],"prefix":"10.1093","volume":"62","author":[{"given":"Brian A.","family":"Kilburn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zophia M.","family":"Duniec-Dmuchkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard E.","family":"Leach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Randall","family":"Armant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"key\n\t\t\t\t20170224181849_R1","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1242\/jcs.99.4.681","article-title":"Implantation, trophoblast differentiation and haemochorial placentation: mechanistic evidence in vivo and in vitro.","volume":"99","year":"1991","journal-title":"J Cell Sci"},{"key":"key\n\t\t\t\t20170224181849_R2","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1002\/jez.1402660606","article-title":"Implantation: a cell biological paradox.","volume":"266","year":"1993","journal-title":"J Exp Zool"},{"key":"key\n\t\t\t\t20170224181849_R3","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1126\/science.7985020","article-title":"Implantation and the placenta: key pieces of the development puzzle.","volume":"266","year":"1994","journal-title":"Science"},{"key":"key\n\t\t\t\t20170224181849_R4","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/humupd\/2.4.307","article-title":"Trophoblast migration during human placental implantation.","volume":"2","year":"1996","journal-title":"Hum Reprod Update"},{"key":"key\n\t\t\t\t20170224181849_R5","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1159\/000147847","article-title":"Epithelial-mesenchymal transition during trophoblast differentiation.","volume":"156","year":"1996","journal-title":"Acta Anat"},{"key":"key\n\t\t\t\t20170224181849_R6","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1172\/JCI115565","article-title":"Distribution patterns of extracellular matrix components and adhesion receptors are intricately modulated during first trimester cytotrophoblast differentiation along the invasive pathway, in vivo.","volume":"89","year":"1992","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20170224181849_R7","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0143-4004(96)80071-3","article-title":"Growth factors, proteases and protease inhibitors in the maternal-fetal dialogue.","volume":"17","year":"1996","journal-title":"Placenta"},{"key":"key\n\t\t\t\t20170224181849_R8","first-page":"2139","article-title":"Human cytotrophoblasts adopt a vascular phenotype as they differentiate.","volume":"99","year":"1997","journal-title":"A strategy for successful endovascular invasion? J Clin Invest"},{"key":"key\n\t\t\t\t20170224181849_R9","doi-asserted-by":"crossref","first-page":"3657","DOI":"10.1242\/dev.120.12.3657","article-title":"Integrin switching regulates normal trophoblast invasion.","volume":"120","year":"1994","journal-title":"Development"},{"key":"key\n\t\t\t\t20170224181849_R10","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1126\/science.2326636","article-title":"A class I antigen, HLA-G, expressed in human trophoblasts.","volume":"248","year":"1990","journal-title":"Science"},{"key":"key\n\t\t\t\t20170224181849_R11","doi-asserted-by":"crossref","first-page":"3771","DOI":"10.4049\/jimmunol.154.8.3771","article-title":"Human placental HLA-G expression is restricted to differentiated cytotrophoblasts.","volume":"154","year":"1995","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170224181849_R12","first-page":"283","article-title":"Oxygen measurements in endometrial and trophoblastic tissues during early pregnancy.","volume":"80","year":"1992","journal-title":"Obstet Gynecol"},{"key":"key\n\t\t\t\t20170224181849_R13","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1172\/JCI118447","article-title":"Hypoxia alters early gestation human cytotrophoblast differentiation\/invasion in vitro and models the placental defects that occur in preeclampsia.","volume":"97","year":"1996","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20170224181849_R14","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1126\/science.277.5332.1669","article-title":"Regulation of human placental development by oxygen tension.","volume":"277","year":"1997","journal-title":"Science"},{"key":"key\n\t\t\t\t20170224181849_R15","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1006\/excr.1993.1139","article-title":"Establishment and characterization of first trimester human trophoblast cells with extended lifespan.","volume":"206","year":"1993","journal-title":"Exp Cell Res"},{"key":"key\n\t\t\t\t20170224181849_R16","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/S0015-0282(16)53526-2","article-title":"The influence of chamber characteristics on the reliability of sperm concentration and movement measurements obtained by manual and videomicrographic analysis.","volume":"53","year":"1990","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20170224181849_R17","doi-asserted-by":"crossref","first-page":"5922","DOI":"10.4049\/jimmunol.160.12.5922","article-title":"HLA-G isoforms produced by placental cytotrophoblasts and found in amniotic fluid are due to unusual glycosylation.","volume":"160","year":"1998","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170224181849_R18","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4.","volume":"227","year":"1970","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170224181849_R19","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcp.1041360309","article-title":"Normal nonmetastatic human trophoblast cells share in vitro invasive properties of malignant cells.","volume":"136","year":"1988","journal-title":"J Cell Physiol"},{"key":"key\n\t\t\t\t20170224181849_R20","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1006\/excr.1994.1237","article-title":"Resistance of malignant trophoblast cells to both the anti-proliferative and anti-invasive effects of transforming growth factor-beta.","volume":"214","year":"1994","journal-title":"Exp Cell Res"},{"key":"key\n\t\t\t\t20170224181849_R21","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1073\/pnas.87.8.3057","article-title":"Human trophoblast-extracellular matrix (ECM) interactions in vitro: ECM thickness modulates morphology and proteolytic activity.","volume":"87","year":"1990","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170224181849_R22","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1083\/jcb.113.2.437","article-title":"92-kD type IV collagenase mediates invasion of human cytotrophoblasts.","volume":"113","year":"1991","journal-title":"J Cell Biol"},{"key":"key\n\t\t\t\t20170224181849_R23","doi-asserted-by":"crossref","first-page":"3300","DOI":"10.1182\/blood.V91.9.3300","article-title":"Hypoxia stimulates urokinase receptor expression through a heme protein-dependent pathway.","volume":"91","year":"1998","journal-title":"Blood"},{"key":"key\n\t\t\t\t20170224181849_R24","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1083\/jcb.109.2.891","article-title":"Adhesive and degradative properties of human placental cytotrophoblast cells in vitro.","volume":"109","year":"1989","journal-title":"J Cell Biol"},{"key":"key\n\t\t\t\t20170224181849_R25","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/0002-9378(94)90107-4","article-title":"Developmental regulation of the expression of 72 and 92 kd type IV collagenases in human trophoblasts: a possible mechanism for control of trophoblast invasion.","volume":"171","year":"1994","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t20170224181849_R26","first-page":"347","article-title":"Distribution of the alpha 1-alpha 6 integrin subunits in human developing and term placenta.","volume":"65","year":"1991","journal-title":"Lab Invest"},{"key":"key\n\t\t\t\t20170224181849_R27","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/0143-4004(95)90100-0","article-title":"Characteristics of trophoblast cells migrating from first trimester chorionic villus explants and propagated in culture.","volume":"16","year":"1995","journal-title":"Placenta"},{"key":"key\n\t\t\t\t20170224181849_R28","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1053\/plac.1999.0393","article-title":"Susceptibility of MHC class I expressing extravillous trophoblast cell lines to killing by natural killer cells.","volume":"20","year":"1999","journal-title":"Placenta"},{"key":"key\n\t\t\t\t20170224181849_R29","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1095\/biolreprod60.4.828","article-title":"Development of cytotrophoblast columns from explanted first-trimester human placental villi: role of fibronectin and integrin alpha 5 beta 1.","volume":"60","year":"1999","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224181849_R30","doi-asserted-by":"crossref","first-page":"11522","DOI":"10.1074\/jbc.270.19.11522","article-title":"\u03b21- and \u03b23-class integrins mediate fibronectin binding activity at the surface of developing mouse peri-implantation blastocysts. Regulation by ligand-induced mobilization of stored receptor.","volume":"270","year":"1995","journal-title":"J Biol Chem"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/biolreprod\/article-pdf\/62\/3\/739\/10596180\/biolreprod0739.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,5]],"date-time":"2025-01-05T07:57:31Z","timestamp":1736063851000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-lookup\/doi\/10.1095\/biolreprod62.3.739"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,3,1]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2000,3,1]]}},"URL":"https:\/\/doi.org\/10.1095\/biolreprod62.3.739","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,3,1]]}}}