{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T14:34:36Z","timestamp":1774362876794,"version":"3.50.1"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,4,1]]},"DOI":"10.1095\/biolreprod64.4.1216","type":"journal-article","created":{"date-parts":[[2005,10,31]],"date-time":"2005-10-31T23:33:39Z","timestamp":1130801619000},"page":"1216-1224","source":"Crossref","is-referenced-by-count":29,"title":["Exposure of Neonatal Female Rats to p-tert-Octylphenol Disrupts Afternoon Surges of Luteinizing Hormone, Follicle-Stimulating Hormone and Prolactin Secretion, and Interferes with Sexual Receptive Behavior in Adulthood1"],"prefix":"10.1093","volume":"64","author":[{"given":"Chandana B.","family":"Herath","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gen","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin-ichi","family":"Katsuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Midori","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira K.","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuyoshi","family":"Taya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","reference":[{"key":"key\n\t\t\t\t20170224185415_R1","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1126\/science.6740328","article-title":"4-Nonylphenol in sewage sludge: accumulation of toxic metabolites from nonionic surfactants","volume":"225","year":"1984","journal-title":"Science"},{"key":"key\n\t\t\t\t20170224185415_R2","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1210\/endo.135.1.8013351","article-title":"Environmentally persistent alkylphenolic compounds are estrogenic","volume":"135","year":"1994","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224185415_R3","doi-asserted-by":"crossref","first-page":"446","DOI":"10.3181\/00379727-216-44195","article-title":"Disruption of rat estrous cyclicity by the environmental estrogen 4-tert-octylphenol.","volume":"216","year":"1997","journal-title":"Proc Soc Exp Biol Med"},{"key":"key\n\t\t\t\t20170224185415_R4","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/s002040050365","article-title":"Toxicokinetics of p-tert-octylphenol in male Wistar rats.","volume":"71","year":"1996","journal-title":"Arch Toxicol"},{"key":"key\n\t\t\t\t20170224185415_R5","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/31307","article-title":"Japanese media fuel fears of \u2018endocrine disrupters\u2019","volume":"393","year":"1998","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170224185415_R6","first-page":"143","article-title":"Sexual differentiation and environmental endocrine disrupters","volume":"12","year":"1998","journal-title":"Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20170224185415_R7","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1210\/endo-89-6-1448","article-title":"Control of the proestrus surge of prolactin and luteinizing hormone secretion by estrogens in the rat","volume":"89","year":"1971","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224185415_R8","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1210\/endo-90-5-1154","article-title":"Sexual differences in the hypothalamic regulation of prolactin secretion","volume":"90","year":"1972","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224185415_R9","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1210\/endo-96-1-57","article-title":"A daily signal for the LH surge in the rat","volume":"96","year":"1975","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224185415_R10","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1210\/endo-96-1-50","article-title":"Role of estrogen as initiator of daily LH surges in the ovariectomized rat","volume":"96","year":"1975","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224185415_R11","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1210\/endo-89-2-331","article-title":"Biphasic effect of progesterone on the release gonadotropin in rats","volume":"89","year":"1971","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224185415_R12","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1677\/joe.0.0600205","article-title":"Oestrogen and progesterone influence on the release of prolactin in ovariectomized rats","volume":"60","year":"1974","journal-title":"J Endocrinol"},{"key":"key\n\t\t\t\t20170224185415_R13","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1210\/endo-117-1-388","article-title":"Central nervous system regions involved in the estrogen-induced afternoon prolactin surges. II. Implantation studies.","volume":"117","year":"1985","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224185415_R14","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1146\/annurev.ne.07.030184.002213","article-title":"Gonadal steroid induction of structural sex differences in the central nervous system","volume":"7","year":"1984","journal-title":"Annu Rev Neurosci"},{"key":"key\n\t\t\t\t20170224185415_R15","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1080\/15287397709529551","article-title":"Perinatal hormonal exposure and the development of neuroendocrine regulatory processes","volume":"3","year":"1977","journal-title":"J Toxicol Environ Health"},{"key":"key\n\t\t\t\t20170224185415_R16","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/0006-8993(75)90755-6","article-title":"Role of fetoneonatal estrogen binding proteins in the association of estrogen with neonatal brain cell nuclear receptors","volume":"96","year":"1975","journal-title":"Brain Res"},{"key":"key\n\t\t\t\t20170224185415_R17","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/0039-128X(71)90035-3","article-title":"Rat estradiol binding plasma protein (EBP)","volume":"18","year":"1971","journal-title":"Steroids"},{"key":"key\n\t\t\t\t20170224185415_R18","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1159\/000122082","article-title":"An evaluation of the inhibition of androgenization of the neonatal female rat brain by barbiturate","volume":"10","year":"1972","journal-title":"Neuroendocrinology"},{"key":"key\n\t\t\t\t20170224185415_R19","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1210\/endo-68-1-62","article-title":"Production of anovulatory, sterile rats, by single injections of testosterone propionate","volume":"68","year":"1961","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224185415_R20","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1210\/endo-68-1-68","article-title":"Evidence that the hypothalamus is responsible for androgen-induced sterility in the female rat","volume":"68","year":"1961","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224185415_R21","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1210\/endo-101-3-741","article-title":"Steroid regulation of luteinizing hormone secretion in normal and androgenized rats at different ages","volume":"101","year":"1977","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224185415_R22","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1210\/endo-101-3-750","article-title":"Correlations between ovarian sensitivity, vaginal cyclicity and luteinizing hormone and prolactin secretion in lightly androgenized rats","volume":"101","year":"1977","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224185415_R23","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1210\/endo-96-2-486","article-title":"Effects of ovarian steroids on plasma LH in normal and persistent estrous adult female rats","volume":"96","year":"1975","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224185415_R24","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1530\/jrf.0.0730215","article-title":"Neonatal androgen abolishes clock-timed gonadotropin release in prepubertal and adult female hamsters","volume":"73","year":"1985","journal-title":"J Reprod Fertil"},{"key":"key\n\t\t\t\t20170224185415_R25","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1677\/joe.0.0250175","article-title":"Studies on mating behavior in the androgen-sterilized rat and their relation to the hypothalamic regulation of sexual behavior in the female rat","volume":"25","year":"1962","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224185415_R26","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1113\/jphysiol.1965.sp007768","article-title":"Sexual differentiation of the brain and its experimental control","volume":"181","year":"1965","journal-title":"J Physiol"},{"key":"key\n\t\t\t\t20170224185415_R27","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1289\/ehp.951031136","article-title":"Gestational and lactational exposure of rats to xenoestrogens results in reduced testicular size and sperm production","volume":"103","year":"1995","journal-title":"Environ Health Perspect"},{"key":"key\n\t\t\t\t20170224185415_R28","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1095\/biolreprod57.2.255","article-title":"Chronic administration of the environmental pollutant 4-tert-octylphenol to adult rats interferes with the secretion of luteinizing hormone, follicle-stimulating hormone, prolactin, and testosterone","volume":"57","year":"1997","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224185415_R29","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1095\/biolreprod57.2.267","article-title":"Chronic administration of 4-tert-octylphenol to adult male rats causes shrinkage of the testes and male accessory sex organs, disrupts spermatogenesis, and increases the incidence of sperm deformities.","volume":"57","year":"1997","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224185415_R30","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1385\/ENDO:9:1:105","article-title":"Disruption of male reproductive tract development by administration of the xenoestrogen, nonylphenol, to male newborn rats","volume":"9","year":"1998","journal-title":"Endocrine"},{"key":"key\n\t\t\t\t20170224185415_R31","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1385\/ENDO:11:1:61","article-title":"Testicular abnormalities in male rats after lactational exposure to nonylphenols","volume":"11","year":"1999","journal-title":"Endocrine"},{"key":"key\n\t\t\t\t20170224185415_R32","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1006\/taap.2000.8940","article-title":"Irreversible effects of neonatal exposure to p-tert-octylphenol on the reproductive tract in female rats.","volume":"165","year":"2000","journal-title":"Toxicol Appl Pharmacol"},{"key":"key\n\t\t\t\t20170224185415_R33","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1210\/endo.138.1.4849","article-title":"Abnormal estrous cyclicity and behavioral hyporesponsiveness to ovarian hormones in genetically obese zucker female rats","volume":"138","year":"1997","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224185415_R34","volume-title":"The Rat Brain in Stereotaxic Coordinates","year":"1986","edition":"2nd ed"},{"key":"key\n\t\t\t\t20170224185415_R35","volume-title":"Biostatistical Analysis.","year":"1984"},{"key":"key\n\t\t\t\t20170224185415_R36","volume-title":"Statistics, Version 6.11","author":"SAS","year":"1987"},{"key":"key\n\t\t\t\t20170224185415_R37","first-page":"198","article-title":"A 24h periodicity in the \u2018LH release apparatus\u2019 of female rats, disclosed by barbiturate sedation","volume":"46","year":"1950","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224185415_R38","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1159\/000125203","article-title":"Spontaneous changes in GnRH release during the rat estrous cycle as measured with repetitive push-pull perfusions of the pituitary gland in the same female rats","volume":"50","year":"1989","journal-title":"Neuroendocrinology"},{"key":"key\n\t\t\t\t20170224185415_R39","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1095\/biolreprod56.2.293","article-title":"New concepts of the neuroendocrine regulation of gonadotropin surges in rats","volume":"56","year":"1997","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170224185415_R40","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1210\/endo-115-2-801","article-title":"Estradiol-induced daily luteinizing hormone and prolactin surges in young and middle-aged rats: correlations with age-related changes in pituitary responsiveness and catecholamine turnover rates in microdissected brain areas","volume":"115","year":"1984","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224185415_R41","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/cne.901510204","article-title":"Atlas of estradiol-concentrating cells in the central nervous system of the female rat","volume":"151","year":"1973","journal-title":"J Comp Neurol"},{"key":"key\n\t\t\t\t20170224185415_R42","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1210\/endo-117-1-382","article-title":"Central nervous system regions involved in the estrogen-induced afternoon prolactin surge. I. Lesion studies.","volume":"117","year":"1985","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224185415_R43","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1210\/endo-102-5-1429","article-title":"Displacements of estradiol from estrogen receptors by simple alkylphenols","volume":"102","year":"1978","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224185415_R44","first-page":"227","article-title":"Central administration of antiserum to vasoactive intestinal peptide delays and reduces luteinizing hormone and prolactin surges in ovariectomized, estrogen-treated rats","volume":"22","year":"1999","journal-title":"Neuroendocrinology"},{"key":"key\n\t\t\t\t20170224185415_R45","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1210\/endo-124-2-878","article-title":"Hypothalamic factors involved in the endogenous stimulatory rhythm regulating prolactin secretion","volume":"124","year":"1989","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224185415_R46","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1159\/000127119","article-title":"Stimulatory effects of vasoactive intestinal peptides and pituitary adenylate cyclase-activating peptide on tuberoinfundibular dopaminergic neuron activity in estrogen-treated ovariectomized rats and their correlation with prolactin secretion","volume":"64","year":"1996","journal-title":"Neuroendocrinology"},{"key":"key\n\t\t\t\t20170224185415_R47","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1210\/endo-104-4-898","article-title":"Localized behavioral effects of tritiated estradiol implants in the ventromedial hypothalamus of female rats","volume":"104","year":"1979","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224185415_R48","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1210\/endo-111-5-1581","article-title":"The site of intrahypothalamic estrogen implants in feminine sexual behavior: an autoradiographic analysis","volume":"111","year":"1982","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224185415_R49","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1210\/endo-106-2-504","article-title":"Priming of estrous responsiveness by implants of 17\u03b2-estradiol in the ventromedial hypothalamic nucleus of female rats","volume":"106","year":"1980","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170224185415_R50","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0006-8993(78)90723-0","article-title":"Evidence for a morphological sex difference within the medial preoptic area of the rat brain","volume":"148","year":"1978","journal-title":"Brain Res"},{"key":"key\n\t\t\t\t20170224185415_R51","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1002\/bms.1200180706","article-title":"Identification and determination of tert-alkylphenols in carp from the Trenton Channel of the Detroit River, Michigan, USA","volume":"18","year":"1989","journal-title":"Biomed Environ Mass Spectrom"},{"key":"key\n\t\t\t\t20170224185415_R52","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1080\/03067319208027027","article-title":"Determination of alkylphenol ethoxylates and their acetic acid derivatives in drinking water by particle beam liquid chromatography\/mass spectometry","volume":"47","year":"1992","journal-title":"Int J Environ Anal Chem"},{"key":"key\n\t\t\t\t20170224185415_R53","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1126\/science.6740328","article-title":"4-Nonylphenol in sewage sludge: accumulation of toxic metabolites from nonionic surfactants","volume":"225","year":"1984","journal-title":"Science"},{"key":"key\n\t\t\t\t20170224185415_R54","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1126\/science.275.5298.405","article-title":"Potency of combined estrogenic pesticides","volume":"275","year":"1997","journal-title":"Science"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/biolreprod\/article-pdf\/64\/4\/1216\/10643774\/biolreprod1216.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T22:01:38Z","timestamp":1554328898000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-lookup\/doi\/10.1095\/biolreprod64.4.1216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,4,1]]},"references-count":54,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2001,4,1]]}},"URL":"https:\/\/doi.org\/10.1095\/biolreprod64.4.1216","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,4,1]]}}}